Abstract:
:Several treatments for skin whitening are available today, but few of them are completely adequate, especially owing to the carcinogenic potential attributed to classical drugs like hydroquinone, arbutin and kojic acid. To provide an alternative and safer technology for whitening, we developed two botanical compounds originated from Brazilian biodiversity, an extract of Schinus terebinthifolius Raddi and a linoleic acid fraction isolated from Passiflora edulis oil. The whitening effect of these compounds was assessed using biochemical assays and in vitro models including cellular assays and equivalent skin. The results showed that S. terebinthifolius Raddi extract is able to reduce the tyrosinase activity in vitro, and the combination of this extract with linoleic acid is able to decrease the level of melanin produced by B16 cells cultured with melanocyte-stimulating hormone. Furthermore, melanin was also reduced in human reconstituted epidermis (containing melanocytes) treated with the compounds. The combination of the compounds may provide a synergistic positive whitening effect rather than their isolated use. Finally, we demonstrated that the performance of these mixed compounds is comparable to classical molecules used for skin whitening, as kojic acid. This new natural mixture could be considered an alternative therapeutic agent for treating hyperpigmentation and an effective component in whitening cosmetics.
journal_name
Int J Cosmet Scijournal_title
International journal of cosmetic scienceauthors
Jorge AT,Arroteia KF,Santos IA,Andres E,Medina SP,Ferrari CR,Lourenço CB,Biaggio RM,Moreira PLdoi
10.1111/j.1468-2494.2012.00736.xsubject
Has Abstractpub_date
2012-10-01 00:00:00pages
435-40issue
5eissn
0142-5463issn
1468-2494journal_volume
34pub_type
杂志文章abstract::A multicentred study derived from the COLIPA in vitro UVA method was performed to assess the influence of test conditions on UVA protection factor (UVAPF) values in terms of amplitude, reproducibility between laboratories and correlation with in vivo UVA results. Eight products with a range of in vivo UVAPF from three...
journal_title:International journal of cosmetic science
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1468-2494.2012.00748.x
更新日期:2013-02-01 00:00:00
abstract::In the present study, we tested a new device called skin phototype diagnosis (SPD) built for the purpose of objectively determining skin phototype. We compared its performance with that of phototype determinations according to Fitzpatrick method and on tristimulus colorimetry (Minolta CR-200). Our population consisted...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1046/j.1467-2494.2002.00136.x
更新日期:2002-08-01 00:00:00
abstract::The vapour pressures of phenethyl alcohol and limonene in their water-in-oil microemulsion region were measured by head space gas chromatography of equilibrated samples. The results showed that the vapour pressure of both fragrance compounds in their mutual solutions without surfactant or water was significantly great...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1046/j.1467-2494.1998.177054.x
更新日期:1998-12-01 00:00:00
abstract::Kajal and surma are eye cosmetics extensively used in Indian subcontinent. Kajal is prepared by burning of vegetable oil and butter oil while surma by grinding of the stones. High performance liquid chromatography and gas chromatography-mass spectrometry instruments were used for quantification and confirmation of 16 ...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1468-2494.2009.00497.x
更新日期:2009-06-01 00:00:00
abstract::Skin acts a major target as well as a principle barrier for topical/transdermal drug delivery. Despite the many advantages of this system, the major obstacle is the low diffusion rate of drugs across the stratum corneum. Several methods have been assessed to increase the permeation rate of drugs temporarily. One simpl...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1467-2494.2005.00264.x
更新日期:2005-08-01 00:00:00
abstract:OBJECTIVE:The goal of this work was to develop a novel polyurethane polymer coating for the surface of the hair that could be used for style setting via the shape memory effect (SME). The features of the films are in accordance with conventional hair styling methods used in the laboratory. METHODS:In this study, a new...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12294
更新日期:2016-06-01 00:00:00
abstract::It is well known that the shelf-life of products containing dihydroxyacetone (DHA) is quite unsatisfactory, and that in this area the adjustment to an acidic pH is the way usually recommended to improve DHA stability. The adoption of this rule, however, is a challenge for the cosmetic chemist not only because of the r...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1467-2494.2007.00381.x
更新日期:2007-06-01 00:00:00
abstract::Synopsis The self-diffusion of salicylic acid has been monitored radiochemically through pigskins (whole and dermal) and human skins (whole, dermal and epidermal). The effects of pH, temperature and changing dimethyl formamide (DMF) concentration on the penetration of salicylic acid through the various skin membranes ...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1467-2494.1981.tb00292.x
更新日期:1981-12-01 00:00:00
abstract::Oleuropein, a phenolic compound derived from olive leaves and oil, is known to possess several biological properties, many of which may be attributed to its antioxidant and free radical-scavenging activities. Nevertheless, up to now, the cosmetic activity of this molecule has not been extensively investigated. The aim...
journal_title:International journal of cosmetic science
pub_type: 临床试验,杂志文章
doi:10.1111/j.1468-2494.2008.00424.x
更新日期:2008-04-01 00:00:00
abstract::The aim of this work was to investigate the effects of 1,18-octadecen-9-dioic acid (dioic acid) and a Rumex occidentalis extract complex for their skin-lightening action in an Indian population. Prior to the clinical study, the efficacy of dioic as an inhibitor of melanogenesis was confirmed on dark-pigmented human me...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12002
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVE:Quinoa (Chenopodium quinoa Willd.) is a seed crop rich in bioactive compounds including phytoecdysones (especially 20-hydroxyecdysone, 20HE), polyphenols, proteins and essential fatty acids. We previously reported a method to leach and concentrate quinoa bioactives into a complex phytochemical mixture termed ...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12185
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:The deposit and adherence of particulate matter (PM) from aerial pollution onto the surface of human hair is a poorly studied phenomenon. OBJECTIVES:(i) To reproduce in vitro the deposit of known PM on standardized hair swatches in a closed box, (ii) to compare in vitro data with those obtained under 'real-...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12416
更新日期:2017-12-01 00:00:00
abstract:OBJECTIVE:This study focused on the formulation of lamellar lyotropic liquid crystal (LLC) loaded with mulberry stem extract (MSE). METHODS:The LLC formulation tested used two oils: n-dodecane or tridecyl salicylate, a co-solvent (propylene glycol) and a single (PEG-7 glyceryl cocoate) or mixed surfactant system. The ...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12116
更新日期:2014-06-01 00:00:00
abstract::Antioxidants play a vital role in protecting the skin from environmental distress. As the skin is constantly exposed to harmful UV radiation, endogenous antioxidants present in the superficial layers of the skin neutralize reactive oxygen species. Over time, antioxidants become depleted and loss their protective effec...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1468-2494.2012.00728.x
更新日期:2013-02-01 00:00:00
abstract:OBJECTIVE:To study the effects of addition of a redox metal, copper, antioxidants and metal chelators on the formation of free radicals in natural white Caucasian hair subsequently exposed to UV light. Three different methods, electron paramagnetic resonance (EPR), a fluorescent probe for hydroxyl radical formation (te...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12601
更新日期:2020-04-01 00:00:00
abstract:OBJECTIVE:Recently, our group reported that extracts prepared from the Australian native plant Terminalia ferdinandiana Exell. are potent inhibitors of the growth malodorous bacteria with similar efficacy to triclosan and through these results, we highlighted a potential biological alternative to the current chemical a...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12567
更新日期:2019-10-01 00:00:00
abstract::Synopsis The modifications of chemical reactivity induced in the human hair during its treatment with oxidative (H(2)O(2)) or reductive (HSO(3)Na) agents via a micellar or a microemulsion system have been investigated. For this purpose, phase diagrams of micellar solutions and microcmulsions with H(2)O(2) or NaSO(3)H ...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1467-2494.1985.tb00404.x
更新日期:1985-06-01 00:00:00
abstract::This paper examines the various methods that are available to the scientist working with natural materials to substantiate their efficacy. The methods discussed are: literature surveys, clinical trials, instrumental measurement, products with Pharmaceutical Licenses, comparison with other plants containing same active...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1046/j.1467-2494.2000.00015.x
更新日期:2000-08-01 00:00:00
abstract::There is an increasing demand in general population regarding skin healthiness and improvement of aesthetical appearance, indicating that people require more information about how to treat healthy skin and to prevent skin disease. This study is the result of a campaign on healthy skin organized by the International So...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1467-2494.2005.00287.x
更新日期:2005-12-01 00:00:00
abstract::On a daily basis, the skin is exposed to many environmental stressors and insults. Over a 24-h natural cycle, during the day, the skin is focused on protection; while at night, the skin is focused on repairing damage that occurred during daytime and getting ready for the next morning. Circadian rhythm provides the pre...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12572
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND:Bromelain is a mixture of proteolytic enzymes found in various tissues of the pineapple plant (Ananas comosus) and other species of Bromeliaceae. Owing to its proteolytic activity, bromelain has been used in the food, medical, pharmaceutical and cosmetic industries, for its cell renewal, anti-ageing, whiteni...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12308
更新日期:2016-10-01 00:00:00
abstract::Synopsis The principles on which stability tests are based are reviewed. The need to differentiate between product stability and product-container compatibility is emphasized. Recognition of this distinction is fundamental to the efficient organisation and execution of stability tests. Attention is also drawn to the d...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1467-2494.1985.tb00423.x
更新日期:1985-12-01 00:00:00
abstract::In this work, a comparative study between two methods to acquire relevant information about a cosmetic formulation has been carried out. A Design of Experiments (DOE) has been applied in two stages to a capillary cosmetic cream: first, a Plackett-Burman (PB) design has been used to reduce the number of variables to be...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1468-2494.2009.00565.x
更新日期:2010-10-01 00:00:00
abstract::Many studies have presented stress-strain relationship of human hair, but most of them have been based on an engineering stress-strain curve, which is not a true representation of stress-strain behaviour. In this study, a more accurate 'true' stress-strain curve of human hair was determined by applying optical techniq...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12031
更新日期:2013-06-01 00:00:00
abstract::This work describes the development, validation and application of a simple and fast high-performance liquid chromatography-with diode array dectection (HPLC-DAD) method for the determination of eight sunscreen agents: benzophenone-3, octocrylene, ethylhexyl methoxycinnamate, ethylhexyl salicylate, homosalate (used in...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1468-2494.2012.00703.x
更新日期:2012-06-01 00:00:00
abstract:OBJECTIVE:Facial attractiveness has been reported to be influenced by visual features such as facial shape and the colour and texture of the skin. However, no empirical studies have examined the effects of facial skin radiance on facial attractiveness. The present study investigated whether types of skin reflection (i....
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12673
更新日期:2020-11-20 00:00:00
abstract::Molecular chaperone, heat shock proteins (HSPs), stabilizes intracellular processes of cells under stress. Little is known about the role of molecular chaperone proteins in the skin pathology, rejuvenation and wound healing, or whether their expression is altered by environmental and physiological stress to the skin o...
journal_title:International journal of cosmetic science
pub_type: 杂志文章,评审
doi:10.1111/j.1468-2494.2010.00601.x
更新日期:2011-02-01 00:00:00
abstract:SYNOPSIS:Despite the extensive use of topical coatings in cosmetics, their effect on the mechanical properties of human skin and the perception of skin tightness in the form of drying stresses is not well understood. We describe the application of a recently developed substrate curvature technique to characterize stres...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1468-2494.2010.00568.x
更新日期:2010-08-01 00:00:00
abstract::The objective of the present work was to evaluate the possible use of Myrosma cannifolia starch L.F. Maranthaceae ('Guapo'), as a raw material in heterogeneous systems or powdered cosmetic and pharmaceutical products formulation. The starch chemical and physical characteristics, physico-chemical properties, and rheolo...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1467-2494.2004.00253.x
更新日期:2005-04-01 00:00:00
abstract:OBJECTIVES:Quantification of stratum corneum (SC) protein levels from tape strippings is frequently used to investigate skin conditions, to correct for amounts of SC protein removed in SC biomarker studies and to determine distribution of topically applied ingredients. In recent years, a rapid and convenient method for...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12274
更新日期:2016-06-01 00:00:00