Sedation for gastroscopy: a comparative study of midazolam and Diazemuls in patients with and without cirrhosis.

abstract：:Responses of human bronchial strip preparations to contractile and relaxant agonists were measured in preparations from non-diseased and from asthmatic lung obtained 3-15 h post-mortem. The potencies of carbachol and histamine were approximately two times less in asthmatic than in non-diseased bronchi. This was statis...

journal_title：British journal of clinical pharmacology

authors： Goldie RG,Spina D,Henry PJ,Lulich KM,Paterson JW

更新日期：1986-12-01 00:00:00

abstract：:The pharmacokinetic basis for using various experimental indices, (urinary drug: metabolite and metabolite:drug + metabolite ratios, urinary metabolite recovery and AUC values), for detecting polymorphic oxidative drug metabolism was examined. Pharmacokinetic determinants in addition to partial metabolic clearance dow...

journal_title：British journal of clinical pharmacology

authors： Jackson PR,Tucker GT,Lennard MS,Woods HF

更新日期：1986-11-01 00:00:00

abstract：AIMS:The protease inhibitor indinavir is characterized by an important interindividual pharmacokinetic variability, which results from the actions of the metabolizing enzymes cytochrome P450 (CYP) 3A and the multidrug efflux pump P-glycoprotein (P-gp), encoded by MDR1. Using a population pharmacokinetic approach, we in...

journal_title：British journal of clinical pharmacology

authors： Solas C,Simon N,Drogoul MP,Quaranta S,Frixon-Marin V,Bourgarel-Rey V,Brunet C,Gastaut JA,Durand A,Lacarelle B,Poizot-Martin I

更新日期：2007-09-01 00:00:00

abstract：:1. Previous studies have demonstrated the presence of antibodies to trifluoroacetylated hepatic proteins (TFA-proteins) in sera from patients with the severe form of halothane-associated hepatitis (halothane hepatitis). The TFA-proteins are produced via cytochrome P450-mediated metabolism of halothane to the reactive ...

journal_title：British journal of clinical pharmacology

authors： Kitteringham NR,Kenna JG,Park BK

更新日期：1995-10-01 00:00:00

abstract：WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT:Randomized controlled trials (RCTs) are believed to be one of the best methods of clinical research because they can minimize systematic errors of various types. Temporal trends in the various aspects of RCTs have been studied in several medical fields (e.g. nephrology, hepatolo...

journal_title：British journal of clinical pharmacology

authors： Falagas ME,Pitsouni EI,Bliziotis IA

更新日期：2008-06-01 00:00:00

abstract：AIMS:To test the hypothesis that inhibition of cytochrome P450 2D6 (CYP2D6) by quinidine increases the antitussive effect of dextromethorphan (DEX) in an induced cough model. METHODS:Twenty-two healthy extensive metaboliser phenotypes for CYP2D6 were studied according to a double-blind, randomised cross-over design af...

journal_title：British journal of clinical pharmacology

authors： Abdul Manap R,Wright CE,Gregory A,Rostami-Hodjegan A,Meller ST,Kelm GR,Lennard MS,Tucker GT,Morice AH

更新日期：1999-09-01 00:00:00

abstract：AIMS:To examine the hypothesis that sildenafil, a phosphodiesterase type 5 inhibitor that inhibits cGMP breakdown, could enhance nitric oxide-mediated vasodilation and reverse endothelial dysfunction in chronic smokers. METHODS:Flow-mediated dilation of the brachial artery and forearm postischemic reactive hyperemia (...

journal_title：British journal of clinical pharmacology

authors： Dishy V,Harris PA,Pierce R,Prasad HC,Sofowora G,Bonar HL,Wood AJ,Stein CM

更新日期：2004-02-01 00:00:00

abstract：:Many studies from around the world show a correlation between increasing age and adverse drug reaction (ADR) rate, at least for some medical conditions. More than 80% of ADRs causing admission or occurring in hospital are type A (dose-related) in nature, and thus predictable from the known pharmacology of the drug and...

journal_title：British journal of clinical pharmacology

authors： Routledge PA,O'Mahony MS,Woodhouse KW

更新日期：2004-02-01 00:00:00

abstract：:The pharmacokinetics of L-tryptophan (5 g and 7.5 g) have been studied after its intravenous administration to healthy subjects and the results compared with those obtained after oral administration (0.7 g-3.5 g). In order to do this, we have re-analysed previously published data relating to oral administration. The d...

journal_title：British journal of clinical pharmacology

authors： Green AR,Aronson JK,Cowen PJ

更新日期：1985-10-01 00:00:00

abstract：:1 In an open, randomized cross-over investigation of thirteen patients (nine and four women, aged 37-67 years) with mild or moderate essential hypertension a comparison between atenolol and metoprolol was carried out in order to study the effects of 50, 100 and 200 mg given once daily on blood pressure and heart rate ...

journal_title：British journal of clinical pharmacology

authors： Rasmussen S,Arnung K,Eskildsen PC,Nielsen PE

更新日期：1981-12-01 00:00:00

abstract：:Individual and population differences in polymorphic cytochrome P450 enzyme function have been known for decades. The biological significance of these differences has now been deciphered with regard to drug metabolism, action and toxicity as well as disposition of endogenous substrates, including neuroactive compounds...

journal_title：British journal of clinical pharmacology

authors： Peñas-Lledó EM,Llerena A

更新日期：2014-04-01 00:00:00

abstract：:1. Potential therapies for ischaemic stroke include agents to reduce oedema, to improve cerebral perfusion, to reduce excitotoxic damage, to minimise free-radical induced injury and to reduce complications such as deep venous thrombosis. 2. Of the anti-oedema drugs, steroids are ineffective and possibly dangerous; int...

journal_title：British journal of clinical pharmacology

authors： Lees KR

更新日期：1992-12-01 00:00:00

abstract：:Three calcium antagonists, diltiazem, flunarizine and verapamil stimulated human sperm motility in vitro. Among them, diltiazem induced the largest amplitude of motility increase. The concentration-response curve of diltiazem was similar in shape to those of calcium chelators. EGTA, a calcium chelator, potentiated the...

journal_title：British journal of clinical pharmacology

authors： Hong CY,Chiang BN,Ku J,Wei YH,Fong JC

更新日期：1985-01-01 00:00:00

abstract：AIMS:SAR247799 is a selective G-protein-biased sphingosine-1 phosphate receptor-1 (S1P1 ) agonist with potential to restore endothelial function in vascular pathologies. SAR247799, a first-in-class molecule differentiated from previous S1P1 -desensitizing molecules developed for multiple sclerosis, can activate S1P1 wi...

journal_title：British journal of clinical pharmacology

authors： Bergougnan L,Armani S,Golor G,Tardat A,Vitse O,Hurbin F,Scemama M,Poitiers F,Radzik D,Gaudin C,Hovsepian L,Muslin AJ,Kirkesseli S,Deutsch P,Parkar AA

更新日期：2020-06-10 00:00:00

abstract：AIMS:To explore the feasibility of delivering community-based drug safety testing (drug checking), to trial service design characteristics and to compare with festival-based testing. METHODS:In total, 171 substances of concern were submitted on 5 dates at 3 venues in 2 UK cities and tested using up to 6 analytical tec...

journal_title：British journal of clinical pharmacology

authors： Measham F

更新日期：2020-03-01 00:00:00

abstract：:1. Twenty-two patients with moderately severe essential hypertension were treated for a period of 12 months with guanfacine (BS 100-141), a new centrally-acting antihypertensive agent. A twice daily schedule was followed and the dose range of guanfacine was 1-8 mg daily. 2. In twenty patients satisfactory blood pressu...

journal_title：British journal of clinical pharmacology

authors： Higuchi M,Overlack A,Stumpe KO

更新日期：1980-01-01 00:00:00

abstract：AIMS:Flavonoids may affect platelet function by several mechanisms, including antagonism of TxA(2) receptors (TP). These TP are present in many tissues and modulate different signalling cascades. We explored whether flavonoids affect platelet TP signalling, and if they bind to TP expressed in other cell types. METHODS...

journal_title：British journal of clinical pharmacology

authors： Guerrero JA,Navarro-Nuñez L,Lozano ML,Martínez C,Vicente V,Gibbins JM,Rivera J

更新日期：2007-08-01 00:00:00

abstract：AIMS:The aim of this study was to perform an up-to-date meta-analysis on the risk of cardiac malformations associated with gestational exposure to paroxetine, taking into account indication, study design and reference category. METHOD:A systematic review of studies published between 1966 and November 2015 was conducte...

journal_title：British journal of clinical pharmacology

authors： Bérard A,Iessa N,Chaabane S,Muanda FT,Boukhris T,Zhao JP

更新日期：2016-04-01 00:00:00

abstract：:In a dog model of partial myocardial ischaemia, superimposed ST segment elevations in epicardial ECGs were inhibited by nicardipine over a cumulative i.v. dose range of 1-20 micrograms kg-1. Over the cumulative i.v. dose range of 0.5-166.5 micrograms kg-1, nicardipine had little overall effect on gross cardiac conduct...

journal_title：British journal of clinical pharmacology

authors： Alps BJ,Calder C,Wilson A

更新日期：1985-01-01 00:00:00

abstract：:The pharmacokinetics of piretanide, a new loop diuretic, were studied in four patients with GFR 4.7-14.8 ml/min. An oral dose of piretanide 18 mg was given at 08.00 h in two patients and at 08.00 h and 14.00 h in two. Blood samples were drawn after 0.5, 1, 2, 3, 4, 6, 8, 10, 12 and 24 h. Serum concentrations of pireta...

journal_title：British journal of clinical pharmacology

authors： Berg KJ,Walstad RA,Bergh K

更新日期：1983-03-01 00:00:00

abstract：:Integration of clinical and preclinical pharmacology in pharmaceutical companies could be improved by several key recommendations: Companies should ensure that there is an adequate pool of trained clinical pharmacologists and preclinical pharmacologists. Training should include topics that allow clinical pharmacologis...

journal_title：British journal of clinical pharmacology

authors： Hunter JA

更新日期：2012-06-01 00:00:00

abstract：:Thiol compounds have been reported to abolish hypoxanthine/xanthine oxidase induced luminol chemiluminescence and this effect has been attributed to scavenging of superoxide (O2-)/(H2O2) produced from hypoxanthine/xanthine oxidase. Yet other workers have reported that thiol compounds have shown little, if any, reactiv...

journal_title：British journal of clinical pharmacology

authors： Clapperton M,McMurray J,Fisher AC,Dargie HJ

更新日期：1995-06-01 00:00:00

abstract：:To examine the importance of acute frusemide-induced renin release in the production of the acute peripheral venous and arterial responses to frusemide in man, the effects of two drugs, previously described as inhibitors of acute frusemide-induced renin release, propranolol and digoxin, were examined. Propranolol abol...

journal_title：British journal of clinical pharmacology

authors： Johnston GD,O'Connor PC,Nicholls DP,Leahey WJ,Finch MB

更新日期：1985-04-01 00:00:00

abstract：AIMS:To investigate the effect of multiple oral dose treatment with the endothelin receptor antagonist bosentan on the pharmacokinetics of digoxin in healthy subjects. METHODS:This was an open-label, randomized, two-way crossover study in 18 evaluable young male subjects. They received, on two occasions which were sep...

journal_title：British journal of clinical pharmacology

authors： Weber C,Banken L,Birnboeck H,Nave S,Schulz R

更新日期：1999-06-01 00:00:00

abstract：AIMS:The aim of this study was to investigate the impact of new insights and revised guidelines on initial and follow-up treatment with antihyperglycaemic drugs over the period 1998-2003. METHODS:The InterAction Database (IADB), which contains pharmacy dispensing data from 53 community pharmacies in the Northern and E...

journal_title：British journal of clinical pharmacology

authors： Lub R,Denig P,van den Berg PB,Hoogenberg K,de Jong-van den Berg LT

更新日期：2006-12-01 00:00:00

abstract：:1. An open-label, randomised study was performed to assess the effect of tenidap sodium on the pharmacodynamics and plasma protein binding of warfarin. 2. Fourteen healthy male volunteers received either a single oral dose of 120 mg tenidap sodium or matching placebo capsules from days 11 to 36. A single oral dose of ...

journal_title：British journal of clinical pharmacology

authors： Apseloff G,Wilner KD,Gerber N

更新日期：1995-01-01 00:00:00

abstract：:1. Studies using human liver microsomes and six recombinant human CYP isoforms (i.e. CYP1A2, 2A6, 2B6, 2D6, 2E1 and 3A4) were performed to identify the cytochrome P450 (CYP) isoform(s) involved in the ring 4-hydroxylation and side-chain N-desisopropylation of propranolol enantiomers in humans. 2. alpha-Naphthoflavone ...

journal_title：British journal of clinical pharmacology

authors： Yoshimoto K,Echizen H,Chiba K,Tani M,Ishizaki T

更新日期：1995-04-01 00:00:00

abstract：AIM:To describe the time to clinical events (death, disability, cognitive impairment and depression) in Parkinson's disease using the time course of disease status and treatment as explanatory variables. METHODS:Disease status based on the Unified Parkinson's Disease Rating Scale (UPDRS) and the time to clinical outco...

journal_title：British journal of clinical pharmacology

authors： Vu TC,Nutt JG,Holford NH

更新日期：2012-08-01 00:00:00

abstract：AIM:To evaluate cases of deep vein thrombosis (DVT) and pulmonary embolism (PE) reported in a prescription event monitoring study of Yasmin, an oral contraceptive. METHODS:Reports of DVT/PE and events suggestive of DVT/PE were followed up by questionnaire. RESULTS:Thirteen cases (DVT five; PE eight), each with possib...

journal_title：British journal of clinical pharmacology

authors： Pearce HM,Layton D,Wilton LV,Shakir SA

更新日期：2005-07-01 00:00:00

abstract：:1. Nebivolol, a selective beta 1-adrenoceptor antagonist with antihypertensive effects, has haemodynamic effects suggestive of a direct vasodilator action. 2. The dorsal hand vein technique was used to determine whether nebivolol has venodilator action in vivo in man. 3. Nebivolol and atenolol were infused into the ph...

journal_title：British journal of clinical pharmacology

authors： Bowman AJ,Chen CP,Ford GA

更新日期：1994-09-01 00:00:00