Hexamidine salts - applications in skin health and personal care products.

Abstract:

:Hexamidine (HEX) has been used as a preservative in topical preparations since the 1950s. A number of studies also indicate that the molecule plays a beneficial role in skin homoeostasis. In this review, we describe the physicochemical properties of hexamidine diisethionate (HEX D) and the corresponding hydrochloride salt (HEX H). The biocidal and protease inhibition properties of HEX are outlined as well as the effects of HEX on lipid processing enzymes, corneocyte maturity, stratum corneum thickness and transepidermal water loss (TEWL). Skin permeation properties of HEX D and HEX H are summarized, and formulation approaches for effective dermal targeting of HEX are discussed.

journal_name

Int J Cosmet Sci

authors

Parisi N,Matts PJ,Lever R,Hadgraft J,Lane ME

doi

10.1111/ics.12392

subject

Has Abstract

pub_date

2017-08-01 00:00:00

pages

361-365

issue

4

eissn

0142-5463

issn

1468-2494

journal_volume

39

pub_type

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