Drug disposition and modelling before and after gastric bypass: immediate and controlled-release metoprolol formulations.

abstract：:1. In 48 patients with chronic asthma who had been receiving treatment with beclomethasone dipropionate aerosol (BDA) at a daily dose of 400 microgram for several years, observations were made on the effect of increasing the dose to 800 microgram daily for 6 months. 2. There was subjective improvement in 37 of the 48 ...

journal_title：British journal of clinical pharmacology

authors： Chatterjee SS

更新日期：1977-01-01 00:00:00

abstract：:Mirabegron is used for the treatment of symptoms associated with overactive bladder syndrome. It selectively stimulates the β3 -adrenoreceptor, which relaxes the detrusor muscle. This improves urine storage by distension of the bladder body. ...

journal_title：British journal of clinical pharmacology

authors： Goulooze SC,Cohen AF,Rissmann R

更新日期：2015-10-01 00:00:00

abstract：UNLABELLED:WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT?: * Two chemically diverse CCK1 receptor antagonists have been shown clinically to inhibit CCK-evoked contraction of human gallbladder [2, 3]. These studies have not examined the relationship between plasma concentration and effect, the latter usually considered to be...

journal_title：British journal of clinical pharmacology

authors： Gerskowitch VP,Hodge J,Hull RA,Shankley NP,Kalindjian SB,McEwen J,Black JW

更新日期：2007-05-01 00:00:00

abstract：:Ethanol aggravates benzodiazepine-induced central nervous depression by pharmacokinetic and/or pharmacodynamic interactions and Ro 15-1788 reverses promptly the hypnotic effects of benzodiazepines. We therefore studied the acute effects of Ro 15-1788 on the ethanol-induced sedation in six healthy male subjects. Subseq...

journal_title：British journal of clinical pharmacology

authors： Klotz U,Ziegler G,Rosenkranz B,Mikus G

更新日期：1986-11-01 00:00:00

abstract：:Propranolol induced changes in blood plasma chemistry were followed in thirty hypertensive patients (WHO I-II) who were seen each week during 14-15 weeks. The initial 4 weeks were a drug free period and the next 2 weeks were a drug adjustment period. After that the patients were on an unchanged propranolol dose for 8 ...

journal_title：British journal of clinical pharmacology

authors： Andreasen F,Jakobsen P,Kornerup HJ,Pedersen EB,Pedersen OL,Weeke J

更新日期：1984-03-01 00:00:00

abstract：:Doxepin and N-desmethyldoxepin concentrations in plasma and breast milk from a lactating mother and in plasma from her infant were measured during an 8 week period using high performance liquid chromatography. Plasma concentrations ranged from 35-68 microgram l-1 for doxepin and 65-131 microgram l-1 for N-desmethyldox...

journal_title：British journal of clinical pharmacology

authors： Kemp J,Ilett KF,Booth J,Hackett LP

更新日期：1985-11-01 00:00:00

abstract：AIM:Pharmacokinetics of small molecule kinase inhibitors (KIs) used in cancer treatment may alter with increasing age, but results are conflicting. This study aims to compare exposure to KIs between older and younger patients (≥70 and <70 years) in clinical practice. METHODS:KI plasma concentrations of routinely treat...

journal_title：British journal of clinical pharmacology

authors： Crombag MBS,van Doremalen JGC,Janssen JM,Rosing H,Schellens JHM,Beijnen JH,Steeghs N,Huitema ADR

更新日期：2018-12-01 00:00:00

abstract：AIMS:To compare gastric acid suppression by netazepide, a gastrin/CCK2 receptor antagonist, with that by a proton pump inhibitor (PPI), and to determine if netazepide can prevent the trophic effects of PPI-induced hypergastrinaemia. METHODS:Thirty healthy subjects completed a double-blind, randomized, parallel group t...

journal_title：British journal of clinical pharmacology

authors： Boyce M,Dowen S,Turnbull G,van den Berg F,Zhao CM,Chen D,Black J

更新日期：2015-05-01 00:00:00

abstract：:1 A system is described for screening new chemical entities in normal human subjects, which is designed to search for novel drug actions at an early stage of drug development. 2 In single (subject) blind experiments, doses are increased incrementally from one subject to next, with immediate feed-back of results from e...

journal_title：British journal of clinical pharmacology

authors： Sullivan TJ,Croft AR,Hanka R,Roberts SJ

更新日期：1980-04-01 00:00:00

abstract：AIMS:The aim was to assess the impact of a campaign for general practitioners (GPs) to reduce clinically-important drug-drug interactions (DDIs) in poly-treated elderly patients. METHODS:We compiled a list of 53 DDIs and analyzed reimbursed prescriptions dispensed to poly-treated (≥four drugs) elderly (>65 years) pati...

journal_title：British journal of clinical pharmacology

authors： Raschi E,Piccinni C,Signoretta V,Lionello L,Bonezzi S,Delfino M,Di Candia L,Di Castri L,Pieraccini F,Carati D,Poluzzi E,De Ponti F,Emilia-Romagna elderly poly-treated patients research group.

更新日期：2015-12-01 00:00:00

abstract：:1. The effect of magnesium hydroxide on the absorption and efficacy of two glibenclamide preparations was investigated in healthy volunteers in two separate studies, using a randomized cross-over design with two phases. 2. A single dose of magnesium hydroxide (850 mg) or water only (150 ml) was given immediately after...

journal_title：British journal of clinical pharmacology

authors： Neuvonen PJ,Kivistö KT

更新日期：1991-08-01 00:00:00

abstract：:Self-poisoning by ingestion or inhalation is common, and it is important to study its various epidemiological manifestations with clear definitions. Data on fatal self-poisonings are recorded nationally within the UK and are codified according to the International Classification of Diseases (ICD) revision relevant at ...

journal_title：British journal of clinical pharmacology

authors： Camidge DR,Wood RJ,Bateman DN

更新日期：2003-12-01 00:00:00

abstract：:The oxidative O-de-ethylation and aromatic 2-hydroxylation of phenacetin have been investigated in panels of extensive (EM, n = 13) and poor (PM, n = 10) metabolizers of debrisoquine. The EM group excreted in the urine significantly more paracetamol (EM: 40.8 +/- 14.9% dose/0-8 h; PM: 29.2 +/- 8.7% dose/0-8 h, 2P less...

journal_title：British journal of clinical pharmacology

authors： Devonshire HW,Kong I,Cooper M,Sloan TP,Idle JR,Smith RL

更新日期：1983-08-01 00:00:00

abstract：:1. The effects of a single oral dose of enalapril 10 mg on serum ACE activity and blood pressure in relation to the ACE genotype were studied in 27 healthy men, n = 9 each of genotype DD, ID and II, in a parallel group study design. 2. Before treatment serum ACE activity differed significantly between the genotypes, w...

journal_title：British journal of clinical pharmacology

authors： Todd GP,Chadwick IG,Higgins KS,Yeo WW,Jackson PR,Ramsay LE

更新日期：1995-02-01 00:00:00

abstract：:A double-blind, crossover study was carried out on the acceptability of three doses of brotizolam (0.125, 0.25 and 0.5 mg) in chronic insomniacs aged between 21 and 75 years (33 men: 42 women). Patients reported a shorter time to fall asleep and less nocturnal awakenings. Improvement in sleep was evident during the fi...

journal_title：British journal of clinical pharmacology

authors： Fritz-Osner A,Arias-Ortiz JL,Dorantes JF,Rabago-Sánchez J,Rodríguez-Tenorio A,Sánchez-Martinez J

更新日期：1983-01-01 00:00:00

abstract：:1 Seventeen men, aged 45-57 yr, with essential hypertension showed obvious and, in the standing position, dose-related reductions in blood pressure during treatment with oral labetalol with weekly dose increments. 2 Pulse rate changes were not related to dose but reduced compared with pre-treatment values. 3 No postur...

journal_title：British journal of clinical pharmacology

authors： Andersson O,Berglund G,Hansson L

更新日期：1976-08-01 00:00:00

abstract：:Enalapril is the result of a targeted research programme to develop a non-mercapto converting enzyme inhibitor with a long duration of action and an improved safety profile for use in the therapy of hypertension and congestive heart failure. Over 3500 patients world-wide have received enalapril or enalaprilat. Long-te...

journal_title：British journal of clinical pharmacology

authors： McFate Smith W,Davies RO,Gabriel MA,Kramsch DM,Moncloa F,Rush JE,Walker JF

更新日期：1984-01-01 00:00:00

abstract：AIMS:In man a neurokinin-1 (NK1) receptor antagonist has previously been shown to be ineffective in the prevention of motion-induced nausea. The antiemetic efficacy of NK1 receptor antagonists against chemotherapy-induced emesis is, however, enhanced when combined with a 5-HT3 receptor antagonist. Hence the efficacy of...

journal_title：British journal of clinical pharmacology

authors： Reid K,Palmer JL,Wright RJ,Clemes SA,Troakes C,Somal HS,House F,Stott JR

更新日期：2000-07-01 00:00:00

abstract：:The oral delivery of peptides and proteins has been hampered by an array of obstacles. However, several promising novel oral delivery systems have been developed. This paper reviews the most advanced oral formulation technologies, and highlights key lessons and implications from studies undertaken to date with these o...

journal_title：British journal of clinical pharmacology

authors： Karsdal MA,Riis BJ,Mehta N,Stern W,Arbit E,Christiansen C,Henriksen K

更新日期：2015-05-01 00:00:00

abstract：AIM:Omalizumab, a humanized IgG monoclonal antibody that binds to human immunoglobulin E (IgE), interrupts the allergic cascade in asthmatic patients. The aim was to compare simultaneously drug exposure and IgE biomarker responses in Japanese and White patient populations. METHODS:An instantaneous equilibrium drug-lig...

journal_title：British journal of clinical pharmacology

authors： Hayashi N,Tsukamoto Y,Sallas WM,Lowe PJ

更新日期：2007-05-01 00:00:00

abstract：:1 Aspirin is partly hydrolyzed to salicylic acid during absorption. Absorbed aspirin is rapidly hydrolyzed systemically. Salicylic acid elimination kinetics are dependent on drug concentration due to the limited capacity of two major biotransformation pathways: formation of salicyluric acid and of salicylphenolic gluc...

journal_title：British journal of clinical pharmacology

authors： Levy G

更新日期：1980-10-01 00:00:00

abstract：:1 The effects of propranolol and atenolol given in random order in a cross-over study to fifteen patients with essential hypertension have been studied. 2 Both drugs were effective in lowering blood pressure and side effects were not markedly different. 3 There was no change in exchangeable sodium or potassium or in t...

journal_title：British journal of clinical pharmacology

authors： Wilkinson R,Stevens IM,Pickering M,Robson V,Hawkins T,Kerr DN,Harry JD

更新日期：1980-07-01 00:00:00

abstract：:1. A rapid intravenous bolus injection of 4.0 g Magnapen (which contains 2.0 g of ampicillin and 2.0 g of flucloxacillin) was to seven patients undergoing total hip replacement immediatly before induction of general anesthesia. Postoperatively the patients patients received 2.0 g Magnapen by intramuscular injection ev...

journal_title：British journal of clinical pharmacology

authors： Parsons RL,Beavis JP,Laurence M,David JA,Paddock GM,Trounce JR

更新日期：1978-08-01 00:00:00

abstract：AIMS:The study was designed to evaluate the relative bioavailability of diclofenac in plasma, subcutaneous adipose and skeletal muscle tissue after repeated topical administration using MIKA Diclofenac Spray Gel (4%), a novel formulation, and after oral dosing using VOLTAREN 50 mg enteric coated tablets. METHODS:Diclo...

journal_title：British journal of clinical pharmacology

authors： Brunner M,Dehghanyar P,Seigfried B,Martin W,Menke G,Müller M

更新日期：2005-11-01 00:00:00

abstract：AIMS:This study assessed the effects of the CYP3A inhibitors lopinavir/ritonavir (LPV/r) on the steady-state pharmacokinetics (PK) of aplaviroc (APL), a CYP3A4 substrate, in healthy subjects. METHODS:In Part 1, APL PK was determined in eight subjects who received a single oral 50-mg APL test dose with/without a single...

journal_title：British journal of clinical pharmacology

authors： Adkison KK,Shachoy-Clark A,Fang L,Lou Y,Otto VR,Berrey MM,Piscitelli SC

更新日期：2006-09-01 00:00:00

abstract：:A double-blind controlled study comparing the effects of intravenous Diazemuls (0.15 mg kg-1) with midazolam (0.07 mg kg-1) in patients with normal liver function and with cirrhosis and portal hypertension is described. The clinical effect of the two drugs was assessed by serial tests of psychomotor function before an...

journal_title：British journal of clinical pharmacology

authors： Hamdy NA,Kennedy HJ,Nicholl J,Triger DR

更新日期：1986-12-01 00:00:00

abstract：WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT:* Only one other study (Becker et al.) has reported on the influence of smoking cessation and smoking resumption on inhaled insulin pharmacokinetics and glucodynamics, concluding that the rapid changes associated with smoking resumption carry the risk for hypoglycaemia and thus ...

journal_title：British journal of clinical pharmacology

authors： Pan AX,de la Peña A,Yeo KP,Chan C,Loh MT,Wise SD,Silverman BL,Muchmore DB

更新日期：2008-04-01 00:00:00

abstract：:1 Cardiovascular responses to intravenous prizidilol hydrochloride (SK&F 92657) 0.86 mg/kg were studied in eight supine resting healthy volunteers. Five subjects were slow and the remaining three were fast acetylators of sulphamethazine. Compared with pre-infusion values, mean resting systolic and diastolic blood pres...

journal_title：British journal of clinical pharmacology

authors： Edmonstone WM,Manghani KK,Bell AJ,McLeod M,Milton-Thompson GJ,Burland WL

更新日期：1981-10-01 00:00:00

abstract：:The acute peripheral vascular and diuretic effects of intravenous frusemide 10 mg and 20 mg were compared with those of bumetanide 250 micrograms and 500 micrograms in a group of 10 salt depleted volunteers. Significant reductions in forearm blood flow (FBF) were observed after frusemide 10 mg (-0.77 ml 100 ml-1 min-1...

journal_title：British journal of clinical pharmacology

authors： Johnston GD,Nicholls DP,Kondowe GB,Finch MB

更新日期：1986-04-01 00:00:00

abstract：:In a randomised crossover study in volunteers plasma midazolam levels were estimated for 24 h following 15 mg by mouth, either preceded by no medication or following 24 h therapy with ranitidine. Administration of the H2-receptor blocker significantly increased bioavailability of the benzodiazepine and resulted in hig...

journal_title：British journal of clinical pharmacology

authors： Elwood RJ,Hildebrand PJ,Dundee JW,Collier PS

更新日期：1983-06-01 00:00:00