Abstract:
:1. The pharmacokinetics of streptokinase (SK) and anistreplase in conventional dosage regimens of 1.5 x 10(6) i.u. of SK infused over 60 min and 30 units of anistreplase over 5 min were studied in 24 consecutive patients presenting with acute myocardial infarction, using a functional bioassay to assess concentrations. 2. The two agents were found to have similar volumes of distribution (5.68 and 5.90 l), but SK was cleared significantly more rapidly than anistreplase, resulting in a shorter terminal phase half-life (0.61 vs 1.16 h) and a shorter mean residence time (0.76 vs 1.55 h).
journal_name
Br J Clin Pharmacoljournal_title
British journal of clinical pharmacologyauthors
Gemmill JD,Hogg KJ,Burns JM,Rae AP,Dunn FG,Fears R,Ferres H,Standring R,Greenwood H,Pierce Ddoi
10.1111/j.1365-2125.1991.tb05502.xsubject
Has Abstract,Author List Incompletepub_date
1991-02-01 00:00:00pages
143-7issue
2eissn
0306-5251issn
1365-2125journal_volume
31pub_type
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