Reductions in portal pressure by selective beta 2-adrenoceptor blockade in patients with cirrhosis and portal hypertension.

abstract：:Mirabegron is used for the treatment of symptoms associated with overactive bladder syndrome. It selectively stimulates the β3 -adrenoreceptor, which relaxes the detrusor muscle. This improves urine storage by distension of the bladder body. ...

journal_title：British journal of clinical pharmacology

authors： Goulooze SC,Cohen AF,Rissmann R

更新日期：2015-10-01 00:00:00

abstract：AIM:The aim was to investigate the population pharmacokinetics of levamisole in children with steroid-sensitive nephrotic syndrome. METHODS:Non-linear mixed effects modelling was performed on samples collected during a randomized controlled trial. Samples were collected from children who were receiving 2.5 mg kg(-1) l...

journal_title：British journal of clinical pharmacology

authors： Kreeftmeijer-Vegter AR,Dorlo TP,Gruppen MP,de Boer A,de Vries PJ

更新日期：2015-08-01 00:00:00

abstract：:Simultaneous cerebrospinal fluid (CSF), total and free plasma valproic acid (VPA) concentrations were measured in 17 patients receiving two weight-adjusted VPA doses as seizure prophylaxis prior to diagnostic myelography or cisternography. Free drug concentrations were similar when measured by equilibrium dialysis (ED...

journal_title：British journal of clinical pharmacology

authors： Rapeport WG,Mendelow AD,French G,MacPherson P,Teasdale E,Agnew E,Thompson GG,Brodie MJ

更新日期：1983-10-01 00:00:00

abstract：AIMS:Medication-related osteonecrosis of the jaw (MRONJ) is an uncommon but potentially debilitating condition, characterised by nonhealing jawbone, with or without mucosal exposure, in the presence of certain drugs. Those already strongly associated with MRONJ include antiresorptives denosumab and bisphosphonates; how...

journal_title：British journal of clinical pharmacology

authors： Teoh L,Moses G,Nguyen AP,McCullough MJ

更新日期：2020-11-27 00:00:00

abstract：:A review of all medication incidents reported to the National Reporting and Learning System (NRLS) in England in Wales between 1 January 2005 and 31 December 2010 was undertaken. The 526,186 medication incident reports represented 9.68% of all patient safety incidents. Medication incidents from acute general hospitals...

journal_title：British journal of clinical pharmacology

authors： Cousins DH,Gerrett D,Warner B

更新日期：2012-10-01 00:00:00

abstract：:1 Two studies were carried out on acutely psychotic patients receiving chlorpromazine (100 mg) 8-hourly. 2 In the pilot study on five patients, plasma chlorpromazine concentrations fell over the course of 3 weeks of treatment and parallel changes were noted in the plasma half-life of antipyrine, salivation rate and ha...

journal_title：British journal of clinical pharmacology

authors： Loga S,Curry S,Lader M

更新日期：1975-06-01 00:00:00

abstract：AIMS:In experimental studies, morphine pharmacokinetics is different in the brain compared with other tissues due to the properties of the blood-brain barrier, including action of efflux pumps. It was hypothesized in this clinical study that active efflux of morphine occurs also in human brain, and that brain injury wo...

journal_title：British journal of clinical pharmacology

authors： Ederoth P,Tunblad K,Bouw R,Lundberg CJ,Ungerstedt U,Nordström CH,Hammarlund-Udenaes M

更新日期：2004-04-01 00:00:00

abstract：AIM:To evaluate a context-learning pharmacotherapy programme for approximately 750 2nd, 3rd and 4th year preclinical medical students with respect to mastering cognitive pharmacotherapeutic skills, i.e. choosing a (drug) treatment and determining patient information. METHODS:The context-learning pharmacotherapy progra...

journal_title：British journal of clinical pharmacology

authors： Vollebregt JA,van Oldenrijk J,Kox D,van Galen SR,Sturm B,Metz JC,Richir MC,de Haan M,Hugtenburg JG,de Vries TP

更新日期：2006-12-01 00:00:00

abstract：AIMS:To establish the dose-response for pharmacodynamics (bronchodilatation), safety and pharmacokinetics for a nebulized formulation of the long acting muscarinic antagonist glycopyrrolate (EP-101) with a high efficiency nebulizer in patients with chronic obstructive pulmonary disease (COPD). METHODS:Patients with mo...

journal_title：British journal of clinical pharmacology

authors： Leaker BR,Barnes PJ,Jones CR,Tutuncu A,Singh D

更新日期：2015-03-01 00:00:00

abstract：:1 A treatment group comprising 635 hypertensive men (casual SBP greater than 175 or DBP greater than 115 twice) was compared with a reference group (n = 391 men; casual SBP greater than 175 or DBP greater than 115 only at screening). All men belonged to the same population sample of 7,455 men aged 47-54 yr. 2 The two ...

journal_title：British journal of clinical pharmacology

authors： Wilhelmsen L,Berglund G,Sannerstedt R,Hansson L,Andersson O,Sievertsson R,Wikstrand J

更新日期：1979-01-01 00:00:00

abstract：:1 A method for the assay of debrisoquine 4-hydroxylase activity in vitro by microsomal fractions of human liver is described. The assay utilises gas chromatography-mass spectrometry with d9-4-hydroxydebrisoquine as internal standard. 2 The limit of detection of 4-hydroxydebrisoquine was 2 ng ml -1 and the coefficient ...

journal_title：British journal of clinical pharmacology

authors： Kahn GC,Boobis AR,Murray S,Brodie MJ,Davies DS

更新日期：1982-05-01 00:00:00

abstract：AIMS:Adrenomedullin (ADM) is an important regulator of endothelial barrier function and vascular tone, and may represent a novel treatment target in sepsis. The non-neutralizing ADM antibody adrecizumab has shown promising results in preclinical sepsis models. In the present study, we investigated the safety, tolerabil...

journal_title：British journal of clinical pharmacology

authors： Geven C,van Lier D,Blet A,Peelen R,Ten Elzen B,Mebazaa A,Kox M,Pickkers P

更新日期：2018-09-01 00:00:00

abstract：:Caffeine (5 mg kg-1) was administered orally to two healthy, non-smoking subjects on three separate occasions--before, and during therapy with the xanthine oxidase inhibitor allopurinol at doses of either 300 or 600 mg daily. Plasma and urinary levels of methylxanthines, endogenous oxypurines and allopurinol and its m...

journal_title：British journal of clinical pharmacology

authors： Grant DM,Tang BK,Campbell ME,Kalow W

更新日期：1986-04-01 00:00:00

abstract：:1 The effect of an intravenous bolus of labetalol (0.6-1.6 mg/kg body weight) on central and peripheral haemodynamics was studied in nine subjects with essential hypertension and in eleven subjects with chronic renal disease and hypertension. 2 The BP reduction amounting to 20/13 mmHg was entirely due to the lowering ...

journal_title：British journal of clinical pharmacology

authors： Bahlmann J,Brod J,Hubrich W,Cachovan M,Pretschner P

更新日期：1979-04-01 00:00:00

abstract：:Theophylline clearance was studied in normal healthy volunteers before and after chronic oral dosing. Oral theophylline clearance showed a significant decrease (P less than 0.001) from 59.3 +/- 6.48 ml/min (mean +/- s.e. mean, n = 10) to 48.0 +/- 6.4 ml/min. Steady-state intravenous clearance decreased by 26 +/- 2% fr...

journal_title：British journal of clinical pharmacology

authors： Efthimiou H,Morgan DJ,Ioannides-Demos L,Raymond K,McLean AJ

更新日期：1984-05-01 00:00:00

abstract：WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT:• Terutroban is a selective TP receptor antagonist, i.e. a specific antagonist of the thromboxane A(2) and prostaglandin endoperoxide receptors, shown to improve endothelial function after a single administration in patients with coronary artery disease. WHAT THIS STUDY ADDS:• ...

journal_title：British journal of clinical pharmacology

authors： Lesault PF,Boyer L,Pelle G,Covali-Noroc A,Rideau D,Akakpo S,Teiger E,Dubois-Randé JL,Adnot S

更新日期：2011-06-01 00:00:00

abstract：AIMS:Three 'weak' opioid analgesics in association with paracetamol are marketed in France as step 2 analgesics: dextropropoxyphene, tramadol and codeine. These combinations are involved in several adverse drug reactions (ADRs), but no data are available about their comparative reporting rate. The aim was to compare th...

journal_title：British journal of clinical pharmacology

authors： Tavassoli N,Lapeyre-Mestre M,Sommet A,Montastruc JL,French Association of Regional Pharmacovigilance Centres.

更新日期：2009-09-01 00:00:00

abstract：:1. Six healthy volunteers received single doses of either nomifensine 100 mg, nomifensine 50 mg or placebo at weekly intervals in a randomized double-blind crossover study. 2. Subjects were subjected to a simulated test of car driving at night. 3. Testing lasted about 1.5 h and consisted of measuring responses to ligh...

journal_title：British journal of clinical pharmacology

authors： Hindmarch I

更新日期：1977-01-01 00:00:00

abstract：:The effects of bopindolol, a new beta-adrenoceptor blocker, on the exercise tolerance of 12 in-patients, mean age 57 (5 years), with stable angina pectoris and documented coronary artery disease were evaluated. All patients received on 4 different days a single oral dose of bopindolol 0.5 mg, bopindolol 1.0 mg, bopind...

journal_title：British journal of clinical pharmacology

authors： Carboni GP,Scardovi AB,D'Ermo M,Prati PL

更新日期：1991-12-01 00:00:00

abstract：:A 12-week double-blind study was performed to compare the safety and efficacy of doxazosin, prazosin and placebo in 172 patients with essential hypertension. According to response, patients received doxazosin 1-16 mg once daily, prazosin 0.5-10 mg twice daily, or placebo. Mean final daily doses were doxazosin 11.3 mg ...

journal_title：British journal of clinical pharmacology

authors： Torvik D,Madsbu HP

更新日期：1986-01-01 00:00:00

abstract：:The effect of salbutamol on bronchoconstriction induced by inhaled sodium metabisulphite has been studied in 12 atopic subjects. Salbutamol (200 micrograms, 3.5 x 10(-7) M) and matched placebo were administered by identical metered dose inhaler 15 min before a dose-response to sodium metabisulphite (1.25-100 mg ml-1) ...

journal_title：British journal of clinical pharmacology

authors： Iredale MJ,Dixon CM,Ind PW

更新日期：1991-11-01 00:00:00

abstract：:1. Mono(ADP-ribosyl)transferase activity has been identified on the external surface of human polymorphonuclear neutrophil leucocytes (PMNs). The enzyme is released from the plasma membrane by phosphoinositide-specific phospholipase C, suggesting a glycosylphosphatidylinositol (GPI) linkage of the enzyme to the plasma...

journal_title：British journal of clinical pharmacology

authors： Allport JR,Donnelly LE,Kefalas P,Lo G,Nunn A,Yadollahi-Farsani M,Rendell NB,Murray S,Taylor GW,MacDermot J

更新日期：1996-07-01 00:00:00

abstract：:1 To assess the potential hazards of nitrazepam therapy of insomnia in the elderly, adverse reactions to nitrazepam were studied in 2111 hospitalized medical patients who received the drug. 2 Manifestations of unwanted central nervous system (CNS) depression (such as drowsiness or 'hangover') were reported in 49 nitra...

journal_title：British journal of clinical pharmacology

authors： Greenblatt DJ,Allen MD

更新日期：1978-05-01 00:00:00

abstract：:Imagine a medicine that is expected to have very limited effects based upon knowledge of its pharmacology and (patho)physiology and that is studied in the wrong population, with low-quality studies that use a surrogate end-point that relates to the clinical end-point in a partial manner at most. Such a medicine would ...

journal_title：British journal of clinical pharmacology

authors： Heuberger JA,Cohen Tervaert JM,Schepers FM,Vliegenthart AD,Rotmans JI,Daniels JM,Burggraaf J,Cohen AF

更新日期：2013-06-01 00:00:00

abstract：AIM:We aimed to establish a method to assess systemic and pre-systemic cytochrome P450 (CYP) 3A activity using ineffective microgram doses of midazolam. METHODS:In an open, one sequence, crossover study, 16 healthy participants received intravenous and oral midazolam at microgram (0.001 mg intravenous and 0.003 mg ora...

journal_title：British journal of clinical pharmacology

authors： Hohmann N,Kocheise F,Carls A,Burhenne J,Haefeli WE,Mikus G

更新日期：2015-02-01 00:00:00

abstract：AIMS:To investigate the spectrum of toxicity of moclobemide overdose, the occurrence of serotonin toxicity, and to estimate toxicokinetic parameters. METHODS:All moclobemide overdoses presenting over a 10-year period to the Hunter Area Toxicology Service were reviewed. Clinical features, complications, length of stay ...

journal_title：British journal of clinical pharmacology

authors： Isbister GK,Hackett LP,Dawson AH,Whyte IM,Smith AJ

更新日期：2003-10-01 00:00:00

abstract：WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT:* The variability in drug metabolism has been recognized as an important factor in the occurrence of adverse effects or lack of therapeutic efficacy. * The metabolism of the third-generation beta(1)-receptor antagonist nebivolol has been shown to be highly dependent on cytochrom...

journal_title：British journal of clinical pharmacology

authors： Lefebvre J,Poirier L,Poirier P,Turgeon J,Lacourciere Y

更新日期：2007-05-01 00:00:00

abstract：:Doxepin and N-desmethyldoxepin concentrations in plasma and breast milk from a lactating mother and in plasma from her infant were measured during an 8 week period using high performance liquid chromatography. Plasma concentrations ranged from 35-68 microgram l-1 for doxepin and 65-131 microgram l-1 for N-desmethyldox...

journal_title：British journal of clinical pharmacology

authors： Kemp J,Ilett KF,Booth J,Hackett LP

更新日期：1985-11-01 00:00:00

abstract：:1. The effect of icatibant (D-Arg-[Hyp3, Thi5, D-Tic7, Oic8] bradykinin) a potent B2-kinin receptor antagonist, was studied on bradykinin-induced vasodilation in the human forearm. 2. Eight healthy normotensive men were studied in a rising dose random-placebo controlled study. Placebo and icatibant (20, 50 and 100 mic...

journal_title：British journal of clinical pharmacology

authors： Cockcroft JR,Chowienczyk PJ,Brett SE,Bender N,Ritter JM

更新日期：1994-10-01 00:00:00

abstract：:The effects of a single dose of sulindac 200 mg and placebo on the capsaicin-induced cough reflex were studied in a two-phase double-blind crossover study in 18 healthy subjects. Sulindac increased the threshold for capsaicin cough response significantly, but did not alter D5, peak response, or the total cough respons...

journal_title：British journal of clinical pharmacology

authors： Foster G,Yeo WW,Ramsay LE

更新日期：1991-02-01 00:00:00