Measurement of blood concentrations of FK506 (tacrolimus) and its metabolites in seven liver graft patients after the first dose by h.p.l.c.-MS and microparticle enzyme immunoassay (MEIA).

abstract：:Clinical pharmacologists in universities play major roles in research and teaching and provide important contributions to National Health Service (NHS) activities, such as work for research ethics, drug and therapeutics, and clinical governance committees. Their research extends from preclinical studies using drugs to...

journal_title：British journal of clinical pharmacology

authors： Webb DJ

更新日期：2012-06-01 00:00:00

abstract：:Caffeine (5 mg kg-1) was administered orally to two healthy, non-smoking subjects on three separate occasions--before, and during therapy with the xanthine oxidase inhibitor allopurinol at doses of either 300 or 600 mg daily. Plasma and urinary levels of methylxanthines, endogenous oxypurines and allopurinol and its m...

journal_title：British journal of clinical pharmacology

authors： Grant DM,Tang BK,Campbell ME,Kalow W

更新日期：1986-04-01 00:00:00

abstract：AIMS:To evaluate if rivaroxaban, an oral factor Xa (FXa) inhibitor, could modify the expression in vitro of inflammatory and oxidative stress biomarkers in abdominal aortic aneurysmal (AAA) sites showing intraluminal thrombus. METHODS:AAA sites with intraluminal mural thrombus were obtained from six patients undergoin...

journal_title：British journal of clinical pharmacology

authors： Moñux G,Zamorano-León JJ,Marqués P,Sopeña B,García-García JM,Laich de Koller G,Calvo-Rico B,García-Fernandez MA,Serrano J,López-Farré A

更新日期：2017-12-01 00:00:00

abstract：:1. Oral micronized progesterone (P) is proposed for the treatment of certain endocrine gynaecological disorders. To examine the effects of P on performance and mood, a randomized, placebo-controlled study of 24 healthy females ages 18-24 years on low-dose oral contraceptives was conducted. 2. Subjects were admitted to...

journal_title：British journal of clinical pharmacology

authors： Freeman EW,Weinstock L,Rickels K,Sondheimer SJ,Coutifaris C

更新日期：1992-03-01 00:00:00

abstract：AIMS:QTc interval-prolonging drugs have been linked to cardiac arrhythmias, cardiac arrest and sudden death. In this study we aimed to quantify the risk of cardiac arrest associated with the use of non-antiarrhythmic QTc-prolonging drugs in an academic hospital setting. METHODS:We performed a case-control study in whi...

journal_title：British journal of clinical pharmacology

authors： De Bruin ML,Langendijk PN,Koopmans RP,Wilde AA,Leufkens HG,Hoes AW

更新日期：2007-02-01 00:00:00

abstract：:1. Mizolastine, a new benzimidazole derivative with potent selective, non-sedative H1-histamine antagonist activity was compared with terfenadine, cetirizine and loratadine using the histamine-induced wheal and flare model in healthy volunteers. 2. Study design was a five way double-blind crossover design using a sing...

journal_title：British journal of clinical pharmacology

authors： Rosenzweig P,Caplain H,Chaufour S,Ulliac N,Cabanis MJ,Thebault JJ

更新日期：1995-11-01 00:00:00

abstract：AIMS:Recently, an apparent protective effect of statins against upper gastrointestinal bleeding (UGB) was postulated in a post hoc analysis of a randomized trial. We aimed to evaluate the effect of statin use on acute nonvariceal UGB alone or in combinations with low-dose aspirin and other antithrombotic drugs. METHOD...

journal_title：British journal of clinical pharmacology

authors： Gulmez SE,Lassen AT,Aalykke C,Dall M,Andries A,Andersen BS,Hansen JM,Andersen M,Hallas J

更新日期：2009-04-01 00:00:00

abstract：:The mydriatic response to eyedrops of the anticholinergic drug tropicamide at very low concentration (0.01%) was studied in subjects with Alzheimer's disease (AD, n = 10) and multi-infarct dementia (MID, n = 10). There was no significant difference in pupillary response between the two groups. The test is unlikely to ...

journal_title：British journal of clinical pharmacology

authors： Treloar AJ,Assin M,Macdonald AJ

更新日期：1996-03-01 00:00:00

abstract：AIMS:The aims of the present study were, firstly, to evaluate long-term trends in the occurrence and treatment of cardiovascular disease (CVD) risk factors and the occurrence of CVD events in children with type 1 diabetes mellitus (T1DM) and, secondly, to assess the determinants of undertreatment of CVD risk factors. ...

journal_title：British journal of clinical pharmacology

authors： Ahmadizar F,Souverein P,de Boer A,Maitland-van der Zee AH

更新日期：2018-04-01 00:00:00

abstract：:The effects of a single dose of sulindac 200 mg and placebo on the capsaicin-induced cough reflex were studied in a two-phase double-blind crossover study in 18 healthy subjects. Sulindac increased the threshold for capsaicin cough response significantly, but did not alter D5, peak response, or the total cough respons...

journal_title：British journal of clinical pharmacology

authors： Foster G,Yeo WW,Ramsay LE

更新日期：1991-02-01 00:00:00

abstract：:1 An in vitro investigation showed that pivampicillin tablets disintegrated more rapidly than pivampicillin capsules. This result was demonstrated and confirmed by gastroscopy in a cross-over study in healthy volunteers. 2 There were no differences in serum levels of ampicillin obtained with the two preparations, but ...

journal_title：British journal of clinical pharmacology

authors： Hey H,Matzen P,Andersen JT,Didriksen E,Nielsen B

更新日期：1979-09-01 00:00:00

abstract：:One hundred different drug advertisements from each of seven leading medical journals have been assessed. Information about drug interactions, adverse reactions, mode of action, absorption, distribution, metabolism, excretion and cost was seldom provided in UK journals. A requirement should exist that drug advertiseme...

journal_title：British journal of clinical pharmacology

authors： Morgan AH,Jeffers TA,Petrie JC,Walker W

更新日期：1976-12-01 00:00:00

abstract：AIMS:Helicobacter pylori (H. pylori) eradication rate varies according to the treatment regimen used and other factors, e.g. antimicrobial resistance and patient compliance. The aim of the present study was to evaluate the influence of patient counselling and follow-up on H. pylori eradication rates and to document the...

journal_title：British journal of clinical pharmacology

authors： Al-Eidan FA,McElnay JC,Scott MG,McConnell JB

更新日期：2002-02-01 00:00:00

abstract：AIMS:Various mathematical models have been developed to estimate glomerular filtration rate (GFR) incorporating variables such as age, gender, height, weight, serum creatinine, and body surface area (BSA). Because adjustments in drug dosing are often based on estimated values of renal function, it is important to defin...

journal_title：British journal of clinical pharmacology

authors： Goerdt PJ,Heim-Duthoy KL,Macres M,Swan SK

更新日期：1997-09-01 00:00:00

abstract：:1 The effect of labetalol has been assessed in an open clinical trial in 19 patients with sub-optimal control of blood pressure on other therapy, and in a placebo-controlled cross-over study. Most patients were taking a diuretic before the trial and they continued to do so during the trial. 2 In the open trial, labeta...

journal_title：British journal of clinical pharmacology

authors： Bolli P,Waal-Manning J,Wood AJ,Simpson FO

更新日期：1976-08-01 00:00:00

abstract：AIMS:To evaluate the electroencephalographic (EEG) effects, blood concentrations, vehicle irritation and dose-effect relationships for diazepam administered nasally. METHODS:The study had a cross-over design with eight healthy volunteers (one drop out). It consisted of four legs with four different administrations: in...

journal_title：British journal of clinical pharmacology

authors： Lindhardt K,Gizurarson S,Stefánsson SB,Olafsson DR,Bechgaard E

更新日期：2001-11-01 00:00:00

abstract：AIMS:To assess the age-associated changes over time of plasma paraxanthine/caffeine (PAX/CAF) ratios used as a probe for CYP1A2 activity. METHODS:Intraindividual and interindividual variabilities in PAX/CAF ratio were compared by phenotyping with caffeine, 16 young and 16 elderly healthy subjects on five occasions. R...

journal_title：British journal of clinical pharmacology

authors： Simon T,Becquemont L,Hamon B,Nouyrigat E,Chodjania Y,Poirier JM,Funck-Brentano C,Jaillon P

更新日期：2001-11-01 00:00:00

abstract：AIMS:The aim of the present study was to assess the effect of policy interventions - i.e. reimbursement decisions, guidelines and regional recommendations - on the prescribing of oral anticoagulant treatment in patients with atrial fibrillation (AF). METHODS:Interrupted time series analyses were carried out using mont...

journal_title：British journal of clinical pharmacology

authors： Komen J,Forslund T,Hjemdahl P,Andersen M,Wettermark B

更新日期：2017-03-01 00:00:00

abstract：:1 We have performed a double-blind, randomized, 7-d cross-over study of the thromboxane synthetase inhibitor dazoxiben (UK 37248) in 20 patients with stable coronary heart disease. 2 All patients had a history of exertional angina of greater than two years duration and no patient had suffered a myocardial infarction i...

journal_title：British journal of clinical pharmacology

authors： Reuben SR,Kuan P,Cairns J,Gyde OH

更新日期：1983-01-01 00:00:00

abstract：:This double-blind study in 60 hospitalized female patients comparing midazolam 15 mg, oxazepam 15 mg and placebo, demonstrated an inter-group difference in favour of midazolam with regard to efficacy. The sleep parameters of onset latency and duration were improved by midazolam. All three compounds were very well tole...

journal_title：British journal of clinical pharmacology

authors： Fischbach R

更新日期：1983-01-01 00:00:00

abstract：:1. The pharmacokinetics and pharmacodynamics of intranasal (IN) and oral 1-deamino-8-D-arginine vasopressin (DDAVP) were compared in 10 Chinese adults with central diabetes insipidus previously controlled on IN DDAVP. This was followed by comparison of the acute pharmacodynamics of commonly used oral preparations (con...

journal_title：British journal of clinical pharmacology

authors： Lam KS,Wat MS,Choi KL,Ip TP,Pang RW,Kumana CR

更新日期：1996-09-01 00:00:00

abstract：AIMS:Inflammation reduces hepatic clearance of many drugs with unknown therapeutic consequences. This study was carried out to examine the effect of rheumatoid arthritis (RA) on the pharmacokinetics and pharmacodynamics of verapamil. METHODS:Eight RA patients were age- and sex-matched with eight healthy volunteers. Th...

journal_title：British journal of clinical pharmacology

authors： Mayo PR,Skeith K,Russell AS,Jamali F

更新日期：2000-12-01 00:00:00

abstract：AIM:The aim was to examine patients' stated preferences to persist with medicines and to explore the influence of psychosocial and sociocognitive factors. METHODS:Community-dwelling, hypertensive patients recruited from nine European countries were invited to complete a discrete choice experiment (DCE) with attributes...

journal_title：British journal of clinical pharmacology

authors： Holmes EA,Morrison VL,Hughes DA

更新日期：2016-08-01 00:00:00

abstract：:The plasma concentration-response relationships of oral and intravenous pindolol and propranolol have been studied in a group of eight healthy male subjects who received each dosage form in a randomized single-blind cross-over manner. Despite similar elimination half-lives, the duration of action of pindolol was longe...

journal_title：British journal of clinical pharmacology

authors： Carruthers SG,Pacha WL,Aellig WH

更新日期：1985-10-01 00:00:00

abstract：AIM:We compared the pharmacokinetic (PK) profiles of co-crystal of tramadol-celecoxib (CTC) vs. each reference product (alone and in open combination) after single (first dose) and multiple dosing. METHODS:Healthy adults aged 18-50 years received, under fasted conditions, 15 twice-daily doses of the following treatmen...

journal_title：British journal of clinical pharmacology

authors： Videla S,Lahjou M,Vaqué A,Sust M,Escriche M,Soler L,Sans A,Sicard E,Gascón N,Encina G,Plata-Salamán C

更新日期：2018-01-01 00:00:00

abstract：:1 Daily treatment of two-kidney clipped renal hypertensive rats with hydrallazine, hydrochlorothiazide (HCTZ) and a new orally active inhibitor of the angiotensin-converting enzyme, captopril (SQ14,225), was correlated with survival rates for up to 9 months. 2 The groups of rats given captopril alone or captopril plus...

journal_title：British journal of clinical pharmacology

authors： Horovitz ZP,Antonaccio MJ,Rubin B,Panasevich RE

更新日期：1979-01-01 00:00:00

abstract：AIMS:To evaluate the comparative efficacy (50% reduction in seizure frequency) and tolerability (premature withdrawal due to adverse events) of anti-epileptic drugs (AEDs) for refractory epilepsy. METHODS:We searched Cochrane Central Register of Controlled Trials (Cochrane Library 2009, issue 2) including Epilepsy Gro...

journal_title：British journal of clinical pharmacology

authors： Bodalia PN,Grosso AM,Sofat R,Macallister RJ,Smeeth L,Dhillon S,Casas JP,Wonderling D,Hingorani AD

更新日期：2013-11-01 00:00:00

abstract：:A potential kinetic interaction between cimetidine and flecainide has been studied in eight healthy males receiving flecainide (200 mg) orally on three occasions: before any treatment and on day 2 and day 7 of 8 days' cimetidine maintenance treatment at 1 g daily. Six days pretreatment with cimetidine induced the foll...

journal_title：British journal of clinical pharmacology

authors： Tjandra-Maga TB,van Hecken A,van Melle P,Verbesselt R,de Schepper PJ

更新日期：1986-07-01 00:00:00

abstract：:1. The absorption and disposition of paracetamol was investigated in 10 healthy male Thai vegetarians and 10 similar non-vegetarians following an oral dose of 20 mg kg-1. 2. The absorption rate of paracetamol was significantly impaired in the vegetarians compared with the non-vegetarians as shown by a lower mean Cmax ...

journal_title：British journal of clinical pharmacology

authors： Prescott LF,Yoovathaworn K,Makarananda K,Saivises R,Sriwatanakul K

更新日期：1993-09-01 00:00:00

abstract：:1. The pharmacokinetics of recombinant erythropoietin, r-Epo, were evaluated after intravenous and subcutaneous administration of 50 u kg-1 to six healthy male volunteers. 2. The calculated mean values (+/- s.d.) for volume of distribution at steady state and clearance after an i.v. dose were 76 (+/- 33) ml kg-1 and 1...

journal_title：British journal of clinical pharmacology

authors： Salmonson T,Danielson BG,Wikström B

更新日期：1990-06-01 00:00:00