Abstract:
:Pretreatment of tissues with potassium channel openers (KCO's) has been observed to be cytoprotective in a broad variety of insults. This phenomenon has been proposed to be intimately linked to activation of mitochondrial potassium channels which apparently modulate the mitochondrial production of reactive oxygen species (ROS). This critical review summarizes literature findings about the mitochondrial production of ROS, the action of KCO's on mitochondrial ROS production and the putative link to the cytoprotective action of these drugs.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Malinska D,Mirandola SR,Kunz WSdoi
10.1016/j.febslet.2010.01.013subject
Has Abstractpub_date
2010-05-17 00:00:00pages
2043-8issue
10eissn
0014-5793issn
1873-3468pii
S0014-5793(10)00032-3journal_volume
584pub_type
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