Abstract:
:Summary The authors studied the combination of Kathon(R) CG and Germall(R) II (0.1%-0.1%) in hydrophilic creams. Their objective was to find an alternative to the use of parabens. Kathon(R) CG was chosen due to its antimicrobial effectiveness and its broad spectrum of activity. It must be indicated, however, that it has only a weak action against Staphylococcus aureus. In order to reinforce its microbicidal action it was combined with Germall(R) II. The Kathon(R) CG-Germall(R) II combination showed addition, indeed even synergy, with respect to Escherichia coli (Gram negative rod) and Aspergillus niger (fungus). In the case of Candida albicans (yeast) the antifungal effect of Kathon(R) CG dominates. Finally, the combination can have effects from addition to antagonism in the case of the three strains of Staphylococcus aureus tested (Gram positive coccus). The time required to eliminate 10(6) UFC of these bacteria per g of cream can often exceed 48 h. If the concentration of Germall(R) II is increased to 0.3% then the effectiveness of the mixture is markedly reinforced. Caution must be observed, however, due to recent apprehensions expressed by certain dermatologists concerning possible allergic reactions due to Kathon(R) CG. A multi-centre patch test study is currently being carried out with this preservative in the dermatological clinics of the five Swiss university hospitals.
journal_name
Int J Cosmet Scijournal_title
International journal of cosmetic scienceauthors
Favet J,Griffiths W,Holzner G,Amacker PA,Schorer Edoi
10.1111/j.1467-2494.1987.tb00463.xsubject
Has Abstractpub_date
1987-04-01 00:00:00pages
59-72issue
2eissn
0142-5463issn
1468-2494pii
ICS59journal_volume
9pub_type
杂志文章abstract:OBJECTIVE:The roots of the herb Paeonia lactiflora ('White Peony') are used in association with other herbs in traditional clinical cosmetic practice in China as oral treatment for skin pigmentary disorders, such as brown or dark pigmentary spots. However, the skin-depigmenting potential of Paeonia lactiflora root extr...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12309
更新日期:2016-10-01 00:00:00
abstract::Body odours are generated from dead skin cells and secreted materials, such as sweat and sebum, through the metabolism of microorganisms living on the skin. Volatile steroids, key compounds in body odours, are also generated through the metabolism of microorganisms. These volatile steroids strengthen the intensity of ...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1467-2494.2006.00297.x
更新日期:2006-02-01 00:00:00
abstract:OBJECTIVES:Ageing leads to characteristic changes in the appearance of facial skin. Among these changes, we can distinguish the skin topographic cues (skin sagging and wrinkles), the dark spots and the dark circles around the eyes. Although skin changes are similar in Caucasian and Chinese faces, the age of occurrence ...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12128
更新日期:2014-08-01 00:00:00
abstract::The comparison of the results of microscopic, conductimetric and rheologic analyses carried out on the same triple W/O/W emulsion, immediately following its manufacture and 10 years later, indicates the remarkable stability of such system. This stability illustrates the great potential of this formula in the protectio...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1046/j.1467-2494.2000.00020.x
更新日期:2000-04-01 00:00:00
abstract:OBJECTIVE:Several studies have shown that a deterioration of skin properties, an impaired cutaneous microcirculatory function and an imbalance of autonomic nervous activity are observed in smokers and in patients with diabetes mellitus or Raynaud's phenomenon. These observations suggest that skin properties are associa...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12373
更新日期:2017-06-01 00:00:00
abstract::The stability constants for the inclusion of fragrance materials with 2-hydroxypropyl-beta-cyclodextrin (2HP-beta-C yD) in aqueous solution have been determined by the static head-space method. The 1:1 stability constants obtained by this method were in reasonable agreement with the corresponding values in the literat...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1046/j.1467-2494.1999.203156.x
更新日期:1999-06-01 00:00:00
abstract::The aim of this work was to investigate the effects of 1,18-octadecen-9-dioic acid (dioic acid) and a Rumex occidentalis extract complex for their skin-lightening action in an Indian population. Prior to the clinical study, the efficacy of dioic as an inhibitor of melanogenesis was confirmed on dark-pigmented human me...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12002
更新日期:2012-12-01 00:00:00
abstract::Skin firmness, elasticity and tone are gradually lost with age. These changes originate in the dermis and correspond to a decrease in the ability of cells, particularly the fibroblasts, to regenerate the molecules which make up the extracellular matrix. Skin ageing is also characterized by a reduction of the epidermal...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1046/j.1467-2494.1998.171748.x
更新日期:1998-06-01 00:00:00
abstract::The process leading to the loss of corneocytes form the skin surface is termed desquamation. In healthy skin it is an orderly and essentially invisible process whereby individual or small groups of corneocytes detach from neighbouring cells to be lost to the environment and replaced by younger cells from the deeper la...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1046/j.1467-2494.2000.00001.x
更新日期:2000-02-01 00:00:00
abstract::Reconstructed human epidermis models (RHE) constitute an innovative alternative to study phototoxicity and photoprotection in the cosmetic industry. However, little information is currently available concerning the harmful effects of solar-simulated radiation (SSR) in these in vitro skin models. In this study, the pho...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1468-2494.2009.00506.x
更新日期:2009-08-01 00:00:00
abstract:OBJECTIVE:Vitamin C and peptides are widely used in cosmetic products but there is a paucity of clinical studies showing that the formulations are effective in treating signs of facial ageing. These 3 clinical studies evaluated the effectiveness of an anti-ageing formula containing natural vitamin C (10%), biopeptides ...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12665
更新日期:2020-10-10 00:00:00
abstract:OBJECTIVE:Arbutin is an effective agent for the treatment of melanin disorders. Arbutin may be converted to hydroquinone under conditions of high temperature, ultraviolet (UV) radiation and dilute acid. The aim of the current study was to develop an analytical method to determine the levels of arbutin and hydroquinone ...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12228
更新日期:2015-12-01 00:00:00
abstract::Lower eyelid sags as well as wrinkles represent age-related morphological changes of the skin surface. However, a quantitative method to evaluate lower eyelid sagging has not been previously established. We designed a new quantitative evaluation method that uses non-invasive skin scanning, which is based on the differ...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1467-2494.2005.00282.x
更新日期:2005-10-01 00:00:00
abstract::There are a variety of biological mechanisms that contribute to specific characteristics of ageing skin; for example, the loss of skin structure proteins, increased susceptibility to UV-induced pigmentation and/or loss of hydration. Each of these biological processes is influenced by specific groups of genes. In this ...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1468-2494.2011.00645.x
更新日期:2011-10-01 00:00:00
abstract::Fading of artificial hair colour has been investigated by simulating actual usage conditions through exposure to artificial radiation in a weatherometer, with 0.35 mW (m(2)nm)(-1) at 340 nm, for 16-48 h, and by periodical washing. Hair colour was produced by using commercial two-part, permanent hair dyes with light au...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1467-2494.2006.00314_3.x
更新日期:2006-06-01 00:00:00
abstract::In the present study, we tested a new device called skin phototype diagnosis (SPD) built for the purpose of objectively determining skin phototype. We compared its performance with that of phototype determinations according to Fitzpatrick method and on tristimulus colorimetry (Minolta CR-200). Our population consisted...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1046/j.1467-2494.2002.00136.x
更新日期:2002-08-01 00:00:00
abstract:OBJECTIVES:Liposomes are commonly used in cosmetic formulations to increase the bioavailability of active ingredients. We have previously shown that polysaccharide coating of liposomes improves their resistance to surfactants and electrolytes. In the current study, we have assessed the impact of coating on the skin pen...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12394
更新日期:2017-08-01 00:00:00
abstract::Synopsis A brief review of new techniques of assessing skin irritancy is presented. Some of the difficulties of assessing minor degrees of irritancy are discussed. ...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1467-2494.1979.tb00229.x
更新日期:1979-12-01 00:00:00
abstract::Molecular chaperone, heat shock proteins (HSPs), stabilizes intracellular processes of cells under stress. Little is known about the role of molecular chaperone proteins in the skin pathology, rejuvenation and wound healing, or whether their expression is altered by environmental and physiological stress to the skin o...
journal_title:International journal of cosmetic science
pub_type: 杂志文章,评审
doi:10.1111/j.1468-2494.2010.00601.x
更新日期:2011-02-01 00:00:00
abstract::Singlet-oxygen is a non-radical reactive oxygen species believed to play a major role in many photooxidation processes in connection with diverse photo-biological processes such as skin ageing or photocarcinogenesis. Dimethylmethoxy chromanol (3,4-dihydro-6-hydroxy-2,2-dimethyl-7-methoxy-1(2H)-benzopyran) is a potent ...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12039
更新日期:2013-06-01 00:00:00
abstract::The perceived skin feel during and after application of skin care products is highly important to the consumer and therefore to cosmetic formulators. Powder particles are commonly incorporated in cosmetic formulations to improve their sensory properties. Although a large variety of cosmetic powders is available, it is...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1468-2494.2012.00734.x
更新日期:2012-10-01 00:00:00
abstract::It is well known that the shelf-life of products containing dihydroxyacetone (DHA) is quite unsatisfactory, and that in this area the adjustment to an acidic pH is the way usually recommended to improve DHA stability. The adoption of this rule, however, is a challenge for the cosmetic chemist not only because of the r...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1467-2494.2007.00381.x
更新日期:2007-06-01 00:00:00
abstract:OBJECTIVE:Lip plumpers should enhance lip volume. It has been shown that no noticeable result was obtained after long term use of these products. The present study has been carried out to assess lip plumpers' short term effectiveness within 2 h from application. METHODS:Effectiveness was assessed using non-invasive te...
journal_title:International journal of cosmetic science
pub_type: 杂志文章,随机对照试验
doi:10.1111/ics.12383
更新日期:2017-08-01 00:00:00
abstract:OBJECTIVE:Equol has been shown to improve skin health and regeneration, due to its antioxidative, phytoestrogenic and epigenetic characteristics. The effects of a topical intervention on skin structure, telomere length and epigenetic markers in skin cells were analysed. METHODS:Sixty-four participants were divided in ...
journal_title:International journal of cosmetic science
pub_type: 杂志文章,随机对照试验
doi:10.1111/ics.12408
更新日期:2017-10-01 00:00:00
abstract::Synopsis An investigation has been carried out into the synthesis of quaternary ammonium salts of triglycerides. The aim of this work was to produce such compounds without breaking the triglyceride skeleton. The reaction of chloracetyl chloride with the triglyceride of ricinoleic acid which is the major constituent (8...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1467-2494.1991.tb00560.x
更新日期:1991-08-01 00:00:00
abstract::The present investigation describes a comparative study for the design of innovative topical formulation for skin hydration. In particular, different colloidal forms based on lipidic components have been produced and characterized. Morphology and dimensional distribution have been investigated by means of electron mic...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1467-2494.2007.00362.x
更新日期:2007-02-01 00:00:00
abstract::The oxidative stress element of unhealthy scalp leads to compromised pre-emergent hair formation and poorly formed hair as it grows. Only cosmetic solutions can minimize the impact of unhealthy hair and to achieve healthy looking and feeling hair, the scalp health must be normalized first. The objectives of this resea...
journal_title:International journal of cosmetic science
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/ics.12289
更新日期:2015-12-01 00:00:00
abstract::The hydroglycolic (HG) extract from 70% propylene glycol (PG) extraction of myrobalan fruits showed the most appreciable antioxidant efficiency towards 1,1-diphenyl-2-picrylhydrazyl (DPPH) in comparison to the extracts from 30, 50, 70 and 100% ethyl alcohol (EA), and 30, 50 and 100% PG . Its total polyphenols were als...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1468-2494.2011.00642.x
更新日期:2011-08-01 00:00:00
abstract::Summary The activity of thioglycolic acid, incorporated in a microemulsion, towards cystine residues present in keratin proteins has been investigated. In an attempt to relate the structural state of the microemulsions to cystine reactivity, an appropriate model system showing a large microemulsion domain with diverse...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1467-2494.1987.tb00476.x
更新日期:1987-10-01 00:00:00
abstract::Synopsis The dichlorophenyl-imidazoldioxolan elubiol is used for skin and hair care in subjects with oily skin or dandruff. A study was conducted in 14 men to evaluate by non-invasive methods the effect of long-term use of elubiol on the sebum output at the skin surface. Measures were made using the Sebumeter SM810 an...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1467-2494.1996.tb00152.x
更新日期:1996-10-01 00:00:00