CYP3A5 phenotype-genotype correlations in a British population.

abstract：AIMS:To evaluate the potential ethnic differences in the pharmacokinetics (PK) and pharmacodynamics (PD) of evolocumab in Caucasian and Asian populations using population PK/PD modelling analysis. METHODS:Data from different ethnic groups in 5 Phase I clinical trials, including two American studies, one Japanese study...

journal_title：British journal of clinical pharmacology

authors： Wang C,Zheng Q,Zhang M,Lu H

更新日期：2019-01-01 00:00:00

abstract：:The elimination of the cardioselective beta-adrenoceptor antagonist atenolol has been studied in 35 neonates by measuring drug concentration in cord blood and in blood obtained at 24 h by heel stab. Elimination rate was assessed by calculating the slopes of lines joining these two concentration points. The slopes had ...

journal_title：British journal of clinical pharmacology

authors： Rubin PC,Butters L,Reynolds B,Evans J,Sumner D,Low RA,Reid JL

更新日期：1983-12-01 00:00:00

abstract：:Cytochrome P450 3A is the main enzyme subfamily involved in the metabolism of a variety of marketed medicines. It is generally believed that the substrate specificity of polymorphic P450 3A5 is similar to that of the predominant P450 3A4 isoform, although some differences in catalytic properties have been found. It ha...

journal_title：British journal of clinical pharmacology

authors： Yamazaki H,Nakamoto M,Shimizu M,Murayama N,Niwa T

更新日期：2010-06-01 00:00:00

abstract：:1. A survey has been conducted amongst 459 members of the Clinical Section of the British Pharmacological Society to ascertain facts about the administration of drugs to healthy volunteers over the period October 1986 to September 1987. 2. A response rate of 87.1% was obtained with 114 individuals being involved in he...

journal_title：British journal of clinical pharmacology

authors： Orme M,Harry J,Routledge P,Hobson S

更新日期：1989-02-01 00:00:00

abstract：:1 An in vitro investigation showed that pivampicillin tablets disintegrated more rapidly than pivampicillin capsules. This result was demonstrated and confirmed by gastroscopy in a cross-over study in healthy volunteers. 2 There were no differences in serum levels of ampicillin obtained with the two preparations, but ...

journal_title：British journal of clinical pharmacology

authors： Hey H,Matzen P,Andersen JT,Didriksen E,Nielsen B

更新日期：1979-09-01 00:00:00

abstract：:The acute peripheral vascular and diuretic effects of intravenous frusemide 10 mg and 20 mg were compared with those of bumetanide 250 micrograms and 500 micrograms in a group of 10 salt depleted volunteers. Significant reductions in forearm blood flow (FBF) were observed after frusemide 10 mg (-0.77 ml 100 ml-1 min-1...

journal_title：British journal of clinical pharmacology

authors： Johnston GD,Nicholls DP,Kondowe GB,Finch MB

更新日期：1986-04-01 00:00:00

abstract：:In six healthy subjects a 250 g steak significantly increased the systemic clearance of indocyanine green. During a steady-state infusion of propranolol there was a rapid decrease (mean 35%) in blood propranolol concentrations within 5 min of feeding and levels were reduced for 30 min before gradually returning toward...

journal_title：British journal of clinical pharmacology

authors： Feely J,Nadeau J,Wood AJ

更新日期：1983-03-01 00:00:00

abstract：:1. Ten healthy subjects received two treatments: a single 1 g oral dose of nalidixic acid (NA) followed 1 h later by either an infinitesimal dilution of the drug (NA 7CH) or by succussed water which served as placebo. The study was repeated 18 months later in 10 different subjects. 2. A further 10 healthy subjects rec...

journal_title：British journal of clinical pharmacology

authors： Ferry N,Bernard N,Pozet N,Gardes E,Bruguier M,Cuisinaud G,Sassard J

更新日期：1991-07-01 00:00:00

abstract：AIMS:The aims of the present study were, firstly, to evaluate long-term trends in the occurrence and treatment of cardiovascular disease (CVD) risk factors and the occurrence of CVD events in children with type 1 diabetes mellitus (T1DM) and, secondly, to assess the determinants of undertreatment of CVD risk factors. ...

journal_title：British journal of clinical pharmacology

authors： Ahmadizar F,Souverein P,de Boer A,Maitland-van der Zee AH

更新日期：2018-04-01 00:00:00

abstract：:In many endoscopy units midazolam is replacing diazepam as the intravenous sedative of first choice. Midazolam is approximately twice as potent as diazepam. Although generally considered a safe drug, there have been a number of recent reports, particularly in the elderly, of the drug causing hypotension, respiratory d...

journal_title：British journal of clinical pharmacology

authors： Bell GD,Spickett GP,Reeve PA,Morden A,Logan RF

更新日期：1987-02-01 00:00:00

abstract：:A potential kinetic interaction between cimetidine and flecainide has been studied in eight healthy males receiving flecainide (200 mg) orally on three occasions: before any treatment and on day 2 and day 7 of 8 days' cimetidine maintenance treatment at 1 g daily. Six days pretreatment with cimetidine induced the foll...

journal_title：British journal of clinical pharmacology

authors： Tjandra-Maga TB,van Hecken A,van Melle P,Verbesselt R,de Schepper PJ

更新日期：1986-07-01 00:00:00

abstract：AIMS:Dexloxiglumide is a new CCK(1) receptor antagonist under investigation for treatment of functional gastrointestinal disorders and is metabolized by CYP3A4 and CYP2C9. The objectives of these two separate randomized, two-period, two-treatment crossover studies were to investigate the effects of steady-state ketocon...

journal_title：British journal of clinical pharmacology

authors： Jakate AS,Roy P,Patel A,Abramowitz W,Persiani S,Wangsa J,Kapil R

更新日期：2005-11-01 00:00:00

abstract：:1. The relative bioavailability of cyclosporin was studied in 11 healthy volunteers after single oral capsule doses of cyclosporin on three separate occasions; fasting, with breakfast and with breakfast together with bile acid tablets (400 mg of cholic acid and 100 mg of dehydrocholic acid). 2. There was a significant...

journal_title：British journal of clinical pharmacology

authors： Lindholm A,Henricsson S,Dahlqvist R

更新日期：1990-05-01 00:00:00

abstract：:The in vitro immunosuppressive effect of deflazacort, a new bone-sparing glucocorticoid, and its biologically active metabolite, 21-deacetyl-deflazacort, was examined on phytohaemagglutinin (PHA) stimulated human peripheral blood lymphocytes (PBL) as well as on natural killer (NK) and killer (K) cell activity. Deflaza...

journal_title：British journal of clinical pharmacology

authors： Langhoff E,Olgaard K

更新日期：1986-02-01 00:00:00

abstract：:1 The inotropic effect of penbutolol, a new beta-adrenergic receptor blocking drug, has been compared with that of propranolol in two similar groups of six subjects each. 2 Inotropic changes were assessed from changes in myocardial contractility index [LV dp-dt/11 T] as well as the slope of the regression line relatin...

journal_title：British journal of clinical pharmacology

authors： Sapru RP,Sharma PL

更新日期：1978-12-01 00:00:00

abstract：:1. Six healthy male human volunteers of mean age 30.8 years (range 23-37) were given single oral doses of xamoterol (20, 50, 100 or 250 mg) and placebo with a 1 week interval between each dose. Xamoterol produced a significant decrease in systolic time intervals (QS2I, LVETI and PEPI) and a significant increase in sys...

journal_title：British journal of clinical pharmacology

authors： James MA,Papouchado M,Channer KS,Jones JV,Marlow HF,Bastain W,Barker NP,Harry JD,Wardleworth AG

更新日期：1990-04-01 00:00:00

abstract：:Cost-containment measures in healthcare provision include the implementation of therapeutic and generic drug substitution strategies in patients whose condition is already well controlled with pharmacotherapy. Treatment for hypertension is frequently targeted for such measures. However, drug acquisition costs are only...

journal_title：British journal of clinical pharmacology

authors： Johnston A,Stafylas P,Stergiou GS

更新日期：2010-09-01 00:00:00

abstract：AIMS:To assess whether hospitalization may assist in correcting errors in anticoagulant therapy among patients with atrial fibrillation (AF). METHODS:Our cohort included patients admitted to our institution with a history of AF between 2016 and 2018. We categorized patient's treatment upon admission and discharge as l...

journal_title：British journal of clinical pharmacology

authors： Angel Y,Zeltser D,Berliner S,Ingbir M,Shapira I,Shenhar-Tsarfaty S,Rogowski O

更新日期：2019-12-01 00:00:00

abstract：:1. The pharmacokinetics of butorphanol were evaluated in 18 female volunteers with varying degrees of renal function following a single, 1 mg transnasal dose of butorphanol tartrate. The creatinine clearance (CLCR) values for subjects in the normal (NOR), moderately impaired (MI), and severely impaired (SI) groups wer...

journal_title：British journal of clinical pharmacology

authors： Shyu WC,Morgenthien EA,Barbhaiya RH

更新日期：1996-05-01 00:00:00

abstract：AIMS:This study compares physicians' recall of the claims of benefits on cardiovascular disease and diabetes made by pharmaceutical sales representatives for drugs approved on the basis of a surrogate outcome, i.e., an off-label claim, compared with those approved on the basis of a serious morbidity or mortality (clini...

journal_title：British journal of clinical pharmacology

authors： Habibi R,Lexchin J,Mintzes B,Holbrook A

更新日期：2017-11-01 00:00:00

abstract：:Highly active antiretroviral therapy is recommended for HIV-infected pregnant women to prevent mother-to-child transmission. The specific physiological background induced by pregnancy leads to significant changes in maternal pharmacokinetics, suggesting potential variability in plasma concentrations of antiretrovirals...

journal_title：British journal of clinical pharmacology

authors： Roustit M,Jlaiel M,Leclercq P,Stanke-Labesque F

更新日期：2008-08-01 00:00:00

abstract：:1 The influence of cimetidine (1000 mg daily) on propranolol steady state plasma levels has been studied in seven normal volunteers. Cimetidine was used as a 200 mg normal release tablet whereas propranolol was given as a 160 mg slow release formulation once daily. 2 After 1 day of cimetidine treatment (day 9 of the s...

journal_title：British journal of clinical pharmacology

authors： Reimann IW,Klotz U,Siems B,Frölich J

更新日期：1981-12-01 00:00:00

abstract：AIMS:To explore the feasibility of delivering community-based drug safety testing (drug checking), to trial service design characteristics and to compare with festival-based testing. METHODS:In total, 171 substances of concern were submitted on 5 dates at 3 venues in 2 UK cities and tested using up to 6 analytical tec...

journal_title：British journal of clinical pharmacology

authors： Measham F

更新日期：2020-03-01 00:00:00

abstract：AIMS:Prescribing errors are common and inadequate preparation of prescribers appears to contribute. A junior doctor-led prescribing tutorial programme has been developed for Edinburgh final year medical students to increase exposure to common prescribing tasks. The aim of this study was to assess the impact of these tu...

journal_title：British journal of clinical pharmacology

authors： Gibson KR,Qureshi ZU,Ross MT,Maxwell SR

更新日期：2014-01-01 00:00:00

abstract：:1 Apparent Vmax and Km for phenytoin were estimated in 40 children (aged 8--33 months) and 21 adults (aged 18--66 years). 2 The derived values of Vmax and Km were used to predict the plasma and salivary concentrations of phenytoin following a change in dose. There was a highly significant correlation between observed ...

journal_title：British journal of clinical pharmacology

authors： Blain PG,Mucklow JC,Bacon CJ,Rawlins MD

更新日期：1981-11-01 00:00:00

abstract：:1. The absorption of ciprofloxacin from different regions of the human gastrointestinal tract was investigated in four healthy males using a remote-controlled drug delivery device (hf-capsule). 2. Significant differences in AUC were observed in the control study (oral administration of ciprofloxacin solution without t...

journal_title：British journal of clinical pharmacology

authors： Harder S,Fuhr U,Beermann D,Staib AH

更新日期：1990-07-01 00:00:00

abstract：AIMS:Antidepressant use has increased in the last decade. Several studies have suggested a possible association between maternal antidepressant use and teratogenic effects. METHODS:The pharmacy prescription database IADB.nl was used for a cohort study in which laxative and antidiarrhoeal medication use in children aft...

journal_title：British journal of clinical pharmacology

authors： Nijenhuis CM,ter Horst PG,van Rein N,Wilffert B,de Jong-van den Berg LT

更新日期：2012-01-01 00:00:00

abstract：:The efficacy of calcitonin gene-related peptide (receptor) (CGRP-(R)) blocking therapeutics in the treatment of acute migraine headache provided proof-of-concept for the involvement of CGRP in the pathophysiology of this disorder. One of the major hurdles for the development of any class of drugs, including CGRP block...

journal_title：British journal of clinical pharmacology

authors： Buntinx L,Vermeersch S,de Hoon J

更新日期：2015-11-01 00:00:00

abstract：:Herbal medicines and products derived from them are a diverse group of products for which different (and often limited) levels of evidence are available. As importantly, such products generally vary in their composition and are at the end of an often poorly understood value chain, which often links producers in biodiv...

journal_title：British journal of clinical pharmacology

authors： Heinrich M

更新日期：2015-07-01 00:00:00

abstract：:1. The antisecretory responses to pH-feedback controlled (maximum dose 800 mg 24 h-1) and fixed-dose (0.25 mg kg-1 h-1) continuous infusions of ranitidine were compared in a randomised, placebo-controlled, cross-over study in 10 healthy male volunteers. 2. To assess tolerance during repeated dosing with ranitidine, th...

journal_title：British journal of clinical pharmacology

authors： Wilder-Smith CH,Halter F,Häcki W,Merki HS

更新日期：1992-05-01 00:00:00