Protein binding of non-steroidal anti-inflammatory drugs in plasma and synovial fluid of arthritic patients.

abstract：AIMS:To examine the feasibility of using the human iris in vivo for the assessment of the interaction between tyramine and monoamine oxidase (MAO) inhibitors. To examine the relative roles of the two forms of MAO in terminating the response to sympathomimetic amines in the iris, by comparing the effects of single oral ...

journal_title：British journal of clinical pharmacology

authors： Bitsios P,Langley RW,Tavernor S,Pyykkö K,Scheinin M,Szabadi E,Bradshaw CM

更新日期：1998-06-01 00:00:00

abstract：:1 Isoxicam was found to inhibit monocyte and neutrophil cell chemotaxis at therapeutic concentrations. 2 The effect was observed after in vitro incubation of normal cells and in vivo in patients with rheumatoid arthritis. 3 Compared to other NSAIDs studied in our laboratory, isoxicam was shown to have a broader spectr...

journal_title：British journal of clinical pharmacology

authors： Martinez JG,Murakami SI,Scheinberg MA

更新日期：1986-01-01 00:00:00

abstract：AIMS:Adrenomedullin (ADM) is an important regulator of endothelial barrier function and vascular tone, and may represent a novel treatment target in sepsis. The non-neutralizing ADM antibody adrecizumab has shown promising results in preclinical sepsis models. In the present study, we investigated the safety, tolerabil...

journal_title：British journal of clinical pharmacology

authors： Geven C,van Lier D,Blet A,Peelen R,Ten Elzen B,Mebazaa A,Kox M,Pickkers P

更新日期：2018-09-01 00:00:00

abstract：:1. The effects of heart failure due to chronic myocardial infarction on the responsiveness to injected angiotensin I and ACE inhibition by intravenous cilazapril (1 mg kg-1) were evaluated. 2. For this purpose one group of 17 rats with a 4-week old myocardial infarction was compared with a group of 10 sham operated ra...

journal_title：British journal of clinical pharmacology

authors： Clozel JP

更新日期：1989-01-01 00:00:00

abstract：:A 12-week double-blind study was performed to compare the safety and efficacy of doxazosin, prazosin and placebo in 172 patients with essential hypertension. According to response, patients received doxazosin 1-16 mg once daily, prazosin 0.5-10 mg twice daily, or placebo. Mean final daily doses were doxazosin 11.3 mg ...

journal_title：British journal of clinical pharmacology

authors： Torvik D,Madsbu HP

更新日期：1986-01-01 00:00:00

abstract：:1. The effects of selective beta-adrenoceptor partial agonist activity on plasma creatine kinase (CK) and skeletal muscle symptoms were studied in normal volunteers. 2. A drug with beta 1-selective partial agonist activity (xamoterol) and one with partial agonist activity acting mainly through beta 2-adrenoceptors (pi...

journal_title：British journal of clinical pharmacology

authors： Tomlinson B,Cruickshank JM,Hayes Y,Renondin JC,Lui JB,Graham BR,Jones A,Lewis AD,Prichard BN

更新日期：1990-11-01 00:00:00

abstract：:The effects of delta-9-tetrahydrocannabinol (0.5 and 1 mg i.v.) on gastric emptying of liquid were investigated in seven normal volunteers and compared with placebo. Despite significant change in pulse rate and psychological parameters consistent with cannabis activity there was no significant effect on the pattern of...

journal_title：British journal of clinical pharmacology

authors： Bateman DN

更新日期：1983-06-01 00:00:00

abstract：:The acute peripheral vascular and diuretic effects of intravenous frusemide 10 mg and 20 mg were compared with those of bumetanide 250 micrograms and 500 micrograms in a group of 10 salt depleted volunteers. Significant reductions in forearm blood flow (FBF) were observed after frusemide 10 mg (-0.77 ml 100 ml-1 min-1...

journal_title：British journal of clinical pharmacology

authors： Johnston GD,Nicholls DP,Kondowe GB,Finch MB

更新日期：1986-04-01 00:00:00

abstract：:1. The systemic effects of inhaled fluticasone propionate (FP), administered via Diskhaler, on the hypothalamo-pituitary-adrenal (HPA) axis were assessed primarily by measuring plasma cortisol at frequent intervals for 20 h after drug administration. 2. FP showed a dose-related suppression of plasma cortisol measured ...

journal_title：British journal of clinical pharmacology

authors： Grahnén A,Eckernäs SA,Brundin RM,Ling-Andersson A

更新日期：1994-12-01 00:00:00

abstract：:The excretion of diazepam, N-desmethyldiazepam, temazepam and oxazepam in breast milk was studied during withdrawal of a 22-year-old patient from combined high dose diazepam and oxazepam therapy. Concentrations of these benzodiazepines in plasma from both the woman and her nursing infant (1 year old) were also documen...

journal_title：British journal of clinical pharmacology

authors： Dusci LJ,Good SM,Hall RW,Ilett KF

更新日期：1990-01-01 00:00:00

abstract：AIMS:We investigated whether the deterioration in asthma control reported following cessation of theophylline was due to tolerance to theophylline. METHODS:Eighteen subjects with mild stable asthma were given oral theophylline 10 mg kg(-1) day(-1) or placebo for 2 weeks in a double-blind crossover study. FEV1 and PD20...

journal_title：British journal of clinical pharmacology

authors： Bennett JA,Thompson Coon J,Pavord ID,Wilding PJ,Tattersfield AE

更新日期：1998-04-01 00:00:00

abstract：:1. The pharmacokinetics of recombinant erythropoietin, r-Epo, were evaluated after intravenous and subcutaneous administration of 50 u kg-1 to six healthy male volunteers. 2. The calculated mean values (+/- s.d.) for volume of distribution at steady state and clearance after an i.v. dose were 76 (+/- 33) ml kg-1 and 1...

journal_title：British journal of clinical pharmacology

authors： Salmonson T,Danielson BG,Wikström B

更新日期：1990-06-01 00:00:00

abstract：:1 Measurements have been made of steady state serum phenytoin concentration, serum half-life of (14)C-labelled phenytoin, and the urinary ratio of the major metabolite of phenytoin to the unchanged drug (p-HPPH: DPH ratio) in epileptic patients on and off sulthiame therapy. 2 Starting sulthiame treatment produced an i...

journal_title：British journal of clinical pharmacology

authors： Houghton GW,Richens A

更新日期：1974-02-01 00:00:00

abstract：:The effects on carotid artery blood flow of atenolol (a selective beta 1-adrenoceptor antagonist) and xamoterol (a beta 1-adrenoceptor partial agonist with 43% agonist activity) were measured using a Doppler technique in eight healthy volunteers. Atenolol produced a decrease in blood pressure and blood velocity flow, ...

journal_title：British journal of clinical pharmacology

authors： Fitzgerald DE,Harry JD

更新日期：1989-01-01 00:00:00

abstract：AIMS:The inhaled allergen challenge model has been used previously to investigate the effects of novel anti-inflammatory drugs in inhaled corticosteroid (ICS)-naïve asthmatics. The aim of this study was to characterize high- and low-dose allergen challenges in asthmatic patients using ICS. METHODS:Twenty-eight asthmat...

journal_title：British journal of clinical pharmacology

authors： Lee WY,Southworth T,Booth S,Singh D

更新日期：2015-03-01 00:00:00

abstract：:This study investigated the effects of placebo, 1 mg, 3 mg, 10 mg and 30 mg ritanserin and 10 mg diazepam on human sleep. Twelve normal volunteers participated in this randomized, double-blind, placebo-controlled cross-over sleep study. A clear dose-response relationship was found for ritanserin with higher doses evok...

journal_title：British journal of clinical pharmacology

authors： Idzikowski C,Mills FJ,James RJ

更新日期：1991-02-01 00:00:00

abstract：AIMS:The role of CYP pharmacogenetics in the bioactivation of cyclophosphamide is still controversial. Recent clinical studies have suggested a role for either CYP2C19 or CYP2B6. The aim of this study was to clarify the role of these pharmacogenes. METHODS:We used a combined in vitro-in vivo approach to determine the ...

journal_title：British journal of clinical pharmacology

authors： Helsby NA,Hui CY,Goldthorpe MA,Coller JK,Soh MC,Gow PJ,De Zoysa JZ,Tingle MD

更新日期：2010-12-01 00:00:00

abstract：AIMS:To assess whether hospitalization may assist in correcting errors in anticoagulant therapy among patients with atrial fibrillation (AF). METHODS:Our cohort included patients admitted to our institution with a history of AF between 2016 and 2018. We categorized patient's treatment upon admission and discharge as l...

journal_title：British journal of clinical pharmacology

authors： Angel Y,Zeltser D,Berliner S,Ingbir M,Shapira I,Shenhar-Tsarfaty S,Rogowski O

更新日期：2019-12-01 00:00:00

abstract：AIMS:To investigate the impact of the specific red blood cell binding on the pharmacokinetics and pharmacodynamics of the nucleoside transport inhibitor draflazine after i.v. administration at various infusion rates. It was also aimed to relate the red blood cell (RBC) occupancy of draflazine to the ex vivo measured ad...

journal_title：British journal of clinical pharmacology

authors： Snoeck E,Piotrovskij V,Jacqmin P,Van Peer A,Danhof M,Ver Donck K,Woestenborghs R,Van Belle H,Van Bortel L,Van Gool R,Dupont AG,Heykants J

更新日期：1997-06-01 00:00:00

abstract：:The effects of bopindolol, a new beta-adrenoceptor blocker, on the exercise tolerance of 12 in-patients, mean age 57 (5 years), with stable angina pectoris and documented coronary artery disease were evaluated. All patients received on 4 different days a single oral dose of bopindolol 0.5 mg, bopindolol 1.0 mg, bopind...

journal_title：British journal of clinical pharmacology

authors： Carboni GP,Scardovi AB,D'Ermo M,Prati PL

更新日期：1991-12-01 00:00:00

abstract：AIMS:Drug-induced liver injury (DILI) is rare compared to the worldwide frequent acute or chronic liver diseases. Therefore, patients included in series of suspected DILI are at high risk of not having DILI, whereby alternative causes may confound the DILI diagnosis. The aim of this review is to evaluate published case...

journal_title：British journal of clinical pharmacology

authors： Teschke R,Danan G

更新日期：2018-07-01 00:00:00

abstract：:1. We have investigated the effect of repeated s.c. Org 10172 (a low molecular weight heparinoid; Lomoparan) treatment (1000 anti-Xa units twice daily for 5 days) on antipyrine (500 mg orally) metabolism, and the effect of enzyme induction by pentobarbitone (100 mg for 12 days) on the pharmacokinetics and pharmacodyna...

journal_title：British journal of clinical pharmacology

authors： De Boer A,Stiekema JC,Danhof M,Breimer DD

更新日期：1991-07-01 00:00:00

abstract：WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT:Rotigotine transdermal patch is a new non-ergolinic dopamine agonist developed for the treatment of Parkinson's disease and restless legs syndrome. Peripheral dopaminergic side-effects of dopamine agonists such as nausea and vomiting can be prevented by the antiemetic agent domp...

journal_title：British journal of clinical pharmacology

authors： Braun M,Cawello W,Boekens H,Horstmann R

更新日期：2009-02-01 00:00:00

abstract：:1 Seventeen men, aged 45-57 yr, with essential hypertension showed obvious and, in the standing position, dose-related reductions in blood pressure during treatment with oral labetalol with weekly dose increments. 2 Pulse rate changes were not related to dose but reduced compared with pre-treatment values. 3 No postur...

journal_title：British journal of clinical pharmacology

authors： Andersson O,Berglund G,Hansson L

更新日期：1976-08-01 00:00:00

abstract：AIM:Lamivudine is used as first line therapy in HIV-infected children. Yet, like many other paediatric drugs, its dose rationale has been based on limited clinical data, without thorough understanding of the effects of growth on drug disposition. Here we use lamivudine to show how a comprehensive population pharmacokin...

journal_title：British journal of clinical pharmacology

authors： Piana C,Zhao W,Adkison K,Burger D,Jacqz-Aigrain E,Danhof M,Della Pasqua O

更新日期：2014-05-01 00:00:00

abstract：AIMS:Paracetamol is frequently involved in intended self-poisoning, and concomitant overdosing of other drugs is commonly reported. The purpose of the study was to investigate further concomitant drug overdose in patients with paracetamol poisoning and to evaluate its effects on the outcome of the paracetamol intoxicat...

journal_title：British journal of clinical pharmacology

authors： Schmidt LE,Dalhoff K

更新日期：2002-05-01 00:00:00

abstract：AIM:Experimental pain models may help to evaluate the mechanisms of analgesics and target the clinical indications for their use. This review, the second in a series of two, addresses how the efficacy of non-opioid analgesics have been assessed in human volunteers using experimental pain models. METHODS:A literature s...

journal_title：British journal of clinical pharmacology

authors： Staahl C,Olesen AE,Andresen T,Arendt-Nielsen L,Drewes AM

更新日期：2009-09-01 00:00:00

abstract：AIMS:Pupillography is a noninvasive and cost-effective method to determine autonomic nerve activity. Genetic variants in cytochrome P450 (CYP), dopamine receptor (DRD2, DRD3), serotonin receptor (HTR2A, HTR2C) and ATP-binding cassette subfamily B (ABCB1) genes, among others, were previously associated with the pharmaco...

journal_title：British journal of clinical pharmacology

authors： Koller D,Saiz-Rodríguez M,Zubiaur P,Ochoa D,Almenara S,Román M,Romero-Palacián D,de Miguel-Cáceres A,Martín S,Navares-Gómez M,Mejía G,Wojnicz A,Abad-Santos F

更新日期：2020-10-01 00:00:00

abstract：:1. Confusion between the criteria for defining and diagnosing hypertension may have misled the search for the causes of hypertension. 2. The systematic approach of molecular genetics appears to offer the best chance of explaining hypertension, but the attractions are partly offset by the large numbers required, and un...

journal_title：British journal of clinical pharmacology

authors： Brown MJ

更新日期：1996-07-01 00:00:00

abstract：AIMS:Previous isobolographic analysis revealed that coadministration of morphine and oxycodone produces synergistic antinociception in laboratory rodents. As both opioids can produce ventilatory depression, this study was designed to determine whether their ventilatory effects were synergistic when coadministered to he...

journal_title：British journal of clinical pharmacology

authors： Ladd LA,Kam PC,Williams DB,Wright AW,Smith MT,Mather LE

更新日期：2005-05-01 00:00:00