Serum protein binding and free concentration of phenytoin and phenobarbitone in pregnancy.

abstract：:1. Confusion between the criteria for defining and diagnosing hypertension may have misled the search for the causes of hypertension. 2. The systematic approach of molecular genetics appears to offer the best chance of explaining hypertension, but the attractions are partly offset by the large numbers required, and un...

journal_title：British journal of clinical pharmacology

authors： Brown MJ

更新日期：1996-07-01 00:00:00

abstract：:1 The acute and chronic (8 weeks) haemodynamic responses to oral flosequinan have been investigated in 12 male patients of mean age 58.9 years with congestive heart failure of N.Y.H.A. classes II and III. 2 Flosequinan 125 mg orally significantly reduced right atrial pressure, pulmonary artery pressure and pulmonary w...

journal_title：British journal of clinical pharmacology

authors： Thomas P,O'Gorman DJ,Sheridan DJ

更新日期：1993-12-01 00:00:00

abstract：WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT:Rosiglitazone is able to increase serum adiponectin levels significantly in Type 2 diabetic patients. :The role of genetic factors that determine the marked interindividual variability in glucose-lowering efficacy of rosiglitazone in Chinese patients is not known. The current st...

journal_title：British journal of clinical pharmacology

authors： Sun H,Gong ZC,Yin JY,Liu HL,Liu YZ,Guo ZW,Zhou HH,Wu J,Liu ZQ

更新日期：2008-06-01 00:00:00

abstract：:1 Two antitussive agents (+/-)-glaucine phosphate and codeine phosphate have been compared with placebo with respect to ventilation, ventilatory response to carbon dioxide, pulse, blood pressure, digit symbol substitution, sedation score and the Zahlen-Verbindung test performance in ten healthy volunteers (22-36 years...

journal_title：British journal of clinical pharmacology

authors： Redpath JB,Pleuvry BJ

更新日期：1982-10-01 00:00:00

abstract：AIMS:Paracetamol-containing combination analgesics are widely prescribed but the use of paracetamol/dextropropoxyphene (co-proxamol) is particularly controversial. We aim to examine the prescribing patterns of the paracetamol-containing analgesics in Ireland. METHODS:A national primary care prescribing database was us...

journal_title：British journal of clinical pharmacology

authors： Usher C,Teeling M,Bennett K,McGowan B,Feely J

更新日期：2005-12-01 00:00:00

abstract：:1 Cimetidine has been reported to reduce serum calcium and parathyroid hormone (PTH) levels in primary hyperparathyroidism, but some studies have reported negative findings. 2 A double-blind, controlled trial of cimetidine in this condition was, therefore, conducted. Eight patients were given cimetidine and placebo fo...

journal_title：British journal of clinical pharmacology

authors： Fisken RA,Wilkinson R,Heath DA

更新日期：1982-11-01 00:00:00

abstract：:The pharmacokinetics of piretanide, a new loop diuretic, were studied in four patients with GFR 4.7-14.8 ml/min. An oral dose of piretanide 18 mg was given at 08.00 h in two patients and at 08.00 h and 14.00 h in two. Blood samples were drawn after 0.5, 1, 2, 3, 4, 6, 8, 10, 12 and 24 h. Serum concentrations of pireta...

journal_title：British journal of clinical pharmacology

authors： Berg KJ,Walstad RA,Bergh K

更新日期：1983-03-01 00:00:00

abstract：AIMS:To investigate the extent of concomitant use of analgesic and psychotropic medicines among home-dwelling elderly people aged at least 75 years in Finland. METHODS:This was a population-based study in Finland, performed as part of Kuopio 75 + study focusing on the clinical epidemiology of diseases, medication and ...

journal_title：British journal of clinical pharmacology

authors： Hartikainen S,Mäntyselkä P,Louhivuori-Laako K,Enlund H,Sulkava R

更新日期：2005-09-01 00:00:00

abstract：:The effects of intravenous boluses of adenosine on respiration and heart rate were compared in young and elderly individuals. Respiratory stimulation and biphasic changes in heart rate were confirmed. The dose-response relationship for the effects of adenosine on respiration and heart-rate did not differ significantly...

journal_title：British journal of clinical pharmacology

authors： Watt AH,Bayer A,Routledge PA,Swift CG

更新日期：1989-02-01 00:00:00

abstract：:The disposition of mexiletine has been studied in five subjects on two occasions with urine pH controlled at 5.0 and at 8.0. With acid urine total plasma clearance was similar in all subjects (462 to 497 ml min-1) and the plasma half-life ranged from 3.8 to 9.2 h (mean 6.7 h). With alkaline urine the total plasma clea...

journal_title：British journal of clinical pharmacology

authors： Mitchell BG,Clements JA,Pottage A,Prescott LF

更新日期：1983-09-01 00:00:00

abstract：:The effect of a high potency antacid and food on the bioavailability of famotidine was studied in 17 healthy volunteers in an open randomized three-way cross-over trial. After an overnight fast, famotidine was administered to each subject as follows: 40 mg famotidine orally alone; 40 mg orally with antacid; and 40 mg ...

journal_title：British journal of clinical pharmacology

authors： Lin JH,Chremos AN,Kanovsky SM,Schwartz S,Yeh KC,Kann J

更新日期：1987-10-01 00:00:00

abstract：WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT:Variants in the CYP2C9 (i.e. *2 and *3) and VKORC1 (i.e. 1173C/T or -1639G/A) genes have been shown to influence warfarin dose requirements. However, these factors seem to explain less of the dose variability in African Americans who have a lower prevalence of the CYP2C9*2 and *...

journal_title：British journal of clinical pharmacology

authors： Schelleman H,Brensinger CM,Chen J,Finkelman BS,Rieder MJ,Kimmel SE

更新日期：2010-09-01 00:00:00

abstract：WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT:Recently, we have shown that the plasma concentration of R-fexofenadine is greater than that of the S-enantiomer. Although itraconazole co-administration is known to increase the bioavailability of a racemic mixture of fexofenadine, little is known about the stereoselective inhi...

journal_title：British journal of clinical pharmacology

authors： Tateishi T,Miura M,Suzuki T,Uno T

更新日期：2008-05-01 00:00:00

abstract：AIMS:To obtain in vivo evidence for the involvement of cytochrome P450 (CYP) 3A4 in the metabolism of brotizolam. METHODS:Fourteen healthy male volunteers received erythromycin 1200 mg day(-1) or placebo for 7 days in a double-blind randomized crossover manner. On the 6th day they received a single oral 0.5-mg dose of...

journal_title：British journal of clinical pharmacology

authors： Tokairin T,Fukasawa T,Yasui-Furukori N,Aoshima T,Suzuki A,Inoue Y,Tateishi T,Otani K

更新日期：2005-08-01 00:00:00

abstract：:1. Potential therapies for ischaemic stroke include agents to reduce oedema, to improve cerebral perfusion, to reduce excitotoxic damage, to minimise free-radical induced injury and to reduce complications such as deep venous thrombosis. 2. Of the anti-oedema drugs, steroids are ineffective and possibly dangerous; int...

journal_title：British journal of clinical pharmacology

authors： Lees KR

更新日期：1992-12-01 00:00:00

abstract：:1. The possibility of a pharmacokinetic interaction between the H2-receptor antagonist cimetidine and the long-acting local anaesthetic agent bupivacaine was studied in seven healthy, non-smoking volunteers. 2. The study consisted of two sessions at a minimum interval of 4 days. In a randomized, crossover fashion, the...

journal_title：British journal of clinical pharmacology

authors： Pihlajamäki KK,Lindberg RL,Jantunen ME

更新日期：1988-10-01 00:00:00

abstract：AIMS:Paracetamol is frequently involved in intended self-poisoning, and concomitant overdosing of other drugs is commonly reported. The purpose of the study was to investigate further concomitant drug overdose in patients with paracetamol poisoning and to evaluate its effects on the outcome of the paracetamol intoxicat...

journal_title：British journal of clinical pharmacology

authors： Schmidt LE,Dalhoff K

更新日期：2002-05-01 00:00:00

abstract：:Concentrations of morphine, morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G) were measured by h.p.l.c. in plasma and cerebrospinal fluid (CSF) samples from 16 patients with cancer receiving oral (controlled-release) morphine. There was a close correlation between plasma and CSF morphine concentrations (r ...

journal_title：British journal of clinical pharmacology

authors： van Dongen RT,Crul BJ,Koopman-Kimenai PM,Vree TB

更新日期：1994-09-01 00:00:00

abstract：AIM:Experimental pain models may help to evaluate the mechanisms of analgesics and target the clinical indications for their use. This review, the second in a series of two, addresses how the efficacy of non-opioid analgesics have been assessed in human volunteers using experimental pain models. METHODS:A literature s...

journal_title：British journal of clinical pharmacology

authors： Staahl C,Olesen AE,Andresen T,Arendt-Nielsen L,Drewes AM

更新日期：2009-09-01 00:00:00

abstract：AIMS:The aim was to assess the impact of a campaign for general practitioners (GPs) to reduce clinically-important drug-drug interactions (DDIs) in poly-treated elderly patients. METHODS:We compiled a list of 53 DDIs and analyzed reimbursed prescriptions dispensed to poly-treated (≥four drugs) elderly (>65 years) pati...

journal_title：British journal of clinical pharmacology

authors： Raschi E,Piccinni C,Signoretta V,Lionello L,Bonezzi S,Delfino M,Di Candia L,Di Castri L,Pieraccini F,Carati D,Poluzzi E,De Ponti F,Emilia-Romagna elderly poly-treated patients research group.

更新日期：2015-12-01 00:00:00

abstract：:1 A system is described for screening new chemical entities in normal human subjects, which is designed to search for novel drug actions at an early stage of drug development. 2 In single (subject) blind experiments, doses are increased incrementally from one subject to next, with immediate feed-back of results from e...

journal_title：British journal of clinical pharmacology

authors： Sullivan TJ,Croft AR,Hanka R,Roberts SJ

更新日期：1980-04-01 00:00:00

abstract：:1 To compare the haemodynamic effects of secondary characteristics of beta-adrenoceptor blockers with an angiotensin converting enzyme inhibitor forty patients with previously untreated mild to moderate hypertension were prescribed either atenolol 50-100 mg day-1, labetalol 200-800 mg day-1, pindolol 10-30 mg day-1 or...

journal_title：British journal of clinical pharmacology

authors： Roberts DH,Tsao Y,Grimmer SF,Winstanley PA,Orme ML,Breckenridge AM

更新日期：1987-08-01 00:00:00

abstract：:1 From an understanding of the biological fate and hypotensive effect of debrisoquine (D) we have assessed the relative importance of true drug resistance, inappropriately low dosage and non-compliance as causes of apparent resistance to treatment with this drug. 2 Among 37 hypertensive patients prescribed D, eleven (...

journal_title：British journal of clinical pharmacology

authors： Silas JH,Tucker GT,Smith AJ

更新日期：1980-04-01 00:00:00

abstract：AIMS:The aims of the present study were, firstly, to evaluate long-term trends in the occurrence and treatment of cardiovascular disease (CVD) risk factors and the occurrence of CVD events in children with type 1 diabetes mellitus (T1DM) and, secondly, to assess the determinants of undertreatment of CVD risk factors. ...

journal_title：British journal of clinical pharmacology

authors： Ahmadizar F,Souverein P,de Boer A,Maitland-van der Zee AH

更新日期：2018-04-01 00:00:00

abstract：AIMS:Variability in responsiveness to clopidogrel is a clinical problem in secondary prevention after cerebral ischaemia which has been suggested to be linked to competitive metabolization of clopidogrel and cytochrome P450 (CYP) 3A4-oxidated statins such as simvastatin. We assessed the hypothesis that simvastatin, in ...

journal_title：British journal of clinical pharmacology

authors： Siepmann T,Heinke D,Kepplinger J,Barlinn K,Gehrisch S,Grählert X,Schwanebeck U,Reichmann H,Puetz V,Bodechtel U,Gahn G

更新日期：2014-11-01 00:00:00

abstract：:Cost-containment measures in healthcare provision include the implementation of therapeutic and generic drug substitution strategies in patients whose condition is already well controlled with pharmacotherapy. Treatment for hypertension is frequently targeted for such measures. However, drug acquisition costs are only...

journal_title：British journal of clinical pharmacology

authors： Johnston A,Stafylas P,Stergiou GS

更新日期：2010-09-01 00:00:00

abstract：:1 The effect of an intravenous bolus of labetalol (0.6--1.6 mg/kg body weight) on central and peripheral haemodynamics was studied in nine subjects with essential hypertension and in eleven subjects with chronic renal disease and hypertension. 2 The BP reduction amounting to 20/13 mmHg was entirely due to the lowering...

journal_title：British journal of clinical pharmacology

authors： Bahlmann J,Brod J,Hubrich W,Cachovan M,Pretschner P

更新日期：1979-01-01 00:00:00

abstract：AIMS:Mycophenolic acid (MPA) suppresses lymphocyte proliferation through inosine monophosphate dehydrogenase (IMPDH) inhibition. Two formulations have been approved: mycophenolate mofetil (MMF) and enteric-coated mycophenolate sodium (EC-MPS). Pantoprazole (PAN) inhibits gastric acid secretion, which may alter MPA expo...

journal_title：British journal of clinical pharmacology

authors： Rissling O,Glander P,Hambach P,Mai M,Brakemeier S,Klonower D,Halleck F,Singer E,Schrezenmeier EV,Dürr M,Neumayer HH,Budde K

更新日期：2015-11-01 00:00:00

abstract：:Intravenous midazolam (mean dose of 6.3 mg) was given to 100 consecutive patients coming to endoscopy. All patients had an ear oximeter attached throughout the procedure to record continuously their levels of oxygen saturation. Eighty-five of the 100 patients had pre-endoscopy respiratory function tests measured, and ...

journal_title：British journal of clinical pharmacology

authors： Bell GD,Reeve PA,Moshiri M,Morden A,Coady T,Stapleton PJ,Logan RF

更新日期：1987-06-01 00:00:00

abstract：:Herbal medicines and products derived from them are a diverse group of products for which different (and often limited) levels of evidence are available. As importantly, such products generally vary in their composition and are at the end of an often poorly understood value chain, which often links producers in biodiv...

journal_title：British journal of clinical pharmacology

authors： Heinrich M

更新日期：2015-07-01 00:00:00