Abstract:
OBJECTIVE:Exposure to UV in humans resulting in sunburn triggers a complex series of events that are a mix of immediate and delayed damage mediation and healing. While studies on the effects of UV exposure on DNA damage and repair have been reported, changes in the oxidative modification of skin proteins are poorly understood at the molecular level, despite the important role played by structural proteins in skin tissue, and the effect of the integrity of these proteins on skin appearance and health. Proteomic molecular mapping of oxidation was here applied to try to enhance understanding of skin damage and recovery from oxidative damage and UVB exposure. METHODS:A redox proteomic-based approach was applied to evaluating skin protein modification when exposed to varying doses of UVB after initial oxidative stress, via tracking changes in protein oxidation during the healing process in vitro using a full-thickness reconstituted human skin tissue model. Bioassays and structural evaluation confirmed that our cultured skin tissues underwent a normal physiological response to UVB exposure. RESULTS:A set of potential skin marker peptides was generated, for use in tracking skin protein oxidative modification. Exposure to UVB after thermal oxidative stress was found to result in higher levels of skin protein oxidation than a non-irradiated control for up to seven days after exposure. Recovery of the skin proteins from oxidative stress, as assessed by the overall protein oxidation levels, was found to be impaired by UVB exposure. Oxidative modification was largely observed in skin structural proteins. CONCLUSION:Exposure of skin proteins to UVB exacerbates oxidative damage to structural skin proteins, with higher exposure levels leading to increasingly impaired recovery from this damage. This has potential implications for the functional performance of the proteins and inter-related skin health and cosmetic appearance.
journal_name
Int J Cosmet Scijournal_title
International journal of cosmetic scienceauthors
Dyer JM,Haines SR,Thomas A,Wang W,Walls RJ,Clerens S,Harland DPdoi
10.1111/ics.12365subject
Has Abstractpub_date
2017-04-01 00:00:00pages
197-205issue
2eissn
0142-5463issn
1468-2494journal_volume
39pub_type
杂志文章abstract::Synopsis The principles on which stability tests are based are reviewed. The need to differentiate between product stability and product-container compatibility is emphasized. Recognition of this distinction is fundamental to the efficient organisation and execution of stability tests. Attention is also drawn to the d...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1467-2494.1985.tb00423.x
更新日期:1985-12-01 00:00:00
abstract:OBJECTIVE:The aim of the study was to develop formulations to deliver physiological lipids into skin in an attempt to repair defective barrier function. METHODS:Physiological cholesterol and linoleic acid were incorporated into basic cream and non-ionic cream to prepare skin repair formulations. Homogeneity and storag...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12491
更新日期:2018-10-01 00:00:00
abstract::Variable skin pH values are being reported in literature, all in the acidic range but with a broad range from pH 4.0 to 7.0. In a multicentre study (N = 330), we have assessed the skin surface pH of the volar forearm before and after refraining from showering and cosmetic product application for 24 h. The average pH d...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1467-2494.2006.00344.x
更新日期:2006-10-01 00:00:00
abstract::The aim of this work was to investigate the effects of 1,18-octadecen-9-dioic acid (dioic acid) and a Rumex occidentalis extract complex for their skin-lightening action in an Indian population. Prior to the clinical study, the efficacy of dioic as an inhibitor of melanogenesis was confirmed on dark-pigmented human me...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12002
更新日期:2012-12-01 00:00:00
abstract::Reconstructed human epidermis models (RHE) constitute an innovative alternative to study phototoxicity and photoprotection in the cosmetic industry. However, little information is currently available concerning the harmful effects of solar-simulated radiation (SSR) in these in vitro skin models. In this study, the pho...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1468-2494.2009.00506.x
更新日期:2009-08-01 00:00:00
abstract:OBJECTIVE:In this study, the influence of three cosmetically relevant, priorly characterized vehicles on skin hydration, sebum content and transepidermal water loss was investigated. The chosen vehicles included a liposomal pre-formulation, a multiple W/O/W emulsion and a microemulsion gel. The in vivo effects of these...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12180
更新日期:2015-04-01 00:00:00
abstract::Cutaneous irritation is a stereotyped response of the skin to any physical or chemical insult. Its main manifestations encompass inflammatory erythema and an alteration of the cutaneous microrelief showing increased roughness, dehydration and erratic desquamation. Several instrumental methods can indirectly assess the...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1046/j.1467-2494.2003.00170.x
更新日期:2003-04-01 00:00:00
abstract::Many studies have presented stress-strain relationship of human hair, but most of them have been based on an engineering stress-strain curve, which is not a true representation of stress-strain behaviour. In this study, a more accurate 'true' stress-strain curve of human hair was determined by applying optical techniq...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12031
更新日期:2013-06-01 00:00:00
abstract::Synopsis An objectivised sensorial method for evaluating the effects of shampoos on the appearance and manageability of the hair is described. Two different shampoos for greasy hair were applied twice weekly for a period of 4 weeks to the right and left sides (split-head tests) of six subjects having greasy hair, the ...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1467-2494.1979.tb00205.x
更新日期:1979-04-01 00:00:00
abstract::The objective of the study was to compare measurements of skin hydration and of biomechanical properties performed on different zones of face and volar forearm. Two short-term (1 h) and two long-term (3 weeks) studies were conducted with a moisturizing and a firming product, respectively, on groups of female volunteer...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1467-2494.2006.00352.x
更新日期:2006-12-01 00:00:00
abstract::Synopsis The non-saponifiable lipidic fractions of avocado and soya bean applied percutaneously to hairless rats for 15 days had been shown to produce biochemical modifications of dermal connective tissue components: increases of soluble collagen and of the ratio soluble collagen/insoluble collagen. In this present st...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1467-2494.1982.tb00310.x
更新日期:1982-08-01 00:00:00
abstract:OBJECTIVES:Liposomes are commonly used in cosmetic formulations to increase the bioavailability of active ingredients. We have previously shown that polysaccharide coating of liposomes improves their resistance to surfactants and electrolytes. In the current study, we have assessed the impact of coating on the skin pen...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12394
更新日期:2017-08-01 00:00:00
abstract::Synopsis Glutathione (GSH) plays an important role in cellular protection during ageing. The hair plucking technique is a non-invasive method for the direct biochemical study of keratinocytes. Hair was taken from the suboccipital area of 63 volunteers (men and women whose ages ranged from 13 to 103 years). The results...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1467-2494.1991.tb00555.x
更新日期:1991-06-01 00:00:00
abstract:OBJECTIVE:Sensory perceptions and performance are important to the success of a lipstick formulation, but in vivo evaluation can be expensive and time-consuming. The goal of this work was to develop and use laboratory test methods to predict the sensory and performance properties of lipstick. METHODS:Twelve model lips...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12482
更新日期:2018-10-01 00:00:00
abstract:SYNOPSIS:Despite the extensive use of topical coatings in cosmetics, their effect on the mechanical properties of human skin and the perception of skin tightness in the form of drying stresses is not well understood. We describe the application of a recently developed substrate curvature technique to characterize stres...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1468-2494.2010.00568.x
更新日期:2010-08-01 00:00:00
abstract:OBJECTIVE:The present investigation is based on the formulation of water-in-oil (w/o) cream preparations of ascorbic acid (AA) at pH 4-6 using different emollients and humectants. METHODS:The preparations were stored in the dark at 30°C for a period of 3 months and were studied for their chemical and physical stabilit...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12152
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND:The effect of photodamage on facial stratum corneum (SC) is still poorly understood. OBJECTIVE:To describe the SC proteome from tape strippings of Caucasian SC from photoexposed cheek and photoprotected post-auricular (PA) site, a global analysis of photodamage on the skin will be developed leading to a bet...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12426
更新日期:2017-12-01 00:00:00
abstract::The objective of the present work was to evaluate the possible use of Myrosma cannifolia starch L.F. Maranthaceae ('Guapo'), as a raw material in heterogeneous systems or powdered cosmetic and pharmaceutical products formulation. The starch chemical and physical characteristics, physico-chemical properties, and rheolo...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1467-2494.2004.00253.x
更新日期:2005-04-01 00:00:00
abstract::On a daily basis, the skin is exposed to many environmental stressors and insults. Over a 24-h natural cycle, during the day, the skin is focused on protection; while at night, the skin is focused on repairing damage that occurred during daytime and getting ready for the next morning. Circadian rhythm provides the pre...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12572
更新日期:2019-12-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to clarify the effects of different body washing methods on skin texture. METHODS:Subjects were nine healthy women in their 20s. Skin on the inside of the forearms was washed every day for 4 weeks with protective washing (right forearm) and with non-protective washing (left fo...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12114
更新日期:2014-04-01 00:00:00
abstract::The phase diagrams were determined of lactic and isohexanoic hydroxy acids as well as salicylic acid with water, a non-ionic surfactant and a paraffinic oil to outline the influence of the hydroxy acids on the structure in a model for a skin lotion. The results showed the influence of the acid to be similar to that of...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1467-2494.2004.00212.x
更新日期:2004-06-01 00:00:00
abstract:OBJECTIVE:We investigated the association of psychosocial problems, menopausal symptoms such as hot flushes, and trends of smoking and use of cosmetics in our previous study. In this follow-up study, we researched psychiatric disorders and psychosocial problems in menopausal women. METHODS:We designed a cohort study w...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12081
更新日期:2013-12-01 00:00:00
abstract:OBJECTIVE:Development of an international harmonized in vitro method for sun protection factor (SPF) assessment is currently in progress because of the lack of both reproducibility and accuracy in the current methodology. The aim of this article was to focus on the principle and mathematical aspects (Part I) of a new a...
journal_title:International journal of cosmetic science
pub_type: 杂志文章,评审
doi:10.1111/ics.12226
更新日期:2015-12-01 00:00:00
abstract:OBJECTIVE:This study focused on the formulation of lamellar lyotropic liquid crystal (LLC) loaded with mulberry stem extract (MSE). METHODS:The LLC formulation tested used two oils: n-dodecane or tridecyl salicylate, a co-solvent (propylene glycol) and a single (PEG-7 glyceryl cocoate) or mixed surfactant system. The ...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12116
更新日期:2014-06-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to perform short-term sensory testing and instrumental (conductivity and rheological) characterization of a fast inverted oil-in-water (o/w) emulsion base, also known as a SWOP (Switch-Oil-Phase) emulsion, and reference o/w and water-in-oil (w/o) emulsion bases under various testing ...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12282
更新日期:2016-06-01 00:00:00
abstract::Synopsis An investigation has been carried out into the synthesis of quaternary ammonium salts of triglycerides. The aim of this work was to produce such compounds without breaking the triglyceride skeleton. The reaction of chloracetyl chloride with the triglyceride of ricinoleic acid which is the major constituent (8...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1467-2494.1991.tb00560.x
更新日期:1991-08-01 00:00:00
abstract::The addition of water to lipsticks in the form of a water-in-oil emulsion is an attractive opportunity for cosmetics manufacturers to deliver hydrophilic molecules to the consumers, as well as improving the moisturizing properties. In this work, the effect of the emulsifier type and water content on the structural pro...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1468-2494.2010.00624.x
更新日期:2011-06-01 00:00:00
abstract::Skin moisturization is not only important for maintaining skin functional properties but also has great impact on the skin's aesthetic properties. The top layer of the skin, the stratum corneum (SC), plays a key role in protecting and preventing against external aggressions as well as in regulating water flux in and o...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1468-2494.2008.00428.x
更新日期:2008-02-01 00:00:00
abstract::Synopsis A rapid method has been developed in order to compare the photostability of several sunscreen agents incorporated in the same type of emulsion. Thin films of the different preparations were spread on quartz plates and irradiated with a solar simulator. Differences in energy distribution according to wavelengt...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1467-2494.1988.tb00002.x
更新日期:1988-04-01 00:00:00
abstract::Summary The powder made with leaflets of a senna, Cassia obovata Coll., is a cosmetic mis-called 'neutral henna' The traditional use of C. obovata is as a laxative. The principal active components of this laxative drug are sennosides A and B. In the Middle Ages the blend of henna (Lawsonia inermis) and senna was calle...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1467-2494.1981.tb00284.x
更新日期:1981-10-01 00:00:00