Abstract:
:Molecular chaperone, heat shock proteins (HSPs), stabilizes intracellular processes of cells under stress. Little is known about the role of molecular chaperone proteins in the skin pathology, rejuvenation and wound healing, or whether their expression is altered by environmental and physiological stress to the skin or systemic disease. The focus of this study was to examine the role of molecular chaperone proteins in the skin's local response to wounding, skin ageing and a range of skin diseases. Free radicals, one form of insult, induce or contribute to adverse effects on the skin, including erythema, oedema, wrinkling, photoaging, inflammation, autoimmune reactions, hypersensitivity, keratinization abnormalities, preneoplastic lesions and skin cancer. A unified view of the molecular and cellular pathogenesis of the skin age-related pathology conditions has led to the search for molecular and chemical chaperones that can slow, arrest or revert disease progression. Specific alpha-crystallin domains and pharmacological imidazole-containing dipeptide chaperone molecules are now emerging that link our biophysical insights with developed skin therapeutic techniques. In this article, we discuss the molecular nature of the stress signals, the mechanisms that underlie activation of the heat shock response, the role of molecular chaperone proteins as skin protective molecules, and strategies for pharmacologically active chaperone molecules and their imidazole-containing dipeptide inducers as regulators of the skin stress response. We discuss how impairment in protein hydration may cause ultrastructural, mechanical and biochemical changes in structural proteins in the aged skin. We have pioneered the molecular chaperone protein activated therapeutic or cosmetic platform to enable simultaneous analysis of water-binding and structuring characteristics for biology of skin ageing and skin disease-related pathways. This cutting-edge technology has improved the way that proteins hydrate in photoaged skin. The mechanisms of skin diseases, ageing, cellular, and signalling pathways mediated by targeting with molecular chaperone protein(s) in patented formulations with imidazole containing dipeptide (N-acetylcarnosine, carcinine, carnosine) are also discussed within this review.
journal_name
Int J Cosmet Scijournal_title
International journal of cosmetic scienceauthors
Babizhayev MA,Nikolayev GM,Nikolayeva JG,Yegorov YEdoi
10.1111/j.1468-2494.2010.00601.xsubject
Has Abstractpub_date
2011-02-01 00:00:00pages
1-16issue
1eissn
0142-5463issn
1468-2494pii
ICS601journal_volume
33pub_type
杂志文章,评审abstract:OBJECTIVE:The objective of our research was to investigate the reduction mechanism of thioglycerol (TG) on hair keratin fibres. METHODS:The structure of cross-sections at various depths of virgin white human hair resulting from the permanent waving process with TG was directly analysed at the molecular level using Ram...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12429
更新日期:2018-02-01 00:00:00
abstract::It is well established that the evaporation of sweat from the human body surface is the main mechanism by which heat balance is maintained following a rise in body core temperature. Since the introduction of the first brand name antiperspirant in the United States during the early 1900s, antiperspirant products design...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1046/j.1467-2494.2003.00184.x
更新日期:2003-08-01 00:00:00
abstract::Solid lipid nanoparticle (SLN) was regarded as new topical delivery systems for pharmaceutical and cosmetic active ingredients. The purpose of this study is to develop carrier systems for organic and inorganic sunscreens based on a matrix composed of carnauba wax and decyl oleate. Formulae (F1-F7) were prepared using ...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1468-2494.2010.00598.x
更新日期:2011-02-01 00:00:00
abstract::Variable skin pH values are being reported in literature, all in the acidic range but with a broad range from pH 4.0 to 7.0. In a multicentre study (N = 330), we have assessed the skin surface pH of the volar forearm before and after refraining from showering and cosmetic product application for 24 h. The average pH d...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1467-2494.2006.00344.x
更新日期:2006-10-01 00:00:00
abstract:OBJECTIVE:To investigate the efficacy of 13 antimicrobial substances (11 substances of natural origin and two conventional preservatives as controls) at two concentrations in an o/w cosmetic emulsion. METHODS:Cosmetic formulations were analysed for total aerobic bacterial count and total combined yeast count according...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12461
更新日期:2018-05-05 00:00:00
abstract::Synopsis We have examined the relationship between human axillary skin microflora and underarm odour (UAO), in particular, the ability of cutaneous bacteria to transform steroids. A study was made of bacterial population density and odour intensity of the axillae of 34 normal male subjects. There was a statistically s...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1467-2494.1990.tb00535.x
更新日期:1990-10-01 00:00:00
abstract:BACKGROUND:Mechanical analysis of human hair may provide the dermatologists with several markers of considerable diagnostic importance. The aim of this study was to analyse the physical and mechanical properties of Tunisian women's hair. METHODS:Surface characteristics were determined with scanning electron microscopy...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12313
更新日期:2016-10-01 00:00:00
abstract::Several treatments for skin whitening are available today, but few of them are completely adequate, especially owing to the carcinogenic potential attributed to classical drugs like hydroquinone, arbutin and kojic acid. To provide an alternative and safer technology for whitening, we developed two botanical compounds ...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1468-2494.2012.00736.x
更新日期:2012-10-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to clarify the effects of different body washing methods on skin texture. METHODS:Subjects were nine healthy women in their 20s. Skin on the inside of the forearms was washed every day for 4 weeks with protective washing (right forearm) and with non-protective washing (left fo...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12114
更新日期:2014-04-01 00:00:00
abstract::Reconstructed human epidermis models (RHE) constitute an innovative alternative to study phototoxicity and photoprotection in the cosmetic industry. However, little information is currently available concerning the harmful effects of solar-simulated radiation (SSR) in these in vitro skin models. In this study, the pho...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1468-2494.2009.00506.x
更新日期:2009-08-01 00:00:00
abstract::Synopsis Oil/water (o/w) microemulsions containing propranolol were studied. Isopropylmyristate was used as the oil, Tween 60 as a surfactant, butanol as a co-surfactant and a buffer of pH 6.5 for the continuous phase. The lipophilicity of propranolol was enhanced by formation of lipophilic ion-pairs to obtain a dispe...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1467-2494.1988.tb00026.x
更新日期:1988-12-01 00:00:00
abstract::The stability constants for the inclusion of fragrance materials with 2-hydroxypropyl-beta-cyclodextrin (2HP-beta-C yD) in aqueous solution have been determined by the static head-space method. The 1:1 stability constants obtained by this method were in reasonable agreement with the corresponding values in the literat...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1046/j.1467-2494.1999.203156.x
更新日期:1999-06-01 00:00:00
abstract::Synopsis This report utilizes a new procedure based on epidermal stripping to analyse unlabelled skin fatty acids. This technique was applied to the study of human dry skin treated with blackcurrant seed oil, an essential fatty acid rich lipid also containing gamma linolenic acid. In human dry skin the usual fatty aci...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1467-2494.1988.tb00014.x
更新日期:1988-08-01 00:00:00
abstract::Lysyl oxidase-like (LOXL) is an extracellular enzyme that catalyses the cross-linking between microfibrils and tropoelastin (TE), thereby ensuring elastic fibre functionality. With ageing, LOXL expression decreases, thus participating in the loss of skin elasticity. In a previous study, we showed that a dill seed extr...
journal_title:International journal of cosmetic science
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1468-2494.2010.00606.x
更新日期:2011-04-01 00:00:00
abstract::Summary The powder made with leaflets of a senna, Cassia obovata Coll., is a cosmetic mis-called 'neutral henna' The traditional use of C. obovata is as a laxative. The principal active components of this laxative drug are sennosides A and B. In the Middle Ages the blend of henna (Lawsonia inermis) and senna was calle...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1467-2494.1981.tb00284.x
更新日期:1981-10-01 00:00:00
abstract:OBJECTIVE:Lipsticks and lip care products may contain saturated hydrocarbons which either stem from mineral oil saturated hydrocarbons (MOSH) or are synthetic, that is polyolefin oligomeric saturated hydrocarbons (POSH). Some of these hydrocarbons are strongly accumulated and form granulomas in human tissues, which pro...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12276
更新日期:2016-04-01 00:00:00
abstract::On a daily basis, the skin is exposed to many environmental stressors and insults. Over a 24-h natural cycle, during the day, the skin is focused on protection; while at night, the skin is focused on repairing damage that occurred during daytime and getting ready for the next morning. Circadian rhythm provides the pre...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12572
更新日期:2019-12-01 00:00:00
abstract::The hydroglycolic (HG) extract from 70% propylene glycol (PG) extraction of myrobalan fruits showed the most appreciable antioxidant efficiency towards 1,1-diphenyl-2-picrylhydrazyl (DPPH) in comparison to the extracts from 30, 50, 70 and 100% ethyl alcohol (EA), and 30, 50 and 100% PG . Its total polyphenols were als...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1468-2494.2011.00642.x
更新日期:2011-08-01 00:00:00
abstract::Synopsis The dichlorophenyl-imidazoldioxolan elubiol is used for skin and hair care in subjects with oily skin or dandruff. A study was conducted in 14 men to evaluate by non-invasive methods the effect of long-term use of elubiol on the sebum output at the skin surface. Measures were made using the Sebumeter SM810 an...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1467-2494.1996.tb00152.x
更新日期:1996-10-01 00:00:00
abstract:OBJECTIVE:To study the effects of addition of a redox metal, copper, antioxidants and metal chelators on the formation of free radicals in natural white Caucasian hair subsequently exposed to UV light. Three different methods, electron paramagnetic resonance (EPR), a fluorescent probe for hydroxyl radical formation (te...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12601
更新日期:2020-04-01 00:00:00
abstract:OBJECTIVES:Facial clinical signs and their integration are the basis of perception than others could have from ourselves, noticeably the age they imagine we are. Facial modifications in motion and their objective measurements before and after application of skin regimen are essential to go further in evaluation capacit...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12198
更新日期:2015-06-01 00:00:00
abstract::The assessment of many aspects of the structure and biological dynamics of the stratum corneum can be conducted using calibrated stripping with adhesive-coated discs (SACD). Squamometry entails staining SACD samples with a toluidine blue-basic fuschsin ethanol-based solution and reading the colorimetric variable Chrom...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:
更新日期:2000-12-01 00:00:00
abstract:BACKGROUND:Xerosis is an abnormally dry and flaky skin condition that is associated with a change in the packing behaviour of the lipid matrix in the stratum corneum (SC), the outermost layer of the skin. This skin condition can lead to an increase in transepidermal water loss (TEWL). As ultralong-chain fatty acids hav...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12404
更新日期:2017-10-01 00:00:00
abstract:OBJECTIVE:The aim of this work was to investigate an alternative hair-dyeing method with vegetable colourants as the tannins, as well as the impact of pre-treatment as the bleaching process. METHODS:Untreated, 1, 2 and 3 times bleached hair tresses that were dyed with tannins in combination with metal salts were chara...
journal_title:International journal of cosmetic science
pub_type: 杂志文章,评审
doi:10.1111/ics.12624
更新日期:2020-08-01 00:00:00
abstract::In recent years the importance of sphingolipids (cerebrosides, sphingomyelin, ceramides, sphingosine-1-phospate, etc.) in skin biology is receiving an increasing interest. Not only are ceramides essential for the barrier function of the skin, especially through their phytosphingosine, sphingosine and 6-hydroxysphingos...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1467-2494.2007.00394.x
更新日期:2007-08-01 00:00:00
abstract::Synopsis An investigation has been carried out into the synthesis of quaternary ammonium salts of triglycerides. The aim of this work was to produce such compounds without breaking the triglyceride skeleton. The reaction of chloracetyl chloride with the triglyceride of ricinoleic acid which is the major constituent (8...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1467-2494.1991.tb00560.x
更新日期:1991-08-01 00:00:00
abstract::Surface structure and surface mechanical properties of human hair have been characterized by atomic force microscopy in the imaging mode and by force vs. distance, F-d, analysis. The effects of treatment by commercial conditioner/shampoo or by aqueous exposure have been investigated. The cuticular structure has been i...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1046/j.1467-2494.2001.00080.x
更新日期:2001-06-01 00:00:00
abstract:OBJECTIVE:A novel microwave-assisted dispersive liquid-liquid microextraction (MADLLME) technique according to the solidification of a floating organic droplet (SFO) and graphite furnace atomic absorption spectrometry (GFAAS) used for the extraction and determination of lead ions in lipsticks and hair dyes made in diff...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12221
更新日期:2015-10-01 00:00:00
abstract::This work describes the development, validation and application of a simple and fast high-performance liquid chromatography-with diode array dectection (HPLC-DAD) method for the determination of eight sunscreen agents: benzophenone-3, octocrylene, ethylhexyl methoxycinnamate, ethylhexyl salicylate, homosalate (used in...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1468-2494.2012.00703.x
更新日期:2012-06-01 00:00:00
abstract::Synopsis The absorption of ultraviolet light by a film of sunscreen product on the surface of the skin is considered from a theoretical standpoint. It is apparent that Beer-Lambert's Law would predict protection factors in excess of the actual factors by many orders of magnitude. The possible reasons for this are disc...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1467-2494.1985.tb00417.x
更新日期:1985-10-01 00:00:00