Salicin regulates the expression of functional 'youth gene clusters' to reflect a more youthful gene expression profile.

Abstract:

:There are a variety of biological mechanisms that contribute to specific characteristics of ageing skin; for example, the loss of skin structure proteins, increased susceptibility to UV-induced pigmentation and/or loss of hydration. Each of these biological processes is influenced by specific groups of genes. In this research, we have identified groups of genes associated with specific clinical signs of skin ageing and refer to these as functional 'youth gene clusters'. In this study, quantitative real-time polymerase chain reaction (qPCR) was used to investigate the effects of topical application of salicin in regulating the expression of functional 'youth gene clusters' to reflect a more youthful skin profile and reduce the appearance of attributes associated with skin ageing. Results showed that salicin significantly influences the gene expression profiles of treated human equivalent full-thickness skin, by regulating the expression of genes associated with various biological processes involving skin structure, skin hydration, pigmentation and cellular differentiation. Based on the findings from this experiment, salicin was identified as a key ingredient that may regulate functional 'youth gene clusters' to reflect a more youthful gene expression profile by increasing the expression of genes responsible for youthful skin and decreasing the expression of genes responsible for the appearance of aged skin.

journal_name

Int J Cosmet Sci

authors

Gopaul R,Knaggs HE,Lephart J

doi

10.1111/j.1468-2494.2011.00645.x

subject

Has Abstract

pub_date

2011-10-01 00:00:00

pages

416-20

issue

5

eissn

0142-5463

issn

1468-2494

journal_volume

33

pub_type

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