Evaluation of noninvasive blood pressure recording by photoplethysmography in clinical studies using angiotensin challenges.

abstract：:1. We investigated the effect of the haemostatic agent ethamsylate on aspirin-induced gastric mucosal bleeding. 2. Eighteen healthy subjects were studied three times: at the end of 48 h periods of treatment with (a) placebo, (b) aspirin 600 mg four times daily, (9 doses) and (c) aspirin 600 mg four times daily with ea...

journal_title：British journal of clinical pharmacology

authors： Daneshmend TK,Stein AG,Bhaskar NK,Hawkey CJ

更新日期：1989-07-01 00:00:00

abstract：:1. The antihypertensive efficacy and tolerability of a low dose combination of the angiotensin converting enzyme inhibitor ramipril (2.5 mg) and the extended release formulation of the dihydropyridine calcium channel antagonist felodipine (5 mg) were assessed in a double-blind, double dummy placebo controlled, randomi...

journal_title：British journal of clinical pharmacology

authors： Bainbridge AD,Macfadyen RJ,Stark S,Lees KR,Reid JL

更新日期：1993-10-01 00:00:00

abstract：:1. The aim of this study was to investigate the dose-related effects of ibuprofen (placebo, 400 and 800 mg rac-ibuprofen [Aktren], administered orally) on experimentally-induced tonic and phasic pain. 2. Eighteen volunteers participated in this randomized, double-blind, three-fold cross-over study. Measurements were o...

journal_title：British journal of clinical pharmacology

authors： Kobal G,Hummel C,Gruber M,Geisslinger G,Hummel T

更新日期：1994-05-01 00:00:00

abstract：:1. Milk and plasma metronidazole and hydroxymetronidazole concentrations were measured in 12 breast-feeding patients following multiple doses of metronidazole (400 mg three times daily). All patients received metronidazole in combination with other broad spectrum antibiotics. 2. Plasma concentrations of both parent dr...

journal_title：British journal of clinical pharmacology

authors： Passmore CM,McElnay JC,Rainey EA,D'Arcy PF

更新日期：1988-07-01 00:00:00

abstract：AIMS:To investigate the driving forces behind increasing utilization of cardiovascular drugs. METHODS:Using register data, all Danish residents as of 1 January 1996 were followed until 2006. Cohort members were censored at death or emigration. Cardiovascular drug utilization on the individual level was traced, applyin...

journal_title：British journal of clinical pharmacology

authors： Kildemoes HW,Støvring H,Andersen M

更新日期：2008-12-01 00:00:00

abstract：AIMS:To investigate the pharmacokinetics of enterally administered cisapride suspension in young infants being treated for gastro-oesophageal reflux disease. METHODS:Plasma cisapride concentrations in 49 subjects (weight: 825-5010 g; n=108 samples, median two per patient; concentration: 14.8-170 ng ml-1 ) were fitted ...

journal_title：British journal of clinical pharmacology

authors： Preechagoon Y,Charles B,Piotrovskij V,Donovan T,Van Peer A

更新日期：1999-11-01 00:00:00

abstract：INTRODUCTION:Irrational medicine use is a global crisis, but incidences are proportionately higher in low and middle-income countries like Sierra Leone. This study explores the structure, functions, and challenges of Drug and Therapeutics Committees (DTC) an intervention towards irrational medicines use recently pilote...

journal_title：British journal of clinical pharmacology

authors： Kabba JA,Koroma MM,James PB,Kitchen C,Xu S,Chang J,Saeed A,Malik UR,Jiang M,Fang Y

更新日期：2021-01-04 00:00:00

abstract：:The renal response to a challenge of maximal water diuresis has been studied in seven subjects pretreated over 48 h with either placebo, probenecid, indomethacin or piroxicam. Probenecid did not alter the excretion of water and sodium chloride when compared with placebo responses, but increased both phosphate and urat...

journal_title：British journal of clinical pharmacology

authors： Dixey JJ,Noormohamed FH,Lant AF,Brewerton DA

更新日期：1988-05-01 00:00:00

abstract：AIMS:Medication-related osteonecrosis of the jaw (MRONJ) is an uncommon but potentially debilitating condition, characterised by nonhealing jawbone, with or without mucosal exposure, in the presence of certain drugs. Those already strongly associated with MRONJ include antiresorptives denosumab and bisphosphonates; how...

journal_title：British journal of clinical pharmacology

authors： Teoh L,Moses G,Nguyen AP,McCullough MJ

更新日期：2020-11-27 00:00:00

abstract：:1. A novel formulation of nicardipine (50% standard (short acting), 50% sustained release) was evaluated in mild hypertension in a double-blind, randomized, placebo-controlled study, using clinic measurements (Hawksley) augmented by home recorded blood pressures (Copal UA 251). 2. Nicardipine 60 mg twice daily for 28 ...

journal_title：British journal of clinical pharmacology

authors： Webster J,Witte K,Rawles J,Petrie JC,Jeffers TA

更新日期：1989-05-01 00:00:00

abstract：:1 beta-adrenoceptor blockade with metoprolol provoked, both at rest and during exercise, a decrease of 'active' renin and angiotensin II together with an increase of 'inactive' renin and unchanged 'total' renin. The significant exercise-provoked increases in angiotensin II, plasma renin activity and 'active', 'inactiv...

journal_title：British journal of clinical pharmacology

authors： Lijnen PJ,Amery AK,Fagard RH,Reybrouck TM,Moerman EJ,De Schaepdryver AF

更新日期：1979-02-01 00:00:00

abstract：:1 We have given fifteen healthy volunteers single doses of racemic (+/-)-propranolol orally (40 mg) and intravenously (5-10 mg) to find out how large the variation was of the ratio between (-)- and (+)-propranolol plasma levels in relation to that of total levels of propranolol and 4-hydroxypropranolol. 2 Total propra...

journal_title：British journal of clinical pharmacology

authors： Von Bahr C,Hermansson J,Tawara K

更新日期：1982-07-01 00:00:00

abstract：AIM:To evaluate safety, tolerability and pharmacokinetics of oral PF-05190457, an oral ghrelin receptor inverse agonist, in healthy adults. METHODS:Single (SAD) and multiple ascending dose (MAD) studies were randomised, placebo-controlled, double-blind studies. Thirty-five healthy men (age 38.2 ± 10.4 years; body mass...

journal_title：British journal of clinical pharmacology

authors： Denney WS,Sonnenberg GE,Carvajal-Gonzalez S,Tuthill T,Jackson VM

更新日期：2017-02-01 00:00:00

abstract：:Eleven HIV-infected men participated in a randomized, two-treatment, two-period crossover study to determine the effect of a 25 g protein meal on zidovudine pharmacokinetics. On two separate occasions, 1 week apart, each patient received 200 mg zidovudine in a fasting state or immediately following the protein meal. A...

journal_title：British journal of clinical pharmacology

authors： Sahai J,Gallicano K,Garber G,McGilveray I,Hawley-Foss N,Turgeon N,Cameron DW

更新日期：1992-06-01 00:00:00

abstract：AIMS:The aim of the present study was to evaluate the disposition of metoprolol after oral administration of an immediate and controlled-release formulation before and after Roux-en-Y gastric bypass (RYGB) surgery in the same individuals and to validate a physiologically based pharmacokinetic (PBPK) model for predictin...

journal_title：British journal of clinical pharmacology

authors： Gesquiere I,Darwich AS,Van der Schueren B,de Hoon J,Lannoo M,Matthys C,Rostami A,Foulon V,Augustijns P

更新日期：2015-11-01 00:00:00

abstract：:1 The influence of cimetidine (1000 mg daily) on propranolol steady state plasma levels has been studied in seven normal volunteers. Cimetidine was used as a 200 mg normal release tablet whereas propranolol was given as a 160 mg slow release formulation once daily. 2 After 1 day of cimetidine treatment (day 9 of the s...

journal_title：British journal of clinical pharmacology

authors： Reimann IW,Klotz U,Siems B,Frölich J

更新日期：1981-12-01 00:00:00

abstract：:Oxycodone chloride (0.07 mg kg-1) was given by intravenous bolus to nine young adult surgical patients on the first postoperative day. Plasma was sampled for up to 12 h. Mean values of t1/2z, CL and Vss were 222 min, 0.78 l min-1 and 2.60 l kg-1, respectively. The concentrations of the metabolite noroxycodone was also...

journal_title：British journal of clinical pharmacology

authors： Pöyhiä R,Olkkola KT,Seppälä T,Kalso E

更新日期：1991-10-01 00:00:00

abstract：:The deployment of artesunate for severe malaria and the artemisinin combination therapies (ACTs) for uncomplicated malaria has been a major advance in antimalarial therapeutics. These drugs have reduced treated mortality, accelerated recovery and reduced treatment failure rates and transmission from the treated infect...

journal_title：British journal of clinical pharmacology

authors： Hanboonkunupakarn B,White NJ

更新日期：2020-07-12 00:00:00

abstract：AIMS:Rifampicin profoundly reduces lopinavir concentrations. Doubled doses of lopinavir/ritonavir compensate for the effect of rifampicin in adults, but fail to provide adequate lopinavir concentrations in young children on rifampicin-based antituberculosis therapy. The objective of this study was to develop a populati...

journal_title：British journal of clinical pharmacology

authors： Zhang C,Denti P,Decloedt EH,Ren Y,Karlsson MO,McIlleron H

更新日期：2013-11-01 00:00:00

abstract：OBJECTIVE:The aim of the present study was to determine the risk of myopathy in older people receiving statin therapy. METHODS:Eligible studies were identified searching Ovid Medline, EMBASE, Scopus, CINAHL, Cochrane and PSYCHINFO databases (1987 to July 2014). The selection criteria comprised randomized controlled st...

journal_title：British journal of clinical pharmacology

authors： Iwere RB,Hewitt J

更新日期：2015-09-01 00:00:00

abstract：:1. The interaction between cyclosporin (CyA) and erythromycin was studied in renal transplant patients following oral and intravenous administration of CyA. 2. Blood and plasma CyA concentrations and blood concentrations of metabolite 17 were measured by h.p.l.c. 3. Erythromycin produced almost a two-fold increase in ...

journal_title：British journal of clinical pharmacology

authors： Gupta SK,Bakran A,Johnson RW,Rowland M

更新日期：1989-04-01 00:00:00

abstract：:1. Alfuzosin is a post-synaptic alpha-adrenoceptor antagonist with antihypertensive and peripheral vasodilator properties. 2. We measured the effect of alfuzosin, 5 mg, on sympathetically-mediated venoconstriction by changes in the venous reflex response (VRR) in a randomised, double-blind, placebo-controlled, crossov...

journal_title：British journal of clinical pharmacology

authors： Sinclair AJ,Davies IB,Warrington SJ

更新日期：1989-01-01 00:00:00

abstract：:1 The effect of RX 72601, neostigmine plus atropine, or saline on neuromuscular blockade with (+)-tubocurarine was studied in a double blind trial in four healthy male volunteers. 2 The methods used to assess neuromuscular function were voluntary grip strength and indirectly evoked muscle twitches. The muscarinic acti...

journal_title：British journal of clinical pharmacology

authors： Dettmar PW,Metcalf G,Smith MH,Gillett GB,Hedges A,Richens A

更新日期：1974-06-01 00:00:00

abstract：AIM:To examine comprehensively the relationship between exposure to four classes of psychotropic drugs including antipsychotics, antidepressants, benzodiazepines (BZDs) and Z-drugs, and motor vehicle accidents (MVAs). METHOD:The authors conducted a matched case-control study of 5183 subjects with MVAs and 31 093 match...

journal_title：British journal of clinical pharmacology

authors： Chang CM,Wu EC,Chen CY,Wu KY,Liang HY,Chau YL,Wu CS,Lin KM,Tsai HJ

更新日期：2013-04-01 00:00:00

abstract：:1 Healthy volunteers received single doses of temazepam 30 mg in conventional gelatin capsules, suppositories or in solution. They experienced marked sedation and sleepiness. The onset of sleepiness was prompt after the administration of the solution; this latter showed the fastest absorption and gave the highest peak...

journal_title：British journal of clinical pharmacology

authors： Fuccella LM

更新日期：1979-01-01 00:00:00

abstract：AIMS:The aim of this study was to perform an up-to-date meta-analysis on the risk of cardiac malformations associated with gestational exposure to paroxetine, taking into account indication, study design and reference category. METHOD:A systematic review of studies published between 1966 and November 2015 was conducte...

journal_title：British journal of clinical pharmacology

authors： Bérard A,Iessa N,Chaabane S,Muanda FT,Boukhris T,Zhao JP

更新日期：2016-04-01 00:00:00

abstract：AIMS:The effects of biologics on reproduction/lactation are mostly unknown although many patients that receive biologics are women of reproductive age. The first objective of this study was to investigate the publicly available data on pregnancy/lactation before and after marketing authorization in Europe of biologics ...

journal_title：British journal of clinical pharmacology

authors： Ghalandari N,Dolhain RJEM,Hazes JMW,Siezen CLE,van der Laan JW,Crijns HJMJ,van Puijenbroek EP,van der Woude CJ

更新日期：2020-03-01 00:00:00

abstract：AIMS:Inherited polymorphisms of codons 16, 27, and 164 of the beta2-adrenergic receptor (B2AR) gene may result in significantly changed functions of this receptor. The aim of the present study was to investigate the frequencies of the main mutations of the B2AR gene in Turks. METHODS:A group of 104 unrelated Turkish s...

journal_title：British journal of clinical pharmacology

authors： Aynacioglu AS,Cascorbi I,Güngör K,Ozkur M,Bekir N,Roots I,Brockmöller J

更新日期：1999-11-01 00:00:00

abstract：:WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • The population pharmacokinetics and limited sampling strategies for ciclosporin monitoring have been extensively studied in renal and liver transplant recipients. Little is known about the pharmacokinetics of ciclosporin in patients undergoing haematopoietic allogeneic stem c...

journal_title：British journal of clinical pharmacology

authors： Wilhelm AJ,de Graaf P,Veldkamp AI,Janssen JJ,Huijgens PC,Swart EL

更新日期：2012-04-01 00:00:00

abstract：:The absorption of the antiemetic metopimazine (MPZ) given as a single dose of (a) 40 mg microenema, (b) 40 mg orally and (c) 10 mg as a 60 min i.v. continuous infusion was investigated in six healthy volunteers. Blood samples were drawn and the serum concentrations of MPZ and its acid metabolite were measured. The bio...

journal_title：British journal of clinical pharmacology

authors： Herrstedt J,Jørgensen M,Angelo HR,Rassing MR,Møller-Sonnergaard J,Dombernowsky P

更新日期：1996-06-01 00:00:00