Preliminary assessment of RX 72601, a new anticholinesterase in man: reversal of competitive neuromuscular blockade.

abstract：:The prevalence of putative poor metaboliser (PM) phenotypes of proguanil oxidation in Caucasian populations is 3-10%. The PM frequency in Oriental populations is unknown. In this study the plasma metabolic ratios of proguanil and dapsone to their principal metabolites cycloguanil and monoacetyldapsone were determined ...

journal_title：British journal of clinical pharmacology

authors： Edstein MD,Shanks GD,Teja-Isavadharm P,Rieckmann KH,Webster HK

更新日期：1994-01-01 00:00:00

abstract：:1. The effects of salmeterol hydroxynaphthoate (50 micrograms, 8.3 x 10(-8) M) and salbutamol (200 micrograms, 3.5 x 10(-7) M) on sGaw were compared in a double-blind, placebo-controlled, randomised study in 10 normal subjects. 2. SGaw increased by 29% (14-43) (mean (CI)), 5 min after salmeterol and by 35% (19-51) at ...

journal_title：British journal of clinical pharmacology

authors： Spring J,Clague J,Ind PW

更新日期：1992-02-01 00:00:00

abstract：:1. A double-blind placebo-controlled study was conducted on the effects of oral terbutaline (beta 2-adrenoceptor agonist) and propranolol (beta 1 beta 2-adrenoceptor antagonist) on basal heat production of skeletal muscle, measured ex vivo by direct microcalorimetry. Terbutaline slow-release 7.5 mg, propranolol 80 mg,...

journal_title：British journal of clinical pharmacology

authors： Fagher B,Liedholm H,Sjögren A,Monti M

更新日期：1993-06-01 00:00:00

abstract：:1. Oral micronized progesterone (P) is proposed for the treatment of certain endocrine gynaecological disorders. To examine the effects of P on performance and mood, a randomized, placebo-controlled study of 24 healthy females ages 18-24 years on low-dose oral contraceptives was conducted. 2. Subjects were admitted to...

journal_title：British journal of clinical pharmacology

authors： Freeman EW,Weinstock L,Rickels K,Sondheimer SJ,Coutifaris C

更新日期：1992-03-01 00:00:00

abstract：AIMS:To examine how pharmaceutical products that were first marketed between 1950 and 1980 were promoted to physicians through advertisements and briefly review advertising regulations and accuracy of the advertisements in the light of modern knowledge. METHODS:We systematically reviewed advertisements promoting drugs...

journal_title：British journal of clinical pharmacology

authors： Green AR,Haddad PM,Aronson JK

更新日期：2018-08-01 00:00:00

abstract：:Exposure-response (ER) analysis has emerged as an important tool to interpret QT data from thorough QT (TQT) studies and allows the prediction of effects in the targeted patient population. Recently, ER analysis has also been applied to data from early clinical pharmacology studies, such as single and multiple ascendi...

journal_title：British journal of clinical pharmacology

authors： Darpo B,Garnett C

更新日期：2013-11-01 00:00:00

abstract：:1 The absorption of effervescent aspirin was studied in normal volunteers of both sexes under varied conditions of activity in both fasting and non-fasting states. 2 Moderate activity resulted in no significant changes in absorption compared with that at rest. 3 In non-fasting subjects the absorption was reduced but t...

journal_title：British journal of clinical pharmacology

authors： Volans GN

更新日期：1974-04-01 00:00:00

abstract：AIMS:Previous studies of the prescription patterns of psychotropic medications in patients with schizophrenia have highlighted a high rate of antipsychotic polypharmacy, but data in Asia are sparse. This study seeks to examine the prevalence of antipsychotic polypharmacy in patients with schizophrenia and compare the d...

journal_title：British journal of clinical pharmacology

authors： Sim K,Su A,Fujii S,Yang SY,Chong MY,Ungvari GS,Si T,Chung EK,Tsang HY,Chan YH,Heckers S,Shinfuku N,Tan CH

更新日期：2004-08-01 00:00:00

abstract：:The effect of urinary pH on flecainide excretion has been evaluated in six healthy subjects after a single oral dose of 300 mg flecainide administered as the acetate salt. The cumulative urinary excretion of unchanged flecainide under acidic conditions (134.0 +/- 16.1 mg; mean +/- s.e. mean) was significantly higher t...

journal_title：British journal of clinical pharmacology

authors： Muhiddin KA,Johnston A,Turner P

更新日期：1984-04-01 00:00:00

abstract：WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT:Rotigotine transdermal patch is a new non-ergolinic dopamine agonist developed for the treatment of Parkinson's disease and restless legs syndrome. Peripheral dopaminergic side-effects of dopamine agonists such as nausea and vomiting can be prevented by the antiemetic agent domp...

journal_title：British journal of clinical pharmacology

authors： Braun M,Cawello W,Boekens H,Horstmann R

更新日期：2009-02-01 00:00:00

abstract：AIM:Pharmacokinetics of small molecule kinase inhibitors (KIs) used in cancer treatment may alter with increasing age, but results are conflicting. This study aims to compare exposure to KIs between older and younger patients (≥70 and <70 years) in clinical practice. METHODS:KI plasma concentrations of routinely treat...

journal_title：British journal of clinical pharmacology

authors： Crombag MBS,van Doremalen JGC,Janssen JM,Rosing H,Schellens JHM,Beijnen JH,Steeghs N,Huitema ADR

更新日期：2018-12-01 00:00:00

abstract：AIM:The aim was to examine patients' stated preferences to persist with medicines and to explore the influence of psychosocial and sociocognitive factors. METHODS:Community-dwelling, hypertensive patients recruited from nine European countries were invited to complete a discrete choice experiment (DCE) with attributes...

journal_title：British journal of clinical pharmacology

authors： Holmes EA,Morrison VL,Hughes DA

更新日期：2016-08-01 00:00:00

abstract：AIMS:Aprepitant and fosaprepitant, commonly used for the prevention of chemotherapy-induced nausea and vomiting, alter cytochrome P450 activity. This systematic review evaluates clinically significant pharmacokinetic drug interactions with aprepitant and fosaprepitant and describes adverse events ascribed to drug inter...

journal_title：British journal of clinical pharmacology

authors： Patel P,Leeder JS,Piquette-Miller M,Dupuis LL

更新日期：2017-10-01 00:00:00

abstract：:1. The 5-hydroxytryptamine 3 receptor antagonist, ICS 205-930, has been reported to have potent effects on gastric smooth muscle and to enhance gastric emptying in animals, but findings in man have been inconsistent. 2. This study investigated the effects of ICS 205-930 on gastric emptying of an isotopically labelled ...

journal_title：British journal of clinical pharmacology

authors： Stacher G,Bergmann H,Granser-Vacariu GV,Wiesnagrotzki S,Wenzelabatzi TA,Gaupmann G,Kugi A,Steinringer H,Schneider C,Höbart J

更新日期：1991-12-01 00:00:00

abstract：AIMS:Antithrombin is increasingly used in paediatric patients, yet there are few age-specific pharmacokinetic data to guide dosing. We aimed to describe the pharmacokinetic profile of human (plasma-derived) antithrombin concentrate in paediatric patients. METHODS:A 5-year retrospective review was performed of patients...

journal_title：British journal of clinical pharmacology

authors： Moffett BS,Diaz R,Galati M,Mahoney D,Teruya J,Yee DL

更新日期：2017-11-01 00:00:00

abstract：AIMS:To analyse clinical outcomes with direct oral anticoagulants in patients with atrial fibrillation according to geographic region. METHODS:We systematically searched MEDLINE, CENTRAL, websites of regulatory agencies, clinical trials registers and conference proceedings for randomized controlled trials of direct or...

journal_title：British journal of clinical pharmacology

authors： Gómez-Outes A,Terleira-Fernández AI,Calvo-Rojas G,Suárez-Gea ML,Vargas-Castrillón E

更新日期：2016-09-01 00:00:00

abstract：AIMS:Tolcapone is a novel catechol-O-methyltransferase (COMT) inhibitor used as an adjunct to levodopa/carbidopa or levodopa/benserazide therapy to improve treatment of Parkinson's disease. The aim of the current study was to investigate the potential effect of tolcapone on the pharmacokinetics of carbidopa. METHODS:T...

journal_title：British journal of clinical pharmacology

authors： Jorga KM,Nicholl DJ

更新日期：1999-09-01 00:00:00

abstract：AIMS:To determine whether repeated once daily administration of grapefruit juice altered the pharmacokinetics or pharmacodynamics of the calcium antagonist amlodipine. METHOD:S The effects of grapefruit juice on the pharmacokinetics and pharmacodynamics of oral and intravenous amlodipine were assessed in 20 healthy me...

journal_title：British journal of clinical pharmacology

authors： Vincent J,Harris SI,Foulds G,Dogolo LC,Willavize S,Friedman HL

更新日期：2000-11-01 00:00:00

abstract：AIMS:Various mathematical models have been developed to estimate glomerular filtration rate (GFR) incorporating variables such as age, gender, height, weight, serum creatinine, and body surface area (BSA). Because adjustments in drug dosing are often based on estimated values of renal function, it is important to defin...

journal_title：British journal of clinical pharmacology

authors： Goerdt PJ,Heim-Duthoy KL,Macres M,Swan SK

更新日期：1997-09-01 00:00:00

abstract：AIMS:To investigate the extent of concomitant use of analgesic and psychotropic medicines among home-dwelling elderly people aged at least 75 years in Finland. METHODS:This was a population-based study in Finland, performed as part of Kuopio 75 + study focusing on the clinical epidemiology of diseases, medication and ...

journal_title：British journal of clinical pharmacology

authors： Hartikainen S,Mäntyselkä P,Louhivuori-Laako K,Enlund H,Sulkava R

更新日期：2005-09-01 00:00:00

abstract：AIMS:The main goal of the study was to describe the pharmacokinetics of maternal zidovudine (ZDV) administration during pregnancy and labour and to evaluate their impact on fetal concentrations and exposures. METHODS:A total of 195 HIV-infected pregnant and non-pregnant women aged 16-59 years were included and 273 mat...

journal_title：British journal of clinical pharmacology

authors： Fauchet F,Treluyer JM,Valade E,Benaboud S,Pannier E,Firtion G,Foissac F,Bouazza N,Urien S,Hirt D

更新日期：2014-12-01 00:00:00

abstract：:To examine the importance of acute frusemide-induced renin release in the production of the acute peripheral venous and arterial responses to frusemide in man, the effects of two drugs, previously described as inhibitors of acute frusemide-induced renin release, propranolol and digoxin, were examined. Propranolol abol...

journal_title：British journal of clinical pharmacology

authors： Johnston GD,O'Connor PC,Nicholls DP,Leahey WJ,Finch MB

更新日期：1985-04-01 00:00:00

abstract：:The effects of separate 7 day pretreatments with sulphinpyrazone (800 mg daily) and cimetidine (1 g daily) on the disposition of (+/-)-verapamil have been examined in eight healthy volunteers (four male, four female). Each subject received single oral (80 mg) and intravenous (0.15 mg/kg) doses of verapamil on differen...

journal_title：British journal of clinical pharmacology

authors： Wing LM,Miners JO,Lillywhite KJ

更新日期：1985-03-01 00:00:00

abstract：WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT:* Therapeutic drug monitoring of serum digoxin concentrations (SDC) is considered useful in enhancing the therapeutic benefits of digoxin and minimizing the incidence of adverse drug reactions. * The quality of requests for SDC has been reported to be generally unsatisfactory. H...

journal_title：British journal of clinical pharmacology

authors： Ellington C,Grgurinovich N,Miners JO,Mangoni AA

更新日期：2007-05-01 00:00:00

abstract：:1. Eight volunteers received in randomized order two 30 microliters drops of either 1% w/v cyclopentolate hydrochloride or a corresponding amount of cyclopentolate polygalacturonate in saline or in acetate buffer in one eye. Cyclopentolate concentrations in plasma were measured by a radioreceptor assay. 2. Peak plasma...

journal_title：British journal of clinical pharmacology

authors： Lahdes K,Huupponen R,Kaila T,Monti D,Saettone MF,Salminen L

更新日期：1993-05-01 00:00:00

abstract：:Eleven HIV-infected men participated in a randomized, two-treatment, two-period crossover study to determine the effect of a 25 g protein meal on zidovudine pharmacokinetics. On two separate occasions, 1 week apart, each patient received 200 mg zidovudine in a fasting state or immediately following the protein meal. A...

journal_title：British journal of clinical pharmacology

authors： Sahai J,Gallicano K,Garber G,McGilveray I,Hawley-Foss N,Turgeon N,Cameron DW

更新日期：1992-06-01 00:00:00

abstract：AIMS:Helicobacter pylori (H. pylori) eradication rate varies according to the treatment regimen used and other factors, e.g. antimicrobial resistance and patient compliance. The aim of the present study was to evaluate the influence of patient counselling and follow-up on H. pylori eradication rates and to document the...

journal_title：British journal of clinical pharmacology

authors： Al-Eidan FA,McElnay JC,Scott MG,McConnell JB

更新日期：2002-02-01 00:00:00

abstract：AIMS:Inhaled corticosteroids alone or in combination with long acting beta2-agonists are indicated for use in mild persistent asthmatics. We set out to evaluate effects on airway hyperresponsiveness (AHR) and airway calibre using hydrofluoroalkane fluticasone/salmeterol (FP/SM) vs. double the dose of fluticasone alone ...

journal_title：British journal of clinical pharmacology

authors： Currie GP,Stenback S,Lipworth BJ

更新日期：2003-07-01 00:00:00

abstract：:WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • The population pharmacokinetics and limited sampling strategies for ciclosporin monitoring have been extensively studied in renal and liver transplant recipients. Little is known about the pharmacokinetics of ciclosporin in patients undergoing haematopoietic allogeneic stem c...

journal_title：British journal of clinical pharmacology

authors： Wilhelm AJ,de Graaf P,Veldkamp AI,Janssen JJ,Huijgens PC,Swart EL

更新日期：2012-04-01 00:00:00

abstract：AIMS:Mexiletine has been reported to be hydroxylated by cytochrome P450 2D6 (CYP2D6) in humans. However, the involvement of CYP1A2 in the metabolism of mexiletine has been proposed based on the interaction with theophylline which is mainly metabolized by CYP1A2. The aim of this study was to clarify the role of human CY...

journal_title：British journal of clinical pharmacology

authors： Nakajima M,Kobayashi K,Shimada N,Tokudome S,Yamamoto T,Kuroiwa Y

更新日期：1998-07-01 00:00:00