A reliability measure of protein-protein interactions and a reliability measure-based search engine.

Abstract:

:Many methods developed for estimating the reliability of protein-protein interactions are based on the topology of protein-protein interaction networks. This paper describes a new reliability measure for protein-protein interactions, which does not rely on the topology of protein interaction networks, but expresses biological information on functional roles, sub-cellular localisations and protein classes as a scoring schema. The new measure is useful for filtering many spurious interactions, as well as for estimating the reliability of protein interaction data. In particular, the reliability measure can be used to search protein-protein interactions with the desired reliability in databases. The reliability-based search engine is available at http://yeast.hpid.org. We believe this is the first search engine for interacting proteins, which is made available to public. The search engine and the reliability measure of protein interactions should provide useful information for determining proteins to focus on.

authors

Park B,Han K

doi

10.1080/10255842.2010.494039

subject

Has Abstract

pub_date

2010-02-01 00:00:00

pages

97-104

issue

1

eissn

1025-5842

issn

1476-8259

pii

913589776

journal_volume

13

pub_type

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