Abstract:
:Many methods developed for estimating the reliability of protein-protein interactions are based on the topology of protein-protein interaction networks. This paper describes a new reliability measure for protein-protein interactions, which does not rely on the topology of protein interaction networks, but expresses biological information on functional roles, sub-cellular localisations and protein classes as a scoring schema. The new measure is useful for filtering many spurious interactions, as well as for estimating the reliability of protein interaction data. In particular, the reliability measure can be used to search protein-protein interactions with the desired reliability in databases. The reliability-based search engine is available at http://yeast.hpid.org. We believe this is the first search engine for interacting proteins, which is made available to public. The search engine and the reliability measure of protein interactions should provide useful information for determining proteins to focus on.
journal_name
Comput Methods Biomech Biomed Enginauthors
Park B,Han Kdoi
10.1080/10255842.2010.494039subject
Has Abstractpub_date
2010-02-01 00:00:00pages
97-104issue
1eissn
1025-5842issn
1476-8259pii
913589776journal_volume
13pub_type
杂志文章abstract::Functional Alignment is a new method to determine the orientation of a joint's primary rotational axis and the associated movement. It employs three unique concepts. First, data analyses are based upon assessment of spatial positions and not upon movement in a time sequence. Second, analyses are conducted on derived j...
journal_title:Computer methods in biomechanics and biomedical engineering
pub_type: 杂志文章
doi:10.1080/10255842.2010.545821
更新日期:2012-01-01 00:00:00
abstract::The aim of this work was to improve the constitutive model of the human mandible and dentition system by taking into account the non-linear material properties of the structural boney matrix that forms the human jaw bone or mandible. Due to the specific structure of the jaw bone the time dependence of the mechanical p...
journal_title:Computer methods in biomechanics and biomedical engineering
pub_type: 杂志文章
doi:10.1080/10255840310001637257
更新日期:2003-10-01 00:00:00
abstract::Numerical predictions of blood flow patterns and hemodynamic stresses in Abdominal Aortic Aneurysms (AAAs) are performed in a two-aneurysm, axisymmetric, rigid wall model using the spectral element method. Homogeneous, Newtonian blood flow is simulated under steady conditions for the range of Reynolds numbers 10 < or ...
journal_title:Computer methods in biomechanics and biomedical engineering
pub_type: 杂志文章
doi:10.1080/1025584021000009742
更新日期:2002-08-01 00:00:00
abstract::Traumatic brain injury (TBI), induced by impact of an object with the head, is a major health problem worldwide. Rats are a well-established animal analogue for study of TBI and the weight-drop impact-acceleration (WDIA) method is a well-established model in rats for creating diffuse TBI, the most common form of TBI s...
journal_title:Computer methods in biomechanics and biomedical engineering
pub_type: 杂志文章
doi:10.1080/10255842.2017.1280733
更新日期:2017-05-01 00:00:00
abstract::At present, computer assisted surgery systems help orthopaedic surgeons both plan and perform surgical procedures. To enable these systems to function, it is crucial to have at one's disposal 3D models of anatomical structures, surgical tools and prostheses (if required). This paper analyses and compares three methods...
journal_title:Computer methods in biomechanics and biomedical engineering
pub_type: 杂志文章
doi:10.1080/10255840903077329
更新日期:2009-02-01 00:00:00
abstract::A three-dimensional finite element model is developed for the simulation of the sound transmission through the human auditory periphery consisting of the external ear canal, middle ear and cochlea. The cochlea is modelled as a straight duct divided into two fluid-filled scalae by the basilar membrane (BM) having an or...
journal_title:Computer methods in biomechanics and biomedical engineering
pub_type: 杂志文章
doi:10.1080/10255842.2012.737458
更新日期:2014-08-01 00:00:00
abstract::Pedestrians are the most vulnerable road user and represent about 23% of the road traffic deaths in the world. A finite element (FE) model corresponding to a 5th percentile female pedestrian (F05-PS) was developed by morphing the Global Human Body Models Consortium (GHBMC) 50th percentile male pedestrian (M50-PS) mode...
journal_title:Computer methods in biomechanics and biomedical engineering
pub_type: 杂志文章
doi:10.1080/10255842.2020.1801652
更新日期:2020-12-01 00:00:00
abstract::The International Society of Biomechanics (ISB) has recommended a standardisation for the motion reporting of almost all human joints. This study proposes an adaptation for the trapeziometacarpal joint. The definition of the segment coordinate system of both trapezium and first metacarpal is based on functional anatom...
journal_title:Computer methods in biomechanics and biomedical engineering
pub_type: 杂志文章
doi:10.1080/10255840802459404
更新日期:2009-06-01 00:00:00
abstract::The purpose of this study is to develop a system capable of performing calculation of temporal gait parameters using two low-cost wireless accelerometers and artificial intelligence-based techniques as part of a larger research project for conducting human gait analysis. Ten healthy subjects of different ages particip...
journal_title:Computer methods in biomechanics and biomedical engineering
pub_type: 杂志文章
doi:10.1080/10255842.2015.1032945
更新日期:2016-01-01 00:00:00
abstract::The aim of this study was to present a new training algorithm using artificial neural networks called multi-objective least absolute shrinkage and selection operator (MOBJ-LASSO) applied to the classification of dynamic gait patterns. The movement pattern is identified by 20 characteristics from the three components o...
journal_title:Computer methods in biomechanics and biomedical engineering
pub_type: 杂志文章
doi:10.1080/10255842.2013.803081
更新日期:2015-01-01 00:00:00
abstract::In this study, the effects of medial collateral ligament (MCL) release and the limb correction strategies with pre-existing MCL laxity on tibiofemoral contact force distribution after high tibial osteotomy (HTO) were investigated. The medial and lateral contact forces of the knee were quantified during simulated stand...
journal_title:Computer methods in biomechanics and biomedical engineering
pub_type: 杂志文章
doi:10.1080/10255842.2018.1549658
更新日期:2019-02-01 00:00:00
abstract::In order to improve the reliability of children's models, the aim of this study was to determine the subject-specific masses and 3D locations of the centres of mass (CoM) of body segments using biplanar X-rays. Previous methods, validated on upper leg segments, were applied to the whole body. Six children and six adul...
journal_title:Computer methods in biomechanics and biomedical engineering
pub_type: 杂志文章
doi:10.1080/10255841003717608
更新日期:2010-12-01 00:00:00
abstract::Understanding of cancellous bone permeability is lacking despite its importance in designing tissue engineering scaffolds for bone regeneration and orthopaedic surgery that relies on infiltration of bone cement into porous cancellous bone. We employed micro-computational fluid dynamics to investigate permeability for ...
journal_title:Computer methods in biomechanics and biomedical engineering
pub_type: 杂志文章
doi:10.1080/10255842.2010.539563
更新日期:2012-01-01 00:00:00
abstract::In this work, we present a technique to semi-automatically quantify the epicardial fat in non-contrasted computed tomography (CT) images. The epicardial fat is very close to the pericardial fat, being separated only by the pericardium that appears in the image as a very thin line, which is hard to detect. Therefore, a...
journal_title:Computer methods in biomechanics and biomedical engineering
pub_type: 杂志文章
doi:10.1080/10255842.2010.499871
更新日期:2011-10-01 00:00:00
abstract::The aim of this paper is to use a poroviscohyperelastic (PVHE) model, which is developed based on the porohyperelastic (PHE) model to explore the mechanical deformation properties of single chondrocytes. Both creep and relaxation responses are investigated by using finite element analysis models of micropipette aspira...
journal_title:Computer methods in biomechanics and biomedical engineering
pub_type: 杂志文章
doi:10.1080/10255842.2014.996875
更新日期:2016-01-01 00:00:00
abstract::We present a one-dimensional (1D) fluid dynamic model that can predict blood flow and blood pressure during exercise using data collected at rest. To facilitate accurate prediction of blood flow, we developed an impedance boundary condition using morphologically derived structured trees. Our model was validated by com...
journal_title:Computer methods in biomechanics and biomedical engineering
pub_type: 杂志文章
doi:10.1080/10255840601068638
更新日期:2007-02-01 00:00:00
abstract::The aim of this study is to evaluate the fracture union or non-union for a specific patient that presented oblique fractures in tibia and fibula, using a mechanistic-based bone healing model. Normally, this kind of fractures can be treated through an intramedullary nail using two possible configurations that depends o...
journal_title:Computer methods in biomechanics and biomedical engineering
pub_type: 杂志文章
doi:10.1080/10255842.2015.1125473
更新日期:2016-09-01 00:00:00
abstract::The purpose of this study was to identify one or more performance-based criteria that may be used to generate predictive optimal control simulations of submaximal pedaling. Two-legged pedaling simulations were generated based on minimizing muscle activation, muscle stress, metabolic energy, time derivative of muscle f...
journal_title:Computer methods in biomechanics and biomedical engineering
pub_type: 杂志文章
doi:10.1080/10255842.2018.1522535
更新日期:2019-01-01 00:00:00
abstract::New trends of numerical models of human joints require more and more computation of both large amplitude joint motions and fine bone stress distribution. Together, these problems are difficult to solve and very CPU time consuming. The goal of this study is to develop a new method to diminish the calculation time for t...
journal_title:Computer methods in biomechanics and biomedical engineering
pub_type: 杂志文章
doi:10.1080/1025584021000016843
更新日期:2002-12-01 00:00:00
abstract::When treating thoracolumbar burst fractures (BF), short-segment posterior fixation (SSPF) represents a less invasive alternative to the traditional long-segment posterior fixation (LSPF) approach. However, hardware failure and loss of sagittal alignment have been reported in patients treated with SSPF. Including pedic...
journal_title:Computer methods in biomechanics and biomedical engineering
pub_type: 杂志文章
doi:10.1080/10255842.2017.1366995
更新日期:2017-10-01 00:00:00
abstract::A novel, coarse-grained, single-framework 'Eulerian' model for blood flow in the microvascular circulation is presented and used to estimate the variations in flow properties that accrue from all of the following: (i) wall position variation, associated with the endothelial cells' (ECs) shape, (ii) glycocalyx layer (G...
journal_title:Computer methods in biomechanics and biomedical engineering
pub_type: 杂志文章
doi:10.1080/10255842.2013.799146
更新日期:2015-01-01 00:00:00
abstract::This paper introduces a 'hypothesis about the growth pattern of the secondary ossification centre (SOC)', whereby two phases are assumed. First, the formation of cartilage canals as an event essential for the development of the SOC. Second, once the canals are merged in the central zone of the epiphysis, molecular fac...
journal_title:Computer methods in biomechanics and biomedical engineering
pub_type: 杂志文章
doi:10.1080/10255842.2010.484810
更新日期:2011-01-01 00:00:00
abstract::Woodpeckers can withstand a fierce impact during pecking without any brain injury. Although directly involved in the whole pecking, the role of the jaw apparatus played in the impact-resistant process of woodpeckers is still not fully clear. We employed finite element analysis, impact tests in vivo, and post-traumatic...
journal_title:Computer methods in biomechanics and biomedical engineering
pub_type: 杂志文章
doi:10.1080/10255842.2020.1838489
更新日期:2021-01-13 00:00:00
abstract::Manual segmentation of articular cartilage from knee joint 3D magnetic resonance images (MRI) is a time consuming and laborious task. Thus, automatic methods are needed for faster and reproducible segmentations. In the present study, we developed a semi-automatic segmentation method based on radial intensity profiles ...
journal_title:Computer methods in biomechanics and biomedical engineering
pub_type: 杂志文章
doi:10.1080/10255842.2017.1375477
更新日期:2017-10-01 00:00:00
abstract::Soft tissue modelling has gained a great deal of importance, for a large part due to its application in surgical training simulators for minimally invasive surgery (MIS). This article provides a structured overview of different continuum-mechanical models that have been developed over the years. It aims at facilitatin...
journal_title:Computer methods in biomechanics and biomedical engineering
pub_type: 杂志文章,评审
doi:10.1080/10255840802020412
更新日期:2008-08-01 00:00:00
abstract::Much attention has been devoted to how playground swing amplitudes are built up by swinger techniques, i.e. body actions. However, very little attention has been given to the requirements that such swinger techniques place on the swinger himself. The purpose of this study was to find out whether different swinger tech...
journal_title:Computer methods in biomechanics and biomedical engineering
pub_type: 杂志文章
doi:10.1080/10255842.2011.572280
更新日期:2012-01-01 00:00:00
abstract::Blunt and rotational head impacts due to vehicular collisions, falls and contact sports cause relative motion between the brain and skull. This increases the normal and shear stresses in the (skull/brain) interface region consisting of cerebrospinal fluid (CSF) and subarachnoid space (SAS) trabeculae. The relative mot...
journal_title:Computer methods in biomechanics and biomedical engineering
pub_type: 杂志文章
doi:10.1080/10255840903064897
更新日期:2009-02-01 00:00:00
abstract::To analyze the biomechanical effect of syndesmotic screw through three and four cortices, a total of 12 finite element models simulating healthy ankles, tibiofibular syndesmosis injured ankles, and post-operative ankles by screw fixations through three or four cortices were built. A set of biomechanical data were obta...
journal_title:Computer methods in biomechanics and biomedical engineering
pub_type: 杂志文章
doi:10.1080/10255842.2018.1472770
更新日期:2018-04-01 00:00:00
abstract::Preoperative planning, or intraoperative navigation of hip surgery, including joint-preserving procedures such as osteotomy or joint-replacing procedures such as total arthroplasty, needs to be performed with a high degree of accuracy to ensure a successful outcome. The ability to precisely localise the hip joint rota...
journal_title:Computer methods in biomechanics and biomedical engineering
pub_type: 杂志文章
doi:10.1080/10255842.2010.495064
更新日期:2011-01-01 00:00:00
abstract::The flow effect on the concentration of platelet active substances in the vicinity of a mural microthrombus is investigated numerically. A three-dimensional model is employed in which the mural microthrombus is modelled as a semisphere attached to a plane surface. The description of the blood flow uses the three-dimen...
journal_title:Computer methods in biomechanics and biomedical engineering
pub_type: 杂志文章
doi:10.1080/01495739808936708
更新日期:1998-01-01 00:00:00