Abstract:
:The present study investigated the effects of chronic pre-exposure to methamphetamine on sexual motivation and performance in male Japanese quail. Quail were pre-exposed to methamphetamine (1.0 or 3.0 mg/kg ip) or saline (ip) once daily for 10 days and locomotor activity was measured. After a 10 day washout period, sexual motivation was measured in a straight-arm runway with visual access to a female at one end. Three to 5 hr after sexual motivation tests, males were allowed to copulate with a receptive female quail and copulatory behavior was assessed. Tests were conducted once per day for 10 days. Results showed that males pre-exposed to methamphetamine had decreased locomotor activity compared to saline controls. Males pre-exposed to METH later ran slower toward a female in the runway and spent less time near her. In contrast, methamphetamine pre-exposed males showed similar copulatory behavior as saline pre-exposed males. The findings suggest that chronic pre-exposure to methamphetamine may impair sexual motivation but not sexual performance. The findings are discussed from a comparative perspective and with regard to their clinical relevance.
journal_name
Exp Clin Psychopharmacoljournal_title
Experimental and clinical psychopharmacologyauthors
Bolin BL,Akins CKdoi
10.1037/a0014505subject
Has Abstractpub_date
2009-02-01 00:00:00pages
10-20issue
1eissn
1064-1297issn
1936-2293pii
2009-01082-002journal_volume
17pub_type
杂志文章abstract::In this study, crack/cocaine-dependent (CD) and non-drug-using matched control (MC) participants were presented with hypothetical immediate and delayed rewards, with 16 delay conditions ranging from 5 min to 25 years. All participants were presented with hypothetical monetary rewards; however, the CD group was also pr...
journal_title:Experimental and clinical psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1037//1064-1297.11.1.18
更新日期:2003-02-01 00:00:00
abstract::Benzodiazepines and alcohol are widely used psychoactive substances that have performance-impairing effects. Research suggests that the impairment profiles for benzodiazepines and alcohol differ, although few cognitive psychopharmacological studies have directly compared these drugs. This double-blind, double-dummy, p...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037/a0018407
更新日期:2010-02-01 00:00:00
abstract::Two studies were conducted to determine the anger-attenuating effects of nicotine as a function of trait hostility. The 1st study examined the effects of nicotine on diary ratings of anger during a 24-hr period in a natural setting in 30 smokers and 30 nonsmokers. Participants took part in 2 monitoring sessions involv...
journal_title:Experimental and clinical psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1037//1064-1297.7.4.454
更新日期:1999-11-01 00:00:00
abstract::Two groups of male Japanese quail (Coturnix japonica) were trained [corrected] to discriminate cocaine from saline in a conditioned approach procedure maintained by sexual reinforcement. For 1 group, cocaine (10 mg/kg ip) was administered prior to a conditioned stimulus (CS) that predicted copulation; saline followed ...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037/1064-1297.12.4.237
更新日期:2004-11-01 00:00:00
abstract::Smoking-related cues tend to produce urges and cardiac responses in smokers. This reactivity has been assumed to reflect prior classical conditioning. However, little direct evidence exists supporting the notion that environmental cues can be classically conditioned to cigarette smoking. In this study, 8 smokers recei...
journal_title:Experimental and clinical psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1037//1064-1297.7.1.56
更新日期:1999-02-01 00:00:00
abstract::A series of experiments in rats explored the possibility that D3/D2 dopamine receptors are involved in behaviors that might be related to compulsion. A series of D3/D2 agonists and antagonists were shown to elicit yawning (D3-receptor mediated) and its inhibition (D2-receptor mediated). In rats with histories of cocai...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037/a0014190
更新日期:2008-12-01 00:00:00
abstract::The ability of nicotine to decrease sensitivity to pain in humans has been a subject of dispute. Decreased sensitivity has been demonstrated in studies involving men, whereas the effect has been less obvious or absent in studies involving predominantly, or entirely, women. To determine whether there are gender differe...
journal_title:Experimental and clinical psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1037//1064-1297.6.1.96
更新日期:1998-02-01 00:00:00
abstract::The authors investigated the effects of a laboratory stressor task on rapid initial orienting and delayed disengagement aspects of attentional bias for alcohol-related cues in social drinkers (N = 58). Participants were randomly allocated to receive a stress induction or control manipulation before completing a visual...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037/a0017090
更新日期:2009-10-01 00:00:00
abstract::This study targeted poly-drug (cocaine plus heroin) abstinence among buprenorphine-maintained participants with a 12-week voucher-based reinforcement therapy (VBRT) phase versus a yoked control condition. Baseline levels of cocaine and heroin use were significant predictors of treatment outcome, regardless of treatmen...
journal_title:Experimental and clinical psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1037//1064-1297.8.2.176
更新日期:2000-05-01 00:00:00
abstract::A retrospective study was conducted to examine aripiprazole's effectiveness and safety in a naturalistic treatment setting in both inpatients and outpatients affected by schizophrenia and other psychotic disorders. All patients with schizophrenia, schizoaffective and delusional disorders, and schizoid and schizotypal ...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037/1064-1297.15.6.569
更新日期:2007-12-01 00:00:00
abstract::Repeated drug administration results in sensitization, tolerance, or no change in subsequent drug-induced alterations of motivated behaviors, such as intracranial self-stimulation (ICSS). For example, repeated mu-opioid agonist administration results in increased expression of mu agonist-induced facilitation of ICSS. ...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037/pha0000287
更新日期:2020-02-01 00:00:00
abstract::Rats were exposed to a diet containing 100 ppm cadmium chloride or a control diet. At 52 days of exposure, rats were trained to discriminate between saline and 5 mg/kg cocaine injections. After acquisition training, successive substitution tests were conducted using cocaine, the indirect dopamine agonist d-amphetamine...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037//1064-1297.7.2.90
更新日期:1999-05-01 00:00:00
abstract::Delayed reward discounting (DRD) is a behavioral economic measure of impulsivity that has been consistently associated with addiction. It has also been identified as a promising addiction endophenotype, linking specific sources of genetic variation to individual risk. A challenge in the studies to date is that levels ...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037/pha0000227
更新日期:2019-02-01 00:00:00
abstract::Prescription stimulant misuse (PSM) is common in young adult college students, at over 10% in the past year, and it is associated with other substance use and risk behaviors. Research focused on the real-time drivers of PSM is absent, impeding prevention and intervention. This research aimed to fill that gap by examin...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037/pha0000386
更新日期:2020-05-28 00:00:00
abstract::Although marijuana is the most commonly used illicit drug in the United States, it is not established whether withdrawal from chronic use results in a clinically significant abstinence syndrome. The present study was conducted to characterize symptoms associated with marijuana withdrawal following chronic use during a...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037//1064-1297.8.4.483
更新日期:2000-11-01 00:00:00
abstract::Increased discounting (devaluing) of delayed rewards is associated with nearly all types of substance use disorders (SUDs) and is also present in individuals with family histories of SUDs. Early life adversity (ELA) likely contributes to these findings as it is common in both individuals with SUDs and their children a...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037/pha0000241
更新日期:2019-04-01 00:00:00
abstract::The nonmedical use of prescription drugs is a widely recognized public health issue, and young adults are particularly vulnerable to their use. Behavioral economic drug purchase tasks capture an individual's strength of desire and motivation for a particular drug. We examined young adult prescription drug purchase and...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037/pha0000052
更新日期:2016-02-01 00:00:00
abstract::It is becoming increasingly evident that the sex of an organism is a critical determinant of responsiveness to opioid analgesics. However, the factors that determine the magnitude and direction of sex differences in opioid antinociception have not been fully elucidated. One factor that has received attention is the re...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章,评审
doi:10.1037/1064-1297.14.1.1
更新日期:2006-02-01 00:00:00
abstract::Alcohol-specific attentional biases (AttB) and approach biases (AppB) are postulated to play a role in alcohol use disorders but their association with drinking in young adults remains unknown. A subsample of young adults with risky alcohol use (N = 296) enrolled in a randomized trial, testing different text message i...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037/pha0000343
更新日期:2020-12-01 00:00:00
abstract::The purpose of this study was to examine the acute effects of alcohol on aggressive behavior in men and women in a laboratory setting. Participants were 526 (261 men and 265 women) healthy social drinkers between 21 and 35 years of age. They were randomly assigned to either an alcohol or a placebo group. Aggression wa...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1037/a0016385
更新日期:2009-06-01 00:00:00
abstract::Among young adults, subjective feelings of alcohol's effects often guide risky decision making. The majority of studies measuring subjective effects have used singular indices ("How drunk do you feel?") which limits our understanding of young adults' full range of subjective states and their individual differences in ...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037/pha0000416
更新日期:2020-07-16 00:00:00
abstract::Some abused drugs have been reported to alter performance on naturalistic tasks such as driving and also on laboratory tasks. The performance effects of several drug classes were examined using a repeated measures design. Eight volunteers were administered 2 doses of ethanol, marijuana, amphetamine, hydromorphone, pen...
journal_title:Experimental and clinical psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1037//1064-1297.5.3.235
更新日期:1997-08-01 00:00:00
abstract::This review outlines the development and use of placebo cigarettes in smoking research. Research on effects of smoking has been disadvantaged by the lack of an adequate placebo condition. Recently, tobacco-based denicotinized cigarettes have been used in smoking research to distinguish effects of smoking due to the de...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章,评审
doi:10.1037//1064-1297.8.3.326
更新日期:2000-08-01 00:00:00
abstract::Antipsychotic polypharmacy refers to the clinical practice of treating a patient with two or more antipsychotic drugs concurrently. There is abundant evidence in the clinical literature that treatment with antipsychotic polypharmacy is associated with an increased prevalence of drug side effects compared with monother...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037/a0031228
更新日期:2013-04-01 00:00:00
abstract::The consumption of alcohol mixed with energy drinks (AmED) has become a popular and controversial practice among young people. Increased rates of impaired driving and injuries have been associated with AmED consumption. The purpose of this study was to examine if the consumption of AmED alters cognitive processing and...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1037/a0026136
更新日期:2012-04-01 00:00:00
abstract::Social learning theory considers self-efficacy as a causal factor in behavior change. However, in line with behavioral theory, recent clinical research suggests self-efficacy ratings may reflect, rather than cause, behavior change. To test these two disparate views, self-efficacy was related to actual smoking abstinen...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037/a0025482
更新日期:2012-02-01 00:00:00
abstract::Substantial evidence links greater impulsivity and stress exposure to poorer smoking cessation outcomes. Results from adolescents also indicate that stress-related change in risk taking can impede cessation attempts. We investigated the effects of stress-related change in impulsivity, risk taking, attention and nicoti...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037/pha0000066
更新日期:2016-04-01 00:00:00
abstract::Nicotine addiction continues to be the main cause of preventable death in developed countries. Women and teen girls appear to be more vulnerable on certain aspects of nicotine addiction compared with men and boys. While the mechanism of gender differences in nicotine addiction is not yet clear, evidence suggests that ...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章,评审
doi:10.1037/a0021265
更新日期:2010-12-01 00:00:00
abstract:BACKGROUND:Despite increases in ecstasy (MDMA) use in the United States, little is known about characteristics linked with recent-onset ecstasy use, especially psychiatric symptoms and deviant behaviors. AIMS:To test whether individuals with high levels of other drug use are more likely to be recent-onset ecstasy user...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037/1064-1297.14.3.275
更新日期:2006-08-01 00:00:00
abstract::Maternal smoking is a leading preventable cause of poor pregnancy outcomes and infant morbidity and mortality. Whereas pregnancy has been thought of as a "window of opportunity" when women are more motivated to change health behaviors such as smoking, only 20% of pregnant women quit smoking upon learning they are preg...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037/1064-1297.14.2.165
更新日期:2006-05-01 00:00:00