A comparison of the clinical and bronchodilating effects of plain and slow-release tablets of terbutaline at steady state.

abstract：:A double-blind controlled study comparing the effects of intravenous Diazemuls (0.15 mg kg-1) with midazolam (0.07 mg kg-1) in patients with normal liver function and with cirrhosis and portal hypertension is described. The clinical effect of the two drugs was assessed by serial tests of psychomotor function before an...

journal_title：British journal of clinical pharmacology

authors： Hamdy NA,Kennedy HJ,Nicholl J,Triger DR

更新日期：1986-12-01 00:00:00

abstract：AIMS:Previous isobolographic analysis revealed that coadministration of morphine and oxycodone produces synergistic antinociception in laboratory rodents. As both opioids can produce ventilatory depression, this study was designed to determine whether their ventilatory effects were synergistic when coadministered to he...

journal_title：British journal of clinical pharmacology

authors： Ladd LA,Kam PC,Williams DB,Wright AW,Smith MT,Mather LE

更新日期：2005-05-01 00:00:00

abstract：:1. We report a method for measuring the concentrations of haloperidol (HL) and its major active metabolite, reduced haloperidol (RHL), in human scalp hair. 2. Hair samples were obtained from 59 patients who had been taking HL at fixed daily doses for more than 4 months and whose compliance was good. A morning pre-dose...

journal_title：British journal of clinical pharmacology

authors： Matsuno H,Uematsu T,Nakashima M

更新日期：1990-02-01 00:00:00

abstract：AIMS:There are insufficient direct comparative studies addressing the impact of the type of statin on their respective efficacy in heart failure (HF). The aim of the current study was to compare the effects of lipophilic (atorvastatin) vs hydrophilic (rosuvastatin) on left ventricular function, inflammatory and fibrosi...

journal_title：British journal of clinical pharmacology

authors： El Said NO,El Wakeel LM,Khorshid H,Darweesh EAG,Ahmed MA

更新日期：2020-12-08 00:00:00

abstract：:1. Nine healthy volunteers received 10 mg nitrendipine or placebo orally in random order. 2. In the subsequent 5 h urinary sodium excretion was 20% higher after nitrendipine, without any significant difference between the volume of urine excreted after nitrendipine or placebo. Mean blood pressure fell by 5 mm Hg (P le...

journal_title：British journal of clinical pharmacology

authors： Forsyth DR,Roberts CJ

更新日期：1990-10-01 00:00:00

abstract：AIMS:Data regarding the cardiac toxicity of cabozantinib lacks. The aim of our study was to assess the risk of cabozantinib-related cardiotoxicity in mRCC patients. METHODS:We performed a multicentre prospective study on mRCC patients treated with cabozantinib between October 2016 and November 2017. Transthoracic echo...

journal_title：British journal of clinical pharmacology

authors： Iacovelli R,Ciccarese C,Fornarini G,Massari F,Bimbatti D,Mosillo C,Rebuzzi SE,Di Nunno V,Grassi M,Fantinel E,Ardizzoni A,Tortora G

更新日期：2019-06-01 00:00:00

abstract：:1 Seventeen men, aged 45-57 yr, with essential hypertension showed obvious and, in the standing position, dose-related reductions in blood pressure during treatment with oral labetalol with weekly dose increments. 2 Pulse rate changes were not related to dose but reduced compared with pre-treatment values. 3 No postur...

journal_title：British journal of clinical pharmacology

authors： Andersson O,Berglund G,Hansson L

更新日期：1976-08-01 00:00:00

abstract：:Small GTPases of the Rho family and their down-stream effectors Rho associated kinases (ROCKs) are the molecules that converge a spectrum of pathophysiological signals triggered by the diabetic milieu and represent promising molecular targets for nephroprotective treatment in diabetes. The review discusses recent stud...

journal_title：British journal of clinical pharmacology

authors： Komers R

更新日期：2013-10-01 00:00:00

abstract：AIMS:To assess whether frequency of placebo administration is associated with duodenal ulcer healing. METHODS:A systematic literature review of randomized clinical trials was undertaken. 79 of 80 trials that met the inclusion criteria. The pooled 4 week placebo healing rate of all duodenal ulcer trials that employed a...

journal_title：British journal of clinical pharmacology

authors： de Craen AJ,Moerman DE,Heisterkamp SH,Tytgat GN,Tijssen JG,Kleijnen J

更新日期：1999-12-01 00:00:00

abstract：AIMS:To investigate impacts of withdrawal and regulatory advice regarding cyclooxygenase-2 (COX-2) inhibitors on UK population rates of gastrointestinal haemorrhage and acute myocardial infarction (MI). METHODS:Ecological time series study of prescribing, mortality and hospital admission trends in people aged > or = 5...

journal_title：British journal of clinical pharmacology

authors： Wheeler BW,Metcalfe C,Gunnell D,Stephens P,Martin RM

更新日期：2009-11-01 00:00:00

abstract：:1. The phenotyping parameters for dextromethorphan and mephenytoin were assessed in 48 normal male volunteers following administration of each metabolic probe drug on separate occasions and together according to a randomized 3-way crossover design. 2. Neither the urinary S-/R-mephenytoin ratio nor the dextromethorphan...

journal_title：British journal of clinical pharmacology

authors： Guttendorf RJ,Britto M,Blouin RA,Foster TS,John W,Pittman KA,Wedlund PJ

更新日期：1990-04-01 00:00:00

abstract：:Voriconazole is an antifungal metabolised by CYP2C19 enzyme, which can be inhibited by proton-pump inhibitors (PPIs). A prospective observational study was carried out to determine the influence of PPIs on voriconazole pharmacokinetic. The 78 patients included were divided into 4 groups: omeprazole (n = 32), pantopraz...

journal_title：British journal of clinical pharmacology

authors： Blanco Dorado S,Maroñas Amigo O,Latorre-Pellicer A,Rodríguez Jato MT,López-Vizcaíno A,Gómez Márquez A,Bardán García B,Belles Medall D,Barbeito Castiñeiras G,Pérez Del Molino Bernal ML,Campos-Toimil M,Otero Espinar F,Blanco Hortas

更新日期：2020-08-01 00:00:00

abstract：:Exposure-response (ER) analysis has emerged as an important tool to interpret QT data from thorough QT (TQT) studies and allows the prediction of effects in the targeted patient population. Recently, ER analysis has also been applied to data from early clinical pharmacology studies, such as single and multiple ascendi...

journal_title：British journal of clinical pharmacology

authors： Darpo B,Garnett C

更新日期：2013-11-01 00:00:00

abstract：AIMS:5-HT1B-receptor mediated vasoconstriction of cranial arteries is a potential mechanism by which 5-HT1B/1D-receptor agonists such as sumatriptan produce their antimigraine effects. 5-HT1B-receptors exist in other blood vessels which may give rise to unwanted vascular effects. Therefore we examined the distribution ...

journal_title：British journal of clinical pharmacology

authors： Razzaque Z,Pickard JD,Ma QP,Shaw D,Morrison K,Wang T,Longmore J

更新日期：2002-03-01 00:00:00

abstract：:The classical taxanes (paclitaxel, docetaxel), the newer taxane cabazitaxel and the nanoparticle-bound nab-paclitaxel are among the most widely used anticancer drugs. Still, the optimal use and the value of pharmacological personalization of the taxanes is still controversial. We give an overview on the pharmacologica...

journal_title：British journal of clinical pharmacology

authors： Muth M,Ojara FW,Kloft C,Joerger M

更新日期：2020-11-28 00:00:00

abstract：WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT:The dominant health economic units upon which new treatment funding decisions are made are the incremental cost per life year gained (LYG) or the cost per quality-adjusted life year (QALY) gained. Neither of these units modifies the amount of health gained, by the amount of heal...

journal_title：British journal of clinical pharmacology

authors： Camidge DR,Oliver JJ,Skinner C,Attwood B,Nussey F,Jodrell D,Webb DJ

更新日期：2008-02-01 00:00:00

abstract：:1 Improvement in physical performance, based on exercise tolerance, self-assessed work and physician-rated functional capacities, is proposed as a measure of efficacy of anti-anginal therapy in the rehabilitation of the cardiac patient. 2 Improved physical performance parallels changes in frequency of anginal attacks ...

journal_title：British journal of clinical pharmacology

authors： Ling AS,Groel JT

更新日期：1979-01-01 00:00:00

abstract：:1 The effect of RX 72601, neostigmine plus atropine, or saline on neuromuscular blockade with (+)-tubocurarine was studied in a double blind trial in four healthy male volunteers. 2 The methods used to assess neuromuscular function were voluntary grip strength and indirectly evoked muscle twitches. The muscarinic acti...

journal_title：British journal of clinical pharmacology

authors： Dettmar PW,Metcalf G,Smith MH,Gillett GB,Hedges A,Richens A

更新日期：1974-06-01 00:00:00

abstract：:1 In a double-blind cross-over study, nine healthy male students received placebo, brompheniramine 12 mg), carbinoxamine (12 mg), clemastine (1 mg), and phenylpropanolamine (50 mg) orally. Three doses of each drug were given: at 08.30 h and 21.00 h on the first day of treatment and at 08.30 h on the following day. 2 P...

journal_title：British journal of clinical pharmacology

authors： Seppälä T,Nuotto E,Korttila K

更新日期：1981-08-01 00:00:00

abstract：:1. The antisecretory responses to pH-feedback controlled (maximum dose 800 mg 24 h-1) and fixed-dose (0.25 mg kg-1 h-1) continuous infusions of ranitidine were compared in a randomised, placebo-controlled, cross-over study in 10 healthy male volunteers. 2. To assess tolerance during repeated dosing with ranitidine, th...

journal_title：British journal of clinical pharmacology

authors： Wilder-Smith CH,Halter F,Häcki W,Merki HS

更新日期：1992-05-01 00:00:00

abstract：:1. The in vitro metabolism of omeprazole was studied in human liver microsomes in order to define the secondary metabolic pathways and identify the cytochrome P450 (CYP) isoforms responsible for the formation of the secondary metabolites of omeprazole. 2. The major secondary omeprazole metabolite was the hydroxysulpho...

journal_title：British journal of clinical pharmacology

authors： Andersson T,Miners JO,Veronese ME,Birkett DJ

更新日期：1994-06-01 00:00:00

abstract：:1. Effects of 3 h infusions of adrenaline (0.4 nmol kg-1 min-1) or placebo and of mental stress evoked by a colour word test (CWT) on adrenergic receptor function were investigated in healthy men. Responses of heart rate, blood pressure, plasma catecholamines, plasma cyclic AMP and plasma free fatty acids (FFA) were e...

journal_title：British journal of clinical pharmacology

authors： Larsson PT,Martinsson A,Olsson G,Hjemdahl P

更新日期：1989-12-01 00:00:00

abstract：AIMS:To explore longitudinal changes in the number and type of medicines used among older people who experience polypharmacy. METHODS:We used pharmaceutical claims for a 10% sample of Australian Pharmaceutical Benefits Scheme beneficiaries to identify people aged 70 years and older who were exposed to 5 or more medici...

journal_title：British journal of clinical pharmacology

authors： Falster MO,Charrier R,Pearson SA,Buckley NA,Daniels B

更新日期：2020-07-31 00:00:00

abstract：AIMS:To evaluate the comparative efficacy (50% reduction in seizure frequency) and tolerability (premature withdrawal due to adverse events) of anti-epileptic drugs (AEDs) for refractory epilepsy. METHODS:We searched Cochrane Central Register of Controlled Trials (Cochrane Library 2009, issue 2) including Epilepsy Gro...

journal_title：British journal of clinical pharmacology

authors： Bodalia PN,Grosso AM,Sofat R,Macallister RJ,Smeeth L,Dhillon S,Casas JP,Wonderling D,Hingorani AD

更新日期：2013-11-01 00:00:00

abstract：:1. We have studied the effects of age, sex and the oral contraceptive pill on platelet fibrinogen 'receptor' density (Bmax) and affinity (Kd). 2. [125I]-fibrinogen binding to gel-filtered platelets was assessed after stimulation with adenosine 5-diphosphate (ADP) and thrombin in 60 normal subjects; 37 females and 23 m...

journal_title：British journal of clinical pharmacology

authors： Cahill M,Mistry R,Chapman C,Wood JK,Barnett DB

更新日期：1992-01-01 00:00:00

abstract：:1 A new osmotic pressure mediated delivery system for metoprolol (Lopresor Oros) has been evaluated by measuring the haemodynamic effects and pharmacokinetics after single and multiple oral dosing in young healthy volunteers. 2 Similar studies have been carried out in the same group using equivalent single and multipl...

journal_title：British journal of clinical pharmacology

authors： Kendall MJ,Jack DB,Woods KL,Laugher SJ,Quarterman CP,John VA

更新日期：1982-03-01 00:00:00

abstract：AIMS:To determine whether repeated once daily administration of grapefruit juice altered the pharmacokinetics or pharmacodynamics of the calcium antagonist amlodipine. METHOD:S The effects of grapefruit juice on the pharmacokinetics and pharmacodynamics of oral and intravenous amlodipine were assessed in 20 healthy me...

journal_title：British journal of clinical pharmacology

authors： Vincent J,Harris SI,Foulds G,Dogolo LC,Willavize S,Friedman HL

更新日期：2000-11-01 00:00:00

abstract：:A method is described for the simultaneous determination of the carboxylic acid and N-acetyl-derivatives of primaquine, in plasma and urine. After oral administration of 45 mg primaquine, to five healthy volunteers, absorption was rapid, with peak primaquine levels of 153.3 +/- 23.5 ng/ml at 3 +/- 1 h, followed by an ...

journal_title：British journal of clinical pharmacology

authors： Mihaly GW,Ward SA,Edwards G,Orme ML,Breckenridge AM

更新日期：1984-04-01 00:00:00

abstract：:1. The conversion of haloperidol (HAL) to reduced haloperidol (RHAL) and then back to HAL has been established in vivo and observed in psychiatric patients. The reduction of HAL to RHAL is known to be catalysed by a ketone reductase, while the nature of oxidation back to HAL is the subject of the present study. 2. We ...

journal_title：British journal of clinical pharmacology

authors： Tyndale RF,Kalow W,Inaba T

更新日期：1991-06-01 00:00:00

abstract：:1 The protein binding of seven non-steroidal anti-inflammatory drugs (indomethacin, tolmetin, salicylic acid, ibuprofen, flurbiprofen, naproxen and GP53,633) and warfarin was investigated by equilibrium dialysis in simultaneous samples of synovial fluid and plasma from 12 arthritic patients. 2 The protein binding of a...

journal_title：British journal of clinical pharmacology

authors： Wanwimolruk S,Brooks PM,Birkett DJ

更新日期：1983-01-01 00:00:00