Abstract:
:The possibility that vigabatrin (VGB) decreases serum phenytoin (PHT) concentration by lowering the oral bioavailability of PHT was investigated in 21 patients with epilepsy. Each patient was switched from oral to intravenous PHT for 5 days before and after combined treatment with VGB. After VGB (2-3.5 g day(-1) for at least 5 weeks), serum PHT concentrations decreased slightly from 87 +/- 25 to 76 +/- 31 micromol l(-1) (means +/- s.d., P < 0.05), but in a subgroup of seven patients the decrease was more prominent (from 72 +/- 22 to 49 +/- 17 micromol l(-1), P < 0.005). At baseline (before VGB), serum PHT remained unaffected (85 +/- 30 micromol l(-1)) after switching PHT dosage to the intravenous route, indicating that the oral availability of the drug was virtually complete. During VGB treatment, serum PHT was also unchanged (74 +/- 34 micromol l(-1)) after switching from oral to intravenous therapy, and this was also true for the subgroup of patients showing a prominent interaction (48 +/- 18 micromol l(-1)). The urinary recoveries of PHT and its metabolites pHPPH and mHPPH remained constant throughout the study. It is concluded that the oral availability of PHT is unaffected by VGB and that the VBG-induced decrease in serum PHT is mediated by alternative mechanisms.
journal_name
Br J Clin Pharmacoljournal_title
British journal of clinical pharmacologyauthors
Gatti G,Bartoli A,Marchiselli R,Michelucci R,Tassinari CA,Pisani F,Zaccara G,Timmings P,Richens A,Perucca Edoi
10.1111/j.1365-2125.1993.tb00422.xkeywords:
subject
Has Abstractpub_date
1993-12-01 00:00:00pages
603-6issue
6eissn
0306-5251issn
1365-2125journal_volume
36pub_type
杂志文章abstract::1 This study was designed to compare in a double-blind randomized crossover trial, atenolol, labetalol, metoprolol and pindolol. Considerable differences in dose (atenolol 138 +/- 13 mg daily; labetalol 308 +/- 34 mg daily; metoprolol 234 +/- 22 mg daily; and pindolol 24 +/-2 mg daily were required to produce similar ...
journal_title:British journal of clinical pharmacology
pub_type: 杂志文章
doi:10.1111/j.1365-2125.1979.tb04774.x
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journal_title:British journal of clinical pharmacology
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journal_title:British journal of clinical pharmacology
pub_type: 杂志文章
doi:10.1111/j.1365-2125.1981.tb01234.x
更新日期:1981-09-01 00:00:00
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journal_title:British journal of clinical pharmacology
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pub_type: 杂志文章
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pub_type: 杂志文章,meta分析
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更新日期:2014-10-01 00:00:00
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pub_type: 杂志文章,多中心研究,评审
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更新日期:2013-11-01 00:00:00
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doi:10.1111/j.1365-2125.1987.tb03002.x
更新日期:1987-01-01 00:00:00
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journal_title:British journal of clinical pharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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doi:
更新日期:1979-01-01 00:00:00
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journal_title:British journal of clinical pharmacology
pub_type: 杂志文章
doi:10.1111/j.1365-2125.1985.tb05043.x
更新日期:1985-08-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:1992-03-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2000-05-01 00:00:00
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更新日期:1974-06-01 00:00:00
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pub_type: 传,历史文章,杂志文章,评审
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更新日期:2016-01-01 00:00:00
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doi:10.1111/j.1365-2125.1981.tb00536.x
更新日期:1981-03-01 00:00:00
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更新日期:2013-12-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1978-07-01 00:00:00