Beta 2-adrenoceptor up-regulation in relation to cAMP production in human lymphocytes after physical exercise.

abstract：:This study investigated the effects of placebo, 1 mg, 3 mg, 10 mg and 30 mg ritanserin and 10 mg diazepam on human sleep. Twelve normal volunteers participated in this randomized, double-blind, placebo-controlled cross-over sleep study. A clear dose-response relationship was found for ritanserin with higher doses evok...

journal_title：British journal of clinical pharmacology

authors： Idzikowski C,Mills FJ,James RJ

更新日期：1991-02-01 00:00:00

abstract：AIMS:Hypertension is a common comorbidity of patients with COVID-19, SARS or HIV infection. Such patients are often concomitantly treated with antiviral and antihypertensive agents, including ritonavir and nifedipine. Since ritonavir is a strong inhibitor of CYP3A and nifedipine is mainly metabolized via CYP3A, the com...

journal_title：British journal of clinical pharmacology

authors： Niu W,Li S,Jin S,Lin X,Zhang M,Cai W,Jiao Z,Xiang X

更新日期：2020-12-02 00:00:00

abstract：:Medroxalol, a new drug which has been reported to possess both alpha- and beta-adrenoceptor antagonist properties, was compared with labetalol in single dose studies in normotensive males. Oral doses of 400 mg of each drug significantly reduced blood pressure, both supine and erect, without significant changes in hear...

journal_title：British journal of clinical pharmacology

authors： Elliott HL,McLean K,Meredith PA,Sumner DJ,Reid JL

更新日期：1984-05-01 00:00:00

abstract：:1 Nineteen pregnant patients whose mean arterial pressure (MAP) was persistently greater than or equal to 103.3 mmHg were given labetalol or methyldopa. 2 Singificant falls (P less than 0.001) in BP only occurred in the group treated with labetalol, and daily BP control was better in this group. 3 Two severely hyperte...

journal_title：British journal of clinical pharmacology

authors： Lamming GD,Symonds EB

更新日期：1979-04-01 00:00:00

abstract：AIMS:The efficacy of activated charcoal alone, and gastric lavage followed by charcoal in reducing the absorption of diazepam, ibuprofen and citalopram was studied in healthy volunteers. METHODS:In a randomized cross-over study with three phases, nine healthy volunteers were administered single oral doses of 5 mg diaz...

journal_title：British journal of clinical pharmacology

authors： Lapatto-Reiniluoto O,Kivistö KT,Neuvonen PJ

更新日期：1999-08-01 00:00:00

abstract：AIMS:The aims of the study were to determine the effect of advice from the Scottish Medicines Consortium (SMC) on the use of medicines within Scotland's National Health Service (NHS) and generate hypotheses that may explain differences in the impact of advice on the use of individual medicines. METHODS:A retrospective...

journal_title：British journal of clinical pharmacology

authors： Bennie M,Dear J,Hems S,Black C,McIver L,Webb DJ

更新日期：2011-02-01 00:00:00

abstract：:Integration of clinical and preclinical pharmacology in pharmaceutical companies could be improved by several key recommendations: Companies should ensure that there is an adequate pool of trained clinical pharmacologists and preclinical pharmacologists. Training should include topics that allow clinical pharmacologis...

journal_title：British journal of clinical pharmacology

authors： Hunter JA

更新日期：2012-06-01 00:00:00

abstract：AIM:The large inter-individual variability in clopidogrel response is attributed to pharmacokinetics. Although, it has been used since the late 1990s the pharmacokinetic fate of clopidogrel and its metabolites are poorly explained. The variable response to clopidogrel is believed to be multi-factorial, caused both by g...

journal_title：British journal of clinical pharmacology

authors： Ganesan S,Williams C,Maslen CL,Cherala G

更新日期：2013-06-01 00:00:00

abstract：:Twelve patients with acute uncomplicated falciparum malaria were admitted to the Hospital for Tropical Diseases for 42 days. The patients were treated with halofantrine 500 mg 6 hourly for three doses and halofantrine and its desbutyl metabolite were analysed in plasma by h.p.l.c. Cmax values of halofantrine and desbu...

journal_title：British journal of clinical pharmacology

authors： Karbwang J,Milton KA,Na Bangchang K,Ward SA,Edwards G,Bunnag D

更新日期：1991-04-01 00:00:00

abstract：:Cefpiramide is a new parenteral cephalosporin mainly excreted in the bile. Eight patients with cholestasis and 11 healthy subjects received a single 1 g i.v. dose. Cefpiramide concentrations in plasma and urine were measured by h.p.l.c. and plasma binding was determined by ultrafiltration. Total clearance of cefpirami...

journal_title：British journal of clinical pharmacology

authors： Demontes-Mainard F,Vinçon G,Labat L,Amouretti M,Necciari J,Kieffer G,Bannwarth B

更新日期：1994-03-01 00:00:00

abstract：AIMS:The aim of this study was to perform an up-to-date meta-analysis on the risk of cardiac malformations associated with gestational exposure to paroxetine, taking into account indication, study design and reference category. METHOD:A systematic review of studies published between 1966 and November 2015 was conducte...

journal_title：British journal of clinical pharmacology

authors： Bérard A,Iessa N,Chaabane S,Muanda FT,Boukhris T,Zhao JP

更新日期：2016-04-01 00:00:00

abstract：:The present study was designed to evaluate the potential anti-ischaemic activity of R 56865 in patients with coronary artery disease, scheduled to undergo percutaneous transluminal coronary angioplasty (PTCA). At baseline a complete haemodynamic profile, including cardiac output and coronary sinus blood flow (CSBF) wa...

journal_title：British journal of clinical pharmacology

authors： Pijl AJ,Van Wezel HB,Koolen JJ,Piek JJ,Koch K,Swaan A,David GK,Visser CA,Van Zwieten PA

更新日期：1995-05-01 00:00:00

abstract：:The rise in plasma adenosine-3',5'-monophosphate occurring in response to insulin induced hypoglycaemia in normal human subjects, was abolished by non-selective beta-adrenoceptor blockade but unaffected by selective beta 1-adrenoceptor blockade. This implies that the rise is secondary to beta 2-adrenoceptor stimulatio...

journal_title：British journal of clinical pharmacology

authors： Armitstead JG,Lightman SL,Brown MJ,Causon RC,Vaughan NJ

更新日期：1983-12-01 00:00:00

abstract：:The classical taxanes (paclitaxel, docetaxel), the newer taxane cabazitaxel and the nanoparticle-bound nab-paclitaxel are among the most widely used anticancer drugs. Still, the optimal use and the value of pharmacological personalization of the taxanes is still controversial. We give an overview on the pharmacologica...

journal_title：British journal of clinical pharmacology

authors： Muth M,Ojara FW,Kloft C,Joerger M

更新日期：2020-11-28 00:00:00

abstract：:1. Azole antifungal agents such as ketoconazole act by inhibiting cytochrome P-450 mediated sterol synthesis in the fungal cell membrane and thus have the potential to interfere with mammalian steroidogenesis. Fluconazole is a novel orally-effective antifungal triazole which has been reported to have more specific eff...

journal_title：British journal of clinical pharmacology

authors： Devenport MH,Crook D,Wynn V,Lees LJ

更新日期：1989-06-01 00:00:00

abstract：AIMS:To analyse clinical outcomes with direct oral anticoagulants in patients with atrial fibrillation according to geographic region. METHODS:We systematically searched MEDLINE, CENTRAL, websites of regulatory agencies, clinical trials registers and conference proceedings for randomized controlled trials of direct or...

journal_title：British journal of clinical pharmacology

authors： Gómez-Outes A,Terleira-Fernández AI,Calvo-Rojas G,Suárez-Gea ML,Vargas-Castrillón E

更新日期：2016-09-01 00:00:00

abstract：AIM:The aim of the study was to simplify the dosing regimen of peginterferon alfa-2a in paediatric patients with chronic hepatitis C. METHODS:A population pharmacokinetic (PK) model was developed using PK data from 14 children aged 2-8 years and 402 adults. Simulations were produced to identify a simplified dosing reg...

journal_title：British journal of clinical pharmacology

authors： Brennan BJ,Lemenuel-Diot A,Snoeck E,McKenna M,Solsky J,Wat C,Mallalieu NL

更新日期：2016-04-01 00:00:00

abstract：:1. The beta-adrenergic blocking potencies of practolol, ICI 66082, tolamolol, acebutolol, H 93/26, H 87/07, pindolol and Ro 3-4787 were compared with that of propranolol, on human and rat adipocytes. 2. A good correlation was found between the potencies on adipocytes of the two species but not between our results and ...

journal_title：British journal of clinical pharmacology

authors： Harms HH,Van der Meer J

更新日期：1975-08-01 00:00:00

abstract：:Ten volunteers carried a 10 mg 24 h -1 transdermal glyceryl trinitrate (GTN) patch for 24 h before moderate exercise. Plasma GTN-concentration increased significantly (P less than 0.05) by 19% to peak value at 15 min. Two hours after patch renewal repeat exercise increased GTN concentration by 56% (P less than 0.001)....

journal_title：British journal of clinical pharmacology

authors： Gjesdal K,Klemsdal TO,Rykke EO,Bredesen JE

更新日期：1991-05-01 00:00:00

abstract：AIM:To develop a semi-mechanistic model, based on glutathione depletion and predict a previously identified intra-individual reduction in busulfan clearance to aid in more precise dosing. METHODS:Busulfan concentration data, measured as part of regular care for allogeneic hematopoietic cell transplantation (HCT) patie...

journal_title：British journal of clinical pharmacology

authors： Langenhorst JB,Boss J,van Kesteren C,Lalmohamed A,Kuball J,Egberts ACG,Boelens JJ,Huitema ADR,van Maarseveen EM

更新日期：2020-08-01 00:00:00

abstract：AIMS:The objective of this study was to estimate the number of fractures attributed to oral corticosteroid use. METHODS:Information was obtained from the General Practice Research Database which contains medical records of general practitioners in the UK. The total number of corticosteroid-related fractures during a c...

journal_title：British journal of clinical pharmacology

authors： van Staa TP,Abenhaim L,Cooper C,Zhang B,Leufkens HG

更新日期：2001-06-01 00:00:00

abstract：:1. The dose-peak effect relationship of lisinopril was evaluated in a double-blind, parallel study in 83 patients with mild to moderate essential hypertension (supine diastolic blood pressure = 95-115 mm Hg). 2. After a 4 week placebo washout, patients were randomly assigned to one of four treatments: lisinopril 2.5, ...

journal_title：British journal of clinical pharmacology

authors： Cirillo VJ,Gomez HJ,Salonen J,Salonen R,Rissanen V,Bolognese JA,Nyberg R,Kristianson K

更新日期：1988-05-01 00:00:00

abstract：:1 The properties of a recently introduced digitalis glycoside, 4-beta-methyl digoxin (medigoxin) were compared to those of a standard digoxin preparation. Using a radioimmunoassay (RIA) technique, serial plasma levels were recorded for 8 h following a single oral dose in five fasting volunteer subjects, and urinary gl...

journal_title：British journal of clinical pharmacology

authors： Hayward RP,Greenwood H,Hamer J

更新日期：1978-07-01 00:00:00

abstract：AIMS:To investigate the driving forces behind increasing utilization of cardiovascular drugs. METHODS:Using register data, all Danish residents as of 1 January 1996 were followed until 2006. Cohort members were censored at death or emigration. Cardiovascular drug utilization on the individual level was traced, applyin...

journal_title：British journal of clinical pharmacology

authors： Kildemoes HW,Støvring H,Andersen M

更新日期：2008-12-01 00:00:00

abstract：WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT:Nitrates may facilitate syncope through various pathways, but the precise mechanism of nitrate-induced syncope is still under debate. The purpose of the present study was to compare the underlying haemodynamic mechanisms in subjects without and with presyncopal symptoms during a...

journal_title：British journal of clinical pharmacology

authors： Tahvanainen A,Koskela J,Leskinen M,Ilveskoski E,Nordhausen K,Kähönen M,Kööbi T,Mustonen J,Pörsti I

更新日期：2011-01-01 00:00:00

abstract：:A single oral dose of lamotrigine was administered to seven volunteers with Gilbert's Syndrome (unconjugated hyperbilirubinaemia). Plasma samples were assayed by high performance liquid chromatography (h.p.l.c.) and pharmacokinetic parameters were compared with those of a group of nine normal volunteers. In the subjec...

journal_title：British journal of clinical pharmacology

authors： Posner J,Cohen AF,Land G,Winton C,Peck AW

更新日期：1989-07-01 00:00:00

abstract：AIMS:Angiotensin II is a putative mediator in bronchial asthma. There have been very few studies investigating the involvement of angiotensin II receptors in bronchial hyper-responsiveness in asthmatic patients. We examined the effect of candesartan cilexetil, a specific angiotensin II type 1 (AT1) receptor antagonist,...

journal_title：British journal of clinical pharmacology

authors： Myou S,Fujimura M,Kamio Y,Kita T,Watanabe K,Ishiura Y,Hashimoto T,Nakao S

更新日期：2002-12-01 00:00:00

abstract：:1 As part of a prospective study on the use of digoxin in a general practice, plasma digoxin concentrations were measured in all patients receiving the drug. 2 A low mean plasma digoxin concentration was observed, suggesting a cautious approach to digitalization. 3 The correlation between plasma digoxin concentration ...

journal_title：British journal of clinical pharmacology

authors： Holt DW,Williamson JD,Volans GN

更新日期：1977-06-01 00:00:00

abstract：:We have measured the psychological effects of acebutolol and atenolol in sixteen patients with essential hypertension. The drugs were administered in a randomized, placebo-controlled, double-blind manner, in single daily doses of 100 mg atenolol, 400 mg acebutolol or placebo for periods of 6 weeks, each drug period be...

journal_title：British journal of clinical pharmacology

authors： Lewis MJ,Jones DM,Dart AM,Henderson AH

更新日期：1984-03-01 00:00:00

abstract：:The effect of urinary pH on flecainide excretion has been evaluated in six healthy subjects after a single oral dose of 300 mg flecainide administered as the acetate salt. The cumulative urinary excretion of unchanged flecainide under acidic conditions (134.0 +/- 16.1 mg; mean +/- s.e. mean) was significantly higher t...

journal_title：British journal of clinical pharmacology

authors： Muhiddin KA,Johnston A,Turner P

更新日期：1984-04-01 00:00:00