Abstract：
:1. In a double-blind placebo controlled four-way crossover study the effects and dose response relationships of xamoterol were studied in nine patients with angina and dyspnoea secondary to chronic left ventricular dysfunction. The duration of exercise on a treadmill and heart rate were measured at the end of each phase of the study at 2 h and 24 h after dosing. 2. Xamoterol at 200 mg and 400 mg orally once daily had no effect on the mean resting heart rate but there was a small (5.7 beats min-1) but significant reduction in resting heart rate on 600 mg at 2-2.5 h after dosing. All three doses of xamoterol significantly reduced the maximum exercise heart rate at 2-2.5 h after dosing. 3. Xamoterol at all three doses significantly increased exercise duration at 2-2.5 h after dosing but not at 24 h. 4. Mean plasma xamoterol concentration at both 2-2.5 h and 24 h after dosing were dose related. The EC50 for xamoterol is 33.5 ng ml-1, where EC50 is the effective plasma concentration required to produce 50% of the maximum effect on exercise heart rate.
journal_name
Br J Clin Pharmacoljournal_title
British journal of clinical pharmacologyauthors
Molajo AO,Bennett DH,Marlow HF,Snow HM,Bastain Wdoi
10.1111/j.1365-2125.1987.tb03183.xsubject
Has Abstractpub_date
1987-09-01 00:00:00pages
373-9issue
3eissn
0306-5251issn
1365-2125journal_volume
24pub_type
临床试验,杂志文章,随机对照试验abstract：AIMS:Probenecid influences transport processes of drugs at several sites in the body and decreases elimination of several quinolones. We sought to explore extent, time course, and mechanism of the interaction between ciprofloxacin and probenecid at renal and nonrenal sites. METHODS:A randomized, two-way crossover stud...
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journal_title：British journal of clinical pharmacology
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pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：British journal of clinical pharmacology
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更新日期：2020-08-01 00:00:00
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journal_title：British journal of clinical pharmacology
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更新日期：1987-01-01 00:00:00
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journal_title：British journal of clinical pharmacology
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1988-10-01 00:00:00
