Selective effects of low doses of apomorphine on spatiotemporal contrast sensitivity in healthy volunteers: a double-blind placebo-controlled study.

abstract：AIM:Characterization of the biliary disposition of GSK1325756, using a non-invasive bile sampling technique and spectrometric analyses, to inform the major routes of metabolic elimination and to enable an assessment of victim drug interaction risk. METHOD:Sixteen healthy, elderly subjects underwent non-invasive bile c...

journal_title：British journal of clinical pharmacology

authors： Bloomer JC,Nash M,Webb A,Miller BE,Lazaar AL,Beaumont C,Guiney WJ

更新日期：2013-02-01 00:00:00

abstract：:1 Seventeen men, aged 45-57 yr, with essential hypertension showed obvious and, in the standing position, dose-related reductions in blood pressure during treatment with oral labetalol with weekly dose increments. 2 Pulse rate changes were not related to dose but reduced compared with pre-treatment values. 3 No postur...

journal_title：British journal of clinical pharmacology

authors： Andersson O,Berglund G,Hansson L

更新日期：1976-08-01 00:00:00

abstract：AIMS:To study the impact of risperidone (RISP) on clozapine (CLZ) biotransformation in vitro in microsomal fractions containing varying expression of CYP oxidases and in vivo in patients. METHODS:Human liver microsomes (n= 11) were assessed for expression of CYPs 1A2, 2D6 and 3A4, because these enzymes mediate RISP an...

journal_title：British journal of clinical pharmacology

authors： Chetty M,d'Esposito F,Zhang WV,Glen J,Dore G,Stankovic Z,Edwards RJ,Ramzan I,Murray M

更新日期：2009-10-01 00:00:00

abstract：:1. In nine patients with essential hypertension, following single and multiple doses of ketanserin, assessments were made of blood pressure and heart rate, QT interval, and pressor responses to phenylephrine and angiotensin II. 2. Significant reductions in blood pressure occurred for 6 h after the first dose, on avera...

journal_title：British journal of clinical pharmacology

authors： Donnelly R,Elliott HL,Meredith PA,Reid JL

更新日期：1987-11-01 00:00:00

abstract：:1. Blood and urine concentrations of the macrolide immunosuppressant FK506 and its metabolites were measured in seven orthotopic liver transplant patients after the first oral dose of FK506 (0.04 +/- 0.02 mg kg-1) used as primary immunosuppressant. A specific h.p.l.c.-MS assay was used, allowing the measurement of par...

journal_title：British journal of clinical pharmacology

authors： Gonschior AK,Christians U,Braun F,Winkler M,Linck A,Baumann J,Sewing KF

更新日期：1994-12-01 00:00:00

abstract：AIMS:To examine the potency of ticlopidine (TCL) as an inhibitor of cytochrome P450s (CYP450s) in vitro using human liver microsomes (HLMs) and recombinant human CYP450s. METHODS:Isoform-specific substrate probes of CYP1A2, 2C19, 2C9, 2D6, 2E1 and 3A4 were incubated in HLMs or recombinant CYPs with or without TCL. Pre...

journal_title：British journal of clinical pharmacology

authors： Ko JW,Desta Z,Soukhova NV,Tracy T,Flockhart DA

更新日期：2000-04-01 00:00:00

abstract：:1 The effect of pregnancy on the binding of phenytoin and phenobarbitone to serum proteins was studied in normal women and in drug treated epileptic women. 2 The binding of both drugs was reduced during pregnancy. The reduction correlated positively with the gestational age and negatively with the serum albumin concen...

journal_title：British journal of clinical pharmacology

authors： Chen SS,Perucca E,Lee JN,Richens A

更新日期：1982-04-01 00:00:00

abstract：AIM:We compared the efficacy of melatonin and placebo as adjuvants in the withdrawal of patients from long term temazepam, zopiclone or zolpidem (here 'BZD') use. METHODS:A double-blind, placebo-controlled, randomized trial was conducted in a primary health care outpatient clinic. Ninety-two men or women (≥55 years) w...

journal_title：British journal of clinical pharmacology

authors： Lähteenmäki R,Puustinen J,Vahlberg T,Lyles A,Neuvonen PJ,Partinen M,Räihä I,Kivelä SL

更新日期：2014-06-01 00:00:00

abstract：:1 The potency of single doses of the aldosterone antagonist SC8109 relative to spironolactone in reversing the urinary electrolyte effects of fludrocortisone was examined in a double-blind, balanced, crossover study in six healthy volunteers. 2 For the urinary ratio log10 10Na/K, the relative potency of SC8109; spiron...

journal_title：British journal of clinical pharmacology

authors： McInnes GT,Harrison IR,Shelton JR,Perkins RM

更新日期：1981-11-01 00:00:00

abstract：AIM:To develop a semi-mechanistic model, based on glutathione depletion and predict a previously identified intra-individual reduction in busulfan clearance to aid in more precise dosing. METHODS:Busulfan concentration data, measured as part of regular care for allogeneic hematopoietic cell transplantation (HCT) patie...

journal_title：British journal of clinical pharmacology

authors： Langenhorst JB,Boss J,van Kesteren C,Lalmohamed A,Kuball J,Egberts ACG,Boelens JJ,Huitema ADR,van Maarseveen EM

更新日期：2020-08-01 00:00:00

abstract：AIM:To investigate the association between risk of lupus and exposure to selected drugs implicated in risk of lupus in a number of case reports. METHODS:In this matched nested case-control study we utilized primary care data from the UK General Practice Research Database recorded between 1987 and 2001. Cases with at l...

journal_title：British journal of clinical pharmacology

authors： Schoonen WM,Thomas SL,Somers EC,Smeeth L,Kim J,Evans S,Hall AJ

更新日期：2010-10-01 00:00:00

abstract：:1 We have performed a double-blind, randomized, 7-d cross-over study of the thromboxane synthetase inhibitor dazoxiben (UK 37248) in 20 patients with stable coronary heart disease. 2 All patients had a history of exertional angina of greater than two years duration and no patient had suffered a myocardial infarction i...

journal_title：British journal of clinical pharmacology

authors： Reuben SR,Kuan P,Cairns J,Gyde OH

更新日期：1983-01-01 00:00:00

abstract：:1 The effects of propranolol and atenolol given in random order in a cross-over study to fifteen patients with essential hypertension have been studied. 2 Both drugs were effective in lowering blood pressure and side effects were not markedly different. 3 There was no change in exchangeable sodium or potassium or in t...

journal_title：British journal of clinical pharmacology

authors： Wilkinson R,Stevens IM,Pickering M,Robson V,Hawkins T,Kerr DN,Harry JD

更新日期：1980-07-01 00:00:00

abstract：:Early clinical features of lead toxicity are non-specific and an occupational history is particularly valuable. Lead in the body comprises 2% in the blood (t1/2 35 days) and 95% in bone and dentine (t1/2 20-30 years). Blood lead may remain elevated for years after cessation from long exposure, due to redistribution fr...

journal_title：British journal of clinical pharmacology

authors： Gordon JN,Taylor A,Bennett PN

更新日期：2002-05-01 00:00:00

abstract：:1. In 48 patients with chronic asthma who had been receiving treatment with beclomethasone dipropionate aerosol (BDA) at a daily dose of 400 microgram for several years, observations were made on the effect of increasing the dose to 800 microgram daily for 6 months. 2. There was subjective improvement in 37 of the 48 ...

journal_title：British journal of clinical pharmacology

authors： Chatterjee SS

更新日期：1977-01-01 00:00:00

abstract：:1. The study was performed to determine the sensitivity and short-term and day-to-day variability of a novel technique based on laser interferometry of ocular fundus pulsations and of non-invasive methods for the quantification of haemodynamic drug effects. An additional aim was to assess sex differences in haemodynam...

journal_title：British journal of clinical pharmacology

authors： Wolzt M,Schmetterer L,Rheinberger A,Salomon A,Unfried C,Breiteneder H,Ehringer H,Eichler HG,Fercher AF

更新日期：1995-04-01 00:00:00

abstract：:Increasing doses of a slow-release potassium supplement were given to nine hypertensive patients previously treated for at least 18 months with bendrofluazide 10 mg daily. Serum potassium and total body potassium (TBK) were measured after 2 months on each dose. No significant increase in serum potassium or TBK occurre...

journal_title：British journal of clinical pharmacology

authors： Wilkinson PR,Tait C,Hesp R,Raftery EB

更新日期：1982-08-01 00:00:00

abstract：:1 The properties of a recently introduced digitalis glycoside, 4-beta-methyl digoxin (medigoxin) were compared to those of a standard digoxin preparation. Using a radioimmunoassay (RIA) technique, serial plasma levels were recorded for 8 h following a single oral dose in five fasting volunteer subjects, and urinary gl...

journal_title：British journal of clinical pharmacology

authors： Hayward RP,Greenwood H,Hamer J

更新日期：1978-07-01 00:00:00

abstract：AIM:To examine comprehensively the relationship between exposure to four classes of psychotropic drugs including antipsychotics, antidepressants, benzodiazepines (BZDs) and Z-drugs, and motor vehicle accidents (MVAs). METHOD:The authors conducted a matched case-control study of 5183 subjects with MVAs and 31 093 match...

journal_title：British journal of clinical pharmacology

authors： Chang CM,Wu EC,Chen CY,Wu KY,Liang HY,Chau YL,Wu CS,Lin KM,Tsai HJ

更新日期：2013-04-01 00:00:00

abstract：:1 A double-blind trial with parallel treatment groups was conducted to compare the safety and efficacy of mianserin with amitriptyline. 2 This was a six week trial with weekly visits. Measurements at each visit included: 21 item Hamilton Depression (HAMD) Scale. Clinical Global Impression (CGI) Scale and Treatment Eme...

journal_title：British journal of clinical pharmacology

authors： Feighner JP,Jacobs RS,Jackson RE,Hendrickson G,Merideth CH,O'Meara PD

更新日期：1983-01-01 00:00:00

abstract：:Catechol-O-methyltransferase (COMT) is of great importance in pharmacology because it catalyzes the metabolism (methylation) of endogenous and xenobiotic catechols. Moreover, inhibition of COMT is the drug target in the management of central nervous system (CNS) disorders such as Parkinson's disease due to its role in...

journal_title：British journal of clinical pharmacology

authors： Ma Z,Liu H,Wu B

更新日期：2014-03-01 00:00:00

abstract：AIMS:Reduced nitric oxide (NO) availability may adversely affect renal perfusion and glomerular filtration. The aim of the present study was to characterize in detail the pharmacological effects of VAS203, an inhibitor of NO synthase, on renal haemodynamics in humans. METHODS:This double-blind, randomized, placebo-con...

journal_title：British journal of clinical pharmacology

authors： Ott C,Bosch A,Winzer N,Friedrich S,Schinzel R,Tegtmeier F,Schmieder RE

更新日期：2019-05-01 00:00:00

abstract：AIMS:To determine the molecular basis of the intermediate extensive metaboliser (EM) CYP2D6 phenotype in healthy Gabonese subjects. METHODS:The CYP2D6 phenotype of 154 healthy Gabonese subjects was assessed by giving the subject a single dose of 30 mg dextromethorphan, and collecting their urine for the next 8 h. The ...

journal_title：British journal of clinical pharmacology

authors： Panserat S,Sica L,Gérard N,Mathieu H,Jacqz-Aigrain E,Krishnamoorthy R

更新日期：1999-01-01 00:00:00

abstract：:The effects of single oral doses of atenolol 50 mg and xamoterol 200 mg (a recently developed partial beta 1-adrenoceptor agonist) on lung function, heart rate and blood pressure were investigated in 11 patients with asthma. Xamoterol caused a significant increase in heart rate and systolic blood pressure, which chang...

journal_title：British journal of clinical pharmacology

authors： Lammers JW,Müller ME,Folgering HT,van Herwaarden CL

更新日期：1986-11-01 00:00:00

abstract：AIM:To evaluate a context-learning pharmacotherapy programme for approximately 750 2nd, 3rd and 4th year preclinical medical students with respect to mastering cognitive pharmacotherapeutic skills, i.e. choosing a (drug) treatment and determining patient information. METHODS:The context-learning pharmacotherapy progra...

journal_title：British journal of clinical pharmacology

authors： Vollebregt JA,van Oldenrijk J,Kox D,van Galen SR,Sturm B,Metz JC,Richir MC,de Haan M,Hugtenburg JG,de Vries TP

更新日期：2006-12-01 00:00:00

abstract：:1. A bicycle exercise test was used to investigate functional capability and haemodynamics in 30 patients with heart failure (13 NYHA Class II, 17 Class III), before and after i.v. xamoterol (Corwin, Carwin, Corwil, Xamtol, ICI 118,587) 0.2 mg kg-1. 2. Resting heart rate fell from 78 to 74 beats min-1 (P less than 0.0...

journal_title：British journal of clinical pharmacology

authors： Virk SJ,Davies MK

更新日期：1989-01-01 00:00:00

abstract：AIMS:Genetic factors, notably CYP2B6 516G→T [rs3745274] and 983T→C [rs28399499], explain much of the interindividual variability in efavirenz pharmacokinetics, but data from Africa are limited. We characterized relationships between genetic polymorphisms and plasma efavirenz concentrations in HIV-infected Black South A...

journal_title：British journal of clinical pharmacology

authors： Sinxadi PZ,Leger PD,McIlleron HM,Smith PJ,Dave JA,Levitt NS,Maartens G,Haas DW

更新日期：2015-07-01 00:00:00

abstract：:1 Plasma concentrations of metoprolol and a pharmacologically active metabolite, H119/66, have been measured in young and elderly volunteers after a single dose of 100 mg metoprolol tartrate and after repeated administrated over a period of 1 week. Whilst concentrations of metoprolol are similar in each group, concent...

journal_title：British journal of clinical pharmacology

authors： Quarterman CP,Kendall MJ,Jack DB

更新日期：1981-03-01 00:00:00

abstract：:1 The anti-hypertensive effect of labetalol given twice or three times daily was evaluated in ambulant subjects with essential hypertension by recording blood pressure directly for 24 h before and after 15 d of labetalol administration (daily dose 600-1800 mg). 2 Labetalol reduced 24 h systolic and diastolic blood pre...

journal_title：British journal of clinical pharmacology

authors： Mancia G,Pomidossi G,Parati G,Bertinieri G,Grassi G,Navone F,Ferrari A,Gregorini L,Zanchetti A

更新日期：1982-06-01 00:00:00

abstract：AIMS:Therapeutic drug monitoring of infliximab can guide clinical decisions in patients with loss of response and in those who can benefit from a de-intensification. The aim of this study was to determine the impact of therapeutic drug monitoring combined with Bayesian forecasting methodology on clinical response in a ...

journal_title：British journal of clinical pharmacology

authors： Santacana Juncosa E,Rodríguez-Alonso L,Padullés Zamora A,Guardiola J,Rodríguez-Moranta F,Serra Nilsson K,Bas Minguet J,Morandeira Rego F,Colom Codina H,Padullés Zamora N

更新日期：2020-06-03 00:00:00