Abstract:
:Hexamidine (HEX) has been used as a preservative in topical preparations since the 1950s. A number of studies also indicate that the molecule plays a beneficial role in skin homoeostasis. In this review, we describe the physicochemical properties of hexamidine diisethionate (HEX D) and the corresponding hydrochloride salt (HEX H). The biocidal and protease inhibition properties of HEX are outlined as well as the effects of HEX on lipid processing enzymes, corneocyte maturity, stratum corneum thickness and transepidermal water loss (TEWL). Skin permeation properties of HEX D and HEX H are summarized, and formulation approaches for effective dermal targeting of HEX are discussed.
journal_name
Int J Cosmet Scijournal_title
International journal of cosmetic scienceauthors
Parisi N,Matts PJ,Lever R,Hadgraft J,Lane MEdoi
10.1111/ics.12392subject
Has Abstractpub_date
2017-08-01 00:00:00pages
361-365issue
4eissn
0142-5463issn
1468-2494journal_volume
39pub_type
杂志文章,评审abstract:OBJECTIVE:To study the effects of addition of a redox metal, copper, antioxidants and metal chelators on the formation of free radicals in natural white Caucasian hair subsequently exposed to UV light. Three different methods, electron paramagnetic resonance (EPR), a fluorescent probe for hydroxyl radical formation (te...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12601
更新日期:2020-04-01 00:00:00
abstract:OBJECTIVE:We investigated the association of psychosocial problems, menopausal symptoms such as hot flushes, and trends of smoking and use of cosmetics in our previous study. In this follow-up study, we researched psychiatric disorders and psychosocial problems in menopausal women. METHODS:We designed a cohort study w...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12081
更新日期:2013-12-01 00:00:00
abstract::Synopsis The manufacturing of toiletries is a complex procedure and many process routes are possible for a given formulation. In the past, considerable attention has been given to the design of manufacturing equipment but there has been relatively little appreciation of the influence of physicochemical interactions du...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1467-2494.1980.tb00235.x
更新日期:1980-04-01 00:00:00
abstract::Several treatments for skin whitening are available today, but few of them are completely adequate, especially owing to the carcinogenic potential attributed to classical drugs like hydroquinone, arbutin and kojic acid. To provide an alternative and safer technology for whitening, we developed two botanical compounds ...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1468-2494.2012.00736.x
更新日期:2012-10-01 00:00:00
abstract::Synopsis The principles on which stability tests are based are reviewed. The need to differentiate between product stability and product-container compatibility is emphasized. Recognition of this distinction is fundamental to the efficient organisation and execution of stability tests. Attention is also drawn to the d...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1467-2494.1985.tb00423.x
更新日期:1985-12-01 00:00:00
abstract:OBJECTIVE:Sensory perceptions and performance are important to the success of a lipstick formulation, but in vivo evaluation can be expensive and time-consuming. The goal of this work was to develop and use laboratory test methods to predict the sensory and performance properties of lipstick. METHODS:Twelve model lips...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12482
更新日期:2018-10-01 00:00:00
abstract:OBJECTIVE:Hyaluronan (HA) plays a role in keratinocyte proliferation and differentiation. In addition, HA has been shown to have different biological activities depending on its molecular weight. It has been reported that HA-mediated CD44 activation regulates keratinocyte differentiation. Therefore, the aim of this stu...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12105
更新日期:2014-02-01 00:00:00
abstract::Stratum corneum (SC) bilayer lipids, specifically fatty acids, ceramides and cholesterol, contribute to the permeability barrier function of the skin. Normal skin cleansing is associated with damage to the SC lipids because cleanser surfactants, in addition to providing the desired effect of solubilizing and facilitat...
journal_title:International journal of cosmetic science
pub_type: 杂志文章,评审
doi:10.1111/ics.12042
更新日期:2013-08-01 00:00:00
abstract::Synopsis We have examined the relationship between human axillary skin microflora and underarm odour (UAO), in particular, the ability of cutaneous bacteria to transform steroids. A study was made of bacterial population density and odour intensity of the axillae of 34 normal male subjects. There was a statistically s...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1467-2494.1990.tb00535.x
更新日期:1990-10-01 00:00:00
abstract::Cutaneous ageing is the result of two distinct, biological processes which may occur concurrently: (i) the passage of time, termed intrinsic ageing and (ii) environmental influences, termed extrinsic ageing. Intrinsic ageing of the skin is a slow process which causes changes in tissue structure and impairs function in...
journal_title:International journal of cosmetic science
pub_type: 杂志文章,评审
doi:10.1111/j.1468-2494.2010.00574.x
更新日期:2010-10-01 00:00:00
abstract::Synopsis The viscosity of cosmetic emulsions is of great practical importance and related to their skin feel. To achieve a desirable and constant viscosity is not an easy task because numerous factors must be considered. Based on theoretical considerations a new surfactant, steareth-5-stearate, has been developed. It ...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1467-2494.1991.tb00546.x
更新日期:1991-02-01 00:00:00
abstract::Acne vulgaris suppresses an individual's self-confidence by causing distress with regard to physical appearance, which affects a significant number of individuals during puberty and is delineated by adolescence. Several treatments have been introduced to decrease the aesthetic and psychological problems caused by acne...
journal_title:International journal of cosmetic science
pub_type: 杂志文章,评审
doi:10.1111/j.1468-2494.2011.00647.x
更新日期:2011-08-01 00:00:00
abstract::Synopsis A rapid method has been developed in order to compare the photostability of several sunscreen agents incorporated in the same type of emulsion. Thin films of the different preparations were spread on quartz plates and irradiated with a solar simulator. Differences in energy distribution according to wavelengt...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1467-2494.1988.tb00002.x
更新日期:1988-04-01 00:00:00
abstract::Synopsis The study of ternary systems leads to the understanding of the physico-chemical aspect and allows the contribution of the different components to a cosmetic formulation to be developed. The present investigation was centred in the zone of transparent get belonging to a previously studied ternary system contai...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1467-2494.1989.tb00490.x
更新日期:1989-02-01 00:00:00
abstract::Synopsis The purpose of this work was to compare the evolution of three multiple emulsions (ME) by different controls. The series of water-in-oil-in-water (W/O/W) multiple emulsions were elaborated and controlled by both the usual analyses which permitted the classification of the multiple emulsions with respect to th...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1467-2494.1993.tb00069.x
更新日期:1993-04-01 00:00:00
abstract:OBJECTIVE:A comprehensive methodology for the simultaneous determination of 15 multiclass organic UV filters in sunscreen cosmetics was developed using high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS). METHODS:Sunscreen cosmetics of various matrices,...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12387
更新日期:2017-08-01 00:00:00
abstract::Synopsis In the last few years a lot of attention has been paid to the development of the in vitro models which would substitute for animals in cutaneous irritancy studies. These models explore either organ or explant cultures using freshly excised skin or serial cultures of isolated skin cells (epidermal keratinocyte...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1467-2494.1992.tb00058.x
更新日期:1992-12-01 00:00:00
abstract::Long cattle tendons were enzymatically disposed of lipoid and accompanying nitrogenous substances. Collagenous hydrolysate of average molecular mass M(a) = 0.830 +/- 1.206 kDa, suitable for application in skin and hair-care preparations, was obtained through hydrolysis by commercial protease (Bacillus subtilis) under ...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1046/j.1467-2494.2002.00151.x
更新日期:2002-10-01 00:00:00
abstract::Good water-impermeable barrier function is vital for healthy skin. Abnormality of the barrier function is observed in a variety of skin diseases, such as atopic dermatitis, psoriasis and contact dermatitis. Moreover, repeated barrier disruption induces epidermal hyperplasia and inflammation. On the other hand, acceler...
journal_title:International journal of cosmetic science
pub_type: 杂志文章,评审
doi:10.1111/j.1468-2494.2008.00487.x
更新日期:2009-04-01 00:00:00
abstract:OBJECTIVE:To evaluate wrinkle improvement and safety of a novel cosmetic dissolving microneedle patches loaded with two active compounds with different hydrophilicities, namely ascorbic acid and retinyl retinoate. METHODS:Clinical studies were performed on 24 Korean women for 12 weeks. Patients in group A were treated...
journal_title:International journal of cosmetic science
pub_type: 杂志文章,随机对照试验
doi:10.1111/ics.12115
更新日期:2014-06-01 00:00:00
abstract:OBJECTIVE:The goal of this work was to develop a novel polyurethane polymer coating for the surface of the hair that could be used for style setting via the shape memory effect (SME). The features of the films are in accordance with conventional hair styling methods used in the laboratory. METHODS:In this study, a new...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12294
更新日期:2016-06-01 00:00:00
abstract::This work describes the development, validation and application of a simple and fast high-performance liquid chromatography-with diode array dectection (HPLC-DAD) method for the determination of eight sunscreen agents: benzophenone-3, octocrylene, ethylhexyl methoxycinnamate, ethylhexyl salicylate, homosalate (used in...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1468-2494.2012.00703.x
更新日期:2012-06-01 00:00:00
abstract::The aim of this study was to determine how worthwhile it would be to combine a newly developed topical slimming product with customized dietary habits not based on calorie restriction, so as to improve the cellulite appearance of the skin. At the beginning of the study, a nutritionist recorded the dietary habits of ea...
journal_title:International journal of cosmetic science
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1468-2494.2010.00630.x
更新日期:2011-08-01 00:00:00
abstract::Essential oils and certain perfumery raw materials exhibit a wide range of beneficial biological activities. Besides the antimicrobial and antioxidant activity, the anti-inflammatory and anti-irritant effects are most often cited. One specific mode of action is the reduction of the formation of the key mediator prosta...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1468-2494.2007.00392.x
更新日期:2007-10-01 00:00:00
abstract::Synopsis Glutathione (GSH) plays an important role in cellular protection during ageing. The hair plucking technique is a non-invasive method for the direct biochemical study of keratinocytes. Hair was taken from the suboccipital area of 63 volunteers (men and women whose ages ranged from 13 to 103 years). The results...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1467-2494.1991.tb00555.x
更新日期:1991-06-01 00:00:00
abstract::Lecithin has an antioxidative potential that depends directly on the content of phospholipids. Purified lecithin with a higher phospholipid content exerts better antioxidative properties. Furthermore, due to its specific physico-chemical properties, amphiphility in particular, the phospholipid the largest portion of t...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1046/j.1467-2494.1999.181682.x
更新日期:1999-08-01 00:00:00
abstract::Synopsis Greasy hair is a common problem in Europe. The first step in developing anti-grease hair products must be to establish a sensitive protocol for measuring any changes in perceived hair greasiness. Sensitive clinical trials and in vivo evaluation methods of determining hair greasiness have been developed that s...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1467-2494.1983.tb00329.x
更新日期:1983-06-01 00:00:00
abstract:OBJECTIVE:The aim of this work was to investigate an alternative hair-dyeing method with vegetable colourants as the tannins, as well as the impact of pre-treatment as the bleaching process. METHODS:Untreated, 1, 2 and 3 times bleached hair tresses that were dyed with tannins in combination with metal salts were chara...
journal_title:International journal of cosmetic science
pub_type: 杂志文章,评审
doi:10.1111/ics.12624
更新日期:2020-08-01 00:00:00
abstract:OBJECTIVE:The objective of this work was to investigate the utility of a new in vitro SPF test method in blinded ring-testing, against new ISO acceptance criteria. METHODS:Twenty four blinded, commercial, emulsion-type, primary sunscreen products, covering the full range of labelled SPF in Europe (SPF6 - 50+), were te...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12459
更新日期:2018-04-20 00:00:00
abstract::A multicentred study derived from the COLIPA in vitro UVA method was performed to assess the influence of test conditions on UVA protection factor (UVAPF) values in terms of amplitude, reproducibility between laboratories and correlation with in vivo UVA results. Eight products with a range of in vivo UVAPF from three...
journal_title:International journal of cosmetic science
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1468-2494.2012.00748.x
更新日期:2013-02-01 00:00:00