Abstract：
:1 The effects of age and sex on the disposition of clobazam (CBZ), a 1.5-benzodiazepine derivative, were evaluated in a series of 29 healthy volunteers aged 18 to 72 years, who ingested single 20 mg oral doses. CBZ kinetics were determined from multiple plasma concentrations measured during 7 days after the dose. 2 CBZ was rapidly absorbed, with peak levels reached an average of 1.5 h after dosing (range 0.5--2.5 h). Mean absorption half-life was 19.7 min. Absorption kinetics were not influenced by age of sex. 3 Elimination half-life ranged from 11 to 77 h, and was significantly longer in elderly v young males (48 v 17 h, P less than 0.01). In women, half-life also increased with age, but differences between young and elderly women were less striking (31 v 49 h, P less than 0.05). 4 Volume of distribution (Vd) was influenced by age and sex. Vd became larger with age regardless of sex, and within each age group was larger in women than in men. Total clearance was unrelated to age in women, but declined significantly with age in men (P less than 0.01). 5 The mean free fraction for CBZ in plasma was 11.5% (range 8.6--15.0%), and tended to increase with age, partly due to a significant age-related decline in plasma albumin concentration (r = -0.68, P less than 0.001). Correction of Vd and clearance for individual differences in binding did not alter their relation to age and sex. 6 As in the case of other benzodiazepines biotransformed by oxidative pathways, the capacity for N-demethylation of CBZ declines with age in men, but age has a minimal effect on CBZ clearance in women.
journal_name
Br J Clin Pharmacoljournal_title
British journal of clinical pharmacologyauthors
Greenblatt DJ,Divoll M,Puri SK,Ho I,Zinny MA,Shader RIdoi
10.1111/j.1365-2125.1981.tb01281.xsubject
Has Abstractpub_date
1981-11-01 00:00:00pages
631-6issue
5eissn
0306-5251issn
1365-2125journal_volume
12pub_type
杂志文章abstract：:The absorption of the antiemetic metopimazine (MPZ) given as a single dose of (a) 40 mg microenema, (b) 40 mg orally and (c) 10 mg as a 60 min i.v. continuous infusion was investigated in six healthy volunteers. Blood samples were drawn and the serum concentrations of MPZ and its acid metabolite were measured. The bio...
journal_title：British journal of clinical pharmacology
pub_type： 临床试验,杂志文章
doi：10.1046/j.1365-2125.1996.35220.x
更新日期：1996-06-01 00:00:00
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journal_title：British journal of clinical pharmacology
pub_type： 杂志文章,随机对照试验
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journal_title：British journal of clinical pharmacology
pub_type： 杂志文章
doi：10.1111/j.1365-2125.2009.03440.x
更新日期：2009-08-01 00:00:00
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journal_title：British journal of clinical pharmacology
pub_type： 杂志文章
doi：10.1111/j.1365-2125.2011.04141.x
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journal_title：British journal of clinical pharmacology
pub_type： 杂志文章
doi：10.1046/j.1365-2125.1998.00048.x
更新日期：1998-07-01 00:00:00
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journal_title：British journal of clinical pharmacology
pub_type： 杂志文章,评审
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更新日期：2011-10-01 00:00:00
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pub_type： 杂志文章
doi：10.1111/bcp.13464
更新日期：2018-03-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：1987-11-01 00:00:00
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journal_title：British journal of clinical pharmacology
pub_type： 杂志文章,随机对照试验
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更新日期：2010-08-01 00:00:00
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journal_title：British journal of clinical pharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1111/j.1365-2125.2008.03116.x
更新日期：2008-05-01 00:00:00
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journal_title：British journal of clinical pharmacology
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1998-12-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
doi：10.1111/bcp.13874
更新日期：2019-04-01 00:00:00
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journal_title：British journal of clinical pharmacology
pub_type： 杂志文章
doi：10.1111/j.1365-2125.1985.tb02770.x
更新日期：1985-01-01 00:00:00
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journal_title：British journal of clinical pharmacology
pub_type： 杂志文章
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更新日期：1984-03-01 00:00:00
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pub_type： 杂志文章
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pub_type： 临床试验,杂志文章,评审
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pub_type： 杂志文章
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journal_title：British journal of clinical pharmacology
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1989-03-01 00:00:00
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journal_title：British journal of clinical pharmacology
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
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journal_title：British journal of clinical pharmacology
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1980-04-01 00:00:00
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journal_title：British journal of clinical pharmacology
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1994-11-01 00:00:00
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pub_type： 杂志文章
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更新日期：2000-10-01 00:00:00
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pub_type： 临床试验,杂志文章
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更新日期：1988-03-01 00:00:00
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journal_title：British journal of clinical pharmacology
pub_type： 杂志文章
doi：10.1111/j.1365-2125.1987.tb03002.x
更新日期：1987-01-01 00:00:00
abstract：:1. The new intravenous bisphosphonate drug aminohydroxypropylidine bisphosphonate (APD) is effective in treating the hypercalcaemia of malignant disease, but the optimum dose regimen is not yet established. We have treated twenty-seven patients with malignant hypercalcaemia (corrected calcium greater than 3.00 mmol l-...
journal_title：British journal of clinical pharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1111/j.1365-2125.1989.tb05426.x
更新日期：1989-09-01 00:00:00
abstract：:The mydriatic response to eyedrops of the anticholinergic drug tropicamide at very low concentration (0.01%) was studied in subjects with Alzheimer's disease (AD, n = 10) and multi-infarct dementia (MID, n = 10). There was no significant difference in pupillary response between the two groups. The test is unlikely to ...
journal_title：British journal of clinical pharmacology
pub_type： 杂志文章
doi：10.1111/j.1365-2125.1996.tb00194.x
更新日期：1996-03-01 00:00:00
abstract：AIMS:The aims of this study were to determine the effects of the nonsteroidal, selective aromatase inhibitor, anastrozole, at steady-state concentrations, on the pharmacokinetics and pharmacodynamics of warfarin, and to assess whether or not anastrozole alone has any anticoagulant activity. METHODS:This was a randomiz...
journal_title：British journal of clinical pharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1046/j.1365-2125.2001.01358.x
更新日期：2001-05-01 00:00:00
abstract：AIMS:To analyse clinical outcomes with direct oral anticoagulants in patients with atrial fibrillation according to geographic region. METHODS:We systematically searched MEDLINE, CENTRAL, websites of regulatory agencies, clinical trials registers and conference proceedings for randomized controlled trials of direct or...
journal_title：British journal of clinical pharmacology
pub_type： 杂志文章,meta分析,评审
doi：10.1111/bcp.13005
更新日期：2016-09-01 00:00:00
