当前位置： SCI文献检索 > BRITISH JOURNAL OF CLINICAL PHARMACOLOGY期刊下所有文献 > Decreased dromotropic response to verapamil despite pronounced increased drug concentration in rheumatoid arthritis.

Decreased dromotropic response to verapamil despite pronounced increased drug concentration in rheumatoid arthritis.

Abstract：

AIMS:Inflammation reduces hepatic clearance of many drugs with unknown therapeutic consequences. This study was carried out to examine the effect of rheumatoid arthritis (RA) on the pharmacokinetics and pharmacodynamics of verapamil. METHODS:Eight RA patients were age- and sex-matched with eight healthy volunteers. The disease severity was assessed, and ECG, blood pressure and verapamil enantiomers concentrations were measured for 12 h post 80 mg oral verapamil. Serum interleukin-6 (IL-6) and nitrite (NO2-) were measured in predose samples. RESULTS:IL-6 and NO2- concentrations were significantly increased in parallel with disease severity. Oral clearance of both S- and R-verapamil was significantly decreased by RA. While the unbound fraction of S- and R-verapamil decreased by 5 and 7-fold, respectively, the unbound AUC remained unchanged for the more potent enantiomer, S-verapamil. AUC of norverapamil enantiomers was increased 2-3-fold. Despite elevated serum drug concentrations in RA, the potential to prolong the PR-interval was significantly reduced by one fold and the effect on the heart rate and blood pressure did not increase. CONCLUSIONS:RA results in increased verapamil concentrations due likely to changes in protein binding, decreased clearance and/or altered hepatic blood flow. A significant decrease in dromotropic effect, despite increased serum drug concentrations, may be attributed to receptor down regulation caused by pro-inflammatory cytokines and/or NO.

journal_name

Br J Clin Pharmacol

journal_title

British journal of clinical pharmacology

authors

Mayo PR,Skeith K,Russell AS,Jamali F

doi

10.1046/j.1365-2125.2000.00314.x

keywords:

subject

Has Abstract

pub_date

2000-12-01 00:00:00

pages

605-13

issue

6

eissn

0306-5251

issn

1365-2125

pii

bcp314

journal_volume

50

pub_type

临床试验,杂志文章

相关文献

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY文献大全
  • Hypnotic efficacy and safety of midazolam and oxazepam in hospitalized female patients.

    abstract：:This double-blind study in 60 hospitalized female patients comparing midazolam 15 mg, oxazepam 15 mg and placebo, demonstrated an inter-group difference in favour of midazolam with regard to efficacy. The sleep parameters of onset latency and duration were improved by midazolam. All three compounds were very well tole...

    journal_title：British journal of clinical pharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1111/j.1365-2125.1983.tb02288.x

    authors： Fischbach R

    更新日期：1983-01-01 00:00:00

  • Pharmacokinetics of co-administered didanosine and stavudine in HIV-seropositive male patients.

    abstract：:The pharmacokinetics of single and co-administered didanosine and stavudine were evaluated in 10 HIV-seropositive subjects in an open, within subject design in which each subject received each of three treatments. Single doses of didanosine 100 mg were alternated randomly with single doses of stavudine 40 mg on days 1...

    journal_title：British journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1111/j.1365-2125.1994.tb04374.x

    authors： Seifert RD,Stewart MB,Sramek JJ,Conrad J,Kaul S,Cutler NR

    更新日期：1994-11-01 00:00:00

  • The immunocytochemical localisation and distribution of cytochrome P-450 in normal human hepatic and extrahepatic tissues with a monoclonal antibody to human cytochrome P-450.

    abstract：:1. The localisation and distribution of cytochrome P-450 in human tissues has been studied by immunocytochemistry using a monoclonal antibody to a major form of human hepatic cytochrome P-450, P-450hA7, which is closely related to cytochromes P-450 HLp and P-450NF. 2. Strong immunoreactivity was identified in hepatocy...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2125.1988.tb03331.x

    authors： Murray GI,Barnes TS,Sewell HF,Ewen SW,Melvin WT,Burke MD

    更新日期：1988-04-01 00:00:00

  • Distribution of venlafaxine and its O-desmethyl metabolite in human milk and their effects in breastfed infants.

    abstract：AIMS:To characterize milk/plasma (M/P) ratio and infant dose, for venlafaxine (V) and its O-desmethyl metabolite (ODV), in breastfeeding women taking venlafaxine for the treatment of depression, and to determine the plasma concentration and effects of these drugs in their infants. METHODS:Six women (mean age 34.5 year...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1046/j.0306-5251.2001.01518.x

    authors： Ilett KF,Kristensen JH,Hackett LP,Paech M,Kohan R,Rampono J

    更新日期：2002-01-01 00:00:00

  • Haemodynamic effects of combined alpha- and beta-adrenoreceptor blockade after intravenous labetalol in hypertensive patients at rest and during exercise.

    abstract：:1 The haemodynamic effects of labetalol 50 mg intravenously were studied in 13 hypertensive patients at rest in the supine and upright positions and during exercise using percutaneous right heart and brachial artery catheterization. 2 Labetalol induced immediate significant reductions in systolic and diastolic blood p...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：

    authors： Koch G

    更新日期：1976-08-01 00:00:00

  • Artemether-lumefantrine co-administration with antiretrovirals: population pharmacokinetics and dosing implications.

    abstract：AIM:Drug-drug interactions between antimalarial and antiretroviral drugs may influence antimalarial treatment outcomes. The aim of this study was to investigate the potential drug-drug interactions between the antimalarial drugs, lumefantrine, artemether and their respective metabolites desbutyl-lumefantrine and dihydr...

    journal_title：British journal of clinical pharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1111/bcp.12529

    authors： Hoglund RM,Byakika-Kibwika P,Lamorde M,Merry C,Ashton M,Hanpithakpong W,Day NP,White NJ,Äbelö A,Tarning J

    更新日期：2015-04-01 00:00:00

  • Therapeutic index of inhaled corticosteroids in asthma: A dose-response comparison on airway hyperresponsiveness and adrenal axis suppression.

    abstract：AIMS:To compare the airway potency, systemic activity and therapeutic index of three inhaled corticosteroids that differ in glucocorticoid receptor binding affinity, physicochemical and pharmacokinetic properties. METHODS:This escalating-dose, placebo-controlled, cross-over study randomised adults with asthma to 1 or ...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/bcp.14406

    authors： Daley-Yates P,Brealey N,Thomas S,Austin D,Shabbir S,Harrison T,Singh D,Barnes N

    更新日期：2020-06-02 00:00:00

  • Interactions of orphenadrine and phenobarbitone with chlorpromazine: plasma concentrations and effects in man.

    abstract：:1 Two studies were carried out on acutely psychotic patients receiving chlorpromazine (100 mg) 8-hourly. 2 In the pilot study on five patients, plasma chlorpromazine concentrations fell over the course of 3 weeks of treatment and parallel changes were noted in the plasma half-life of antipyrine, salivation rate and ha...

    journal_title：British journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1111/j.1365-2125.1975.tb01576.x

    authors： Loga S,Curry S,Lader M

    更新日期：1975-06-01 00:00:00

  • Regulatory challenges for new drugs to treat obesity and comorbid metabolic disorders.

    abstract：:Obesity is a major cause of morbidity and mortality through cardio- and cerebrovascular diseases and cancer. The metabolic consequences of obesity include dyslipidaemia, hypertension, proinflammatory atherogenesis, pre-diabetes and Type 2 diabetes. For a significant proportion of patients, pharmacotherapy to tackle ob...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2125.2009.03549.x

    authors： Heal DJ,Gosden J,Smith SL

    更新日期：2009-12-01 00:00:00

  • The pharmacokinetics, antihistamine and concentration-effect relationship of ebastine in healthy subjects.

    abstract：:1. The kinetics and effects of ebastine 10 and 50 mg were studied after oral dosing in healthy subjects. 2. The parent drug was extensively metabolised during the first pass to its carboxylic acid derivative, carebastine. 3. The pharmacokinetics of carebastine were linear over the dose range studied and the terminal e...

    journal_title：British journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1111/j.1365-2125.1988.tb05288.x

    authors： Vincent J,Liminana R,Meredith PA,Reid JL

    更新日期：1988-11-01 00:00:00

  • Efficacy and safety of nebulized glycopyrrolate for administration using a high efficiency nebulizer in patients with chronic obstructive pulmonary disease.

    abstract：AIMS:To establish the dose-response for pharmacodynamics (bronchodilatation), safety and pharmacokinetics for a nebulized formulation of the long acting muscarinic antagonist glycopyrrolate (EP-101) with a high efficiency nebulizer in patients with chronic obstructive pulmonary disease (COPD). METHODS:Patients with mo...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章,随机对照试验

    doi：10.1111/bcp.12517

    authors： Leaker BR,Barnes PJ,Jones CR,Tutuncu A,Singh D

    更新日期：2015-03-01 00:00:00

  • Antipsychotic polypharmacy in patients with schizophrenia: a multicentre comparative study in East Asia.

    abstract：AIMS:Previous studies of the prescription patterns of psychotropic medications in patients with schizophrenia have highlighted a high rate of antipsychotic polypharmacy, but data in Asia are sparse. This study seeks to examine the prevalence of antipsychotic polypharmacy in patients with schizophrenia and compare the d...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章,多中心研究

    doi：10.1111/j.1365-2125.2004.02102.x

    authors： Sim K,Su A,Fujii S,Yang SY,Chong MY,Ungvari GS,Si T,Chung EK,Tsang HY,Chan YH,Heckers S,Shinfuku N,Tan CH

    更新日期：2004-08-01 00:00:00

  • Reports of hypoglycaemia associated with the use of ACE inhibitors and other drugs: a case/non-case study in the French pharmacovigilance system database.

    abstract：AIMS:To test the existence of an association between reports of hypoglycaemia and angiotensin converting enzyme inhibitors, in a spontaneous reports database. METHODS:The French Pharmacovigilance database was examined for an association between adverse drug reaction reports mentioning hypoglycaemia, and angiotensin co...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2125.1997.00615.x

    authors： Moore N,Kreft-Jais C,Haramburu F,Noblet C,Andrejak M,Ollagnier M,Bégaud B

    更新日期：1997-11-01 00:00:00

  • Plasma levels of (+) and (-)-propranolol and 4-hydroxypropranolol after administration of racemic (+/-)-propranolol in man.

    abstract：:1 We have given fifteen healthy volunteers single doses of racemic (+/-)-propranolol orally (40 mg) and intravenously (5-10 mg) to find out how large the variation was of the ratio between (-)- and (+)-propranolol plasma levels in relation to that of total levels of propranolol and 4-hydroxypropranolol. 2 Total propra...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2125.1982.tb04937.x

    authors： Von Bahr C,Hermansson J,Tawara K

    更新日期：1982-07-01 00:00:00

  • Unwarranted claims of drug efficacy in pharmaceutical sales visits: are drugs approved on the basis of surrogate outcomes promoted appropriately?

    abstract：AIMS:This study compares physicians' recall of the claims of benefits on cardiovascular disease and diabetes made by pharmaceutical sales representatives for drugs approved on the basis of a surrogate outcome, i.e., an off-label claim, compared with those approved on the basis of a serious morbidity or mortality (clini...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/bcp.13360

    authors： Habibi R,Lexchin J,Mintzes B,Holbrook A

    更新日期：2017-11-01 00:00:00

  • Anticonvulsant therapy and cortisol elimination.

    abstract：:The effect of anticonvulsant therapy on early morning concentration of cortisol in saliva and plasma was assessed in a group of epileptic patients receiving regular phenytoin medication and the results compared with those obtained from a group of normal subjects not receiving drug therapy. Values of cortisol in matche...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2125.1985.tb05042.x

    authors： Evans PJ,Walker RF,Peters JR,Dyas J,Riad-Fahmy D,Thomas JP,Rimmer E,Tsanaclis L,Scanlon MF

    更新日期：1985-08-01 00:00:00

  • Model informed dosing of hydroxycholoroquine in COVID-19 patients: Learnings from the recent experience, remaining uncertainties and gaps.

    abstract：AIMS:In the absence of a commonly agreed dosing protocol based on pharmacokinetic (PK) considerations, the dose and treatment duration for hydroxychloroquine (HCQ) in COVID-19 disease currently vary across national guidelines and clinical study protocols. We have used a model-based approach to explore the relative impa...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/bcp.14436

    authors： Thémans P,Dauby N,Schrooyen L,Lebout F,Delforge M,Nasreddine R,Libois A,Payen MC,Konopnicki D,Wuillaume F,Lescrainier C,Verlinden V,Dogné JM,Hamdani J,Musuamba FT

    更新日期：2020-06-19 00:00:00

  • Antiplatelet therapy: thrombin receptor antagonists.

    abstract：:Activated platelets stimulate thrombus formation in response to rupture of an atherosclerotic plaque or endothelial cell erosion, promoting atherothrombotic disease. Multiple pathways contribute to platelet activation. Aspirin, an irreversible inhibitor of thromboxane A2 synthesis, in combination with clopidogrel, an ...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章,评审

    doi：10.1111/j.1365-2125.2010.03884.x

    authors： Tello-Montoliu A,Tomasello SD,Ueno M,Angiolillo DJ

    更新日期：2011-10-01 00:00:00

  • Drug resistance, inappropriate dosing and non-compliance in hypertensive patients.

    abstract：:1 From an understanding of the biological fate and hypotensive effect of debrisoquine (D) we have assessed the relative importance of true drug resistance, inappropriately low dosage and non-compliance as causes of apparent resistance to treatment with this drug. 2 Among 37 hypertensive patients prescribed D, eleven (...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2125.1980.tb01072.x

    authors： Silas JH,Tucker GT,Smith AJ

    更新日期：1980-04-01 00:00:00

  • The first-in-human study of CNTO 7160, an anti-interleukin-33 receptor monoclonal antibody, in healthy subjects and patients with asthma or atopic dermatitis.

    abstract：AIMS:To assess safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD) and immunogenicity of CNTO 7160, an anti-interleukin-33 receptor (IL-33R) monoclonal antibody, in healthy subjects and patients with asthma or atopic dermatitis (AD). METHODS:In Part 1 of this Phase I, randomized, double-blind, placebo-c...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/bcp.14361

    authors： Nnane I,Frederick B,Yao Z,Raible D,Shu C,Badorrek P,van den Boer M,Branigan P,Duffy K,Baribaud F,Fink D,Yang TY,Xu Z

    更新日期：2020-12-01 00:00:00

  • Pleiotropic effects of statins on the treatment of chronic periodontitis--a systematic review.

    abstract：AIM:Statins are inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase and are an important group of hypolipidaemic drugs, widely used in the treatment of hypercholesterolaemia and cardiovascular disease. Some studies have shown that statins are able to modulate inflammation and alveolar bone loss. METHODS:In o...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/bcp.12564

    authors： Estanislau IM,Terceiro IR,Lisboa MR,Teles Pde B,Carvalho Rde S,Martins RS,Moreira MM

    更新日期：2015-06-01 00:00:00

  • Toward a robust tool for pharmacokinetic-based personalization of treatment with tacrolimus in solid organ transplantation: A model-based meta-analysis approach.

    abstract：AIMS:The objective of this study is to develop a generic model for tacrolimus pharmacokinetics modelling using a meta-analysis approach, that could serve as a first step towards a prediction tool to inform pharmacokinetics-based optimal dosing of tacrolimus in different populations and indications. METHODS:A systemati...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章,meta分析

    doi：10.1111/bcp.14110

    authors： Nanga TM,Doan TTP,Marquet P,Musuamba FT

    更新日期：2019-12-01 00:00:00

  • Effects of policy interventions on the introduction of novel oral anticoagulants in Stockholm: an interrupted time series analysis.

    abstract：AIMS:The aim of the present study was to assess the effect of policy interventions - i.e. reimbursement decisions, guidelines and regional recommendations - on the prescribing of oral anticoagulant treatment in patients with atrial fibrillation (AF). METHODS:Interrupted time series analyses were carried out using mont...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/bcp.13150

    authors： Komen J,Forslund T,Hjemdahl P,Andersen M,Wettermark B

    更新日期：2017-03-01 00:00:00

  • Laboratory investigation of effect of acute doses of nomifensine on a simulated aspect of night-time car driving performance.

    abstract：:1. Six healthy volunteers received single doses of either nomifensine 100 mg, nomifensine 50 mg or placebo at weekly intervals in a randomized double-blind crossover study. 2. Subjects were subjected to a simulated test of car driving at night. 3. Testing lasted about 1.5 h and consisted of measuring responses to ligh...

    journal_title：British journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1111/j.1365-2125.1977.tb05748.x

    authors： Hindmarch I

    更新日期：1977-01-01 00:00:00

  • Post-market safety warnings for drugs approved in Canada under the Notice of Compliance with conditions policy.

    abstract：AIMS:Health Canada has developed a pathway to approve drugs that have limited efficacy and safety data, the Notice of Compliance with conditions (NOC/c) policy. Increased safety reporting is required for these drugs but there has not been any systematic review of their post-market safety. This study compares safety war...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/bcp.12552

    authors： Lexchin J

    更新日期：2015-05-01 00:00:00

  • A simple collection method for saliva in children: potential for home monitoring of carbamazepine therapy.

    abstract：:We have developed a method of monitoring plasma concentrations of antiepileptic drugs which uses salivary samples, and is suitable for home monitoring in children. To validate the method, paired plasma and saliva samples from 39 children aged between 2 and 15 years were assayed for carbamazepine and its active metabol...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2125.1993.tb05700.x

    authors： Chee KY,Lee D,Byron D,Naidoo D,Bye A

    更新日期：1993-03-01 00:00:00

  • The pharmacokinetics of endralazine in essential hypertensives and in normotensive subjects.

    abstract：:The direct-acting vasodilator, endralazine, in combination with a beta-adrenoceptor blocker significantly reduced the blood pressures of normotensive volunteers and of patients with essential hypertension. The mean terminal elimination half-life for endralazine of 136 min in hypertensive patients did not differ signif...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2125.1983.tb02139.x

    authors： Meredith PA,Elliott HL,McSharry DR,Kelman AW,Reid JL

    更新日期：1983-07-01 00:00:00

  • The acute changes seen in cardiac glycoside receptor sites, 86rubidium uptake and intracellular sodium concentrations in the erythrocytes of patients during the early phases of digoxin therapy are not found during chronic therapy: pharmacological and ther

    abstract：:1 Measurements of the binding of 12-alpha-[3H]-digoxin to the membranes of intact erythrocytes, erythrocyte 86rubidium uptake and intraerythrocytic sodium concentrations have been made in the red cells of various groups of patients--those who have not received digoxin, those during the early phases of treatment, those...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2125.1979.tb05811.x

    authors： Ford AR,Aronson JK,Grahame-Smith DG,Carver JG

    更新日期：1979-08-01 00:00:00

  • Myopathy in older people receiving statin therapy: a systematic review and meta-analysis.

    abstract：OBJECTIVE:The aim of the present study was to determine the risk of myopathy in older people receiving statin therapy. METHODS:Eligible studies were identified searching Ovid Medline, EMBASE, Scopus, CINAHL, Cochrane and PSYCHINFO databases (1987 to July 2014). The selection criteria comprised randomized controlled st...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章,meta分析,评审

    doi：10.1111/bcp.12687

    authors： Iwere RB,Hewitt J

    更新日期：2015-09-01 00:00:00

  • Lack of inhibitory effect of metronidazole on theophylline disposition in healthy subjects.

    abstract：:The effect of metronidazole, at a dose of 1.2 g daily, on theophylline disposition was studied in 10 healthy adult volunteers. Neither theophylline half-life, volume of distribution nor total body clearance was altered by the anti-microbial. It is concluded that metronidazole does not impair theophylline metabolism de...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2125.1987.tb03146.x

    authors： Adebayo GI,Mabadeje AF

    更新日期：1987-07-01 00:00:00