Abstract:
:There are a variety of biological mechanisms that contribute to specific characteristics of ageing skin; for example, the loss of skin structure proteins, increased susceptibility to UV-induced pigmentation and/or loss of hydration. Each of these biological processes is influenced by specific groups of genes. In this research, we have identified groups of genes associated with specific clinical signs of skin ageing and refer to these as functional 'youth gene clusters'. In this study, quantitative real-time polymerase chain reaction (qPCR) was used to investigate the effects of topical application of salicin in regulating the expression of functional 'youth gene clusters' to reflect a more youthful skin profile and reduce the appearance of attributes associated with skin ageing. Results showed that salicin significantly influences the gene expression profiles of treated human equivalent full-thickness skin, by regulating the expression of genes associated with various biological processes involving skin structure, skin hydration, pigmentation and cellular differentiation. Based on the findings from this experiment, salicin was identified as a key ingredient that may regulate functional 'youth gene clusters' to reflect a more youthful gene expression profile by increasing the expression of genes responsible for youthful skin and decreasing the expression of genes responsible for the appearance of aged skin.
journal_name
Int J Cosmet Scijournal_title
International journal of cosmetic scienceauthors
Gopaul R,Knaggs HE,Lephart Jdoi
10.1111/j.1468-2494.2011.00645.xsubject
Has Abstractpub_date
2011-10-01 00:00:00pages
416-20issue
5eissn
0142-5463issn
1468-2494journal_volume
33pub_type
杂志文章abstract:BACKGROUND:Cosmetics are products used over long periods by the public, and their safety is very important. Several types of human tests are used widely for the evaluation of cosmetics including single patch tests, in-use tests, human repeated insult patch test (HRIPT). However, there is no clear and well-defined publi...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12095
更新日期:2014-02-01 00:00:00
abstract::This work describes the development, validation and application of a simple and fast high-performance liquid chromatography-with diode array dectection (HPLC-DAD) method for the determination of eight sunscreen agents: benzophenone-3, octocrylene, ethylhexyl methoxycinnamate, ethylhexyl salicylate, homosalate (used in...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1468-2494.2012.00703.x
更新日期:2012-06-01 00:00:00
abstract::The objective of the study was to compare measurements of skin hydration and of biomechanical properties performed on different zones of face and volar forearm. Two short-term (1 h) and two long-term (3 weeks) studies were conducted with a moisturizing and a firming product, respectively, on groups of female volunteer...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1467-2494.2006.00352.x
更新日期:2006-12-01 00:00:00
abstract::Synopsis The ability of baseline transepidermal water loss (TEWL) measurements to predict the response of healthy subjects to a standard soap chamber irritation insult was evaluated. Chambers containing surfactant solutions were applied to the forearms of normal volunteers for five consecutive days. TEWL was measured ...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1467-2494.1986.tb00452.x
更新日期:1986-10-01 00:00:00
abstract:OBJECTIVES:Ageing leads to characteristic changes in the appearance of facial skin. Among these changes, we can distinguish the skin topographic cues (skin sagging and wrinkles), the dark spots and the dark circles around the eyes. Although skin changes are similar in Caucasian and Chinese faces, the age of occurrence ...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12128
更新日期:2014-08-01 00:00:00
abstract::Synopsis In this study a compact, hand-held, solid state erythema meter using light emitting diodes is described. This device has been constructed and used to compare with visual assessments of ultraviolet radiation in human subjects. A statistically significant correlation was obtained between erythema index and visu...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1467-2494.1990.tb00521.x
更新日期:1990-04-01 00:00:00
abstract::Microbiological quality control of personal care products using traditional methods can take between 5 and 7 days to complete. This is frequently the rate limiting step in product release. Companies are looking to improve manufacturing efficiencies and to maximize resources by releasing products faster. ATP biolumines...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1046/j.1467-2494.1998.171736.x
更新日期:1998-02-01 00:00:00
abstract:BACKGROUND:Xerosis is an abnormally dry and flaky skin condition that is associated with a change in the packing behaviour of the lipid matrix in the stratum corneum (SC), the outermost layer of the skin. This skin condition can lead to an increase in transepidermal water loss (TEWL). As ultralong-chain fatty acids hav...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12404
更新日期:2017-10-01 00:00:00
abstract::The perceived skin feel during and after application of skin care products is highly important to the consumer and therefore to cosmetic formulators. Powder particles are commonly incorporated in cosmetic formulations to improve their sensory properties. Although a large variety of cosmetic powders is available, it is...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1468-2494.2012.00734.x
更新日期:2012-10-01 00:00:00
abstract::Summary The activity of thioglycolic acid, incorporated in a microemulsion, towards cystine residues present in keratin proteins has been investigated. In an attempt to relate the structural state of the microemulsions to cystine reactivity, an appropriate model system showing a large microemulsion domain with diverse...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1467-2494.1987.tb00476.x
更新日期:1987-10-01 00:00:00
abstract::Synopsis The manufacturing of toiletries is a complex procedure and many process routes are possible for a given formulation. In the past, considerable attention has been given to the design of manufacturing equipment but there has been relatively little appreciation of the influence of physicochemical interactions du...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1467-2494.1980.tb00235.x
更新日期:1980-04-01 00:00:00
abstract:OBJECTIVE:To demonstrate the in vitro activities of panthenol, palmitoylethanolamide (PEA), and niacinamide (NAM) and determine the biophysical properties, clinical safety, tolerability together with efficacy of two developmental anti-redness (AR) formulations containing these ingredients, in alleviating facial redness...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12559
更新日期:2019-12-01 00:00:00
abstract:OBJECTIVE:To investigate the efficacy of 13 antimicrobial substances (11 substances of natural origin and two conventional preservatives as controls) at two concentrations in an o/w cosmetic emulsion. METHODS:Cosmetic formulations were analysed for total aerobic bacterial count and total combined yeast count according...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12461
更新日期:2018-05-05 00:00:00
abstract:OBJECTIVE:As skin ages, impaired extracellular matrix (ECM) protein synthesis and increased action of degradative enzymes manifest as atrophy, wrinkling and laxity. There is mounting evidence for the functional role of exogenous peptides across many areas, including in offsetting the effects of cutaneous ageing. Here, ...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12635
更新日期:2020-08-01 00:00:00
abstract::Synopsis The non-saponifiable lipidic fractions of avocado and soya bean applied percutaneously to hairless rats for 15 days had been shown to produce biochemical modifications of dermal connective tissue components: increases of soluble collagen and of the ratio soluble collagen/insoluble collagen. In this present st...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1467-2494.1982.tb00310.x
更新日期:1982-08-01 00:00:00
abstract::The phase diagrams were determined of lactic and isohexanoic hydroxy acids as well as salicylic acid with water, a non-ionic surfactant and a paraffinic oil to outline the influence of the hydroxy acids on the structure in a model for a skin lotion. The results showed the influence of the acid to be similar to that of...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1467-2494.2004.00212.x
更新日期:2004-06-01 00:00:00
abstract::Good water-impermeable barrier function is vital for healthy skin. Abnormality of the barrier function is observed in a variety of skin diseases, such as atopic dermatitis, psoriasis and contact dermatitis. Moreover, repeated barrier disruption induces epidermal hyperplasia and inflammation. On the other hand, acceler...
journal_title:International journal of cosmetic science
pub_type: 杂志文章,评审
doi:10.1111/j.1468-2494.2008.00487.x
更新日期:2009-04-01 00:00:00
abstract:OBJECTIVE:To determine whether the coordination environment of copper in hair is affected by the shampoo used. METHODS:Electron paramagnetic resonance (EPR) spectroscopy to discriminate between mixed oxygen/nitrogen and mixed oxygen/sulphur coordination of copper after treatment with two different shampoos. RESULTS:C...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12178
更新日期:2015-02-01 00:00:00
abstract:OBJECTIVES:Facial clinical signs and their integration are the basis of perception than others could have from ourselves, noticeably the age they imagine we are. Facial modifications in motion and their objective measurements before and after application of skin regimen are essential to go further in evaluation capacit...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12198
更新日期:2015-06-01 00:00:00
abstract::In the past few years, the hair follicle has started revealing its beauty and mysteries. The existence of a growth and regeneration cycle, together with a unique tissue organization and complex regulatory network, make it a true paradigm of tissue homeostasis and dermal-epithelial crosstalk. In this brief review, I wi...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1046/j.0412-5463.2001.00109.x
更新日期:2002-02-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to establish a comparative analysis of the chemical and enzymatic stability of α- and β-arbutins as potential sources of the substance of concern hydroquinone (HQ). The study was performed using an array of techniques including HPLC-PDA, nuclear magnetic resonance (NMR) and optical r...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12275
更新日期:2016-04-01 00:00:00
abstract:OBJECTIVE:To evaluate wrinkle improvement and safety of a novel cosmetic dissolving microneedle patches loaded with two active compounds with different hydrophilicities, namely ascorbic acid and retinyl retinoate. METHODS:Clinical studies were performed on 24 Korean women for 12 weeks. Patients in group A were treated...
journal_title:International journal of cosmetic science
pub_type: 杂志文章,随机对照试验
doi:10.1111/ics.12115
更新日期:2014-06-01 00:00:00
abstract::Synopsis This paper reports preliminary results of a study carried out on liquid crystal emulsions added to three different inorganic sunscreens: ultrafine zinc oxide, ultrafine titanium dioxide (inorganic-treated) and ultrafine titanium dioxide (organic-treated hydrophobically). The aim of the work was to investigate...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1467-2494.1994.tb00101.x
更新日期:1994-12-01 00:00:00
abstract::Synopsis The aim of this work was to evaluate several plant extracts with regard to ultraviolet absorption spectra in view of a possible application as antisolar agents. Liquid and dry extracts of Hamamelis virginiana, Matricaria recutita, Aesculus hippocastanum, Rhamnus purshiana and Cinnamomum zeylanicum were prepar...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1467-2494.1996.tb00140.x
更新日期:1996-06-01 00:00:00
abstract::Synopsis Glutathione (GSH) plays an important role in cellular protection during ageing. The hair plucking technique is a non-invasive method for the direct biochemical study of keratinocytes. Hair was taken from the suboccipital area of 63 volunteers (men and women whose ages ranged from 13 to 103 years). The results...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1467-2494.1991.tb00555.x
更新日期:1991-06-01 00:00:00
abstract::Synopsis A modified procedure for the determination of total N-nitroso compounds in personal care products was evaluated in collaborative studies organized through the UK Cosmetic Toiletry and Perfumery Association (CTPA). The method offers a true 'totals'determination in that a solution of the whole sample is analyse...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1467-2494.1995.tb00127.x
更新日期:1995-12-01 00:00:00
abstract::The assessment of many aspects of the structure and biological dynamics of the stratum corneum can be conducted using calibrated stripping with adhesive-coated discs (SACD). Squamometry entails staining SACD samples with a toluidine blue-basic fuschsin ethanol-based solution and reading the colorimetric variable Chrom...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:
更新日期:2000-12-01 00:00:00
abstract::The causative substances for axillary osmidrosis, which are often found in apocrine sweat, are the decomposed/denatured products of short-chain fatty acid and other biological metabolite compounds produced by axillary-resident bacteria. Conventional underarm deodorants suppress the process of odour production mostly b...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1467-2494.2006.00322.x
更新日期:2006-08-01 00:00:00
abstract:OBJECTIVE:A novel microwave-assisted dispersive liquid-liquid microextraction (MADLLME) technique according to the solidification of a floating organic droplet (SFO) and graphite furnace atomic absorption spectrometry (GFAAS) used for the extraction and determination of lead ions in lipsticks and hair dyes made in diff...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12221
更新日期:2015-10-01 00:00:00
abstract::In this work, a comparative study between two methods to acquire relevant information about a cosmetic formulation has been carried out. A Design of Experiments (DOE) has been applied in two stages to a capillary cosmetic cream: first, a Plackett-Burman (PB) design has been used to reduce the number of variables to be...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1468-2494.2009.00565.x
更新日期:2010-10-01 00:00:00