CYP2D6 variation, behaviour and psychopathology: implications for pharmacogenomics-guided clinical trials.

abstract：:Metabolomics is recognized as a powerful top-down system biological approach to understand genetic-environment-health paradigms paving new avenues to identify clinically relevant biomarkers. It is nowadays commonly used in clinical applications shedding new light on physiological regulatory processes of complex mammal...

journal_title：British journal of clinical pharmacology

authors： Collino S,Martin FP,Rezzi S

更新日期：2013-03-01 00:00:00

abstract：:The effect of isotonic bicycle exercise on beta 2-adrenoceptors and cAMP production in lymphocytes was studied. The origin of the newly exposed receptors was studied by measuring radioligand binding in the presence of hydrophylic or lipophylic 'cold' ligands. During exercise beta 2-adrenoceptor density increased from ...

journal_title：British journal of clinical pharmacology

authors： Graafsma SJ,van Tits LJ,Willems PH,Hectors MP,Rodrigues de Miranda JF,De Pont JJ,Thien T

更新日期：1990-01-01 00:00:00

abstract：:Little is known about the administration of direct-acting oral anticoagulants (DOACs) and the occurrence of alopecia. Our aim was to analyse the reports of alopecia following DOAC administration received until 2 May 2018 from VigiBase, the World Health Organization database. A descriptive analysis of age, sex, serious...

journal_title：British journal of clinical pharmacology

authors： Bonaldo G,Vaccheri A,Motola D

更新日期：2020-08-01 00:00:00

abstract：:The effect of metronidazole, at a dose of 1.2 g daily, on theophylline disposition was studied in 10 healthy adult volunteers. Neither theophylline half-life, volume of distribution nor total body clearance was altered by the anti-microbial. It is concluded that metronidazole does not impair theophylline metabolism de...

journal_title：British journal of clinical pharmacology

authors： Adebayo GI,Mabadeje AF

更新日期：1987-07-01 00:00:00

abstract：:Oxycodone chloride (0.07 mg kg-1) was given by intravenous bolus to nine young adult surgical patients on the first postoperative day. Plasma was sampled for up to 12 h. Mean values of t1/2z, CL and Vss were 222 min, 0.78 l min-1 and 2.60 l kg-1, respectively. The concentrations of the metabolite noroxycodone was also...

journal_title：British journal of clinical pharmacology

authors： Pöyhiä R,Olkkola KT,Seppälä T,Kalso E

更新日期：1991-10-01 00:00:00

abstract：AIMS:Thiazolidinediones (TZDs) not only enhance cellular glucose transport but are reported to have potent anti-inflammatory effects. These effects may play an important role in the insulin sensitizing mechanism, and possibly precede the effects on parameters of glucoregulation. We sought to investigate whether these a...

journal_title：British journal of clinical pharmacology

authors： van Doorn M,Kemme M,Ouwens M,van Hoogdalem EJ,Jones R,Romijn H,de Kam M,Schoemaker R,Burggraaf K,Cohen A

更新日期：2006-10-01 00:00:00

abstract：AIMS:microRNA-122 (miR-122) is a hepatotoxicity biomarker with utility in the management of paracetamol overdose and in drug development. Renal dysfunction and haemodialysis have been associated with a reduction in circulating microRNA. The objective of this study was to determine their effect on miR-122. METHODS:Bloo...

journal_title：British journal of clinical pharmacology

authors： Rivoli L,Vliegenthart AD,de Potter CM,van Bragt JJ,Tzoumas N,Gallacher P,Farrah TE,Dhaun N,Dear JW

更新日期：2017-03-01 00:00:00

abstract：:Acute myeloid leukaemia (AML) is a haematopoietic stem cell disorder, that is characterized by the clonal expansion of myeloid blasts and suppression of normal haematopoiesis. The 3 + 7 regimen is the backbone of standard first-line induction therapy among young/fit patients. However, in elderly and/or unfit patients ...

journal_title：British journal of clinical pharmacology

authors： Kucukyurt S,Eskazan AE

更新日期：2019-12-01 00:00:00

abstract：:1. Preliminary results are reported from a long-term study aimed at recording the concentrations of serum lipids and lipoproteins at 6, 12 and 24 months of treatment with pindolol in young/middle-aged males with moderate hypertension. 2. Seventy-three patients have been recruited, of whom 47 have completed 6 months tr...

journal_title：British journal of clinical pharmacology

authors： Carlson LA,Ribacke M,Terent A

更新日期：1987-01-01 00:00:00

abstract：:1. The aim of this study was to investigate the dose-related effects of ibuprofen (placebo, 400 and 800 mg rac-ibuprofen [Aktren], administered orally) on experimentally-induced tonic and phasic pain. 2. Eighteen volunteers participated in this randomized, double-blind, three-fold cross-over study. Measurements were o...

journal_title：British journal of clinical pharmacology

authors： Kobal G,Hummel C,Gruber M,Geisslinger G,Hummel T

更新日期：1994-05-01 00:00:00

abstract：:1 In an open, randomized cross-over investigation of thirteen patients (nine and four women, aged 37-67 years) with mild or moderate essential hypertension a comparison between atenolol and metoprolol was carried out in order to study the effects of 50, 100 and 200 mg given once daily on blood pressure and heart rate ...

journal_title：British journal of clinical pharmacology

authors： Rasmussen S,Arnung K,Eskildsen PC,Nielsen PE

更新日期：1981-12-01 00:00:00

abstract：AIMS:Adrenomedullin (ADM) is an important regulator of endothelial barrier function and vascular tone, and may represent a novel treatment target in sepsis. The non-neutralizing ADM antibody adrecizumab has shown promising results in preclinical sepsis models. In the present study, we investigated the safety, tolerabil...

journal_title：British journal of clinical pharmacology

authors： Geven C,van Lier D,Blet A,Peelen R,Ten Elzen B,Mebazaa A,Kox M,Pickkers P

更新日期：2018-09-01 00:00:00

abstract：:The absorption of the antiemetic metopimazine (MPZ) given as a single dose of (a) 40 mg microenema, (b) 40 mg orally and (c) 10 mg as a 60 min i.v. continuous infusion was investigated in six healthy volunteers. Blood samples were drawn and the serum concentrations of MPZ and its acid metabolite were measured. The bio...

journal_title：British journal of clinical pharmacology

authors： Herrstedt J,Jørgensen M,Angelo HR,Rassing MR,Møller-Sonnergaard J,Dombernowsky P

更新日期：1996-06-01 00:00:00

abstract：:1 Plasma concentrations of metoprolol and a pharmacologically active metabolite, H119/66, have been measured in young and elderly volunteers after a single dose of 100 mg metoprolol tartrate and after repeated administrated over a period of 1 week. Whilst concentrations of metoprolol are similar in each group, concent...

journal_title：British journal of clinical pharmacology

authors： Quarterman CP,Kendall MJ,Jack DB

更新日期：1981-03-01 00:00:00

abstract：AIMS:Within the new psychoactive substances (NPS) scenario, several hundred different molecules, mostly including synthetic cannabinoids and cathinones, have been identified so far. The aims of the paper were to: (i) identify the number of synthetic cathinones mentioned in a range of psychonaut, NPS-related, online sou...

journal_title：British journal of clinical pharmacology

authors： Schifano F,Napoletano F,Arillotta D,Zangani C,Gilgar L,Guirguis A,Corkery JM,Vento A

更新日期：2020-03-01 00:00:00

abstract：AIMS:To compare gastric acid suppression by netazepide, a gastrin/CCK2 receptor antagonist, with that by a proton pump inhibitor (PPI), and to determine if netazepide can prevent the trophic effects of PPI-induced hypergastrinaemia. METHODS:Thirty healthy subjects completed a double-blind, randomized, parallel group t...

journal_title：British journal of clinical pharmacology

authors： Boyce M,Dowen S,Turnbull G,van den Berg F,Zhao CM,Chen D,Black J

更新日期：2015-05-01 00:00:00

abstract：AIMS:To obtain in vivo evidence for the involvement of cytochrome P450 (CYP) 3A4 in the metabolism of brotizolam. METHODS:Fourteen healthy male volunteers received erythromycin 1200 mg day(-1) or placebo for 7 days in a double-blind randomized crossover manner. On the 6th day they received a single oral 0.5-mg dose of...

journal_title：British journal of clinical pharmacology

authors： Tokairin T,Fukasawa T,Yasui-Furukori N,Aoshima T,Suzuki A,Inoue Y,Tateishi T,Otani K

更新日期：2005-08-01 00:00:00

abstract：:Studies were done to examine the influence of the menstrual cycle on the elimination kinetics of paracetamol. Salivary concentrations of paracetamol were determined after oral administration of 1 g of paracetamol on day 3, 10, 14, 20 and 25 of the menstrual cycle in normal healthy women volunteers with regular menstru...

journal_title：British journal of clinical pharmacology

authors： Somaja L,Thangam J

更新日期：1987-03-01 00:00:00

abstract：:Submaximal dose pentagastrin tests conducted in normal male volunteers with L-643.441, a novel histamine H2-receptor antagonist, indicate that it is a potent and long-acting inhibitor of gastric acid secretion. The effect appears dose-dependent and single doses of 50 mg are sufficient to reduce secretory potential by ...

journal_title：British journal of clinical pharmacology

authors： Henry DA,Somerville KW,Kitchingman GK,Holmes IB,Tobert JA,Langman MJ

更新日期：1985-08-01 00:00:00

abstract：:The plasma concentrations of the tetracyclic antidepressant maprotiline and its effect on histamine-induced bronchoconstriction were measured after single (50 mg) and multiple (50 mg twice daily) oral doses in healthy subjects. Histamine-induced bronchoconstriction was abolished after a single dose of maprotiline and ...

journal_title：British journal of clinical pharmacology

authors： Firkusny L,Gleiter CH

更新日期：1994-04-01 00:00:00

abstract：AIMS:Mycophenolic acid (MPA) suppresses lymphocyte proliferation through inosine monophosphate dehydrogenase (IMPDH) inhibition. Two formulations have been approved: mycophenolate mofetil (MMF) and enteric-coated mycophenolate sodium (EC-MPS). Pantoprazole (PAN) inhibits gastric acid secretion, which may alter MPA expo...

journal_title：British journal of clinical pharmacology

authors： Rissling O,Glander P,Hambach P,Mai M,Brakemeier S,Klonower D,Halleck F,Singer E,Schrezenmeier EV,Dürr M,Neumayer HH,Budde K

更新日期：2015-11-01 00:00:00

abstract：:1. The population pharmacokinetics of lisinopril were investigated using data collected from two multicentre trials of lisinopril in the treatment of hypertension in elderly patients (n = 40) and patients with renal disease (n = 20). 2. Lisinopril was started at doses of 2.5-5 mg daily and increased at 2-4 weekly inte...

journal_title：British journal of clinical pharmacology

authors： Thomson AH,Kelly JG,Whiting B

更新日期：1989-01-01 00:00:00

abstract：AIMS:Glucocorticoids suppress the release of tumour necrosis factor-alpha (TNF-alpha) by macrophages in vitro and cause monocytopaenia in vivo. These actions may contribute to anti-inflammatory and immunosuppressant effects. We therefore examined relationships between prednisolone concentration, suppression of monocyte...

journal_title：British journal of clinical pharmacology

authors： Steer JH,Vuong Q,Joyce DA

更新日期：1997-04-01 00:00:00

abstract：:A new anti-spasticity agent, brolitene, has been assessed in patients with spasticity of spinal or cerebral origin. Twenty-seven patients were entered in a double-blind cross-over trial lasting 6 weeks, using a fixed dose of six tablets (1200 mg brolitene) per day. Clinical assessment failed to show any therapeutic ef...

journal_title：British journal of clinical pharmacology

authors： Perkin GD,Aminoff MJ

更新日期：1976-10-01 00:00:00

abstract：:1. Since salt depletion stimulates the renal prostaglandin system to maintain renal function, the effects of indomethacin and ibuprofen upon renal haemodynamics, electrolyte excretion and renin release were examined in eight healthy male volunteers on a salt restricted diet, before and after frusemide administration. ...

journal_title：British journal of clinical pharmacology

authors： Passmore AP,Copeland S,Johnston GD

更新日期：1990-03-01 00:00:00

abstract：:Aims We investigated whether venoconstriction by α-adrenoceptor stimulation, and venodilation by β-adrenoceptor stimulation and nitroglycerin are altered in patients with diabetes mellitus (DM). Methods Eight male patients with non insulin-dependent DM and eight age-matched control subjects were included. The patients...

journal_title：British journal of clinical pharmacology

authors： Harada K,Ohmori M,Kitoh Y,Sugimoto KI,Fujimura A

更新日期：1999-04-01 00:00:00

abstract：AIMS:The primary objective of this study was to characterize the pharmacokinetics and pharmacodynamics of single daily doses of donepezil (5 and 10 mg) each evening for 28 consecutive days. A secondary objective was to measure the plasma protein binding of donepezil at steady state. METHODS:This was a double-blind, ra...

journal_title：British journal of clinical pharmacology

authors： Tiseo PJ,Rogers SL,Friedhoff LT

更新日期：1998-11-01 00:00:00

abstract：AIMS:Carbamazepine (CBZ) is an inducer of cytochrome P450 enzymes, which have been implicated in many drug interactions. However, for immunosuppressant and anti-HIV drugs, whose main site of action is the lymphocyte, induction of P-glycoprotein (Pgp) may also be important. In this study, we have investigated whether CB...

journal_title：British journal of clinical pharmacology

authors： Owen A,Goldring C,Morgan P,Park BK,Pirmohamed M

更新日期：2006-08-01 00:00:00

abstract：:Increasing doses of a slow-release potassium supplement were given to nine hypertensive patients previously treated for at least 18 months with bendrofluazide 10 mg daily. Serum potassium and total body potassium (TBK) were measured after 2 months on each dose. No significant increase in serum potassium or TBK occurre...

journal_title：British journal of clinical pharmacology

authors： Wilkinson PR,Tait C,Hesp R,Raftery EB

更新日期：1982-08-01 00:00:00

abstract：AIMS:To investigate the driving forces behind increasing utilization of cardiovascular drugs. METHODS:Using register data, all Danish residents as of 1 January 1996 were followed until 2006. Cohort members were censored at death or emigration. Cardiovascular drug utilization on the individual level was traced, applyin...

journal_title：British journal of clinical pharmacology

authors： Kildemoes HW,Støvring H,Andersen M

更新日期：2008-12-01 00:00:00