Have COX-2 inhibitors influenced the co-prescription of anti-ulcer drugs with NSAIDs?

abstract：AIMS:This study was conducted to determine whether atenolol was able to decrease BP level and mitigate BP increase during dynamic resistance exercise performed at three different intensities in hypertensives. METHODS:Ten essential hypertensives (systolic/diastolic BP between 140/90 and 160/105mmHg) were blindly studie...

journal_title：British journal of clinical pharmacology

authors： Gomides RS,Costa LA,Souza DR,Queiroz AC,Fernandes JR,Ortega KC,Junior DM,Tinucci T,Forjaz CL

更新日期：2010-11-01 00:00:00

abstract：:Widespread use of cocaine and its attendant toxicity has produced a wealth of benchwork studies and small animal investigations that evaluated the effects of cocaine on the cardiovascular system. Despite this wealth of knowledge, very little is known about the frequency or types of arrhythmias in patients with signifi...

journal_title：British journal of clinical pharmacology

authors： Hoffman RS

更新日期：2010-05-01 00:00:00

abstract：:1. The three dimensional requirements for inhibition of ACE (angiotensin converting enzyme) were investigated in order to facilitate design of a more potent and selective antihypertensive agent. 2. All compounds designed possessed a bicyclic unit incorporating carboxylate and amidic carbonyl groups together with a thi...

journal_title：British journal of clinical pharmacology

authors： Attwood MR

更新日期：1989-01-01 00:00:00

abstract：AIMS:To compare the effects of two long-acting calcium antagonists of different types on cardiovascular stress responses in hypertension. METHODS:One-hundred and forty-five patients with mild to moderate hypertension and a mean (+/- s.e.mean) age of 51 +/- 0.9 years received for 8 weeks the phenylalkylamine verapamil ...

journal_title：British journal of clinical pharmacology

authors： Lefrandt JD,Heitmann J,Sevre K,Castellano M,Hausberg M,Fallon M,Urbigkeit A,Rostrup M,Agabiti-Rosei E,Rahn KH,Murphy M,Zannad F,de Kam PJ,Smit AJ

更新日期：2001-12-01 00:00:00

abstract：:1 The new converting enzyme inhibitor RHC 3659 was tested in 15 male volunteers. The study consisted of two parts: first, the ability of a single oral dose (5, 10, 20, 40 or 80 mg) to inhibit the pressor response to exogenous angiotensin I was tested with blood pressure and heart rate monitored continuously through an...

journal_title：British journal of clinical pharmacology

authors： Burnier M,Turini GA,Brunner HR,Porchet M,Kruithof D,Vukovich RA,Gavras H

更新日期：1981-12-01 00:00:00

abstract：AIMS:Continuous noninvasive blood pressure measurement by photoplethysmography has been regularly used in the experimental paradigm of angiotensin challenges, applied to the phase I clinical testing of angiotensin-converting enzyme inhibitors and angiotensin receptor antagonists. This work aims to evaluate the performa...

journal_title：British journal of clinical pharmacology

authors： Buclin T,Buchwalder-Csajka C,Brunner HR,Biollaz J

更新日期：1999-10-01 00:00:00

abstract：:Regulatory science underpins the objective evaluation of medicinal products. It is therefore imperative that regulatory science and expertise remain at the cutting edge so that innovations of ever-increasing complexity are translated safely and swiftly into effective, high-quality therapies. We undertook a comprehensi...

journal_title：British journal of clinical pharmacology

authors： Hines PA,Guy RH,Brand A,Humphreys AJ,Papaluca-Amati M

更新日期：2020-12-01 00:00:00

abstract：AIMS:Breakthrough bleeding or even unwanted pregnancies have been reported in women during concomitant therapy with oral contraceptives and St John's wort extract. The aim of the present study was to investigate the effects of St John's wort extract on oral contraceptive therapy with respect to ovarian activity, breakt...

journal_title：British journal of clinical pharmacology

authors： Pfrunder A,Schiesser M,Gerber S,Haschke M,Bitzer J,Drewe J

更新日期：2003-12-01 00:00:00

abstract：:1. The objective of this study was to investigate the efficacy of home-medicated non-steroidal anti-inflammatory (NSAID) analgesics, using an electronic patient diary. Single doses of ketoprofen 25 mg and ketoprofen 50 mg were compared with ibuprofen 200 mg and placebo in the treatment of a single occasion of episodic...

journal_title：British journal of clinical pharmacology

authors： van Gerven JM,Schoemaker RC,Jacobs LD,Reints A,Ouwersloot-van der Meij MJ,Hoedemaker HG,Cohen AF

更新日期：1996-10-01 00:00:00

abstract：AIMS:The main goal of the study was to describe the pharmacokinetics of maternal zidovudine (ZDV) administration during pregnancy and labour and to evaluate their impact on fetal concentrations and exposures. METHODS:A total of 195 HIV-infected pregnant and non-pregnant women aged 16-59 years were included and 273 mat...

journal_title：British journal of clinical pharmacology

authors： Fauchet F,Treluyer JM,Valade E,Benaboud S,Pannier E,Firtion G,Foissac F,Bouazza N,Urien S,Hirt D

更新日期：2014-12-01 00:00:00

abstract：:Voriconazole is an antifungal metabolised by CYP2C19 enzyme, which can be inhibited by proton-pump inhibitors (PPIs). A prospective observational study was carried out to determine the influence of PPIs on voriconazole pharmacokinetic. The 78 patients included were divided into 4 groups: omeprazole (n = 32), pantopraz...

journal_title：British journal of clinical pharmacology

authors： Blanco Dorado S,Maroñas Amigo O,Latorre-Pellicer A,Rodríguez Jato MT,López-Vizcaíno A,Gómez Márquez A,Bardán García B,Belles Medall D,Barbeito Castiñeiras G,Pérez Del Molino Bernal ML,Campos-Toimil M,Otero Espinar F,Blanco Hortas

更新日期：2020-08-01 00:00:00

abstract：AIMS:To test the existence of an association between reports of hypoglycaemia and angiotensin converting enzyme inhibitors, in a spontaneous reports database. METHODS:The French Pharmacovigilance database was examined for an association between adverse drug reaction reports mentioning hypoglycaemia, and angiotensin co...

journal_title：British journal of clinical pharmacology

authors： Moore N,Kreft-Jais C,Haramburu F,Noblet C,Andrejak M,Ollagnier M,Bégaud B

更新日期：1997-11-01 00:00:00

abstract：:The frequency distributions of the 0-8 h urinary metabolic ratios of debrisoquine and mephenytoin were measured in 111 healthy, unrelated Sinhalese resident in Sri Lanka. Blood samples were taken from 77 of these subjects for CYP2D6 genotyping. Bimodality in the distribution of the log10 debrisoquine/4-hydroxydebrisoq...

journal_title：British journal of clinical pharmacology

authors： Weerasuriya K,Jayakody RL,Smith CA,Wolf CR,Tucker GT,Lennard MS

更新日期：1994-11-01 00:00:00

abstract：:The hypertensive disorders of pregnancy (HDP) are a leading cause of maternal mortality and morbidity in both well and under-resourced settings. Maternal, fetal, and neonatal complications of the HDP are concentrated among, but not limited to, women with pre-eclampsia. Pre-eclampsia is a systemic disorder of endotheli...

journal_title：British journal of clinical pharmacology

authors： Magee LA,Abalos E,von Dadelszen P,Sibai B,Easterling T,Walkinshaw S,CHIPS Study Group.

更新日期：2011-09-01 00:00:00

abstract：:1 A double-blind entry to a trial of an active non-steroidal anti-inflammatory drug, flurbiprofen against placebo was undertaken until 100 patients with classical rheumatoid arthritis had been allocated to each treatment. 2 Each patient was given a long-term supply of drug and was asked to vary their own dosage within...

journal_title：British journal of clinical pharmacology

authors： Rooney PJ,Capell HA,Paterson S,Buchanan WW,Dick WC

更新日期：1978-05-01 00:00:00

abstract：AIMS:To examine the effects of salbutamol and L-arginine, two compounds acting largely on the endothelium, and the endothelium-independent agent nitroglycerin on blood pressure, arterial compliance, cardiac function and vascular resistance. METHODS:Continuous radial pulse wave analysis, whole-body impedance cardiograp...

journal_title：British journal of clinical pharmacology

authors： Tahvanainen A,Leskinen M,Koskela J,Ilveskoski E,Alanko J,Kähönen M,Kööbi T,Lehtimäki L,Moilanen E,Mustonen J,Pörsti I

更新日期：2009-07-01 00:00:00

abstract：AIMS:To demonstrate the bioequivalence of macitentan/tadalafil fixed-dose combination (FDC) tablets with single-component tablets of macitentan and tadalafil in healthy subjects. METHODS:Studies AC-077-101 and AC-077-103 were single-centre, open-label, single-dose, 2-period, randomized, crossover Phase 1 studies condu...

journal_title：British journal of clinical pharmacology

authors： Grill S,Bruderer S,Sidharta PN,Antonova M,Globig S,Carlson J,Schultz A,Csonka D

更新日期：2020-12-01 00:00:00

abstract：:1. Metoprolol (ME), pindolol (PI) and propranolol (PR) were studied in nine subjects at different doses and at 'maximum beta-adrenoceptor blockade' at a defined exercise load. Exercise tests were performed after each dosing period; isoprenaline stimulation was studied at the highest dose level. 2. ME and PR reduced he...

journal_title：British journal of clinical pharmacology

authors： Gugler R,Krist R,Raczinski H,Höffgen K,Bodem G

更新日期：1980-10-01 00:00:00

abstract：AIMS:The aims of the present study were to evaluate the pharmacokinetic properties of dihydroartemisinin (DHA) and piperaquine, potential drug-drug interactions with concomitant primaquine treatment, and piperaquine effects on the electrocardiogram in healthy volunteers. METHODS:The population pharmacokinetic properti...

journal_title：British journal of clinical pharmacology

authors： Chotsiri P,Wattanakul T,Hoglund RM,Hanboonkunupakarn B,Pukrittayakamee S,Blessborn D,Jittamala P,White NJ,Day NPJ,Tarning J

更新日期：2017-12-01 00:00:00

abstract：WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT:Desmopressin is a known haemostatic agent and is also being used, albeit at lower doses, during the diagnostic work-up of Cushing's syndrome, a condition characterized by excess cortisol concentrations and frequent thromboembolic events. No study has yet evaluated whether admini...

journal_title：British journal of clinical pharmacology

authors： Pecori Giraldi F,Ambrogio AG,Fatti LM,Rubini V,Cozzi G,Scacchi M,Federici AB,Cavagnini F

更新日期：2011-01-01 00:00:00

abstract：:Many studies from around the world show a correlation between increasing age and adverse drug reaction (ADR) rate, at least for some medical conditions. More than 80% of ADRs causing admission or occurring in hospital are type A (dose-related) in nature, and thus predictable from the known pharmacology of the drug and...

journal_title：British journal of clinical pharmacology

authors： Routledge PA,O'Mahony MS,Woodhouse KW

更新日期：2004-02-01 00:00:00

abstract：:Catechol-O-methyltransferase (COMT) is of great importance in pharmacology because it catalyzes the metabolism (methylation) of endogenous and xenobiotic catechols. Moreover, inhibition of COMT is the drug target in the management of central nervous system (CNS) disorders such as Parkinson's disease due to its role in...

journal_title：British journal of clinical pharmacology

authors： Ma Z,Liu H,Wu B

更新日期：2014-03-01 00:00:00

abstract：AIMS:5-hydroxytryptamine3 receptor antagonists act antiemetically and slow colonic transit. This study evaluated effects of the high-affinity 5-HT3 antagonist, cilansetron, on fasting, meal-and anticholinesterase-stimulated phasic contractile activity of the human sigmoid colon as well as on bowel habits and stool cons...

journal_title：British journal of clinical pharmacology

authors： Stacher G,Weber U,Stacher-Janotta G,Bauer P,Huber K,Holzäpfel A,Krause G,Steinborn C

更新日期：2000-05-01 00:00:00

abstract：:1 The disposition in urine of debrisoquine and its hydroxylated metabolites has been studied in subjects of the 'extensive metabolizer' (EM; n = 5) and 'poor metabolizer' (PM; n = 5) phenotypes. The 4-hydroxylation of debrisoquine by PM subjects following a 10 mg oral dose was capacity-limited and displayed significan...

journal_title：British journal of clinical pharmacology

authors： Sloan TP,Lancaster R,Shah RR,Idle JR,Smith RL

更新日期：1983-04-01 00:00:00

abstract：:1 The bronchodilating efficacy and the degree of beta2-adrenoceptor selectivity of rimiterol, salbutamol and isoprenaline were determined in seven subjects who exhibited histamine-induced bronchoconstriction. 2 Rimiterol, 0.5 (high dose) and 0.05 (low dose) mug kg-1 min-1, salbutamol, 0.3 and 0.03 mug kg-1 min-1, isop...

journal_title：British journal of clinical pharmacology

authors： Marlin GE,Turner P

更新日期：1975-02-01 00:00:00

abstract：AIMS:The aim of the present study was to determine how the pharmacokinetics of meloxicam are affected by kidney dysfunction and consequently to define the appropriate dose for the use of meloxicam in patients with mild or moderate renal impairment. METHODS:Meloxicam was administered to subjects with mild (creatinine c...

journal_title：British journal of clinical pharmacology

authors： Boulton-Jones JM,Geddes CG,Heinzel G,Türck D,Nehmiz G,Bevis PJ

更新日期：1997-01-01 00:00:00

abstract：:Mirabegron is used for the treatment of symptoms associated with overactive bladder syndrome. It selectively stimulates the β3 -adrenoreceptor, which relaxes the detrusor muscle. This improves urine storage by distension of the bladder body. ...

journal_title：British journal of clinical pharmacology

authors： Goulooze SC,Cohen AF,Rissmann R

更新日期：2015-10-01 00:00:00

abstract：AIMS:Various mathematical models have been developed to estimate glomerular filtration rate (GFR) incorporating variables such as age, gender, height, weight, serum creatinine, and body surface area (BSA). Because adjustments in drug dosing are often based on estimated values of renal function, it is important to defin...

journal_title：British journal of clinical pharmacology

authors： Goerdt PJ,Heim-Duthoy KL,Macres M,Swan SK

更新日期：1997-09-01 00:00:00

abstract：:1. N-hydroxylation is thought to be an essential step in the haemotoxicity of dapsone (DDS). To investigate both metabolism-dependent and cell-selective drug toxicity in vitro we have developed a three-compartment system in which an hepatic drug metabolizing system is contained within a central compartment separated b...

journal_title：British journal of clinical pharmacology

authors： Tingle MD,Park BK

更新日期：1993-07-01 00:00:00

abstract：AIMS:The protease inhibitor indinavir is characterized by an important interindividual pharmacokinetic variability, which results from the actions of the metabolizing enzymes cytochrome P450 (CYP) 3A and the multidrug efflux pump P-glycoprotein (P-gp), encoded by MDR1. Using a population pharmacokinetic approach, we in...

journal_title：British journal of clinical pharmacology

authors： Solas C,Simon N,Drogoul MP,Quaranta S,Frixon-Marin V,Bourgarel-Rey V,Brunet C,Gastaut JA,Durand A,Lacarelle B,Poizot-Martin I

更新日期：2007-09-01 00:00:00