Hypnotic efficacy and safety of midazolam and oxazepam in hospitalized female patients.

abstract：AIMS:The aim of the present study was to describe the real-life usage patterns of paracetamol. METHODS:The Echantillon Généraliste de Bénéficiaires (EGB) database, the permanent 1/97 representative sample from the French national healthcare insurance system, was searched in 2011 to identify usage patterns, concomitant...

journal_title：British journal of clinical pharmacology

authors： Duong M,Gulmez SE,Salvo F,Abouelfath A,Lassalle R,Droz C,Blin P,Moore N

更新日期：2016-08-01 00:00:00

abstract：AIMS:Paraquat poisoning is a medical problem in many parts of Asia and the Pacific. The mortality rate is extremely high as there is no effective treatment. We analyzed data collected during an ongoing cohort study on self-poisoning and from a randomized controlled trial assessing the efficacy of immunosuppressive ther...

journal_title：British journal of clinical pharmacology

authors： Wunnapuk K,Mohammed F,Gawarammana I,Liu X,Verbeeck RK,Buckley NA,Roberts MS,Musuamba FT

更新日期：2014-10-01 00:00:00

abstract：AIM:To characterize the romiplostim dose-response in subjects with low or intermediate-1 risk myelodysplastic syndromes (MDS) receiving subcutaneous romiplostim. METHODS:Data from 44 MDS subjects receiving subcutaneous romiplostim (dose range 300-1500 μg week(-1) ) were used to develop a pharmacodynamic model consisti...

journal_title：British journal of clinical pharmacology

authors： Perez Ruixo JJ,Doshi S,Wang YM,Mould DR

更新日期：2013-06-01 00:00:00

abstract：:1 The haemodynamic effects of labetalol 50 mg intravenously were studied in 13 hypertensive patients at rest in the supine and upright positions and during exercise using percutaneous right heart and brachial artery catheterization. 2 Labetalol induced immediate significant reductions in systolic and diastolic blood p...

journal_title：British journal of clinical pharmacology

authors： Koch G

更新日期：1976-08-01 00:00:00

abstract：:1. The elimination of antipyrine was investigated before and after intravenous administration of haem arginate (3 mg haem kg-1 day-1 on three or four successive days) to six patients with variegate porphyria in remission. 2. Haem arginate decreased the faecal content of protoporphyrin from 557 +/- 91 to 118 +/- 32 (me...

journal_title：British journal of clinical pharmacology

authors： Tokola O,Mustajoki P,Himberg JJ

更新日期：1988-12-01 00:00:00

abstract：:Children are not small adults. However, the main thesis of this review will be that children's responses to drugs have much in common with the responses in adults and indeed in other mammals. Often, it is assumed that drug effects differ in children but in reality this perception often arises because the drugs have no...

journal_title：British journal of clinical pharmacology

authors： Stephenson T

更新日期：2005-06-01 00:00:00

abstract：:Regulating drugs does not end when market access has been granted. Monitoring drugs over the life cycle has become state of the art, inherent to evolving legislation and societal need. Here, we explore how the drug label could move along in a changing playing-field and become a sustainable label for the future. A dial...

journal_title：British journal of clinical pharmacology

authors： Gispen-de Wied CC,Weemers J,Boon W,Mol PGM,Stolk P

更新日期：2019-10-01 00:00:00

abstract：AIMS:Aprepitant and fosaprepitant, commonly used for the prevention of chemotherapy-induced nausea and vomiting, alter cytochrome P450 activity. This systematic review evaluates clinically significant pharmacokinetic drug interactions with aprepitant and fosaprepitant and describes adverse events ascribed to drug inter...

journal_title：British journal of clinical pharmacology

authors： Patel P,Leeder JS,Piquette-Miller M,Dupuis LL

更新日期：2017-10-01 00:00:00

abstract：AIMS:To determine whether a medicine review and education programme influences the compliance and knowledge of older people in general practice. METHODS:Older people taking at least three medicines were randomly allocated to a control or intervention group. Both groups received three visits from a clinical pharmacist:...

journal_title：British journal of clinical pharmacology

authors： Lowe CJ,Raynor DK,Purvis J,Farrin A,Hudson J

更新日期：2000-08-01 00:00:00

abstract：AIMS:To test the existence of an association between reports of hypoglycaemia and angiotensin converting enzyme inhibitors, in a spontaneous reports database. METHODS:The French Pharmacovigilance database was examined for an association between adverse drug reaction reports mentioning hypoglycaemia, and angiotensin co...

journal_title：British journal of clinical pharmacology

authors： Moore N,Kreft-Jais C,Haramburu F,Noblet C,Andrejak M,Ollagnier M,Bégaud B

更新日期：1997-11-01 00:00:00

abstract：AIMS:To estimate the rates of common adverse events in patients treated with the proton pump inhibitors omeprazole, lansoprazole and pantoprazole in general practice in England. METHODS:In prescription-event monitoring cohort studies, data on dispensed prescriptions prescribed by general practitioners in England soon ...

journal_title：British journal of clinical pharmacology

authors： Martin RM,Dunn NR,Freemantle S,Shakir S

更新日期：2000-10-01 00:00:00

abstract：AIMS:Homeopathic medicines are frequently purchased over the counter (OTC). Respiratory complaints are the most frequent reason for such purchases. Children with upper respiratory tract infection (URTI) are frequent users of homeopathy. This study investigates the effect of self treatment with one of three self selecte...

journal_title：British journal of clinical pharmacology

authors： Steinsbekk A,Bentzen N,Fønnebø V,Lewith G

更新日期：2005-04-01 00:00:00

abstract：:The pharmacokinetic behaviour and the bioavailability of midazolam were investigated in six volunteers after intravenous (0.15 mg/kg) and oral administration (10, 20 and 40 mg). Following rapid intravenous injection of midazolam, the plasma concentration of the substance decreased to approximately 10% within 2 h owing...

journal_title：British journal of clinical pharmacology

authors： Heizmann P,Eckert M,Ziegler WH

更新日期：1983-01-01 00:00:00

abstract：AIM:To develop a semi-mechanistic model, based on glutathione depletion and predict a previously identified intra-individual reduction in busulfan clearance to aid in more precise dosing. METHODS:Busulfan concentration data, measured as part of regular care for allogeneic hematopoietic cell transplantation (HCT) patie...

journal_title：British journal of clinical pharmacology

authors： Langenhorst JB,Boss J,van Kesteren C,Lalmohamed A,Kuball J,Egberts ACG,Boelens JJ,Huitema ADR,van Maarseveen EM

更新日期：2020-08-01 00:00:00

abstract：AIMS:Naloxegol, a polyethylene glycol conjugated derivative of the opioid antagonist naloxone, is in clinical development for treatment of opioid-induced constipation (OIC). The aim of the study was to develop a population pharmacokinetic model describing the concentration vs. time profile of orally administered naloxe...

journal_title：British journal of clinical pharmacology

authors： Al-Huniti N,Chapel S,Xu H,Bui KH,Sostek M

更新日期：2016-01-01 00:00:00

abstract：:1. The pharmacokinetics of methylprednisolone (MP) were studied in five normal subjects following intravenous doses of 20, 40 and 80 mg methylprednisolone sodium succinate (MPSS) and an oral dose of 20 mg methylprednisolone as 4 x 5 mg tablets. Plasma concentrations of MP and MPSS were measured by both high performanc...

journal_title：British journal of clinical pharmacology

authors： Al-Habet SM,Rogers HJ

更新日期：1989-03-01 00:00:00

abstract：:1 Aspirin is partly hydrolyzed to salicylic acid during absorption. Absorbed aspirin is rapidly hydrolyzed systemically. Salicylic acid elimination kinetics are dependent on drug concentration due to the limited capacity of two major biotransformation pathways: formation of salicyluric acid and of salicylphenolic gluc...

journal_title：British journal of clinical pharmacology

authors： Levy G

更新日期：1980-10-01 00:00:00

abstract：:1. Recent work has demonstrated artificial penile erection after intracavernous injection of prostaglandin E1 (PGE1). A possible dose-response relationship between PGE1 and its erectile action was examined in a double-blind, cross-over designed, placebo-controlled study. 2. Twenty patients aged (mean +/- s.d.) 45 +/- ...

journal_title：British journal of clinical pharmacology

authors： Schramek P,Waldhauser M

更新日期：1989-11-01 00:00:00

abstract：:1. The antitussive properties of bronchodilators were evaluated in a total of 47 normal volunteers. 2. Cough was induced by inhalation of ultrasonically nebulized solutions of distilled water and hypotonic saline. 3. Inhaled fenoterol hydrobromide (360 micrograms; 20 volunteers) and inhaled ipratropium bromide (72 mic...

journal_title：British journal of clinical pharmacology

authors： Lowry R,Higenbottam T,Johnson T,Godden D

更新日期：1987-10-01 00:00:00

abstract：:In many endoscopy units midazolam is replacing diazepam as the intravenous sedative of first choice. Midazolam is approximately twice as potent as diazepam. Although generally considered a safe drug, there have been a number of recent reports, particularly in the elderly, of the drug causing hypotension, respiratory d...

journal_title：British journal of clinical pharmacology

authors： Bell GD,Spickett GP,Reeve PA,Morden A,Logan RF

更新日期：1987-02-01 00:00:00

abstract：AIMS:The aim was to examine relationships between total and unbound mycophenolic acid (MPA) and prednisolone exposure and clinical outcomes in patients with lupus nephritis. METHODS:Six blood samples were drawn pre- and at 1, 2, 4, 6 and 8 h post-dose and total and unbound MPA and prednisolone pre-dose (C0 ), maximum ...

journal_title：British journal of clinical pharmacology

authors： Abd Rahman AN,Tett SE,Abdul Gafor HA,McWhinney BC,Staatz CE

更新日期：2015-11-01 00:00:00

abstract：AIM:Propylene glycol (PG) is often applied as an excipient in drug formulations. As these formulations may also be used in neonates, the aim of this study was to characterize the pharmacokinetics of propylene glycol, co-administered intravenously with paracetamol (800 mg PG/1000 mg paracetamol) or phenobarbital (700 mg...

journal_title：British journal of clinical pharmacology

authors： De Cock RF,Knibbe CA,Kulo A,de Hoon J,Verbesselt R,Danhof M,Allegaert K

更新日期：2013-01-01 00:00:00

abstract：AIMS:The objective of this study was to estimate the number of fractures attributed to oral corticosteroid use. METHODS:Information was obtained from the General Practice Research Database which contains medical records of general practitioners in the UK. The total number of corticosteroid-related fractures during a c...

journal_title：British journal of clinical pharmacology

authors： van Staa TP,Abenhaim L,Cooper C,Zhang B,Leufkens HG

更新日期：2001-06-01 00:00:00

abstract：AIMS:It has been shown that the cellular uptake and cytotoxicity of anthracyclines decrease with increasing cell density in vitro, an event termed 'the inocculum effect'. It is not known whether such an effect occurs in vivo. In this study the relationships between white blood cell (WBC) count, plasma and cellular conc...

journal_title：British journal of clinical pharmacology

authors： Bogason A,Quartino AL,Lafolie P,Masquelier M,Karlsson MO,Paul C,Gruber A,Vitols S

更新日期：2011-04-01 00:00:00

abstract：AIMS:The cytochrome P450 enzyme CYP2C9 catalyses the 4'-hydroxylation of the nonsteroidal analgesic drug diclofenac in humans. We studied the influences of the known amino acid variants, CYP2C9*2 (Arg144Cys) and CYP2C9*3 (Ile359Leu), on diclofenac pharmacokinetics after a 50-mg oral dose of diclofenac in healthy volunt...

journal_title：British journal of clinical pharmacology

authors： Kirchheiner J,Meineke I,Steinbach N,Meisel C,Roots I,Brockmöller J

更新日期：2003-01-01 00:00:00

abstract：:1 The protein binding of seven non-steroidal anti-inflammatory drugs (indomethacin, tolmetin, salicylic acid, ibuprofen, flurbiprofen, naproxen and GP53,633) and warfarin was investigated by equilibrium dialysis in simultaneous samples of synovial fluid and plasma from 12 arthritic patients. 2 The protein binding of a...

journal_title：British journal of clinical pharmacology

authors： Wanwimolruk S,Brooks PM,Birkett DJ

更新日期：1983-01-01 00:00:00

abstract：:The influence of cimetidine pretreatment on the pharmacokinetics of 5-fluorouracil (5FU) has been studied in 15 ambulant patients with carcinoma. Neither pretreatment with a single dose of cimetidine (400 mg) nor with daily treatment at 1000 mg for 1 week altered 5FU pharmacokinetics. Pretreatment with cimetidine for ...

journal_title：British journal of clinical pharmacology

authors： Harvey VJ,Slevin ML,Dilloway MR,Clark PI,Johnston A,Lant AF

更新日期：1984-09-01 00:00:00

abstract：:1 Seventeen men, aged 45-57 yr, with essential hypertension showed obvious and, in the standing position, dose-related reductions in blood pressure during treatment with oral labetalol with weekly dose increments. 2 Pulse rate changes were not related to dose but reduced compared with pre-treatment values. 3 No postur...

journal_title：British journal of clinical pharmacology

authors： Andersson O,Berglund G,Hansson L

更新日期：1976-08-01 00:00:00

abstract：:Propranolol induced changes in blood plasma chemistry were followed in thirty hypertensive patients (WHO I-II) who were seen each week during 14-15 weeks. The initial 4 weeks were a drug free period and the next 2 weeks were a drug adjustment period. After that the patients were on an unchanged propranolol dose for 8 ...

journal_title：British journal of clinical pharmacology

authors： Andreasen F,Jakobsen P,Kornerup HJ,Pedersen EB,Pedersen OL,Weeke J

更新日期：1984-03-01 00:00:00

abstract：:1. Nitric oxide is recognised as an important biological mediator, which is thought to be involved in cardiovascular homeostasis. The purpose of this study was to investigate the effects of basal nitric oxide synthesis on cardiac function in man, by blocking nitric oxide synthesis with NG-monomethyl-L-arginine (L-NMMA...

journal_title：British journal of clinical pharmacology

authors： Clarkson PB,Lim PO,MacDonald TM

更新日期：1995-10-01 00:00:00