Effect of the degree of polar mismatching on traffic jam formation in fast axonal transport.

Abstract:

:This paper simulates an axon with a region of reversed microtubule (MT) polarity, and investigates how the degree of polar mismatching in this region affects the formation of organelle traps in the axon. The model is based on modified Smith-Simmons equations governing molecular-motor-assisted transport in neurons. It is established that the structure that develops as a result of a region with disoriented MTs consists of two organelle traps, the trap to the left of this region accumulates plus-end-oriented organelles and the trap to the right of this region accumulates minus-end-oriented organelles. The presence of such a structure is shown to inhibit the transport of organelles down the axon. The degree by which the transport of organelles is inhibited depends on the degree of polar mismatching of MTs in the region between MT traps. Four cases with a different degree of polar mismatching are investigated.

authors

Kuznetsov AV

doi

10.1080/10255840903505154

subject

Has Abstract

pub_date

2010-12-01 00:00:00

pages

711-22

issue

6

eissn

1025-5842

issn

1476-8259

pii

920291996

journal_volume

13

pub_type

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