In vitro release of propranolol from oil/water microemuisions.

Abstract:

:Synopsis Oil/water (o/w) microemulsions containing propranolol were studied. Isopropylmyristate was used as the oil, Tween 60 as a surfactant, butanol as a co-surfactant and a buffer of pH 6.5 for the continuous phase. The lipophilicity of propranolol was enhanced by formation of lipophilic ion-pairs to obtain a disperse phase that could act as a reservoir; octanoic acid was used as counter-ion. The diffusion rates of propranolol from microemulsions through a hydrophilic membrane decreased as the concentration of octanoic acid increased. The apparent permeability constant, determined at the beginning of the experiment, was 2.9 x 10(-9) cm s(-1) for propranolol alone and diminished until 3.5 x 10(-10) cm s(-1) in the presence of octanoic acid, at a concentration of 16.4 times that of propranolol.

journal_name

Int J Cosmet Sci

authors

Gasco MR,Carlotti ME,Trotta M

doi

10.1111/j.1467-2494.1988.tb00026.x

subject

Has Abstract

pub_date

1988-12-01 00:00:00

pages

263-9

issue

6

eissn

0142-5463

issn

1468-2494

pii

ICS263

journal_volume

10

pub_type

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