The effect of food and bile acid administration on the relative bioavailability of cyclosporin.

abstract：AIMS:We investigated whether the deterioration in asthma control reported following cessation of theophylline was due to tolerance to theophylline. METHODS:Eighteen subjects with mild stable asthma were given oral theophylline 10 mg kg(-1) day(-1) or placebo for 2 weeks in a double-blind crossover study. FEV1 and PD20...

journal_title：British journal of clinical pharmacology

authors： Bennett JA,Thompson Coon J,Pavord ID,Wilding PJ,Tattersfield AE

更新日期：1998-04-01 00:00:00

abstract：:The effects of single oral doses of atenolol 50 mg and xamoterol 200 mg (a recently developed partial beta 1-adrenoceptor agonist) on lung function, heart rate and blood pressure were investigated in 11 patients with asthma. Xamoterol caused a significant increase in heart rate and systolic blood pressure, which chang...

journal_title：British journal of clinical pharmacology

authors： Lammers JW,Müller ME,Folgering HT,van Herwaarden CL

更新日期：1986-11-01 00:00:00

abstract：:Although blood pressure measured at the brachial artery plays a central role in our understanding and management of cardiovascular risk, in recent years great emphasis has been placed on the importance of central blood pressure. It seems straightforward that knowledge of the blood pressure directly affecting the major...

journal_title：British journal of clinical pharmacology

authors： Tomlinson LA,Wilkinson IB

更新日期：2012-08-01 00:00:00

abstract：:1. The phenotyping parameters for dextromethorphan and mephenytoin were assessed in 48 normal male volunteers following administration of each metabolic probe drug on separate occasions and together according to a randomized 3-way crossover design. 2. Neither the urinary S-/R-mephenytoin ratio nor the dextromethorphan...

journal_title：British journal of clinical pharmacology

authors： Guttendorf RJ,Britto M,Blouin RA,Foster TS,John W,Pittman KA,Wedlund PJ

更新日期：1990-04-01 00:00:00

abstract：AIMS:(i) To model the effects of the monoclonal antibody ATM-027 on the number of target cells and on the receptor density on the cell surface as measured by Fluorescence Activated Cell Sorter analysis, (ii) to investigate the effects of categorizing a continuous scale, and (iii) to simulate a phase II trial from phase...

journal_title：British journal of clinical pharmacology

authors： Zingmark PH,Edenius C,Karlsson MO

更新日期：2004-10-01 00:00:00

abstract：AIMS:Vancomycin is an important antibiotic for critically ill patients with Gram-positive bacterial infections. Critically ill patients typically have severely altered pathophysiology, which leads to inefficacy or toxicity. Model-informed precision dosing may aid in optimizing the dose, but prospectively validated tool...

journal_title：British journal of clinical pharmacology

authors： Ter Heine R,Keizer RJ,van Steeg K,Smolders EJ,van Luin M,Derijks HJ,de Jager CPC,Frenzel T,Brüggemann R

更新日期：2020-12-01 00:00:00

abstract：:Ten volunteers carried a 10 mg 24 h -1 transdermal glyceryl trinitrate (GTN) patch for 24 h before moderate exercise. Plasma GTN-concentration increased significantly (P less than 0.05) by 19% to peak value at 15 min. Two hours after patch renewal repeat exercise increased GTN concentration by 56% (P less than 0.001)....

journal_title：British journal of clinical pharmacology

authors： Gjesdal K,Klemsdal TO,Rykke EO,Bredesen JE

更新日期：1991-05-01 00:00:00

abstract：:1. The primary action of the converting enzyme inhibitors to prevent the formation of angiotensin II can explain a decrease in peripheral vascular resistance in patients with elevated, but not in those with normal or reduced plasma renin levels. 2. The inhibition of the breakdown of bradykinin will potentiate the vaso...

journal_title：British journal of clinical pharmacology

authors： Vanhoutte PM,Auch-Schwelk W,Biondi ML,Lorenz RR,Schini VB,Vidal MJ

更新日期：1989-01-01 00:00:00

abstract：:Phenytoin drug reaction with eosinophilia and systemic symptoms (DRESS) in 3 Aboriginal Australians positive for HLA-B*56:02 has been previously reported. We report the allele frequency of HLA-B*56:02 in 2 South Australian populations, 1 Aboriginal (4.8%, 95% confidence interval 2.4-7.8%) and the other European (0%). ...

journal_title：British journal of clinical pharmacology

authors： Somogyi AA,Barratt DT,Phillips EJ,Moore K,Ilyas F,Gabb GM

更新日期：2019-09-01 00:00:00

abstract：AIMS:To predict the drug interactions of amiodarone and other drugs, the inhibitory effects and inactivation potential for human cytochrome P450 (CYP) enzymes by amiodarone and its N-dealkylated metabolite, desethylamiodarone were examined. METHODS:The inhibition or inactivation potency of amiodarone and desethylamiod...

journal_title：British journal of clinical pharmacology

authors： Ohyama K,Nakajima M,Suzuki M,Shimada N,Yamazaki H,Yokoi T

更新日期：2000-03-01 00:00:00

abstract：:Serum creatinine and drug concentrations were measured at 0, 1, 2, 3, 6, 9 and 12 months in 30 consecutive patients started on amiodarone. In 28 of these patients with no obvious cause for altered renal function, mean serum creatinine increased to 11% above baseline (P < 0.005). Rising creatinine concentrations correl...

journal_title：British journal of clinical pharmacology

authors： Pollak PT,Sharma AD,Carruthers SG

更新日期：1993-08-01 00:00:00

abstract：AIM:We compared the pharmacokinetic (PK) profiles of co-crystal of tramadol-celecoxib (CTC) vs. each reference product (alone and in open combination) after single (first dose) and multiple dosing. METHODS:Healthy adults aged 18-50 years received, under fasted conditions, 15 twice-daily doses of the following treatmen...

journal_title：British journal of clinical pharmacology

authors： Videla S,Lahjou M,Vaqué A,Sust M,Escriche M,Soler L,Sans A,Sicard E,Gascón N,Encina G,Plata-Salamán C

更新日期：2018-01-01 00:00:00

abstract：:1 Comparison of phenytoin clearance showed a marked increase in people over 65 years of age compared with people under 45 years of age. 2 This difference was apparent if phenytoin was given orally or intravenously. 3 Phenytoin clearance correlated inversely with phenytoin binding and plasma albumin, both of which were...

journal_title：British journal of clinical pharmacology

authors： Hayes MJ,Langman MJ,Short AH

更新日期：1975-02-01 00:00:00

abstract：AIMS:To describe age- and gender-related prescription patterns of diuretics in community-dwelling elderly, and to compare diuretics to other cardiovascular (CV) medications. METHODS:Cross-sectional study of patient-specific prescription data derived from a panel of 10 Dutch community pharmacies. Determination of propo...

journal_title：British journal of clinical pharmacology

authors： van Kraaij DJ,Jansen RW,de Gier JJ,Gribnau FW,Hoefnagels WH

更新日期：1998-10-01 00:00:00

abstract：AIMS:Our study aimed to evaluate the impacts of the cytochrome P450 (CYP) 2B6-G516T and CYP2D6 genetic polymorphisms on pharmacokinetic and clinical parameters in patients receiving methadone maintenance treatment. METHODS:Opioid PhArmacoLogy (OPAL) was a clinical survey of the sociodemographic characteristics, histor...

journal_title：British journal of clinical pharmacology

authors： Victorri-Vigneau C,Verstuyft C,Bouquié R,Laforgue EJ,Hardouin JB,Leboucher J,Le Geay B,Dano C,Challet-Bouju G,Grall-Bronnec M

更新日期：2019-07-01 00:00:00

abstract：:1. In 48 patients with chronic asthma who had been receiving treatment with beclomethasone dipropionate aerosol (BDA) at a daily dose of 400 microgram for several years, observations were made on the effect of increasing the dose to 800 microgram daily for 6 months. 2. There was subjective improvement in 37 of the 48 ...

journal_title：British journal of clinical pharmacology

authors： Chatterjee SS

更新日期：1977-01-01 00:00:00

abstract：AIMS:Several cases of acute non-infectious cholestatic hepatitis recently appeared in Italy following consumption of Curcuma longa-containing dietary supplements. The aim of this research was to describe the Tuscan (Italy) cases of acute hepatitis and to compare them with similar cases of hepatotoxicity published in th...

journal_title：British journal of clinical pharmacology

authors： Lombardi N,Crescioli G,Maggini V,Ippoliti I,Menniti-Ippolito F,Gallo E,Brilli V,Lanzi C,Mannaioni G,Firenzuoli F,Vannacci A

更新日期：2020-07-13 00:00:00

abstract：AIMS:Three 'weak' opioid analgesics in association with paracetamol are marketed in France as step 2 analgesics: dextropropoxyphene, tramadol and codeine. These combinations are involved in several adverse drug reactions (ADRs), but no data are available about their comparative reporting rate. The aim was to compare th...

journal_title：British journal of clinical pharmacology

authors： Tavassoli N,Lapeyre-Mestre M,Sommet A,Montastruc JL,French Association of Regional Pharmacovigilance Centres.

更新日期：2009-09-01 00:00:00

abstract：:1. The cardiovascular responses of mianserin hydrochloride and tricyclic antidepressant drugs were investigated using non-invasive methods of cardiac investigation. A study of the interaction of mianserin and antihypertensive drug therapy is reported. 2. In six normal volunteers, mianserin hydrochloride 20 mg was show...

journal_title：British journal of clinical pharmacology

authors： Burgess CD,Turner P,Wadsworth J

更新日期：1978-01-01 00:00:00

abstract：:1. A new method for perfusing a 10 cm segment of jejunum in humans has been used in seven subjects to study the effect of the amino acid L-leucine (40 mM) on the intestinal absorption of levodopa (2.5 mM). The tube contains six channels and has two inflatable balloons, which enable a perfusion of a closed and defined ...

journal_title：British journal of clinical pharmacology

authors： Lennernäs H,Nilsson D,Aquilonius SM,Ahrenstedt O,Knutson L,Paalzow LK

更新日期：1993-03-01 00:00:00

abstract：AIMS:Previous in vivo studies with sumatriptan, a 5HT1-receptor agonist, have demonstrated vasopressor responses in the pulmonary and systemic arterial circulation. Pulmonary artery wedge pressure (PAWP) also increases after sumatriptan injection, raising the possibility of an additional venoconstrictive action or a ne...

journal_title：British journal of clinical pharmacology

authors： Hood S,Birnie D,Hillis S

更新日期：1997-03-01 00:00:00

abstract：:Plasma and synovial fluid concentrations of the enantiomers of flurbiprofen were measured in 15 rheumatoid patients receiving 100 mg racemic flurbiprofen twice daily. Pharmacokinetic parameters showed considerable variability within the group of patients, although differences in S(+)/R(-) plasma concentration ratios w...

journal_title：British journal of clinical pharmacology

authors： Young MA,Aarons L,Toon S

更新日期：1991-01-01 00:00:00

abstract：:1. The pharmacokinetics of levodopa and paracetamol after single oral doses have been investigated in eight healthy young volunteers in the fasted state and following isocaloric meals containing either 10.5 g or 30.5 g of protein. 2. The initial peak and maximum plasma drug concentrations and the times at which these ...

journal_title：British journal of clinical pharmacology

authors： Robertson DR,Higginson I,Macklin BS,Renwick AG,Waller DG,George CF

更新日期：1991-04-01 00:00:00

abstract：:1. Nitric oxide is recognised as an important biological mediator, which is thought to be involved in cardiovascular homeostasis. The purpose of this study was to investigate the effects of basal nitric oxide synthesis on cardiac function in man, by blocking nitric oxide synthesis with NG-monomethyl-L-arginine (L-NMMA...

journal_title：British journal of clinical pharmacology

authors： Clarkson PB,Lim PO,MacDonald TM

更新日期：1995-10-01 00:00:00

abstract：:Since many factors may alter lung epithelial permeability (LEP) to water soluble molecules, the effect of histamine on the absorption and clearance of inhaled sodium cromoglycate was examined in seven mildly asthmatic patients with hyperresponsive airways and eight normal subjects. The subjects underwent histamine cha...

journal_title：British journal of clinical pharmacology

authors： Richards R,Fowler C,Simpson S,Renwick AG,Holgate ST

更新日期：1992-03-01 00:00:00

abstract：:The effects of separate 7 day pretreatments with sulphinpyrazone (800 mg daily) and cimetidine (1 g daily) on the disposition of (+/-)-verapamil have been examined in eight healthy volunteers (four male, four female). Each subject received single oral (80 mg) and intravenous (0.15 mg/kg) doses of verapamil on differen...

journal_title：British journal of clinical pharmacology

authors： Wing LM,Miners JO,Lillywhite KJ

更新日期：1985-03-01 00:00:00

abstract：:1. The effects of simvastatin and pravastatin on measures of central nervous system activity were investigated in a double-blind, placebo-controlled, randomised crossover study. 2. Twenty-five healthy volunteers sequentially took 40 mg day-1 simvastatin, 40 mg day-1 pravastatin or placebo for 4 weeks, separated by a 4...

journal_title：British journal of clinical pharmacology

authors： Harrison RW,Ashton CH

更新日期：1994-03-01 00:00:00

abstract：AIMS:QTc interval-prolonging drugs have been linked to cardiac arrhythmias, cardiac arrest and sudden death. In this study we aimed to quantify the risk of cardiac arrest associated with the use of non-antiarrhythmic QTc-prolonging drugs in an academic hospital setting. METHODS:We performed a case-control study in whi...

journal_title：British journal of clinical pharmacology

authors： De Bruin ML,Langendijk PN,Koopmans RP,Wilde AA,Leufkens HG,Hoes AW

更新日期：2007-02-01 00:00:00

abstract：:We have introduced to the course in pharmacology for medical students a simple human experiment that demonstrates the efficacy of activated charcoal in gastrointestinal drug binding. Sixty-one students were given 40 mg frusemide with water, water only, or 40 mg frusemide and 8 g activated charcoal with water either im...

journal_title：British journal of clinical pharmacology

authors： Kivistö KT,Neuvonen PJ

更新日期：1990-09-01 00:00:00

abstract：OBJECTIVE:To establish weight-based dose bands for commonly used oral medicines, given in liquid forms, for children in the UK that could be used for prescribing and administering accurate and safe drug doses. METHODS:A list of commonly prescribed, oral liquid medications was established from the medication dispensing...

journal_title：British journal of clinical pharmacology

authors： Rashed AN,Tomlin S

更新日期：2020-12-10 00:00:00