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Lack of effect of cimetidine on the pharmacokinetics of bupivacaine in healthy subjects.

Abstract：

:1. The possibility of a pharmacokinetic interaction between the H2-receptor antagonist cimetidine and the long-acting local anaesthetic agent bupivacaine was studied in seven healthy, non-smoking volunteers. 2. The study consisted of two sessions at a minimum interval of 4 days. In a randomized, crossover fashion, the volunteers received bupivacaine HCl 1.4 mg kg-1 by i.m. injection at two occasions, once after no premedication, and once after two oral doses of 400 mg cimetidine. The concentrations of bupivacaine and its metabolites, 4'-hydroxybupivacaine and desbutylbupivacaine, were assayed by h.p.l.c., in serum up to 8 h and in urine fractions up to 24 h. 3. No influence of cimetidine on the pharmacokinetics of bupivacaine or on the serum cumulation of urinary recovery of its measured metabolites was detected. 4. These data suggest that cimetidine may be used safely as a premedication before local anaesthetic procedures with bupivacaine.

journal_name

Br J Clin Pharmacol

journal_title

British journal of clinical pharmacology

authors

Pihlajamäki KK,Lindberg RL,Jantunen ME

doi

10.1111/j.1365-2125.1988.tb03398.x

subject

Has Abstract

pub_date

1988-10-01 00:00:00

pages

403-6

issue

4

eissn

0306-5251

issn

1365-2125

journal_volume

26

pub_type

临床试验,杂志文章,随机对照试验

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