A screening procedure for total N-nitroso contaminants in personal care products: results of collaborative studies undertaken by a CTPA Working Group.

Abstract:

:Synopsis A modified procedure for the determination of total N-nitroso compounds in personal care products was evaluated in collaborative studies organized through the UK Cosmetic Toiletry and Perfumery Association (CTPA). The method offers a true 'totals'determination in that a solution of the whole sample is analysed. Samples are dissolved/suspended in water or aqueous THF, and nitrite/nitrite ester interferences are removed by prior treatment with sulphamic acid. The treated test solution is denitrosated in a single reaction with HBr/acetic acid, in refluxing n-propyl acetate, and 'total'N-nitroso compounds are determined in a chemiluminescence reaction of the released nitric oxide with ozone. The use of a propyl acetate denitrosation solvent and of higher concentrations of HBr have improved both the sensitivity (routine limit of determination at 10 mugkg(-1)) and water tolerance of the method. The method was shown to recover N-nitrosamines quantitatively, and to be sufficiently repeatable and reproducible to be used as a screening technique for N-nitroso compounds in personal care products.

journal_name

Int J Cosmet Sci

authors

Challis BC,Colling J,Cromie DD,Guthrie WG,Pollock JR,Taylor P,Telling GM,Wallace L

doi

10.1111/j.1467-2494.1995.tb00127.x

subject

Has Abstract

pub_date

1995-12-01 00:00:00

pages

219-31

issue

6

eissn

0142-5463

issn

1468-2494

pii

ICS219

journal_volume

17

pub_type

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