Direct-acting oral anticoagulants and alopecia: The valuable support of postmarketing data.

abstract：:Nine young and 12 elderly healthy volunteers received nisoldipine 10 mg once a day for 7 days. Plasma nisoldipine concentrations were measured on Day 1 and on Day 7. Higher plasma drug concentrations were observed in the elderly group than in the young group with the values for AUC being approximately doubled in the e...

journal_title：British journal of clinical pharmacology

authors： Baksi AK,Edwards JS,Ahr G

更新日期：1991-03-01 00:00:00

abstract：:Regulatory science underpins the objective evaluation of medicinal products. It is therefore imperative that regulatory science and expertise remain at the cutting edge so that innovations of ever-increasing complexity are translated safely and swiftly into effective, high-quality therapies. We undertook a comprehensi...

journal_title：British journal of clinical pharmacology

authors： Hines PA,Guy RH,Brand A,Humphreys AJ,Papaluca-Amati M

更新日期：2020-12-01 00:00:00

abstract：AIMS:The therapeutic action of tricyclic agents may be accompanied by unwanted effects on the cardiovascular system. The evidence for the effects on vascular and nonvascular smooth muscle comes from animal studies. Whether these studies can be extrapolated to human vessels remains to be determined. Therefore, the prese...

journal_title：British journal of clinical pharmacology

authors： Vila JM,Medina P,Segarra G,Lluch P,Pallardó F,Flor B,Lluch S

更新日期：1999-08-01 00:00:00

abstract：AIMS:To characterize potential mechanism-based inactivation (MBI) of major human drug-metabolizing cytochromes P450 (CYP) by monoamine oxidase (MAO) inhibitors, including the antitubercular drug isoniazid. METHODS:Human liver microsomal CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A activities were investigated following c...

journal_title：British journal of clinical pharmacology

authors： Polasek TM,Elliot DJ,Somogyi AA,Gillam EM,Lewis BC,Miners JO

更新日期：2006-05-01 00:00:00

abstract：:1 We have performed a double-blind, randomized, 7-d cross-over study of the thromboxane synthetase inhibitor dazoxiben (UK 37248) in 20 patients with stable coronary heart disease. 2 All patients had a history of exertional angina of greater than two years duration and no patient had suffered a myocardial infarction i...

journal_title：British journal of clinical pharmacology

authors： Reuben SR,Kuan P,Cairns J,Gyde OH

更新日期：1983-01-01 00:00:00

abstract：AIMS:To investigate presence or absence of clinically relevant drug interactions (pharmacokinetic and safety/tolerability) of OBE022 with standard-of-care medicines for preterm labour, enabling coadministration and further clinical development. METHODS:Part A: open-label, randomized, 3-period crossover assessing coadm...

journal_title：British journal of clinical pharmacology

authors： Pohl O,Marchand L,Gotteland JP,Coates S,Täubel J,Lorch U

更新日期：2019-07-01 00:00:00

abstract：:1 A new osmotic pressure mediated delivery system for metoprolol (Lopresor Oros) has been evaluated by measuring the haemodynamic effects and pharmacokinetics after single and multiple oral dosing in young healthy volunteers. 2 Similar studies have been carried out in the same group using equivalent single and multipl...

journal_title：British journal of clinical pharmacology

authors： Kendall MJ,Jack DB,Woods KL,Laugher SJ,Quarterman CP,John VA

更新日期：1982-03-01 00:00:00

abstract：AIMS:To evaluate the comparative efficacy (50% reduction in seizure frequency) and tolerability (premature withdrawal due to adverse events) of anti-epileptic drugs (AEDs) for refractory epilepsy. METHODS:We searched Cochrane Central Register of Controlled Trials (Cochrane Library 2009, issue 2) including Epilepsy Gro...

journal_title：British journal of clinical pharmacology

authors： Bodalia PN,Grosso AM,Sofat R,Macallister RJ,Smeeth L,Dhillon S,Casas JP,Wonderling D,Hingorani AD

更新日期：2013-11-01 00:00:00

abstract：AIMS:To investigate the effect of multiple oral dose treatment with the endothelin receptor antagonist bosentan on the pharmacokinetics of digoxin in healthy subjects. METHODS:This was an open-label, randomized, two-way crossover study in 18 evaluable young male subjects. They received, on two occasions which were sep...

journal_title：British journal of clinical pharmacology

authors： Weber C,Banken L,Birnboeck H,Nave S,Schulz R

更新日期：1999-06-01 00:00:00

abstract：:1 This study was performed because dose-related effects of heroin on human sleep had not been described previously, and to discover if heroin produces a morphine-like insomnia. 2 After three adaptation nights, the sleep of seven male nondependent opiate addicts was studied following i.m. doses of heroin (3, 6, 12 mg/7...

journal_title：British journal of clinical pharmacology

authors： Kay DC,Pickworth WB,Neider GL

更新日期：1981-02-01 00:00:00

abstract：:1. The pharmacokinetics and pharmacodynamics of a single dose of trandolapril, an angiotensin converting enzyme (ACE) inhibitor with an active metabolite, trandolaprilat, which is in part further metabolised prior to renal elimination, were evaluated in 31 subjects with a wide range of renal function (creatinine clear...

journal_title：British journal of clinical pharmacology

authors： Bevan EG,McInnes GT,Aldigier JC,Conte JJ,Grunfeld JP,Harper SJ,Meyer BH,Pauly N,Wilkinson R

更新日期：1993-02-01 00:00:00

abstract：AIMS:The objectives were to investigate the pharmacokinetics, pharmacodynamics and safety of ilaprazole infusion in healthy subjects and patients with esomeprazole as positive control, and then recommend the dosage regimen for Phase 2b/3 studies. METHODS:Three clinical studies were performed. First, 16 healthy subject...

journal_title：British journal of clinical pharmacology

authors： Wang H,Shao F,Liu X,Xu W,Ou N,Qin X,Liu F,Hou X,Hu H,Jiang J

更新日期：2019-11-01 00:00:00

abstract：:Residual effects of brotizolam (0.25 mg) and flurazepam (30 mg) were studied in healthy young adults. Performance and subjective assessments were observed from 7 to 8 h after overnight ingestion, and effects were compared with that of placebo. Visuo-motor coordination, visuo-mental processing time, visuo-motor reactio...

journal_title：British journal of clinical pharmacology

authors： Krueger H,Müller-Limmroth W

更新日期：1983-01-01 00:00:00

abstract：AIMS:The aim of this work is to understand the process of drug administration and identify points in the workflow that resulted in interventions by clinical information systems in order to improve patient safety. METHODS:To identify a generic way to structure the drug administration process we performed peer-group dis...

journal_title：British journal of clinical pharmacology

authors： Seidling HM,Lampert A,Lohmann K,Schiele JT,Send AJ,Witticke D,Haefeli WE

更新日期：2013-09-01 00:00:00

abstract：:The pharmacokinetics of single and co-administered didanosine and stavudine were evaluated in 10 HIV-seropositive subjects in an open, within subject design in which each subject received each of three treatments. Single doses of didanosine 100 mg were alternated randomly with single doses of stavudine 40 mg on days 1...

journal_title：British journal of clinical pharmacology

authors： Seifert RD,Stewart MB,Sramek JJ,Conrad J,Kaul S,Cutler NR

更新日期：1994-11-01 00:00:00

abstract：AIMS:Data regarding the cardiac toxicity of cabozantinib lacks. The aim of our study was to assess the risk of cabozantinib-related cardiotoxicity in mRCC patients. METHODS:We performed a multicentre prospective study on mRCC patients treated with cabozantinib between October 2016 and November 2017. Transthoracic echo...

journal_title：British journal of clinical pharmacology

authors： Iacovelli R,Ciccarese C,Fornarini G,Massari F,Bimbatti D,Mosillo C,Rebuzzi SE,Di Nunno V,Grassi M,Fantinel E,Ardizzoni A,Tortora G

更新日期：2019-06-01 00:00:00

abstract：:The effects of a single dose of sulindac 200 mg and placebo on the capsaicin-induced cough reflex were studied in a two-phase double-blind crossover study in 18 healthy subjects. Sulindac increased the threshold for capsaicin cough response significantly, but did not alter D5, peak response, or the total cough respons...

journal_title：British journal of clinical pharmacology

authors： Foster G,Yeo WW,Ramsay LE

更新日期：1991-02-01 00:00:00

abstract：:1 Study I evaluated the absorption of oxprenolol in the ileum, compared to jejunum, in healthy volunteers by an intestinal perfusion technique. Around 80 mg of drug were delivered as a saline solution directly in the small bowel. 2 Samples taken 30 cm distally to the site of perfusion showed that 63% of perfused oxpre...

journal_title：British journal of clinical pharmacology

authors： Godbillon J,Vidon N,Palma R,Pfeiffer A,Franchisseur C,Bovet M,Gosset G,Bernier JJ,Hirtz J

更新日期：1987-09-01 00:00:00

abstract：WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT:Randomized controlled trials (RCTs) are believed to be one of the best methods of clinical research because they can minimize systematic errors of various types. Temporal trends in the various aspects of RCTs have been studied in several medical fields (e.g. nephrology, hepatolo...

journal_title：British journal of clinical pharmacology

authors： Falagas ME,Pitsouni EI,Bliziotis IA

更新日期：2008-06-01 00:00:00

abstract：AIMS:To evaluate if rivaroxaban, an oral factor Xa (FXa) inhibitor, could modify the expression in vitro of inflammatory and oxidative stress biomarkers in abdominal aortic aneurysmal (AAA) sites showing intraluminal thrombus. METHODS:AAA sites with intraluminal mural thrombus were obtained from six patients undergoin...

journal_title：British journal of clinical pharmacology

authors： Moñux G,Zamorano-León JJ,Marqués P,Sopeña B,García-García JM,Laich de Koller G,Calvo-Rico B,García-Fernandez MA,Serrano J,López-Farré A

更新日期：2017-12-01 00:00:00

abstract：AIMS:Breakthrough bleeding or even unwanted pregnancies have been reported in women during concomitant therapy with oral contraceptives and St John's wort extract. The aim of the present study was to investigate the effects of St John's wort extract on oral contraceptive therapy with respect to ovarian activity, breakt...

journal_title：British journal of clinical pharmacology

authors： Pfrunder A,Schiesser M,Gerber S,Haschke M,Bitzer J,Drewe J

更新日期：2003-12-01 00:00:00

abstract：:1 A double-blind entry to a trial of an active non-steroidal anti-inflammatory drug, flurbiprofen against placebo was undertaken until 100 patients with classical rheumatoid arthritis had been allocated to each treatment. 2 Each patient was given a long-term supply of drug and was asked to vary their own dosage within...

journal_title：British journal of clinical pharmacology

authors： Rooney PJ,Capell HA,Paterson S,Buchanan WW,Dick WC

更新日期：1978-05-01 00:00:00

abstract：:1. Using human mononuclear leucocytes as target cells, we have investigated the bioactivation of dapsone (DDS) to a cytotoxic metabolite in the presence of microsomes from nine human livers. Values for NADPH dependent toxicity ranged from 8.8-27% (15.8 +/- 5.9%) and were similar to those for microsomes from control mi...

journal_title：British journal of clinical pharmacology

authors： Coleman MD,Breckenridge AM,Park BK

更新日期：1989-10-01 00:00:00

abstract：:1 Roth et al. (1972) have proposed that within the affective disorders there are two distinct syndromes--anxiety and depression--differentiated by the relative predominance of these symptoms, the presence or absence of premorbid maladaptive traits, and the natural outcome of the disorder. 2 Goldberg (1982) on the othe...

journal_title：British journal of clinical pharmacology

authors： Russell GF,De Silva P

更新日期：1983-01-01 00:00:00

abstract：WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT:• The topical second generation anti-histamine azelastine hydrochloride (AZE) and the potent corticosteroid fluticasone propionate (FP) are well established first-line treatments in allergic rhinitis (AR). • MP29-02, a novel intranasal AZE and FP formulation, has been shown to c...

journal_title：British journal of clinical pharmacology

authors： Derendorf H,Munzel U,Petzold U,Maus J,Mascher H,Hermann R,Bousquet J

更新日期：2012-07-01 00:00:00

abstract：:Mirabegron is used for the treatment of symptoms associated with overactive bladder syndrome. It selectively stimulates the β3 -adrenoreceptor, which relaxes the detrusor muscle. This improves urine storage by distension of the bladder body. ...

journal_title：British journal of clinical pharmacology

authors： Goulooze SC,Cohen AF,Rissmann R

更新日期：2015-10-01 00:00:00

abstract：AIM:To evaluate the resistance to oxidation of human lipoproteins after hypolipidaemic therapy. METHODS:VLDL and LDL samples were obtained from patients with Familial Combined Hyperlipidaemia included in a randomized, double-blind, cross-over study, with 8 weeks of active treatment (gemfibrozil, 600 mg twice daily, or...

journal_title：British journal of clinical pharmacology

authors： Vázquez M,Zambón D,Hernández Y,Adzet T,Merlos M,Ros E,Laguna JC

更新日期：1998-03-01 00:00:00

abstract：:The ability to recall details of current and prior drug therapy was evaluated in two studies employing a total of 94 patients with inflammatory polyarthritis. Ten per cent of patients were unable to completely recall the names of their current anti-inflammatory drugs and eighty-three per cent of patients to completely...

journal_title：British journal of clinical pharmacology

authors： Bellamy N,Grace E,Hanna B,Grant E,Tugwell P,Buchanan WW

更新日期：1984-06-01 00:00:00

abstract：:The effect of isotonic bicycle exercise on beta 2-adrenoceptors and cAMP production in lymphocytes was studied. The origin of the newly exposed receptors was studied by measuring radioligand binding in the presence of hydrophylic or lipophylic 'cold' ligands. During exercise beta 2-adrenoceptor density increased from ...

journal_title：British journal of clinical pharmacology

authors： Graafsma SJ,van Tits LJ,Willems PH,Hectors MP,Rodrigues de Miranda JF,De Pont JJ,Thien T

更新日期：1990-01-01 00:00:00

abstract：:Studies were done to examine the influence of the menstrual cycle on the elimination kinetics of paracetamol. Salivary concentrations of paracetamol were determined after oral administration of 1 g of paracetamol on day 3, 10, 14, 20 and 25 of the menstrual cycle in normal healthy women volunteers with regular menstru...

journal_title：British journal of clinical pharmacology

authors： Somaja L,Thangam J

更新日期：1987-03-01 00:00:00