Abstract:
OBJECTIVE:Equol has been shown to improve skin health and regeneration, due to its antioxidative, phytoestrogenic and epigenetic characteristics. The effects of a topical intervention on skin structure, telomere length and epigenetic markers in skin cells were analysed. METHODS:Sixty-four participants were divided in four groups and three of them treated topically with the following: emulsion with Equol powder (Isoflavandiol-E-55-RS®); emulsion with microencapsulated Equol (Vesisorb® Isoflavandiol-E-55-RS®) and an emulsion with lecithin (Vesisorb® placebo). A control group of 6 volunteers did not receive any intervention. The active compound was a 0.5% equol-racemate. For 58 participants, all samples were collected. Structural analysis, molecular analysis and questionnaires were performed at the start of the study and after 8 weeks of intervention, twice a day. Structural skin parameters were analysed by Visioscan® VC 98 and Cutometer® dual MPA 580. Molecular analyses from epidermal cells collected by skin stripping of the forehead included telomere length and LINE-1 methylation, following DNA extraction, bisulfite conversion and qPCR as well as high-resolution melting curve analysis. Effects of nutrition and lifestyle habits were evaluated with a standardized food and lifestyle questionnaire. RESULTS AND DISCUSSION:The surface analysis showed significant improvements in skin roughness, skin texture and skin smoothness after both interventions. Cutometer® dual MPA 580 measurement revealed improvement of skin firmness and elasticity parameters for both preparations. A decrease in mean LINE-1 methylation (n.s.) and telomere length (sign. P < 0.05) was observed in the sample group with age. In the treated groups, significantly longer telomeres were observed after intervention. Whether changes in telomere length reflect changes in the regulation of telomerase, epigenetic interactions or turnover of keratinocytes needs further research. Stability and availability of preparations in skin seems to be high as not many significant differences in the activity of pure or encapsulated substances were seen. CONCLUSION:The results of this study indicate that equol has beneficial effects on structural as well as molecular skin parameters and encourages further investigations to decipher the epigenetic regulation of skin ageing and interactions of equol.
journal_name
Int J Cosmet Scijournal_title
International journal of cosmetic scienceauthors
Magnet U,Urbanek C,Gaisberger D,Tomeva E,Dum E,Pointner A,Haslberger AGdoi
10.1111/ics.12408subject
Has Abstractpub_date
2017-10-01 00:00:00pages
535-542issue
5eissn
0142-5463issn
1468-2494journal_volume
39pub_type
杂志文章,随机对照试验abstract::Summary The activity of thioglycolic acid, incorporated in a microemulsion, towards cystine residues present in keratin proteins has been investigated. In an attempt to relate the structural state of the microemulsions to cystine reactivity, an appropriate model system showing a large microemulsion domain with diverse...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1467-2494.1987.tb00476.x
更新日期:1987-10-01 00:00:00
abstract::Several treatments for skin whitening are available today, but few of them are completely adequate, especially owing to the carcinogenic potential attributed to classical drugs like hydroquinone, arbutin and kojic acid. To provide an alternative and safer technology for whitening, we developed two botanical compounds ...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1468-2494.2012.00736.x
更新日期:2012-10-01 00:00:00
abstract::Antioxidants play a vital role in protecting the skin from environmental distress. As the skin is constantly exposed to harmful UV radiation, endogenous antioxidants present in the superficial layers of the skin neutralize reactive oxygen species. Over time, antioxidants become depleted and loss their protective effec...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1468-2494.2012.00728.x
更新日期:2013-02-01 00:00:00
abstract:OBJECTIVE:To demonstrate the in vitro activities of panthenol, palmitoylethanolamide (PEA), and niacinamide (NAM) and determine the biophysical properties, clinical safety, tolerability together with efficacy of two developmental anti-redness (AR) formulations containing these ingredients, in alleviating facial redness...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12559
更新日期:2019-12-01 00:00:00
abstract:OBJECTIVE:The goal of this work was to develop a novel polyurethane polymer coating for the surface of the hair that could be used for style setting via the shape memory effect (SME). The features of the films are in accordance with conventional hair styling methods used in the laboratory. METHODS:In this study, a new...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12294
更新日期:2016-06-01 00:00:00
abstract::Scars are well known to have a stratum corneum that is malfunctional. Increases in transepidermal water loss and decreases in stratum corneum capacitance and conductance have been reported. Occlusion therapy is a well-known route to improving the signs and symptoms of scarring. Until recently that has been assumed to ...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1468-2494.2012.751.x
更新日期:2012-09-23 00:00:00
abstract::Skin moisturization is not only important for maintaining skin functional properties but also has great impact on the skin's aesthetic properties. The top layer of the skin, the stratum corneum (SC), plays a key role in protecting and preventing against external aggressions as well as in regulating water flux in and o...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1468-2494.2008.00428.x
更新日期:2008-02-01 00:00:00
abstract::Synopsis The aim of this work was to evaluate several plant extracts with regard to ultraviolet absorption spectra in view of a possible application as antisolar agents. Liquid and dry extracts of Hamamelis virginiana, Matricaria recutita, Aesculus hippocastanum, Rhamnus purshiana and Cinnamomum zeylanicum were prepar...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1467-2494.1996.tb00140.x
更新日期:1996-06-01 00:00:00
abstract:OBJECTIVES:Hyaluronan (HA), an important constituent of extracellular matrix in the skin, has many biological activities such as hydration that contributes to firmness and bounciness of the skin. We have reported that reduction in HA in the papillary dermis and over-expression of HYBID (HYaluronan Binding protein Invol...
journal_title:International journal of cosmetic science
pub_type: 杂志文章,随机对照试验
doi:10.1111/ics.12505
更新日期:2019-02-01 00:00:00
abstract:OBJECTIVE:To determine the homogeneity in the distribution of two cutaneous functions (hydration and elasticity) along the entire human face. MATERIAL AND METHODS:The half faces (right or left, randomly chosen) of two groups of Caucasian women were measured on 24 different small sites (elasticity) and 41 others (hydra...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12488
更新日期:2018-10-01 00:00:00
abstract:OBJECTIVES:Liposomes are commonly used in cosmetic formulations to increase the bioavailability of active ingredients. We have previously shown that polysaccharide coating of liposomes improves their resistance to surfactants and electrolytes. In the current study, we have assessed the impact of coating on the skin pen...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12394
更新日期:2017-08-01 00:00:00
abstract:OBJECTIVES:Facial clinical signs and their integration are the basis of perception than others could have from ourselves, noticeably the age they imagine we are. Facial modifications in motion and their objective measurements before and after application of skin regimen are essential to go further in evaluation capacit...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12198
更新日期:2015-06-01 00:00:00
abstract::The present investigation describes a comparative study for the design of innovative topical formulation for skin hydration. In particular, different colloidal forms based on lipidic components have been produced and characterized. Morphology and dimensional distribution have been investigated by means of electron mic...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1467-2494.2007.00362.x
更新日期:2007-02-01 00:00:00
abstract::The phase diagrams were determined of lactic and isohexanoic hydroxy acids as well as salicylic acid with water, a non-ionic surfactant and a paraffinic oil to outline the influence of the hydroxy acids on the structure in a model for a skin lotion. The results showed the influence of the acid to be similar to that of...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1467-2494.2004.00212.x
更新日期:2004-06-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to perform short-term sensory testing and instrumental (conductivity and rheological) characterization of a fast inverted oil-in-water (o/w) emulsion base, also known as a SWOP (Switch-Oil-Phase) emulsion, and reference o/w and water-in-oil (w/o) emulsion bases under various testing ...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12282
更新日期:2016-06-01 00:00:00
abstract::The photostabilities of four sunscreen products have been assessed in vitro by applying sunscreen to a substrate and measuring the spectral transmission prior to, and after exposure to a source of ultraviolet (UV) radiation. Results were independent of whether an application thickness of 1 or 2 mg/cm ; 2 was used, and...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1046/j.1467-2494.1999.203163.x
更新日期:1999-10-01 00:00:00
abstract::The comparison of the results of microscopic, conductimetric and rheologic analyses carried out on the same triple W/O/W emulsion, immediately following its manufacture and 10 years later, indicates the remarkable stability of such system. This stability illustrates the great potential of this formula in the protectio...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1046/j.1467-2494.2000.00020.x
更新日期:2000-04-01 00:00:00
abstract:OBJECTIVE:Arbutin is an effective agent for the treatment of melanin disorders. Arbutin may be converted to hydroquinone under conditions of high temperature, ultraviolet (UV) radiation and dilute acid. The aim of the current study was to develop an analytical method to determine the levels of arbutin and hydroquinone ...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12228
更新日期:2015-12-01 00:00:00
abstract::Sun exposure during leisure activity evokes fatigue. We employed the Advanced Trail Making Test (ATMT), a recently developed objective method of evaluating brain function performance used to measure mental fatigue, for objective determination of fatigue development caused by solar exposure to the human body. First, a ...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.0142-5463.2004.00200.x
更新日期:2004-02-01 00:00:00
abstract:OBJECTIVE:To determine whether the coordination environment of copper in hair is affected by the shampoo used. METHODS:Electron paramagnetic resonance (EPR) spectroscopy to discriminate between mixed oxygen/nitrogen and mixed oxygen/sulphur coordination of copper after treatment with two different shampoos. RESULTS:C...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12178
更新日期:2015-02-01 00:00:00
abstract::Essential oils and certain perfumery raw materials exhibit a wide range of beneficial biological activities. Besides the antimicrobial and antioxidant activity, the anti-inflammatory and anti-irritant effects are most often cited. One specific mode of action is the reduction of the formation of the key mediator prosta...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1468-2494.2007.00392.x
更新日期:2007-10-01 00:00:00
abstract::Dandruff is characterized by a flaky, pruritic scalp and affects up to half the world's population post-puberty. The aetiology of dandruff is multifactorial, influenced by Malassezia, sebum production and individual susceptibility. The commensal yeast Malassezia is a strong contributory factor to dandruff formation, b...
journal_title:International journal of cosmetic science
pub_type: 杂志文章,评审
doi:10.1111/j.1468-2494.2012.00723.x
更新日期:2012-08-01 00:00:00
abstract:OBJECTIVE:Hyaluronan (HA) plays a role in keratinocyte proliferation and differentiation. In addition, HA has been shown to have different biological activities depending on its molecular weight. It has been reported that HA-mediated CD44 activation regulates keratinocyte differentiation. Therefore, the aim of this stu...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12105
更新日期:2014-02-01 00:00:00
abstract::Cutaneous irritation is a stereotyped response of the skin to any physical or chemical insult. Its main manifestations encompass inflammatory erythema and an alteration of the cutaneous microrelief showing increased roughness, dehydration and erratic desquamation. Several instrumental methods can indirectly assess the...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1046/j.1467-2494.2003.00170.x
更新日期:2003-04-01 00:00:00
abstract::Sweat and skin surface pH are critical parameters in determining the performance of antiperspirants. The mechanism of action, the so-called 'plug theory' first proposed by Reller and Luedders, involves the expression of eccrine sweat onto the surface of the skin into which the solid antiperspirant salts, typically an ...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1046/j.1467-2494.2001.00092.x
更新日期:2001-08-01 00:00:00
abstract::Synopsis The non-saponifiable lipidic fractions of avocado and soya bean applied percutaneously to hairless rats for 15 days had been shown to produce biochemical modifications of dermal connective tissue components: increases of soluble collagen and of the ratio soluble collagen/insoluble collagen. In this present st...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1467-2494.1982.tb00310.x
更新日期:1982-08-01 00:00:00
abstract:OBJECTIVE:Recently, our group reported that extracts prepared from the Australian native plant Terminalia ferdinandiana Exell. are potent inhibitors of the growth malodorous bacteria with similar efficacy to triclosan and through these results, we highlighted a potential biological alternative to the current chemical a...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12567
更新日期:2019-10-01 00:00:00
abstract:OBJECTIVE:To understand the drivers of body skin discomfort and to validate a new index to assess its severity. This index should be sensitive enough to capture changes in response to treatment. METHODS:Previous consumer studies suggested seven potential main dimensions behind skin discomfort. Four of them refer to se...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12490
更新日期:2018-10-01 00:00:00
abstract::Synopsis The purpose of this work was to compare the evolution of three multiple emulsions (ME) by different controls. The series of water-in-oil-in-water (W/O/W) multiple emulsions were elaborated and controlled by both the usual analyses which permitted the classification of the multiple emulsions with respect to th...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1467-2494.1993.tb00069.x
更新日期:1993-04-01 00:00:00
abstract::Lysyl oxidase-like (LOXL) is an extracellular enzyme that catalyses the cross-linking between microfibrils and tropoelastin (TE), thereby ensuring elastic fibre functionality. With ageing, LOXL expression decreases, thus participating in the loss of skin elasticity. In a previous study, we showed that a dill seed extr...
journal_title:International journal of cosmetic science
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1468-2494.2010.00606.x
更新日期:2011-04-01 00:00:00