The influence of Org 10172, a low molecular weight heparinoid, on antipyrine metabolism and the effect of enzyme induction on the response to Org 10172.

abstract：:Scientific advice (SA) is an important tool offered by regulators to help developers generate robust evidence on a medicine's benefits and risks. Drawing on accumulated experience and looking at the SA provided by the European Medicines Agency in 2018 to advanced therapy medicinal products originally developed by publ...

journal_title：British journal of clinical pharmacology

authors： Tavridou A,Rogers D,Bonelli M,Schiel A,Hidalgo-Simon A

更新日期：2020-11-25 00:00:00

abstract：AIM:To use non-linear mixed effects modelling and simulation techniques to predict whether PF-04878691, a toll-like receptor 7 (TLR7) agonist, would produce sufficient antiviral efficacy while maintaining an acceptable side effect profile in a 'proof of concept' (POC) study in chronic hepatitis C (HCV) patients. METHO...

journal_title：British journal of clinical pharmacology

authors： Jones HM,Chan PL,van der Graaf PH,Webster R

更新日期：2012-01-01 00:00:00

abstract：:In a double-blind trial the effects on ventilatory function (FEV1), heart rate and blood pressure of oral pirbuterol and oral salbutamol in various single doses were studied in ten patients with chronic asthma. Pirbuterol (15 mg) and salbutamol (4 mg) produced equal peak levels of bronchodilatation. There was no signi...

journal_title：British journal of clinical pharmacology

authors： Willey RF,Grant IW,Pocock SJ

更新日期：1976-08-01 00:00:00

abstract：AIMS:Hypertension is a common comorbidity of patients with COVID-19, SARS or HIV infection. Such patients are often concomitantly treated with antiviral and antihypertensive agents, including ritonavir and nifedipine. Since ritonavir is a strong inhibitor of CYP3A and nifedipine is mainly metabolized via CYP3A, the com...

journal_title：British journal of clinical pharmacology

authors： Niu W,Li S,Jin S,Lin X,Zhang M,Cai W,Jiao Z,Xiang X

更新日期：2020-12-02 00:00:00

abstract：AIMS:In the Swiss heroin substitution trials, patients are treated with self-administered diacetylmorphine (heroin). Intravenous administration is not possible in patients that have venosclerosis. Earlier studies have demonstrated that oral diacetylmorphine may be used, although it is completely converted to morphine p...

journal_title：British journal of clinical pharmacology

authors： Halbsguth U,Rentsch KM,Eich-Höchli D,Diterich I,Fattinger K

更新日期：2008-12-01 00:00:00

abstract：:1. The inhibitory effect of sufotidine, a new histamine H2-receptor antagonist, on gastric secretion of acid and pepsin was studied in six healthy male volunteers. This was a three-way, cross-over, randomized, double-blind study. On each of 3 study days, the drug in a dose of 600 mg, or placebo, was administered eithe...

journal_title：British journal of clinical pharmacology

authors： Johnston DA,Wormsley KG

更新日期：1989-10-01 00:00:00

abstract：:1. In a double-blind placebo controlled four-way crossover study the effects and dose response relationships of xamoterol were studied in nine patients with angina and dyspnoea secondary to chronic left ventricular dysfunction. The duration of exercise on a treadmill and heart rate were measured at the end of each pha...

journal_title：British journal of clinical pharmacology

authors： Molajo AO,Bennett DH,Marlow HF,Snow HM,Bastain W

更新日期：1987-09-01 00:00:00

abstract：:1. A new method for perfusing a 10 cm segment of jejunum in humans has been used in seven subjects to study the effect of the amino acid L-leucine (40 mM) on the intestinal absorption of levodopa (2.5 mM). The tube contains six channels and has two inflatable balloons, which enable a perfusion of a closed and defined ...

journal_title：British journal of clinical pharmacology

authors： Lennernäs H,Nilsson D,Aquilonius SM,Ahrenstedt O,Knutson L,Paalzow LK

更新日期：1993-03-01 00:00:00

abstract：AIMS:We investigated whether the deterioration in asthma control reported following cessation of theophylline was due to tolerance to theophylline. METHODS:Eighteen subjects with mild stable asthma were given oral theophylline 10 mg kg(-1) day(-1) or placebo for 2 weeks in a double-blind crossover study. FEV1 and PD20...

journal_title：British journal of clinical pharmacology

authors： Bennett JA,Thompson Coon J,Pavord ID,Wilding PJ,Tattersfield AE

更新日期：1998-04-01 00:00:00

abstract：:1. Compliance with digoxin therapy has been assessed in a group of fifty patients receiving the drug in general practice but not attending hospital. 2. Compliance was estimated by comparing plasma digoxin concentrations before and after a 10 day period of measured digoxin consumption and by tablet counting. 3. Twelve ...

journal_title：British journal of clinical pharmacology

authors： Johnston GD,McDevitt DG

更新日期：1978-10-01 00:00:00

abstract：AIM:This study aims to investigate the clinical and demographic factors influencing gentamicin pharmacokinetics in a large cohort of unselected premature and term newborns and to evaluate optimal regimens in this population. METHODS:All gentamicin concentration data, along with clinical and demographic characteristics...

journal_title：British journal of clinical pharmacology

authors： Fuchs A,Guidi M,Giannoni E,Werner D,Buclin T,Widmer N,Csajka C

更新日期：2014-11-01 00:00:00

abstract：:Both the acute blood pressure lowering and renal effects of the calcium antagonist nicardipine and those after 1 week's treatment were investigated in 10 normotensive volunteers and in 10 patients with mild to moderate essential hypertension. After 1 week of placebo, nicardipine was administered orally for 1 week (20 ...

journal_title：British journal of clinical pharmacology

authors： van Schaik BA,van Nistelrooy AE,Geyskes GG

更新日期：1984-07-01 00:00:00

abstract：:1. The possibility of a pharmacokinetic interaction between the H2-receptor antagonist cimetidine and the long-acting local anaesthetic agent bupivacaine was studied in seven healthy, non-smoking volunteers. 2. The study consisted of two sessions at a minimum interval of 4 days. In a randomized, crossover fashion, the...

journal_title：British journal of clinical pharmacology

authors： Pihlajamäki KK,Lindberg RL,Jantunen ME

更新日期：1988-10-01 00:00:00

abstract：:Metabolomics is recognized as a powerful top-down system biological approach to understand genetic-environment-health paradigms paving new avenues to identify clinically relevant biomarkers. It is nowadays commonly used in clinical applications shedding new light on physiological regulatory processes of complex mammal...

journal_title：British journal of clinical pharmacology

authors： Collino S,Martin FP,Rezzi S

更新日期：2013-03-01 00:00:00

abstract：:Vertigo is associated with a wide range of vestibular pathologies. It increasingly affects the elderly, with a high cost to society. Solutions include vestibular suppressants and vestibular rehabilitation, which form the mainstay of therapy. Antihistamines represent the largest class of agents used to combat vestibula...

journal_title：British journal of clinical pharmacology

authors： Dyhrfjeld-Johnsen J,Attali P

更新日期：2019-10-01 00:00:00

abstract：:We studied the effect of 3 weeks' treatment with 4 x 200 mg of sulphinpyrazone daily (six healthy volunteers) on proaggregatory thromboxane A2 (TxA2) and antiaggregatory prostacyclin (PGI2). Platelet TxA2 production was evaluated by measuring its stable metabolite, immunoreactive thromboxane B2, from serum, and vessel...

journal_title：British journal of clinical pharmacology

authors： Viinikka L,Toivanen J,Ylikorkala O

更新日期：1982-09-01 00:00:00

abstract：AIMS:To assess the prevalence of potentially inappropriate medications (PIMs) use in a population of community-based multicompartment compliance aid (MCA) users in north-east Scotland. METHODS:Data for MCAs dispensed by 48 of the 50 community pharmacies in Aberdeen City between 1st June to 31st October 2014, together ...

journal_title：British journal of clinical pharmacology

authors： Counter D,Stewart D,MacLeod J,McLay JS

更新日期：2017-07-01 00:00:00

abstract：:1. The three dimensional requirements for inhibition of ACE (angiotensin converting enzyme) were investigated in order to facilitate design of a more potent and selective antihypertensive agent. 2. All compounds designed possessed a bicyclic unit incorporating carboxylate and amidic carbonyl groups together with a thi...

journal_title：British journal of clinical pharmacology

authors： Attwood MR

更新日期：1989-01-01 00:00:00

abstract：AIM:Our aim was to compare the practicability of six different potentially inappropriate medication (PIM) criteria in geriatric outpatients with polypharmacy. METHODS:We analysed baseline data from the Medication Safety Review Clinic in Taiwanese Elders (MSRC-Taiwan) study. The prevalence and correlates of PIMs were d...

journal_title：British journal of clinical pharmacology

authors： Chang CB,Chen JH,Wen CJ,Kuo HK,Lu IS,Chiu LS,Wu SC,Chan DC

更新日期：2011-09-01 00:00:00

abstract：AIMS:To investigate the pharmacokinetics of enterally administered cisapride suspension in young infants being treated for gastro-oesophageal reflux disease. METHODS:Plasma cisapride concentrations in 49 subjects (weight: 825-5010 g; n=108 samples, median two per patient; concentration: 14.8-170 ng ml-1 ) were fitted ...

journal_title：British journal of clinical pharmacology

authors： Preechagoon Y,Charles B,Piotrovskij V,Donovan T,Van Peer A

更新日期：1999-11-01 00:00:00

abstract：AIM:Omalizumab, a humanized IgG monoclonal antibody that binds to human immunoglobulin E (IgE), interrupts the allergic cascade in asthmatic patients. The aim was to compare simultaneously drug exposure and IgE biomarker responses in Japanese and White patient populations. METHODS:An instantaneous equilibrium drug-lig...

journal_title：British journal of clinical pharmacology

authors： Hayashi N,Tsukamoto Y,Sallas WM,Lowe PJ

更新日期：2007-05-01 00:00:00

abstract：:1 We have given fifteen healthy volunteers single doses of racemic (+/-)-propranolol orally (40 mg) and intravenously (5-10 mg) to find out how large the variation was of the ratio between (-)- and (+)-propranolol plasma levels in relation to that of total levels of propranolol and 4-hydroxypropranolol. 2 Total propra...

journal_title：British journal of clinical pharmacology

authors： Von Bahr C,Hermansson J,Tawara K

更新日期：1982-07-01 00:00:00

abstract：WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT:Venous thromboembolism is a frequent complication in critically ill patients that has a negative impact on patient outcomes. Critically ill patients have significantly lower plasma anti-factor-Xa activity levels compared with control patients after administration of subcutaneous...

journal_title：British journal of clinical pharmacology

authors： Gouya G,Palkovits S,Kapiotis S,Madl C,Locker G,Stella A,Wolzt M,Heinz G

更新日期：2012-11-01 00:00:00

abstract：:1. alpha-Bromoisovalerylurea (BIU) is a racemic drug that is metabolized by glutathione conjugation. The urinary excretion of the separate diastereomeric mercapturates formed from (S)- and (R)-BIU in healthy young human volunteers was investigated. 2. A pronounced stereoselectivity was observed: the mercapturate forme...

journal_title：British journal of clinical pharmacology

authors： te Koppele JM,Schipper C,Breimer DD,Mulder GJ

更新日期：1989-08-01 00:00:00

abstract：AIMS:SAR247799 is a selective G-protein-biased sphingosine-1 phosphate receptor-1 (S1P1 ) agonist with potential to restore endothelial function in vascular pathologies. SAR247799, a first-in-class molecule differentiated from previous S1P1 -desensitizing molecules developed for multiple sclerosis, can activate S1P1 wi...

journal_title：British journal of clinical pharmacology

authors： Bergougnan L,Armani S,Golor G,Tardat A,Vitse O,Hurbin F,Scemama M,Poitiers F,Radzik D,Gaudin C,Hovsepian L,Muslin AJ,Kirkesseli S,Deutsch P,Parkar AA

更新日期：2020-06-10 00:00:00

abstract：:It is recognised that randomised controlled trials are not feasible for capturing rare adverse events. There is an increasing trend towards observational research methodologies using large population-based health databases. These databases offer more scope for adequate sample sizes, allowing for comprehensive patient ...

journal_title：British journal of clinical pharmacology

authors： Chan EW,Liu KQ,Chui CS,Sing CW,Wong LY,Wong IC

更新日期：2015-10-01 00:00:00

abstract：AIMS:A recent case report had suggested a citrus soft drink (Sun Drop) may have caused clinically relevant elevations in ciclosporin levels through a grapefruit juice-like mechanism via inactivation of intestinal cytochrome P450 3A4 (CYP3A4). This study was conducted to investigate the effect of grapefruit juice and ci...

journal_title：British journal of clinical pharmacology

authors： Schwarz UI,Johnston PE,Bailey DG,Kim RB,Mayo G,Milstone A

更新日期：2006-10-01 00:00:00

abstract：AIMS:To assess whether hepatic impairment influences the pharmacokinetics of ziprasidone. METHODS:Thirty subjects with normal hepatic function or a primary diagnosis of clinically significant cirrhosis (Child-Pugh A or B) were enrolled into an open-label, multicentre, multiple-dose study. The subjects with chronic, st...

journal_title：British journal of clinical pharmacology

authors： Everson G,Lasseter KC,Anderson KE,Bauer LA,Carithens RL Jr,Wilner KD,Johnson A,Anziano RJ,Smolarek TA,Turncliff RZ

更新日期：2000-01-01 00:00:00

abstract：:1 The new converting enzyme inhibitor RHC 3659 was tested in 15 male volunteers. The study consisted of two parts: first, the ability of a single oral dose (5, 10, 20, 40 or 80 mg) to inhibit the pressor response to exogenous angiotensin I was tested with blood pressure and heart rate monitored continuously through an...

journal_title：British journal of clinical pharmacology

authors： Burnier M,Turini GA,Brunner HR,Porchet M,Kruithof D,Vukovich RA,Gavras H

更新日期：1981-12-01 00:00:00

abstract：AIMS:AT9283 is used to treat patients with solid tumours and patients with leukaemia. However, the maximum tolerated dose (MTD) for children with leukaemia remains unknown due to early termination of the Phase I trial. The aim of this study was to develop a population model of AT9283 to describe the pharmacokinetics in...

journal_title：British journal of clinical pharmacology

authors： Duong JK,Griffin MJ,Hargrave D,Vormoor J,Edwards D,Boddy AV

更新日期：2017-08-01 00:00:00