The effect on paracetamol absorption of stimulation and blockade of beta-adrenoceptors.

Abstract:

:1 The effect of drugs acting on beta-adrenoceptors on the absorption and excretion of paracetamol was studied in 26 volunteers and nine patients with mild hypertension, each subject acting as his/her own control. 2 Isoprenaline given 30 min before paracetamol significantly slowed absorption, the effect being dose related, and blocked by prior administration of propranolol. 3 When isoprenaline was given immediately before the paracetamol, absorption was not altered, although a cardiovascular response was seen. 4 Oral salbutamol also delayed paracetamol absorption. 5 Propranolol given alone increased the rate of paracetamol absorption. 6 These results with the changes in the rate of gastric emptying produced by these agents.

journal_name

Br J Clin Pharmacol

authors

Clark RA,Holdsworth CD,Rees MR,Howlett PJ

doi

10.1111/j.1365-2125.1980.tb00510.x

subject

Has Abstract

pub_date

1980-12-01 00:00:00

pages

555-9

issue

6

eissn

0306-5251

issn

1365-2125

journal_volume

10

pub_type

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