Abstract：
:Synopsis The ocular irritation potential of 107 cosmetics and toiletries was compared using the rabbit's eye Draize test (IOMA), a cytotoxicity in vitro method (CFIO), and the hen's egg chorioallantoic membrane test (HET-CAM). There was a good correlation between both alternative methods and the Draize test. Non-correlating results were observed in 12 cases with the HET-CAM method (six false positives, two false negatives, four technical failures) and in 14 cases with the CFIO method (ten false positives, four false negatives). However, all clearly irritant products were detected. False negatives were only found in products whose ocular irritation index lay close to the boundary (IOMA = 15) between the slightly and the moderately irritant products. None of the products was falsely found to be negative by both alternative methods. Therefore, the risk of underestimating the ocular irritation potential was avoided. The coupling of these two methods seemed to be of interest as an alternative approach to the assessment of the potential for ocular irritation of cosmetics and toiletries.
journal_name
Int J Cosmet Scijournal_title
International journal of cosmetic scienceauthors
Boue-Grabot M,Bernardin G,Chaumond S,Pinon JFdoi
10.1111/j.1467-2494.1995.tb00124.xsubject
Has Abstractpub_date
1995-10-01 00:00:00pages
207-15issue
5eissn
0142-5463issn
1468-2494pii
ICS207journal_volume
17pub_type
杂志文章abstract：:Synopsis We have examined the relationship between human axillary skin microflora and underarm odour (UAO), in particular, the ability of cutaneous bacteria to transform steroids. A study was made of bacterial population density and odour intensity of the axillae of 34 normal male subjects. There was a statistically s...
journal_title：International journal of cosmetic science
pub_type： 杂志文章
doi：10.1111/j.1467-2494.1990.tb00535.x
更新日期：1990-10-01 00:00:00
abstract：:Synopsis The manufacturing of toiletries is a complex procedure and many process routes are possible for a given formulation. In the past, considerable attention has been given to the design of manufacturing equipment but there has been relatively little appreciation of the influence of physicochemical interactions du...
journal_title：International journal of cosmetic science
pub_type： 杂志文章
doi：10.1111/j.1467-2494.1980.tb00235.x
更新日期：1980-04-01 00:00:00
abstract：:Synopsis The ability of baseline transepidermal water loss (TEWL) measurements to predict the response of healthy subjects to a standard soap chamber irritation insult was evaluated. Chambers containing surfactant solutions were applied to the forearms of normal volunteers for five consecutive days. TEWL was measured ...
journal_title：International journal of cosmetic science
pub_type： 杂志文章
doi：10.1111/j.1467-2494.1986.tb00452.x
更新日期：1986-10-01 00:00:00
abstract：:The hydroglycolic (HG) extract from 70% propylene glycol (PG) extraction of myrobalan fruits showed the most appreciable antioxidant efficiency towards 1,1-diphenyl-2-picrylhydrazyl (DPPH) in comparison to the extracts from 30, 50, 70 and 100% ethyl alcohol (EA), and 30, 50 and 100% PG . Its total polyphenols were als...
journal_title：International journal of cosmetic science
pub_type： 杂志文章
doi：10.1111/j.1468-2494.2011.00642.x
更新日期：2011-08-01 00:00:00
abstract：OBJECTIVE:Zinc pyrithione (ZnPT) is widely used as an anti-fungal active in commercial anti-dandruff (AD) shampoos. The AD efficacy of ZnPT is highly dependent on the deposition of ZnPT particles onto the scalp during the process of shampoo application and rinse-off. Since ZnPT materials with different particle sizes a...
journal_title：International journal of cosmetic science
pub_type： 杂志文章
doi：10.1111/ics.12493
更新日期：2018-10-01 00:00:00
abstract：OBJECTIVE:The objective of this study was to clarify the effects of different body washing methods on skin texture. METHODS:Subjects were nine healthy women in their 20s. Skin on the inside of the forearms was washed every day for 4 weeks with protective washing (right forearm) and with non-protective washing (left fo...
journal_title：International journal of cosmetic science
pub_type： 杂志文章
doi：10.1111/ics.12114
更新日期：2014-04-01 00:00:00
abstract：:In this work, a comparative study between two methods to acquire relevant information about a cosmetic formulation has been carried out. A Design of Experiments (DOE) has been applied in two stages to a capillary cosmetic cream: first, a Plackett-Burman (PB) design has been used to reduce the number of variables to be...
journal_title：International journal of cosmetic science
pub_type： 杂志文章
doi：10.1111/j.1468-2494.2009.00565.x
更新日期：2010-10-01 00:00:00
abstract：:A multicentred study derived from the COLIPA in vitro UVA method was performed to assess the influence of test conditions on UVA protection factor (UVAPF) values in terms of amplitude, reproducibility between laboratories and correlation with in vivo UVA results. Eight products with a range of in vivo UVAPF from three...
journal_title：International journal of cosmetic science
pub_type： 杂志文章,多中心研究
doi：10.1111/j.1468-2494.2012.00748.x
更新日期：2013-02-01 00:00:00
abstract：BACKGROUND:In order to comply with the European legislation concerning the risk assessment of skin sensitizers, considerable progress has been made in developing alternative methods, such as human cell line activation test (h-CLAT). H-CLAT is based on cytometric measurement of fluorescence emitted by anti-CD54 and anti...
journal_title：International journal of cosmetic science
pub_type： 杂志文章
doi：10.1111/ics.12530
更新日期：2019-06-01 00:00:00
abstract：:Synopsis A technique was developed to evaluate the relative slip of ten test talcs and two control talcs (one with known good slip and one with known poor slip properties). The study was conducted under double-blind conditions with a naive panel of 19 subjects, who with minimal training ranked the 12 talcs. The rankin...
journal_title：International journal of cosmetic science
pub_type： 杂志文章
doi：10.1111/j.1467-2494.1992.tb00041.x
更新日期：1992-04-01 00:00:00
abstract：:Essential oils and certain perfumery raw materials exhibit a wide range of beneficial biological activities. Besides the antimicrobial and antioxidant activity, the anti-inflammatory and anti-irritant effects are most often cited. One specific mode of action is the reduction of the formation of the key mediator prosta...
journal_title：International journal of cosmetic science
pub_type： 杂志文章
doi：10.1111/j.1468-2494.2007.00392.x
更新日期：2007-10-01 00:00:00
abstract：OBJECTIVE:Hyaluronan (HA) plays a role in keratinocyte proliferation and differentiation. In addition, HA has been shown to have different biological activities depending on its molecular weight. It has been reported that HA-mediated CD44 activation regulates keratinocyte differentiation. Therefore, the aim of this stu...
journal_title：International journal of cosmetic science
pub_type： 杂志文章
doi：10.1111/ics.12105
更新日期：2014-02-01 00:00:00
abstract：:Lecithin has an antioxidative potential that depends directly on the content of phospholipids. Purified lecithin with a higher phospholipid content exerts better antioxidative properties. Furthermore, due to its specific physico-chemical properties, amphiphility in particular, the phospholipid the largest portion of t...
journal_title：International journal of cosmetic science
pub_type： 杂志文章
doi：10.1046/j.1467-2494.1999.181682.x
更新日期：1999-08-01 00:00:00
abstract：:The assessment of many aspects of the structure and biological dynamics of the stratum corneum can be conducted using calibrated stripping with adhesive-coated discs (SACD). Squamometry entails staining SACD samples with a toluidine blue-basic fuschsin ethanol-based solution and reading the colorimetric variable Chrom...
journal_title：International journal of cosmetic science
pub_type： 杂志文章
doi：
更新日期：2000-12-01 00:00:00
abstract：:Synopsis The mechanism of colour change during the pigment dispersion process and during powder application to the skin surface was studied by examining the colour extension properties of Yellow. Red, and Black iron oxides in white powder bases. A new measure for the evaluation of the degree of colour extension was de...
journal_title：International journal of cosmetic science
pub_type： 杂志文章
doi：10.1111/j.1467-2494.1985.tb00391.x
更新日期：1985-02-01 00:00:00
abstract：:The photostabilities of four sunscreen products have been assessed in vitro by applying sunscreen to a substrate and measuring the spectral transmission prior to, and after exposure to a source of ultraviolet (UV) radiation. Results were independent of whether an application thickness of 1 or 2 mg/cm ; 2 was used, and...
journal_title：International journal of cosmetic science
pub_type： 杂志文章
doi：10.1046/j.1467-2494.1999.203163.x
更新日期：1999-10-01 00:00:00
abstract：BACKGROUND:Xerosis is an abnormally dry and flaky skin condition that is associated with a change in the packing behaviour of the lipid matrix in the stratum corneum (SC), the outermost layer of the skin. This skin condition can lead to an increase in transepidermal water loss (TEWL). As ultralong-chain fatty acids hav...
journal_title：International journal of cosmetic science
pub_type： 杂志文章
doi：10.1111/ics.12404
更新日期：2017-10-01 00:00:00
abstract：:Lysyl oxidase-like (LOXL) is an extracellular enzyme that catalyses the cross-linking between microfibrils and tropoelastin (TE), thereby ensuring elastic fibre functionality. With ageing, LOXL expression decreases, thus participating in the loss of skin elasticity. In a previous study, we showed that a dill seed extr...
journal_title：International journal of cosmetic science
pub_type： 杂志文章,随机对照试验
doi：10.1111/j.1468-2494.2010.00606.x
更新日期：2011-04-01 00:00:00
abstract：:Skin firmness, elasticity and tone are gradually lost with age. These changes originate in the dermis and correspond to a decrease in the ability of cells, particularly the fibroblasts, to regenerate the molecules which make up the extracellular matrix. Skin ageing is also characterized by a reduction of the epidermal...
journal_title：International journal of cosmetic science
pub_type： 杂志文章
doi：10.1046/j.1467-2494.1998.171748.x
更新日期：1998-06-01 00:00:00
abstract：:Many studies have presented stress-strain relationship of human hair, but most of them have been based on an engineering stress-strain curve, which is not a true representation of stress-strain behaviour. In this study, a more accurate 'true' stress-strain curve of human hair was determined by applying optical techniq...
journal_title：International journal of cosmetic science
pub_type： 杂志文章
doi：10.1111/ics.12031
更新日期：2013-06-01 00:00:00
abstract：:Synopsis In the last few years a lot of attention has been paid to the development of the in vitro models which would substitute for animals in cutaneous irritancy studies. These models explore either organ or explant cultures using freshly excised skin or serial cultures of isolated skin cells (epidermal keratinocyte...
journal_title：International journal of cosmetic science
pub_type： 杂志文章
doi：10.1111/j.1467-2494.1992.tb00058.x
更新日期：1992-12-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to perform short-term sensory testing and instrumental (conductivity and rheological) characterization of a fast inverted oil-in-water (o/w) emulsion base, also known as a SWOP (Switch-Oil-Phase) emulsion, and reference o/w and water-in-oil (w/o) emulsion bases under various testing ...
journal_title：International journal of cosmetic science
pub_type： 杂志文章
doi：10.1111/ics.12282
更新日期：2016-06-01 00:00:00
abstract：:Synopsis The synthesis of 5-alkoxy and 5-aryloxymethylene-1,3,3-trimethyl-2-oxabicyclo[2.2.2]octan-6-ones by reaction of (+)-5-hydroxymethylene-1,3,3-trimethyl-2-oxabicyclo[2.2.2]octan-6-one with a number of saturated or unsaturated alcohols and phenols in order to check how substituents affected the fragrance, is des...
journal_title：International journal of cosmetic science
pub_type： 杂志文章
doi：10.1111/j.1467-2494.1995.tb00108.x
更新日期：1995-04-01 00:00:00
abstract：:Synopsis The study of ternary systems leads to the understanding of the physico-chemical aspect and allows the contribution of the different components to a cosmetic formulation to be developed. The present investigation was centred in the zone of transparent get belonging to a previously studied ternary system contai...
journal_title：International journal of cosmetic science
pub_type： 杂志文章
doi：10.1111/j.1467-2494.1989.tb00490.x
更新日期：1989-02-01 00:00:00
abstract：:The objective of the present work was to evaluate the possible use of Myrosma cannifolia starch L.F. Maranthaceae ('Guapo'), as a raw material in heterogeneous systems or powdered cosmetic and pharmaceutical products formulation. The starch chemical and physical characteristics, physico-chemical properties, and rheolo...
journal_title：International journal of cosmetic science
pub_type： 杂志文章
doi：10.1111/j.1467-2494.2004.00253.x
更新日期：2005-04-01 00:00:00
abstract：:There are a variety of biological mechanisms that contribute to specific characteristics of ageing skin; for example, the loss of skin structure proteins, increased susceptibility to UV-induced pigmentation and/or loss of hydration. Each of these biological processes is influenced by specific groups of genes. In this ...
journal_title：International journal of cosmetic science
pub_type： 杂志文章
doi：10.1111/j.1468-2494.2011.00645.x
更新日期：2011-10-01 00:00:00
abstract：:Synopsis Wound healing involves the activity of epithelial cells and fibroblasts. This process is particularly accompanied by an increase in the proliferative capacity of the fibroblasts and by the biosynthesis of constitutive proteins of connective tissue. To study the action of wound healing drugs on the growth of f...
journal_title：International journal of cosmetic science
pub_type： 杂志文章
doi：10.1111/j.1467-2494.1984.tb00358.x
更新日期：1984-02-01 00:00:00
abstract：OBJECTIVE:Exposure to UV in humans resulting in sunburn triggers a complex series of events that are a mix of immediate and delayed damage mediation and healing. While studies on the effects of UV exposure on DNA damage and repair have been reported, changes in the oxidative modification of skin proteins are poorly und...
journal_title：International journal of cosmetic science
pub_type： 杂志文章
doi：10.1111/ics.12365
更新日期：2017-04-01 00:00:00
abstract：BACKGROUND:Bromelain is a mixture of proteolytic enzymes found in various tissues of the pineapple plant (Ananas comosus) and other species of Bromeliaceae. Owing to its proteolytic activity, bromelain has been used in the food, medical, pharmaceutical and cosmetic industries, for its cell renewal, anti-ageing, whiteni...
journal_title：International journal of cosmetic science
pub_type： 杂志文章
doi：10.1111/ics.12308
更新日期：2016-10-01 00:00:00
abstract：:Synopsis An investigation has been carried out into the synthesis of quaternary ammonium salts of triglycerides. The aim of this work was to produce such compounds without breaking the triglyceride skeleton. The reaction of chloracetyl chloride with the triglyceride of ricinoleic acid which is the major constituent (8...
journal_title：International journal of cosmetic science
pub_type： 杂志文章
doi：10.1111/j.1467-2494.1991.tb00560.x
更新日期：1991-08-01 00:00:00
