Gaps in predicting clinical doses for cannabinoids therapy: Overview of issues for pharmacokinetics and pharmacodynamics modelling.

abstract：:1. Eight healthy subjects were investigated on four occasions at least 1 week apart when they either ate a standard 3100 kJ cold meal or fasted. One hour earlier, either 50 mg atenolol or placebo was administered. 2. Eating was followed by prominent changes of systolic cardiovascular function: a rise of heart rate (+7...

journal_title：British journal of clinical pharmacology

authors： De Mey C,Enterling D,Meineke I

更新日期：1993-11-01 00:00:00

abstract：AIMS:Canagliflozin is a recently approved drug for use in the treatment of type 2 diabetes. The potential for canagliflozin to cause clinical drug-drug interactions (DDIs) was assessed. METHODS:DDI potential of canagliflozin was investigated using in vitro test systems containing drug metabolizing enzymes or transport...

journal_title：British journal of clinical pharmacology

authors： Mamidi RNVS,Dallas S,Sensenhauser C,Lim HK,Scheers E,Verboven P,Cuyckens F,Leclercq L,Evans DC,Kelley MF,Johnson MD,Snoeys J

更新日期：2017-05-01 00:00:00

abstract：:1. We report a method for measuring the concentrations of haloperidol (HL) and its major active metabolite, reduced haloperidol (RHL), in human scalp hair. 2. Hair samples were obtained from 59 patients who had been taking HL at fixed daily doses for more than 4 months and whose compliance was good. A morning pre-dose...

journal_title：British journal of clinical pharmacology

authors： Matsuno H,Uematsu T,Nakashima M

更新日期：1990-02-01 00:00:00

abstract：AIM:Sunitinib is an oral tyrosine kinase inhibitor approved for the treatment of renal cell carcinoma (RCC) and gastrointestinal stromal tumor (GIST). Because of the large interpatient pharmacokinetic variability and established exposure-response and exposure-toxicity relationships in clinical trial patients, therapeut...

journal_title：British journal of clinical pharmacology

authors： Westerdijk K,Krens SD,van der Graaf WTA,Mulder SF,van Herpen CML,Smilde T,van Erp NP,Desar IME

更新日期：2020-05-01 00:00:00

abstract：AIMS:This study investigated the safety, tolerability and pharmacokinetics after administration of a specific Cannabis sativa cultivar extract, standardised to cannabidiol (CBD) content as sublingual wafer or oil formulation compared to nabiximols oromucosal spray. METHODS:For the single-dose study, the design was an ...

journal_title：British journal of clinical pharmacology

authors： Hosseini A,McLachlan AJ,Lickliter JD

更新日期：2020-10-19 00:00:00

abstract：AIMS:To study reporting of hypoglycaemia in angiotensin receptor blocker (ARB) users, and to investigate the possibility of confounding. METHODS:The French pharmacovigilance database was examined for an association between hypoglycaemia and ARBs or other drugs using reports notified between 1996 and 2005. This associa...

journal_title：British journal of clinical pharmacology

authors： Grégoire F,Pariente A,Fourrier-Reglat A,Haramburu F,Bégaud B,Moore N

更新日期：2008-07-01 00:00:00

abstract：WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT:Oxycodone is an opioid analgesic that is metabolized mainly in the liver by cytochrome P450 (CYP) 2D6 and 3A4 enzymes. So far, the effects of CYP2D6 or CYP3A4 inhibitors on the pharmacokinetics of oxycodone in humans have not been systematically studied. WHAT THIS STUDY ADDS:Dr...

journal_title：British journal of clinical pharmacology

authors： Grönlund J,Saari TI,Hagelberg NM,Neuvonen PJ,Olkkola KT,Laine K

更新日期：2010-07-01 00:00:00

abstract：AIM:Propylene glycol (PG) is often applied as an excipient in drug formulations. As these formulations may also be used in neonates, the aim of this study was to characterize the pharmacokinetics of propylene glycol, co-administered intravenously with paracetamol (800 mg PG/1000 mg paracetamol) or phenobarbital (700 mg...

journal_title：British journal of clinical pharmacology

authors： De Cock RF,Knibbe CA,Kulo A,de Hoon J,Verbesselt R,Danhof M,Allegaert K

更新日期：2013-01-01 00:00:00

abstract：:1 Minute ventilation, alveolar PCO2, CO2 production and heart rate were measured in eight normal subjects before and during infusions of noradrenaline 0.2, 1.0 and 5.0 micrograms min-1 and isoprenaline 0.04, 0.2 and 1.0 microgram min-1. 2 These measurements were repeated after propranolol 3.5 mg, atenolol 8 mg or meto...

journal_title：British journal of clinical pharmacology

authors： Butland RJ,Pang JA,Geddes DM

更新日期：1982-11-01 00:00:00

abstract：AIMS:The study was designed to evaluate the relative bioavailability of diclofenac in plasma, subcutaneous adipose and skeletal muscle tissue after repeated topical administration using MIKA Diclofenac Spray Gel (4%), a novel formulation, and after oral dosing using VOLTAREN 50 mg enteric coated tablets. METHODS:Diclo...

journal_title：British journal of clinical pharmacology

authors： Brunner M,Dehghanyar P,Seigfried B,Martin W,Menke G,Müller M

更新日期：2005-11-01 00:00:00

abstract：:Alpha 1-acid glycoprotein (AAG) concentrations and propranolol binding were investigated in the serum of elderly hospitalized patients with acute illness, and healthy elderly and young subjects. Significantly greater AAG concentrations and reduced unbound propranolol fraction were observed in the elderly with acute di...

journal_title：British journal of clinical pharmacology

authors： Paxton JW,Briant RH

更新日期：1984-11-01 00:00:00

abstract：:1. In order to define factors which influence plasma catecholamine levels, and which might be controlled in the interests of reproducability and comparability, plasma noradrenaline plus adrenaline (NA + A) was measured repeatedly in normal subjects by a double isotope technique. 2. Age and posture were important deter...

journal_title：British journal of clinical pharmacology

authors： Saar N,Gordon RD

更新日期：1979-10-01 00:00:00

abstract：:Ten volunteers carried a 10 mg 24 h -1 transdermal glyceryl trinitrate (GTN) patch for 24 h before moderate exercise. Plasma GTN-concentration increased significantly (P less than 0.05) by 19% to peak value at 15 min. Two hours after patch renewal repeat exercise increased GTN concentration by 56% (P less than 0.001)....

journal_title：British journal of clinical pharmacology

authors： Gjesdal K,Klemsdal TO,Rykke EO,Bredesen JE

更新日期：1991-05-01 00:00:00

abstract：AIMS:Paraquat poisoning is a medical problem in many parts of Asia and the Pacific. The mortality rate is extremely high as there is no effective treatment. We analyzed data collected during an ongoing cohort study on self-poisoning and from a randomized controlled trial assessing the efficacy of immunosuppressive ther...

journal_title：British journal of clinical pharmacology

authors： Wunnapuk K,Mohammed F,Gawarammana I,Liu X,Verbeeck RK,Buckley NA,Roberts MS,Musuamba FT

更新日期：2014-10-01 00:00:00

abstract：AIMS:To describe the pharmacokinetic-pharmacodynamic (PK-PD) characteristics of the direct thrombin inhibitor dabigatran in hip replacement patients by assessing coagulation parameters activated partial thromboplastin time (aPTT) and ecarin clotting time (ECT), interindividual variability and factors affecting PD respo...

journal_title：British journal of clinical pharmacology

authors： Liesenfeld KH,Schäfer HG,Trocóniz IF,Tillmann C,Eriksson BI,Stangier J

更新日期：2006-11-01 00:00:00

abstract：AIM:To evaluate safety, tolerability and pharmacokinetics of oral PF-05190457, an oral ghrelin receptor inverse agonist, in healthy adults. METHODS:Single (SAD) and multiple ascending dose (MAD) studies were randomised, placebo-controlled, double-blind studies. Thirty-five healthy men (age 38.2 ± 10.4 years; body mass...

journal_title：British journal of clinical pharmacology

authors： Denney WS,Sonnenberg GE,Carvajal-Gonzalez S,Tuthill T,Jackson VM

更新日期：2017-02-01 00:00:00

abstract：:Paracetamol overdose prior to the introduction of acetylcysteine was associated with significant morbidity. Acetylcysteine is now the mainstay of treatment for paracetamol poisoning and has effectively reduced rates of hepatotoxicity and death. The current three-bag intravenous regimen with an initial high loading dos...

journal_title：British journal of clinical pharmacology

authors： Chiew AL,Isbister GK,Duffull SB,Buckley NA

更新日期：2016-03-01 00:00:00

abstract：AIM:To examine comprehensively the relationship between exposure to four classes of psychotropic drugs including antipsychotics, antidepressants, benzodiazepines (BZDs) and Z-drugs, and motor vehicle accidents (MVAs). METHOD:The authors conducted a matched case-control study of 5183 subjects with MVAs and 31 093 match...

journal_title：British journal of clinical pharmacology

authors： Chang CM,Wu EC,Chen CY,Wu KY,Liang HY,Chau YL,Wu CS,Lin KM,Tsai HJ

更新日期：2013-04-01 00:00:00

abstract：:1 The pharmacokinetics of single oral doses of nortriptyline were studied in twenty patients with chronic renal failure, eight of whom were receiving treatment with haemodialysis. 2 The median nortriptyline half-life was 25.2 h (range 14.5-140.0 h) and the median nortriptyline clearance was 32.3 l/h (range 8.1-122.0 l...

journal_title：British journal of clinical pharmacology

authors： Dawlilng S,Lynn K,Rosser R,Braithwaite R

更新日期：1981-07-01 00:00:00

abstract：:The mydriatic response to eyedrops of the anticholinergic drug tropicamide at very low concentration (0.01%) was studied in subjects with Alzheimer's disease (AD, n = 10) and multi-infarct dementia (MID, n = 10). There was no significant difference in pupillary response between the two groups. The test is unlikely to ...

journal_title：British journal of clinical pharmacology

authors： Treloar AJ,Assin M,Macdonald AJ

更新日期：1996-03-01 00:00:00

abstract：:1. The objective of this study was to investigate the efficacy of home-medicated non-steroidal anti-inflammatory (NSAID) analgesics, using an electronic patient diary. Single doses of ketoprofen 25 mg and ketoprofen 50 mg were compared with ibuprofen 200 mg and placebo in the treatment of a single occasion of episodic...

journal_title：British journal of clinical pharmacology

authors： van Gerven JM,Schoemaker RC,Jacobs LD,Reints A,Ouwersloot-van der Meij MJ,Hoedemaker HG,Cohen AF

更新日期：1996-10-01 00:00:00

abstract：:1 Norfenfluramine is thought to be the major active metabolite of fenfluramine in man. Therefore its in vitro effect on lipogenesis in human adipose tissue from twelve patients was investigated. 2 Although inhibition of lipogenesis was demonstrated, the concentrations of norfenfluramine necessary (>1 mM) were much hig...

journal_title：British journal of clinical pharmacology

authors： Ashwell M

更新日期：1974-10-01 00:00:00

abstract：:This study investigated the effects of placebo, 1 mg, 3 mg, 10 mg and 30 mg ritanserin and 10 mg diazepam on human sleep. Twelve normal volunteers participated in this randomized, double-blind, placebo-controlled cross-over sleep study. A clear dose-response relationship was found for ritanserin with higher doses evok...

journal_title：British journal of clinical pharmacology

authors： Idzikowski C,Mills FJ,James RJ

更新日期：1991-02-01 00:00:00

abstract：:A 12-week double-blind study was performed to compare the safety and efficacy of doxazosin, prazosin and placebo in 172 patients with essential hypertension. According to response, patients received doxazosin 1-16 mg once daily, prazosin 0.5-10 mg twice daily, or placebo. Mean final daily doses were doxazosin 11.3 mg ...

journal_title：British journal of clinical pharmacology

authors： Torvik D,Madsbu HP

更新日期：1986-01-01 00:00:00

abstract：:The effect of anticonvulsant therapy on early morning concentration of cortisol in saliva and plasma was assessed in a group of epileptic patients receiving regular phenytoin medication and the results compared with those obtained from a group of normal subjects not receiving drug therapy. Values of cortisol in matche...

journal_title：British journal of clinical pharmacology

authors： Evans PJ,Walker RF,Peters JR,Dyas J,Riad-Fahmy D,Thomas JP,Rimmer E,Tsanaclis L,Scanlon MF

更新日期：1985-08-01 00:00:00

abstract：WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT:* Exposure to bosentan was lower in paediatric pulmonary arterial hypertension (PAH) patients treated with the marketed adult formulation at a dose of about 2 mg kg(-1) when compared with adult PAH patients. * In healthy adult subjects, bosentan pharmacokinetics are less than do...

journal_title：British journal of clinical pharmacology

authors： Beghetti M,Haworth SG,Bonnet D,Barst RJ,Acar P,Fraisse A,Ivy DD,Jais X,Schulze-Neick I,Galiè N,Morganti A,Dingemanse J,Kusic-Pajic A,Berger RM

更新日期：2009-12-01 00:00:00

abstract：:Activated platelets stimulate thrombus formation in response to rupture of an atherosclerotic plaque or endothelial cell erosion, promoting atherothrombotic disease. Multiple pathways contribute to platelet activation. Aspirin, an irreversible inhibitor of thromboxane A2 synthesis, in combination with clopidogrel, an ...

journal_title：British journal of clinical pharmacology

authors： Tello-Montoliu A,Tomasello SD,Ueno M,Angiolillo DJ

更新日期：2011-10-01 00:00:00

abstract：:1 The effect of once daily nadolol therapy in sixteen ambulant patients with essential hypertension has been closely assessed during exercise and over 24 h by continuous intra-arterial recording. 2 The drug was well tolerated and showed similar efficacy to other beta-adrenoceptor blocking agents. Whilst blood pressure...

journal_title：British journal of clinical pharmacology

authors： Hornung RS,Gould BA,Kieso H,Raftery EB

更新日期：1982-07-01 00:00:00

abstract：:Adverse drug reactions come at a considerable cost on society. Social media are a potentially invaluable reservoir of information for pharmacovigilance, yet their true value remains to be fully understood. In order to realize the benefits social media holds, a number of technical, regulatory and ethical challenges rem...

journal_title：British journal of clinical pharmacology

authors： Sloane R,Osanlou O,Lewis D,Bollegala D,Maskell S,Pirmohamed M

更新日期：2015-10-01 00:00:00

abstract：:1. The effects of sodium octanoate and sodium salicylate on the rectal absorption of cefoxitin were investigated in healthy volunteers. Drug solutions were given either as a bolus or as a zero-order infusion. 2. On rectal infusion sodium octanoate and sodium salicylate both enhanced mean cefoxitin bioavailability (+/-...

journal_title：British journal of clinical pharmacology

authors： Van Hoogdalem EJ,Wackwitz AT,De Boer AG,Cohen AF,Breimer DD

更新日期：1989-01-01 00:00:00