5-hydroxytryptamine and depression: a model for the interaction of normal variance with pathology.

abstract：AIM:To characterize the romiplostim dose-response in subjects with low or intermediate-1 risk myelodysplastic syndromes (MDS) receiving subcutaneous romiplostim. METHODS:Data from 44 MDS subjects receiving subcutaneous romiplostim (dose range 300-1500 μg week(-1) ) were used to develop a pharmacodynamic model consisti...

journal_title：British journal of clinical pharmacology

authors： Perez Ruixo JJ,Doshi S,Wang YM,Mould DR

更新日期：2013-06-01 00:00:00

abstract：AIMS:To evaluate putative associations between drugs and dilated cardiomyopathy. METHODS:We used the case/noncase method in the French PharmacoVigilance Database (FPVD). Cases were all the observations with dilated cardiomyopathy registered into the FPVD between 1 January 1990 and 30 June 2007. Noncases were all other...

journal_title：British journal of clinical pharmacology

authors： Montastruc G,Favreliere S,Sommet A,Pathak A,Lapeyre-Mestre M,Perault-Pochat MC,Montastruc JL,French Association of Regional PharmacoVigilance Centres.

更新日期：2010-03-01 00:00:00

abstract：:1. Ototoxicity is a common and troublesome side-effect of high-dose aspirin treatment but there has been little previous study of the relationships between the degree of ototoxicity and the plasma concentrations of salicylate. 2. In order to investigate the relationships between aspirin dose, total and unbound plasma ...

journal_title：British journal of clinical pharmacology

authors： Day RO,Graham GG,Bieri D,Brown M,Cairns D,Harris G,Hounsell J,Platt-Hepworth S,Reeve R,Sambrook PN

更新日期：1989-12-01 00:00:00

abstract：AIMS:In the absence of a commonly agreed dosing protocol based on pharmacokinetic (PK) considerations, the dose and treatment duration for hydroxychloroquine (HCQ) in COVID-19 disease currently vary across national guidelines and clinical study protocols. We have used a model-based approach to explore the relative impa...

journal_title：British journal of clinical pharmacology

authors： Thémans P,Dauby N,Schrooyen L,Lebout F,Delforge M,Nasreddine R,Libois A,Payen MC,Konopnicki D,Wuillaume F,Lescrainier C,Verlinden V,Dogné JM,Hamdani J,Musuamba FT

更新日期：2020-06-19 00:00:00

abstract：:Model-based prediction on clinical doses for cannabinoids therapy is beneficial in the clinical setting, especially for seriously ill patients with both altered pharmacokinetics and pharmacodynamic responses. The objective of this article is to review the currently available PK and/or PD models of Δ9-tetrahydrocannabi...

journal_title：British journal of clinical pharmacology

authors： Liu Z,Martin JH

更新日期：2018-11-01 00:00:00

abstract：:A new anti-spasticity agent, brolitene, has been assessed in patients with spasticity of spinal or cerebral origin. Twenty-seven patients were entered in a double-blind cross-over trial lasting 6 weeks, using a fixed dose of six tablets (1200 mg brolitene) per day. Clinical assessment failed to show any therapeutic ef...

journal_title：British journal of clinical pharmacology

authors： Perkin GD,Aminoff MJ

更新日期：1976-10-01 00:00:00

abstract：AIMS:Previous in vivo studies with sumatriptan, a 5HT1-receptor agonist, have demonstrated vasopressor responses in the pulmonary and systemic arterial circulation. Pulmonary artery wedge pressure (PAWP) also increases after sumatriptan injection, raising the possibility of an additional venoconstrictive action or a ne...

journal_title：British journal of clinical pharmacology

authors： Hood S,Birnie D,Hillis S

更新日期：1997-03-01 00:00:00

abstract：AIMS:Aprepitant and fosaprepitant, commonly used for the prevention of chemotherapy-induced nausea and vomiting, alter cytochrome P450 activity. This systematic review evaluates clinically significant pharmacokinetic drug interactions with aprepitant and fosaprepitant and describes adverse events ascribed to drug inter...

journal_title：British journal of clinical pharmacology

authors： Patel P,Leeder JS,Piquette-Miller M,Dupuis LL

更新日期：2017-10-01 00:00:00

abstract：:1 From an understanding of the biological fate and hypotensive effect of debrisoquine (D) we have assessed the relative importance of true drug resistance, inappropriately low dosage and non-compliance as causes of apparent resistance to treatment with this drug. 2 Among 37 hypertensive patients prescribed D, eleven (...

journal_title：British journal of clinical pharmacology

authors： Silas JH,Tucker GT,Smith AJ

更新日期：1980-04-01 00:00:00

abstract：AIMS:Medication-related osteonecrosis of the jaw (MRONJ) is an uncommon but potentially debilitating condition, characterised by nonhealing jawbone, with or without mucosal exposure, in the presence of certain drugs. Those already strongly associated with MRONJ include antiresorptives denosumab and bisphosphonates; how...

journal_title：British journal of clinical pharmacology

authors： Teoh L,Moses G,Nguyen AP,McCullough MJ

更新日期：2020-11-27 00:00:00

abstract：:1. Hydrochlorothiazide (HCT, 50-75 mg) was administered orally to seven patients with cardiac failure. 2. Plasma levels and urinary concentration of HCT were determined by GLC. 3. The gastrointestinal uptake of the diuretic in three patients was reduced to approximately half that seen in healthy controls. 4. Plasma ha...

journal_title：British journal of clinical pharmacology

authors： Beermann B,Groschinsky-Grind M

更新日期：1979-06-01 00:00:00

abstract：:1. The effects of selective beta-adrenoceptor partial agonist activity on plasma creatine kinase (CK) and skeletal muscle symptoms were studied in normal volunteers. 2. A drug with beta 1-selective partial agonist activity (xamoterol) and one with partial agonist activity acting mainly through beta 2-adrenoceptors (pi...

journal_title：British journal of clinical pharmacology

authors： Tomlinson B,Cruickshank JM,Hayes Y,Renondin JC,Lui JB,Graham BR,Jones A,Lewis AD,Prichard BN

更新日期：1990-11-01 00:00:00

abstract：WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT:• Clinical cases reported that fatal acute liver failure occurred when paracetamol (acetaminophen) was co-administrated with some tyrosine kinase inhibitors (TKIs). The direct inhibition of UDP-glucuronosyltransferase activities has been identified as a mechanism of potentiation...

journal_title：British journal of clinical pharmacology

authors： Liu Y,Ramírez J,Ratain MJ

更新日期：2011-06-01 00:00:00

abstract：:1 Norfenfluramine is thought to be the major active metabolite of fenfluramine in man. Therefore its in vitro effect on lipogenesis in human adipose tissue from twelve patients was investigated. 2 Although inhibition of lipogenesis was demonstrated, the concentrations of norfenfluramine necessary (>1 mM) were much hig...

journal_title：British journal of clinical pharmacology

authors： Ashwell M

更新日期：1974-10-01 00:00:00

abstract：:1. A questionnaire examining the use of, and knowledge about over-the-counter (OTC) drugs was administered verbally to representatives from 200 urban and 200 rural households. Self-medication was common in both groups but there were more drugs present in rural (336 items) than urban homes (231 items) with the differen...

journal_title：British journal of clinical pharmacology

authors： Stein CM,Gora NP,Macheka BM

更新日期：1989-06-01 00:00:00

abstract：:The importance of number of tablets for patient compliance was investigated in 160 patients with mild-moderate essential hypertension treated with a beta-adrenoceptor blocker and a thiazide diuretic. Mean BP at entry 146 +/- 16/92 +/- 8 mm Hg. All patients were given pindolol 10 mg and clopamide 5 mg in one combinatio...

journal_title：British journal of clinical pharmacology

authors： Asplund J,Danielson M,Ohman P

更新日期：1984-05-01 00:00:00

abstract：AIMS:We aimed to examine the frequency of high-dose (defined as mean chlorpromazine mg equivalent doses above 1000) antipsychotic prescriptions in schizophrenia and their clinical correlates in the context of a comparison between studies in 2001 and 2004 within six East Asian countries and territories. METHODS:Prescri...

journal_title：British journal of clinical pharmacology

authors： Sim K,Su HC,Fujii S,Yang SY,Chong MY,Ungvari G,Si T,He YL,Chung EK,Chan YH,Shinfuku N,Kua EH,Tan CH,Sartorius N

更新日期：2009-01-01 00:00:00

abstract：:Theophylline clearance was studied in normal healthy volunteers before and after chronic oral dosing. Oral theophylline clearance showed a significant decrease (P less than 0.001) from 59.3 +/- 6.48 ml/min (mean +/- s.e. mean, n = 10) to 48.0 +/- 6.4 ml/min. Steady-state intravenous clearance decreased by 26 +/- 2% fr...

journal_title：British journal of clinical pharmacology

authors： Efthimiou H,Morgan DJ,Ioannides-Demos L,Raymond K,McLean AJ

更新日期：1984-05-01 00:00:00

abstract：:The psychomotor and cardiovascular effects of minaprine 100 mg, a novel antidepressant, were compared with amitriptyline 25 mg, as a positive control, and placebo in a single dose randomised double-blind crossover trial using an automated psychomotor test battery (APT), postural sway (PS), blood pressure (BP) and puls...

journal_title：British journal of clinical pharmacology

authors： Kinirons MT,Jackson SH,Kalra L,Trevit RT,Swift CG

更新日期：1993-10-01 00:00:00

abstract：AIMS:Antihistamines make up the first line of treatments against motion-sickness. Still, their efficacy and specific mechanism have come into question. The aim of this study was to investigate the effect of meclizine on motion-sensitivity. METHODS:This study was carried out as a triple-blinded randomized trial involvi...

journal_title：British journal of clinical pharmacology

authors： Wibble T,Engström J,Verrecchia L,Pansell T

更新日期：2020-08-01 00:00:00

abstract：:1. Six healthy male human volunteers of mean age 30.8 years (range 23-37) were given single oral doses of xamoterol (20, 50, 100 or 250 mg) and placebo with a 1 week interval between each dose. Xamoterol produced a significant decrease in systolic time intervals (QS2I, LVETI and PEPI) and a significant increase in sys...

journal_title：British journal of clinical pharmacology

authors： James MA,Papouchado M,Channer KS,Jones JV,Marlow HF,Bastain W,Barker NP,Harry JD,Wardleworth AG

更新日期：1990-04-01 00:00:00

abstract：AIMS:In post-marketing setting, spontaneous reporting by physicians is a mode of surveillance of adverse effects associated with drug use. The objective of this study was to quantitatively assess under-reporting of adverse drug reactions (ADRs) in general practice. METHODS:A random sample of 100 general practitioners ...

journal_title：British journal of clinical pharmacology

authors： Moride Y,Haramburu F,Requejo AA,Bégaud B

更新日期：1997-02-01 00:00:00

abstract：:The irritable bowel syndrome (IBS) remains a therapeutic challenge in part because of the limited understanding of the pathophysiology. The placebo response rate varies in randomized controlled trials from 20 to 70%, and can persist for up to at least 1 year. It is contentious whether dietary fibre and bulking agents ...

journal_title：British journal of clinical pharmacology

authors： Talley NJ

更新日期：2003-10-01 00:00:00

abstract：AIMS:The Transdermal Delivery System (TDS) is a liquid formulation that can be applied to the skin via a metered pump spray to deliver drug to the systemic circulation. The aims of this study were to assess the ability of the TDS preparation to deliver testosterone systemically, and to characterize the pharmacokinetic ...

journal_title：British journal of clinical pharmacology

authors： Chik Z,Johnston A,Tucker AT,Chew SL,Michaels L,Alam CA

更新日期：2006-03-01 00:00:00

abstract：AIM:Characterization of the biliary disposition of GSK1325756, using a non-invasive bile sampling technique and spectrometric analyses, to inform the major routes of metabolic elimination and to enable an assessment of victim drug interaction risk. METHOD:Sixteen healthy, elderly subjects underwent non-invasive bile c...

journal_title：British journal of clinical pharmacology

authors： Bloomer JC,Nash M,Webb A,Miller BE,Lazaar AL,Beaumont C,Guiney WJ

更新日期：2013-02-01 00:00:00

abstract：AIMS:To investigate the extent of concomitant use of analgesic and psychotropic medicines among home-dwelling elderly people aged at least 75 years in Finland. METHODS:This was a population-based study in Finland, performed as part of Kuopio 75 + study focusing on the clinical epidemiology of diseases, medication and ...

journal_title：British journal of clinical pharmacology

authors： Hartikainen S,Mäntyselkä P,Louhivuori-Laako K,Enlund H,Sulkava R

更新日期：2005-09-01 00:00:00

abstract：:The steady-state pharmacokinetic interaction between nefazodone and cimetidine was evaluated in a three-period crossover study consisting of three treatments of 1 week duration with a 1 week washout between treatments. The 18 healthy, male study subjects received: nefazodone hydrochloride 200 mg twice daily (every 12 ...

journal_title：British journal of clinical pharmacology

authors： Barbhaiya RH,Shukla UA,Greene DS

更新日期：1995-08-01 00:00:00

abstract：AIM:We encountered a case of fetal toxicity due to ductus arteriosus (DA) constriction in a 36-week pregnant woman who had applied multiple ketoprofen patches. The aim of the present study was to present the case and develop a model to predict quantitatively the fetal toxicity risk of transdermal administration of keto...

journal_title：British journal of clinical pharmacology

authors： Tanaka S,Kanagawa T,Momma K,Hori S,Satoh H,Nagamatsu T,Fujii T,Kimura T,Sawada Y

更新日期：2017-11-01 00:00:00

abstract：:A double-blind, crossover study was carried out on the acceptability of three doses of brotizolam (0.125, 0.25 and 0.5 mg) in chronic insomniacs aged between 21 and 75 years (33 men: 42 women). Patients reported a shorter time to fall asleep and less nocturnal awakenings. Improvement in sleep was evident during the fi...

journal_title：British journal of clinical pharmacology

authors： Fritz-Osner A,Arias-Ortiz JL,Dorantes JF,Rabago-Sánchez J,Rodríguez-Tenorio A,Sánchez-Martinez J

更新日期：1983-01-01 00:00:00

abstract：WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT:The dominant health economic units upon which new treatment funding decisions are made are the incremental cost per life year gained (LYG) or the cost per quality-adjusted life year (QALY) gained. Neither of these units modifies the amount of health gained, by the amount of heal...

journal_title：British journal of clinical pharmacology

authors： Camidge DR,Oliver JJ,Skinner C,Attwood B,Nussey F,Jodrell D,Webb DJ

更新日期：2008-02-01 00:00:00