Evaluation of long-term treatment of essential hypertension with guanfacine.

abstract：AIMS:This paper describes the pharmacokinetics and effects of propofol in short-term sedated paediatric patients. METHODS:Six mechanically ventilated children aged 1-5 years received a 6 h continuous infusion of propofol 6% at the rate of 2 or 3 mg kg-1 h-1 for sedation following cardiac surgery. A total of seven arte...

journal_title：British journal of clinical pharmacology

authors： Knibbe CA,Melenhorst-de Jong G,Mestrom M,Rademaker CM,Reijnvaan AF,Zuideveld KP,Kuks PF,van Vught H,Danhof M

更新日期：2002-10-01 00:00:00

abstract：:Aims We investigated whether venoconstriction by α-adrenoceptor stimulation, and venodilation by β-adrenoceptor stimulation and nitroglycerin are altered in patients with diabetes mellitus (DM). Methods Eight male patients with non insulin-dependent DM and eight age-matched control subjects were included. The patients...

journal_title：British journal of clinical pharmacology

authors： Harada K,Ohmori M,Kitoh Y,Sugimoto KI,Fujimura A

更新日期：1999-04-01 00:00:00

abstract：:Adverse drug reactions come at a considerable cost on society. Social media are a potentially invaluable reservoir of information for pharmacovigilance, yet their true value remains to be fully understood. In order to realize the benefits social media holds, a number of technical, regulatory and ethical challenges rem...

journal_title：British journal of clinical pharmacology

authors： Sloane R,Osanlou O,Lewis D,Bollegala D,Maskell S,Pirmohamed M

更新日期：2015-10-01 00:00:00

abstract：:The effects of the proton pump inhibitor lansoprazole on the bioavailability of a low-dose oral contraceptive (OC), containing 0.03 mg ethinyloestradiol (EE) and 0.15 mg levonorgestrel (LNG), were investigated. Twenty-four healthy females (aged 19-35 years; weight 60.6 +/- 7.1 kg) participated in a multiple-dose, plac...

journal_title：British journal of clinical pharmacology

authors： Fuchs W,Sennewald R,Klotz U

更新日期：1994-10-01 00:00:00

abstract：AIM:To examine comprehensively the relationship between exposure to four classes of psychotropic drugs including antipsychotics, antidepressants, benzodiazepines (BZDs) and Z-drugs, and motor vehicle accidents (MVAs). METHOD:The authors conducted a matched case-control study of 5183 subjects with MVAs and 31 093 match...

journal_title：British journal of clinical pharmacology

authors： Chang CM,Wu EC,Chen CY,Wu KY,Liang HY,Chau YL,Wu CS,Lin KM,Tsai HJ

更新日期：2013-04-01 00:00:00

abstract：:Monohydroxy acids (HETEs) and leukotriene B4 (LTB4) metabolites of arachidonic acid were measured in skin of healthy volunteers after ultraviolet B irradiation, and in the uninvolved skin of psoriatics after topical dithranol application. Exudate was collected from suction bullae on control and inflamed abdominal skin...

journal_title：British journal of clinical pharmacology

authors： Black AK,Barr RM,Wong E,Brain S,Greaves MW,Dickinson R,Shroot B,Hensby CN

更新日期：1985-09-01 00:00:00

abstract：AIMS:In the Swiss heroin substitution trials, patients are treated with self-administered diacetylmorphine (heroin). Intravenous administration is not possible in patients that have venosclerosis. Earlier studies have demonstrated that oral diacetylmorphine may be used, although it is completely converted to morphine p...

journal_title：British journal of clinical pharmacology

authors： Halbsguth U,Rentsch KM,Eich-Höchli D,Diterich I,Fattinger K

更新日期：2008-12-01 00:00:00

abstract：AIMS:Oral L-arginine supplementation has been used in several studies to improve endothelium-dependent, nitric oxide (NO)-mediated vasodilation. L-Arginine treatment is hampered by extensive presystemic elimination due to intestinal arginase activity. In contrast, L-citrulline is readily absorbed and at least in part c...

journal_title：British journal of clinical pharmacology

authors： Schwedhelm E,Maas R,Freese R,Jung D,Lukacs Z,Jambrecina A,Spickler W,Schulze F,Böger RH

更新日期：2008-01-01 00:00:00

abstract：AIMS:To determine the induction effect of rifampicin on the activity of 4'-hydroxylase in poor metabolizers (PMs) with m1 mutation of S-mephenytoin 4'-hydroxylation and the relationship of the effect with gene dose. METHODS:Seven extensive metabolizers (EMs) of S-mephenytoin 4'-hydroxylation and five PMs with m1 mutat...

journal_title：British journal of clinical pharmacology

authors： Feng HJ,Huang SL,Wang W,Zhou HH

更新日期：1998-01-01 00:00:00

abstract：AIMS:Previously, we determined the phenotyping of in vivo nicotine metabolism and the genotyping of the CYP2A6 gene (CYP2A6*1 A, CYP2A6*1B, CYP2A6*2, CYP2A6*3, CYP2A6*4 and CYP2A6*5 ) in 92 Japanese and 209 Koreans. In the study, we found one Korean and four Japanese subjects genotyped as CYP2A6*1B/CYP2A6*4 who reveale...

journal_title：British journal of clinical pharmacology

authors： Yoshida R,Nakajima M,Watanabe Y,Kwon JT,Yokoi T

更新日期：2002-11-01 00:00:00

abstract：AIMS:To evaluate putative associations between drugs and dilated cardiomyopathy. METHODS:We used the case/noncase method in the French PharmacoVigilance Database (FPVD). Cases were all the observations with dilated cardiomyopathy registered into the FPVD between 1 January 1990 and 30 June 2007. Noncases were all other...

journal_title：British journal of clinical pharmacology

authors： Montastruc G,Favreliere S,Sommet A,Pathak A,Lapeyre-Mestre M,Perault-Pochat MC,Montastruc JL,French Association of Regional PharmacoVigilance Centres.

更新日期：2010-03-01 00:00:00

abstract：:Intravenous midazolam (mean dose of 6.3 mg) was given to 100 consecutive patients coming to endoscopy. All patients had an ear oximeter attached throughout the procedure to record continuously their levels of oxygen saturation. Eighty-five of the 100 patients had pre-endoscopy respiratory function tests measured, and ...

journal_title：British journal of clinical pharmacology

authors： Bell GD,Reeve PA,Moshiri M,Morden A,Coady T,Stapleton PJ,Logan RF

更新日期：1987-06-01 00:00:00

abstract：AIMS:With rising use worldwide, pregabalin is increasingly implicated in poisoning deaths. We aimed to investigate the clinical effects and complications of pregabalin poisoning. METHODS:This is a retrospective review of patients presenting with pregabalin poisoning to two tertiary toxicology units from 1 July 2014 to...

journal_title：British journal of clinical pharmacology

authors： Isoardi KZ,Polkinghorne G,Harris K,Isbister GK

更新日期：2020-12-01 00:00:00

abstract：:1 The anti-hypertensive effect of labetalol given twice or three times daily was evaluated in ambulant subjects with essential hypertension by recording blood pressure directly for 24 h before and after 15 d of labetalol administration (daily dose 600-1800 mg). 2 Labetalol reduced 24 h systolic and diastolic blood pre...

journal_title：British journal of clinical pharmacology

authors： Mancia G,Pomidossi G,Parati G,Bertinieri G,Grassi G,Navone F,Ferrari A,Gregorini L,Zanchetti A

更新日期：1982-06-01 00:00:00

abstract：:1. Studies using human liver microsomes and six recombinant human CYP isoforms (i.e. CYP1A2, 2A6, 2B6, 2D6, 2E1 and 3A4) were performed to identify the cytochrome P450 (CYP) isoform(s) involved in the ring 4-hydroxylation and side-chain N-desisopropylation of propranolol enantiomers in humans. 2. alpha-Naphthoflavone ...

journal_title：British journal of clinical pharmacology

authors： Yoshimoto K,Echizen H,Chiba K,Tani M,Ishizaki T

更新日期：1995-04-01 00:00:00

abstract：AIMS:Little is known about the effects of comorbidities and patient characteristics on treatment initiation of lipid-lowering drugs (LLDs), which can be helpful in the evaluation of the risks and benefits of LLDs. METHODS:Baseline characteristics among subjects who received their first ever-recorded LLD prescription i...

journal_title：British journal of clinical pharmacology

authors： Yang CC,Jick SS,Testa MA

更新日期：2003-03-01 00:00:00

abstract：AIMS:Variability in responsiveness to clopidogrel is a clinical problem in secondary prevention after cerebral ischaemia which has been suggested to be linked to competitive metabolization of clopidogrel and cytochrome P450 (CYP) 3A4-oxidated statins such as simvastatin. We assessed the hypothesis that simvastatin, in ...

journal_title：British journal of clinical pharmacology

authors： Siepmann T,Heinke D,Kepplinger J,Barlinn K,Gehrisch S,Grählert X,Schwanebeck U,Reichmann H,Puetz V,Bodechtel U,Gahn G

更新日期：2014-11-01 00:00:00

abstract：:1 The influence of cimetidine (1000 mg daily) on propranolol steady state plasma levels has been studied in seven normal volunteers. Cimetidine was used as a 200 mg normal release tablet whereas propranolol was given as a 160 mg slow release formulation once daily. 2 After 1 day of cimetidine treatment (day 9 of the s...

journal_title：British journal of clinical pharmacology

authors： Reimann IW,Klotz U,Siems B,Frölich J

更新日期：1981-12-01 00:00:00

abstract：AIMS:The pharmacokinetics and dose proportionality of rizatriptan single oral doses from 2.5 to 15 mg administered as solutions to healthy volunteers were studied. METHODS:In a randomized, crossover study with four periods, twenty-four healthy volunteers (12 males and 12 females) took single oral doses of 2.5, 5, 10, ...

journal_title：British journal of clinical pharmacology

authors： Lee Y,Conroy JA,Stepanavage ME,Mendel CM,Somers G,McLoughlin DA,Olah TV,De Smet M,Keymeulen B,Rogers JD

更新日期：1999-04-01 00:00:00

abstract：:1 Methimazole plasma concentrations were measured in two groups of hyperthyroid subjects after the oral administration of either carbimazole or methimazole. 2 With the HPLC method it was also possible to measure the concentration of a methimazole metabolite, 3-methyl-2-thiohydantoin in one patient. 3 Large interindivi...

journal_title：British journal of clinical pharmacology

authors： Skellern GG,Knight BI,Low CK,Alexander WD,McLarty DG,Kalk WJ

更新日期：1980-02-01 00:00:00

abstract：AIMS:To analyse clinical outcomes with direct oral anticoagulants in patients with atrial fibrillation according to geographic region. METHODS:We systematically searched MEDLINE, CENTRAL, websites of regulatory agencies, clinical trials registers and conference proceedings for randomized controlled trials of direct or...

journal_title：British journal of clinical pharmacology

authors： Gómez-Outes A,Terleira-Fernández AI,Calvo-Rojas G,Suárez-Gea ML,Vargas-Castrillón E

更新日期：2016-09-01 00:00:00

abstract：:1. Milk and plasma metronidazole and hydroxymetronidazole concentrations were measured in 12 breast-feeding patients following multiple doses of metronidazole (400 mg three times daily). All patients received metronidazole in combination with other broad spectrum antibiotics. 2. Plasma concentrations of both parent dr...

journal_title：British journal of clinical pharmacology

authors： Passmore CM,McElnay JC,Rainey EA,D'Arcy PF

更新日期：1988-07-01 00:00:00

abstract：AIMS:The role of CYP pharmacogenetics in the bioactivation of cyclophosphamide is still controversial. Recent clinical studies have suggested a role for either CYP2C19 or CYP2B6. The aim of this study was to clarify the role of these pharmacogenes. METHODS:We used a combined in vitro-in vivo approach to determine the ...

journal_title：British journal of clinical pharmacology

authors： Helsby NA,Hui CY,Goldthorpe MA,Coller JK,Soh MC,Gow PJ,De Zoysa JZ,Tingle MD

更新日期：2010-12-01 00:00:00

abstract：:1. The study was performed to determine the sensitivity and short-term and day-to-day variability of a novel technique based on laser interferometry of ocular fundus pulsations and of non-invasive methods for the quantification of haemodynamic drug effects. An additional aim was to assess sex differences in haemodynam...

journal_title：British journal of clinical pharmacology

authors： Wolzt M,Schmetterer L,Rheinberger A,Salomon A,Unfried C,Breiteneder H,Ehringer H,Eichler HG,Fercher AF

更新日期：1995-04-01 00:00:00

abstract：:Metabolomics is recognized as a powerful top-down system biological approach to understand genetic-environment-health paradigms paving new avenues to identify clinically relevant biomarkers. It is nowadays commonly used in clinical applications shedding new light on physiological regulatory processes of complex mammal...

journal_title：British journal of clinical pharmacology

authors： Collino S,Martin FP,Rezzi S

更新日期：2013-03-01 00:00:00

abstract：:1. The systemic effects of inhaled fluticasone propionate (FP), administered via Diskhaler, on the hypothalamo-pituitary-adrenal (HPA) axis were assessed primarily by measuring plasma cortisol at frequent intervals for 20 h after drug administration. 2. FP showed a dose-related suppression of plasma cortisol measured ...

journal_title：British journal of clinical pharmacology

authors： Grahnén A,Eckernäs SA,Brundin RM,Ling-Andersson A

更新日期：1994-12-01 00:00:00

abstract：AIM:To evaluate safety, tolerability and pharmacokinetics of oral PF-05190457, an oral ghrelin receptor inverse agonist, in healthy adults. METHODS:Single (SAD) and multiple ascending dose (MAD) studies were randomised, placebo-controlled, double-blind studies. Thirty-five healthy men (age 38.2 ± 10.4 years; body mass...

journal_title：British journal of clinical pharmacology

authors： Denney WS,Sonnenberg GE,Carvajal-Gonzalez S,Tuthill T,Jackson VM

更新日期：2017-02-01 00:00:00

abstract：:Adopted guidelines reflect a harmonised European approach to a specific scientific issue and should reflect the most recent scientific knowledge. However, whilst EU regulations are mandatory for all member states and EU directives must be followed by national laws in line with the directive, EMA guidelines do not have...

journal_title：British journal of clinical pharmacology

authors： Ollivier C,Thomson A,Manolis E,Blake K,Karlsson KE,Knibbe CAJ,Pons G,Hemmings R

更新日期：2019-04-01 00:00:00

abstract：:The effect of acute migraine attack and rectally given metoclopramide on the absorption of orally given tolfenamic acid (300 mg) was investigated in seven female patients in a crossover study consisting of four phases, two without migraine and two during migraine. Metoclopramide hydrochloride (20 mg) or placebo was gi...

journal_title：British journal of clinical pharmacology

authors： Tokola RA,Neuvonen PJ

更新日期：1984-01-01 00:00:00

abstract：:The effects of high and low urine flow rates on the urinary metabolic ratios for paracetamol glucuronidation, sulphation and oxidation were determined at steady-state in seven healthy young adult volunteers. Metabolic partial clearances were unaffected by urine flow rate, but individual paracetamol metabolic ratios va...

journal_title：British journal of clinical pharmacology

authors： Miners JO,Osborne NJ,Tonkin AL,Birkett DJ

更新日期：1992-10-01 00:00:00