Perturbation of paracetamol urinary metabolic ratios by urine flow rate.

abstract：AIM:To investigate the effect of sepsis upon the volume of distribution (Vd) of gentamicin in neonates. METHODS:A retrospective chart review was conducted of neonates admitted to Dunedin Hospital who had gentamicin concentrations performed between 1st January 2000 and 30th October 2003. Data from 277 neonates, includi...

journal_title：British journal of clinical pharmacology

authors： Lingvall M,Reith D,Broadbent R

更新日期：2005-01-01 00:00:00

abstract：:The effects of two single oral doses of ibopamine (150 and 600 mg) on heart rate, blood pressure, urine flow, sodium, potassium and creatinine excretion were studied in normal volunteers. No significant change was observed in urine flow, sodium, potassium or creatinine excretion at either dose. No significant change w...

journal_title：British journal of clinical pharmacology

authors： Harvey JN,Worth DP,Brown J,Lee MR

更新日期：1984-06-01 00:00:00

abstract：:Since many factors may alter lung epithelial permeability (LEP) to water soluble molecules, the effect of histamine on the absorption and clearance of inhaled sodium cromoglycate was examined in seven mildly asthmatic patients with hyperresponsive airways and eight normal subjects. The subjects underwent histamine cha...

journal_title：British journal of clinical pharmacology

authors： Richards R,Fowler C,Simpson S,Renwick AG,Holgate ST

更新日期：1992-03-01 00:00:00

abstract：:1 A treatment group comprising 635 hypertensive men (casual SBP greater than 175 or DBP greater than 115 twice) was compared with a reference group (n = 391 men; casual SBP greater than 175 or DBP greater than 115 only at screening). All men belonged to the same population sample of 7,455 men aged 47-54 yr. 2 The two ...

journal_title：British journal of clinical pharmacology

authors： Wilhelmsen L,Berglund G,Sannerstedt R,Hansson L,Andersson O,Sievertsson R,Wikstrand J

更新日期：1979-01-01 00:00:00

abstract：:1 Cimetidine has been reported to reduce serum calcium and parathyroid hormone (PTH) levels in primary hyperparathyroidism, but some studies have reported negative findings. 2 A double-blind, controlled trial of cimetidine in this condition was, therefore, conducted. Eight patients were given cimetidine and placebo fo...

journal_title：British journal of clinical pharmacology

authors： Fisken RA,Wilkinson R,Heath DA

更新日期：1982-11-01 00:00:00

abstract：AIMS:To investigate the driving forces behind increasing utilization of cardiovascular drugs. METHODS:Using register data, all Danish residents as of 1 January 1996 were followed until 2006. Cohort members were censored at death or emigration. Cardiovascular drug utilization on the individual level was traced, applyin...

journal_title：British journal of clinical pharmacology

authors： Kildemoes HW,Støvring H,Andersen M

更新日期：2008-12-01 00:00:00

abstract：AIM:In short-term studies, hormonal contraceptives (HC) have been suggested to induce a rise in blood pressure (BP) and urinary albumin excretion (UAE), while the effect of HC in renal function (GFR) is still under debate. Data on long-term and withdrawal effects of HC use on these outcomes are, however, not available....

journal_title：British journal of clinical pharmacology

authors： Atthobari J,Gansevoort RT,Visser ST,de Jong PE,de Jong-van den Berg LT,PREVEND Study Group.

更新日期：2007-02-01 00:00:00

abstract：AIMS:To evaluate the potential ethnic differences in the pharmacokinetics (PK) and pharmacodynamics (PD) of evolocumab in Caucasian and Asian populations using population PK/PD modelling analysis. METHODS:Data from different ethnic groups in 5 Phase I clinical trials, including two American studies, one Japanese study...

journal_title：British journal of clinical pharmacology

authors： Wang C,Zheng Q,Zhang M,Lu H

更新日期：2019-01-01 00:00:00

abstract：:The single oral dose pharmacokinetics of carbamazepine-10, 11-epoxide (CBZ-E) were investigated in six normal volunteers during a control session and during concurrent treatment with valpromide (VPM) (300 mg twice daily for 8 days). VPM caused a prolongation of the CBZ-E half-life from 6.4 +/- 1.4 to 20.5 +/- 6.3 h an...

journal_title：British journal of clinical pharmacology

authors： Pisani F,Fazio A,Oteri G,Spina E,Perucca E,Bertilsson L

更新日期：1988-05-01 00:00:00

abstract：AIMS:BG00010 is a protein in the glial cell line-derived neurotrophic factor (GDNF) family. It is a selective ligand for the GDNF family receptor alpha-3 (GFRα3) co-receptor that normalizes cellular changes resulting from damage or disease, and potentially alleviates neuropathic pain. The main objectives of this study ...

journal_title：British journal of clinical pharmacology

authors： Okkerse P,Hay JL,Versage E,Tang Y,Galluppi G,Ravina B,Verma A,Williams L,Aycardi E,Groeneveld GJ

更新日期：2016-07-01 00:00:00

abstract：:Three hypothalamic regulatory hormones, thyrotrophin-releasing hormone (TRH), luteinizing hormone/follicle-stimulating hormone-releasing hormone (LH/FSH-RH) and growth hormone-release inhibiting hormone (GH-RIH) given intravenously had no effect on the electroencephalographic response known as the contingent negative ...

journal_title：British journal of clinical pharmacology

authors： Ashton H,Millman JE,Telford R,Thompson JW,Davies TF,Hall R

更新日期：1976-08-01 00:00:00

abstract：:1. alpha-Bromoisovalerylurea (BIU) is a racemic drug that is metabolized by glutathione conjugation. The urinary excretion of the separate diastereomeric mercapturates formed from (S)- and (R)-BIU in healthy young human volunteers was investigated. 2. A pronounced stereoselectivity was observed: the mercapturate forme...

journal_title：British journal of clinical pharmacology

authors： te Koppele JM,Schipper C,Breimer DD,Mulder GJ

更新日期：1989-08-01 00:00:00

abstract：AIMS:To investigate the effect of multiple oral dose treatment with the endothelin receptor antagonist bosentan on the pharmacokinetics of digoxin in healthy subjects. METHODS:This was an open-label, randomized, two-way crossover study in 18 evaluable young male subjects. They received, on two occasions which were sep...

journal_title：British journal of clinical pharmacology

authors： Weber C,Banken L,Birnboeck H,Nave S,Schulz R

更新日期：1999-06-01 00:00:00

abstract：:1. In a double-blind placebo controlled four-way crossover study the effects and dose response relationships of xamoterol were studied in nine patients with angina and dyspnoea secondary to chronic left ventricular dysfunction. The duration of exercise on a treadmill and heart rate were measured at the end of each pha...

journal_title：British journal of clinical pharmacology

authors： Molajo AO,Bennett DH,Marlow HF,Snow HM,Bastain W

更新日期：1987-09-01 00:00:00

abstract：:Caffeine (5 mg kg-1) was administered orally to two healthy, non-smoking subjects on three separate occasions--before, and during therapy with the xanthine oxidase inhibitor allopurinol at doses of either 300 or 600 mg daily. Plasma and urinary levels of methylxanthines, endogenous oxypurines and allopurinol and its m...

journal_title：British journal of clinical pharmacology

authors： Grant DM,Tang BK,Campbell ME,Kalow W

更新日期：1986-04-01 00:00:00

abstract：:Eleven patients with stable rheumatoid disease (RD) who were receiving regular corticosteroid therapy (CS) were investigated to discover the effect on plasma prednisolone levels of additional therapy with the non-steroidal anti-inflammatory (NSAI) drugs, indomethacin and naproxen. There was a highly significant (P les...

journal_title：British journal of clinical pharmacology

authors： Rae SA,Williams IA,English J,Baylis EM

更新日期：1982-09-01 00:00:00

abstract：AIM:To assess the relative contribution of intestinal and hepatic CYP3A inhibition to the interaction between the prototypic CYP3A substrate midazolam and clarithromycin in the elderly. METHODS:On day 1, 16 volunteers (eight male, eight female) aged 65-75 years weighing 59-112 kg received simultaneous doses of midazol...

journal_title：British journal of clinical pharmacology

authors： Quinney SK,Haehner BD,Rhoades MB,Lin Z,Gorski JC,Hall SD

更新日期：2008-01-01 00:00:00

abstract：:A free lignocaine index was developed on the basis of measurements of plasma lignocaine and its principle binding protein, alpha 1-acid glycoprotein (AAG) in 80 samples from 16 patients admitted to the coronary care unit and given prophylactic lignocaine therapy. The free drug fraction, fu, of lignocaine was determine...

journal_title：British journal of clinical pharmacology

authors： Routledge PA,Lazar JD,Barchowsky A,Stargel WW,Wagner GS,Shand DG

更新日期：1985-12-01 00:00:00

abstract：AIMS:This study compares physicians' recall of the claims of benefits on cardiovascular disease and diabetes made by pharmaceutical sales representatives for drugs approved on the basis of a surrogate outcome, i.e., an off-label claim, compared with those approved on the basis of a serious morbidity or mortality (clini...

journal_title：British journal of clinical pharmacology

authors： Habibi R,Lexchin J,Mintzes B,Holbrook A

更新日期：2017-11-01 00:00:00

abstract：AIMS:This paper describes the pharmacokinetics and effects of propofol in short-term sedated paediatric patients. METHODS:Six mechanically ventilated children aged 1-5 years received a 6 h continuous infusion of propofol 6% at the rate of 2 or 3 mg kg-1 h-1 for sedation following cardiac surgery. A total of seven arte...

journal_title：British journal of clinical pharmacology

authors： Knibbe CA,Melenhorst-de Jong G,Mestrom M,Rademaker CM,Reijnvaan AF,Zuideveld KP,Kuks PF,van Vught H,Danhof M

更新日期：2002-10-01 00:00:00

abstract：:Ten volunteers carried a 10 mg 24 h -1 transdermal glyceryl trinitrate (GTN) patch for 24 h before moderate exercise. Plasma GTN-concentration increased significantly (P less than 0.05) by 19% to peak value at 15 min. Two hours after patch renewal repeat exercise increased GTN concentration by 56% (P less than 0.001)....

journal_title：British journal of clinical pharmacology

authors： Gjesdal K,Klemsdal TO,Rykke EO,Bredesen JE

更新日期：1991-05-01 00:00:00

abstract：:Ten healthy normal volunteers received an intravenous infusion of erythromycin lactobionate over 60 min to a total dose of 800 mg (n = 9), and 524 mg (n = 1). Blood samples were collected at 10 min intervals for 100 min and gastric contents aspirated, via a nasogastric tube, from pre-dose to 105 min after start of inf...

journal_title：British journal of clinical pharmacology

authors： Downey KM,Chaput de Saintonge DM

更新日期：1986-03-01 00:00:00

abstract：AIMS:To test the hypothesis that inhibition of cytochrome P450 2D6 (CYP2D6) by quinidine increases the antitussive effect of dextromethorphan (DEX) in an induced cough model. METHODS:Twenty-two healthy extensive metaboliser phenotypes for CYP2D6 were studied according to a double-blind, randomised cross-over design af...

journal_title：British journal of clinical pharmacology

authors： Abdul Manap R,Wright CE,Gregory A,Rostami-Hodjegan A,Meller ST,Kelm GR,Lennard MS,Tucker GT,Morice AH

更新日期：1999-09-01 00:00:00

abstract：:1. The effects of the voltage dependent calcium channel blocking agent nifedipine, and of a calcium free bathing medium, on the responses of human blood vessels obtained postmortem to various agonists have been compared with those of the rat aorta. The human vessels studied were digital arteries, basilar arteries and ...

journal_title：British journal of clinical pharmacology

authors： Iwanov V,Moulds RF

更新日期：1991-01-01 00:00:00

abstract：:The plasma concentrations of the tetracyclic antidepressant maprotiline and its effect on histamine-induced bronchoconstriction were measured after single (50 mg) and multiple (50 mg twice daily) oral doses in healthy subjects. Histamine-induced bronchoconstriction was abolished after a single dose of maprotiline and ...

journal_title：British journal of clinical pharmacology

authors： Firkusny L,Gleiter CH

更新日期：1994-04-01 00:00:00

abstract：:The effect of acute migraine attack and rectally given metoclopramide on the absorption of orally given tolfenamic acid (300 mg) was investigated in seven female patients in a crossover study consisting of four phases, two without migraine and two during migraine. Metoclopramide hydrochloride (20 mg) or placebo was gi...

journal_title：British journal of clinical pharmacology

authors： Tokola RA,Neuvonen PJ

更新日期：1984-01-01 00:00:00

abstract：AIMS:The Transdermal Delivery System (TDS) is a liquid formulation that can be applied to the skin via a metered pump spray to deliver drug to the systemic circulation. The aims of this study were to assess the ability of the TDS preparation to deliver testosterone systemically, and to characterize the pharmacokinetic ...

journal_title：British journal of clinical pharmacology

authors： Chik Z,Johnston A,Tucker AT,Chew SL,Michaels L,Alam CA

更新日期：2006-03-01 00:00:00

abstract：:The effects of the proton pump inhibitor lansoprazole on the bioavailability of a low-dose oral contraceptive (OC), containing 0.03 mg ethinyloestradiol (EE) and 0.15 mg levonorgestrel (LNG), were investigated. Twenty-four healthy females (aged 19-35 years; weight 60.6 +/- 7.1 kg) participated in a multiple-dose, plac...

journal_title：British journal of clinical pharmacology

authors： Fuchs W,Sennewald R,Klotz U

更新日期：1994-10-01 00:00:00

abstract：AIMS:The aims of the present study were, firstly, to evaluate long-term trends in the occurrence and treatment of cardiovascular disease (CVD) risk factors and the occurrence of CVD events in children with type 1 diabetes mellitus (T1DM) and, secondly, to assess the determinants of undertreatment of CVD risk factors. ...

journal_title：British journal of clinical pharmacology

authors： Ahmadizar F,Souverein P,de Boer A,Maitland-van der Zee AH

更新日期：2018-04-01 00:00:00

abstract：PURPOSE:Prescribed daily dose (PDD), the number of doses prescribed to be taken per day, is used to calculate medication adherence using pharmacy claims data. PDD can be substituted by (i) one dose per day (1DD), (ii) an estimate based on the 75th percentile of days taken by patients to refill a script (PDD75 ) or (iii...

journal_title：British journal of clinical pharmacology

authors： Ung D,Dalli LL,Lopez D,Sanfilippo FM,Kim J,Andrew NE,Thrift AG,Cadilhac DA,Anderson CS,Kilkenny MF

更新日期：2020-07-08 00:00:00