Dose effects of triazolam and alcohol on cognitive performance in healthy volunteers.

Abstract:

:Benzodiazepines and alcohol are widely used psychoactive substances that have performance-impairing effects. Research suggests that the impairment profiles for benzodiazepines and alcohol differ, although few cognitive psychopharmacological studies have directly compared these drugs. This double-blind, double-dummy, placebo-controlled, repeated measures study directly compared the acute dose effects of triazolam (0.125, 0.25 mg/70 kg) and alcohol (0.40, 0.80 g/kg) in 20 social drinkers. At doses that produced comparable psychomotor impairment, triazolam was more likely to impair several objective measures of cognitive performance (e.g., episodic memory, divided attention) and to slow performance across several measures. However, only alcohol impaired accuracy on the digit symbol substitution and semantic memory tasks. In addition to objective measures, both drugs impaired awareness of performance impairments (i.e., metacognition) such that participants overestimated impairment, and the magnitude of this effect was generally larger for alcohol. Only triazolam impaired other measures of metacognition (e.g., error detection on a choice reaction time task). Future research might examine the clinical implications of the performance impairments reported here given the widespread use of benzodiazepines and alcohol.

authors

Kleykamp BA,Griffiths RR,Mintzer MZ

doi

10.1037/a0018407

subject

Has Abstract

pub_date

2010-02-01 00:00:00

pages

1-16

issue

1

eissn

1064-1297

issn

1936-2293

pii

2010-02775-001

journal_volume

18

pub_type

杂志文章
  • Analytic complexities associated with group therapy in substance abuse treatment research: problems, recommendations, and future directions.

    abstract::In community-based alcoholism and drug abuse treatment programs, the vast majority of interventions are delivered in a group therapy context. In turn, treatment providers and funding agencies have called for more research on interventions delivered in groups in an effort to make the emerging empirical literature on th...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章,评审

    doi:10.1037/1064-1297.14.2.265

    authors: Morgan-Lopez AA,Fals-Stewart W

    更新日期:2006-05-01 00:00:00

  • Abstinence symptoms during withdrawal from chronic marijuana use.

    abstract::Although marijuana is the most commonly used illicit drug in the United States, it is not established whether withdrawal from chronic use results in a clinically significant abstinence syndrome. The present study was conducted to characterize symptoms associated with marijuana withdrawal following chronic use during a...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1037//1064-1297.8.4.483

    authors: Kouri EM,Pope HG Jr

    更新日期:2000-11-01 00:00:00

  • The observing-response procedure: a novel method to study drug-associated conditioned reinforcement.

    abstract::In this experiment, the observing-response procedure was adapted for use with drug self-administration. Rats' responding for oral ethanol was sometimes reinforced on a random-ratio schedule, whereas at other times it had no effect (i.e., extinction). Behavior producing stimuli associated with the otherwise unsignaled ...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1037//1064-1297.10.1.3

    authors: Shahan TA

    更新日期:2002-02-01 00:00:00

  • Effects of reduced nicotine content cigarettes on individual withdrawal symptoms over time and during abstinence.

    abstract::In the United States, the Food and Drug Administration (FDA) has initiated a public dialogue about reducing the nicotine content of cigarettes. A reduced-nicotine standard could increase withdrawal symptoms among current smokers. We examined the impact of switching smokers to cigarettes that varied in nicotine content...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1037/pha0000179

    authors: Dermody SS,McClernon FJ,Benowitz N,Luo X,Tidey JW,Smith TT,Vandrey R,Hatsukami D,Donny EC

    更新日期:2018-06-01 00:00:00

  • Neural outcome processing of peer-influenced risk-taking behavior in late adolescence: Preliminary evidence for gene × environment interactions.

    abstract::Adolescent brains are particularly susceptible to the rewarding properties of risky decisions in social contexts. Individual differences in genetic influences on dopamine transmission moderate neural outcome processing of risky decisions and may exert pronounced effects on adolescent risk-taking behavior (RTB) and cor...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1037/pha0000105

    authors: Webber TA,Soder HE,Potts GF,Park JY,Bornovalova MA

    更新日期:2017-02-01 00:00:00

  • Derived relations moderate the association between changes in the strength of commitment language and cocaine treatment response.

    abstract::The psycholinguistic analysis of client-counselor interactions indicates that how individuals talk about their substance use is associated with treatment outcome. However, the processes by which client speech influences out-of-session behaviors have not been clearly delineated. This study investigated the relationship...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1037/pha0000063

    authors: Carpenter KM,Amrhein PC,Bold KW,Mishlen K,Levin FR,Raby WN,Evans SM,Foltin RW,Nunes EV

    更新日期:2016-04-01 00:00:00

  • Getting back to basics: commentary on McSweeney, Murphy, and Kowal (2005).

    abstract::The review article "Regulation of Drug Taking by Sensitization and Habituation" by F. K. McSweeney, E. S. Murphy, and B. P. Kowal introduces 2 basic principles of behavior, sensitization and habituation, into a comprehensive model for studying drug intake and drug addiction. A key assumption of the model is that the r...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 评论,杂志文章

    doi:10.1037/1064-1297.13.3.187

    authors: Rowlett JK

    更新日期:2005-08-01 00:00:00

  • Proximal versus distal cues to smoke: the effects of environments on smokers' cue-reactivity.

    abstract::Smokers are highly reactive to smoking-related cues that are directly linked, or most proximal, to actual smoking behavior (e.g., lit cigarettes). However, over the course of smoking, proximal cues may not be the only stimuli to become strongly associated with smoking. Distal cues, such as the environments in which sm...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1037/1064-1297.16.3.207

    authors: Conklin CA,Robin N,Perkins KA,Salkeld RP,McClernon FJ

    更新日期:2008-06-01 00:00:00

  • The behavioral economics of the bottomless cup: The effects of alcohol cup price on consumption in college students.

    abstract::Heavy drinking among college students is a public health concern in part due to the accessibility of alcohol and promotions such as "happy hours," which discount the price of alcohol. In addition, consuming alcohol at unregulated off-campus parties may result in greater alcohol consumption, higher blood alcohol concen...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1037/pha0000360

    authors: Morrell MN,Reed DD,Martinetti MP

    更新日期:2020-03-19 00:00:00

  • Contingency management for behavior change: applications to promote brief smoking cessation among opioid-maintained patients.

    abstract::Cigarette smoking is highly prevalent among patients who are being treated for opioid-dependence, yet there have been limited scientific efforts to promote smoking cessation in this population. Contingency management (CM) is a behavioral treatment that provides monetary incentives contingent upon biochemical evidence ...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1037/a0022039

    authors: Dunn KE,Saulsgiver KA,Sigmon SC

    更新日期:2011-02-01 00:00:00

  • Development and validation of the Wisconsin Smoking Withdrawal Scale.

    abstract::The accurate assessment of nicotine withdrawal is important theoretically and clinically. A 28-item scale, the Wisconsin Smoking Withdrawal Scale, was developed that contains 7 reliable subscales tapping the major symptom elements of the nicotine withdrawal syndrome. Coefficients alpha for the subscales range from .75...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1037//1064-1297.7.4.354

    authors: Welsch SK,Smith SS,Wetter DW,Jorenby DE,Fiore MC,Baker TB

    更新日期:1999-11-01 00:00:00

  • Craving is associated with smoking relapse: findings from three prospective studies.

    abstract::In a combined sample of more than 2600 smokers, immediate postcessation craving is shown to be prospectively associated with smokers' ability to maintain abstinence. Relapse is strikingly rapid among those reporting high levels of craving following cessation. More than 32% of those with high craving scores relapsed wi...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1037//1064-1297.5.2.137

    authors: Killen JD,Fortmann SP

    更新日期:1997-05-01 00:00:00

  • Computer-controlled drug doses for IV drug self-administration.

    abstract::This report describes a novel procedure for computer-controlled drug-dose determination for IV drug self-administration studies. By modifying the duration of each infusion of a single concentration of a drug solution, five or more unit doses (mg/kg/inj) can be dispensed from the same syringe. The advantages of this pr...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1037/a0023037

    authors: Fivel PA

    更新日期:2011-04-01 00:00:00

  • "Buzzwords": Crowd-sourcing and quantifying U.S. young adult terminology for subjective effects of alcohol and marijuana use.

    abstract::Prevalence of heavy alcohol use remain high, and daily marijuana use is at an all-time high in young adults. As perceptions of drug effects may guide risky decision making, understanding subjective feelings for alcohol and marijuana use is critical. Existing laboratory-based and diary metrics (0-100 rating of "how dru...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1037/pha0000344

    authors: Linden-Carmichael AN,Masters LD,Lanza ST

    更新日期:2020-12-01 00:00:00

  • A preliminary investigation of rapid smoking as a lapse-responsive treatment for tobacco dependence.

    abstract::Lapses within the first 2 weeks of a smoking cessation attempt are strongly associated with a return to regular smoking (S. L. Kenford et al., 1994). Unfortunately, little is known about how to prevent an initial lapse from progressing to a full relapse, and presently there are no validated lapse-responsive therapeuti...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1037/1064-1297.14.4.429

    authors: Juliano LM,Houtsmuller EJ,Stitzer ML

    更新日期:2006-11-01 00:00:00

  • The language of subjective alcohol effects: Do young adults vary in their feelings of intoxication?

    abstract::Among young adults, subjective feelings of alcohol's effects often guide risky decision making. The majority of studies measuring subjective effects have used singular indices ("How drunk do you feel?") which limits our understanding of young adults' full range of subjective states and their individual differences in ...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1037/pha0000416

    authors: Linden-Carmichael AN,Allen HK,Lanza ST

    更新日期:2020-07-16 00:00:00

  • The roles of sex, anxious reactivity to bodily arousal, and anxiety sensitivity in coping motives for cigarette smoking among adolescents.

    abstract::Evidence suggests that smoking to cope among adolescents is associated with a number of problematic outcomes (e.g., greater smoking frequency, higher rates of dependence). It is thus imperative to better understand factors that may increase the likelihood of smoking to cope among adolescents. Research suggests anxiety...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1037/pha0000071

    authors: Bilsky SA,Feldner MT,Knapp AA,Rojas SM,Leen-Feldner EW

    更新日期:2016-06-01 00:00:00

  • How does regulation of drug intake come about? Comment on Lynch and Carroll (2001).

    abstract::W. J. Lynch and M. E. Carroll (2001) suggested 3 processes that contribute to the regulation of drug intake over time when drugs serve as reinforcers. The commentator suggests that none of these processes are necessary for drugs to function as reinforcers and hence are either secondary or superfluous to the study of d...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 评论,杂志文章

    doi:10.1037//1064-1297.9.2.155

    authors: Woods JH

    更新日期:2001-05-01 00:00:00

  • Genetic influences on delayed reward discounting: A genome-wide prioritized subset approach.

    abstract::Delayed reward discounting (DRD) is a behavioral economic measure of impulsivity that has been consistently associated with addiction. It has also been identified as a promising addiction endophenotype, linking specific sources of genetic variation to individual risk. A challenge in the studies to date is that levels ...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1037/pha0000227

    authors: MacKillop J,Gray JC,Weafer J,Sanchez-Roige S,Palmer AA,de Wit H

    更新日期:2019-02-01 00:00:00

  • Utility of component-process approaches for understanding complex alcohol-related behavior within an executive functioning framework: comment on Giancola (2000).

    abstract::P. R. Giancola's (2000) macroconstruct framework of executive functions (EF) characterizes how cognitive processes work together to inhibit aggressive responding in provocative situations, and how alcohol intoxication increases the likelihood of aggression by disrupting these processes. His framework can be considered...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 评论,杂志文章

    doi:10.1037//1064-1297.8.4.598

    authors: Bates ME

    更新日期:2000-11-01 00:00:00

  • Scripted imagery manipulations and smoking cue reactivity in a clinical sample of self-quitters.

    abstract::The affectively valenced scripts used by S. Tiffany (1990) suggest that different scripts produce relatively equivalent levels of cue reactivity, although it is unclear if these laboratory findings generalize to clinical samples. In this study, cessation-motivated smokers were tested 7 days before they tried to quit s...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1037//1064-1297.6.2.179

    authors: Shadel WG,Niaura R,Abrams DB,Goldstein MG,Rohsenow DJ,Sirota AD,Monti PM

    更新日期:1998-05-01 00:00:00

  • Diazepam impairs temporal dynamics of visual attention.

    abstract::The effect of benzodiazepines on attention has been the object of few investigations. Studies using the spatial cueing paradigm (Posner's paradigm) have reported inconsistent results, which are likely due to methodological and/or dose differences but suggest impaired disengagement of attention from the cue to the targ...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1037/1064-1297.15.1.115

    authors: Boucart M,Waucquier N,Michael GA,Libersa C

    更新日期:2007-02-01 00:00:00

  • Pain inhibition, nicotine, and gender.

    abstract::The ability of nicotine to decrease sensitivity to pain in humans has been a subject of dispute. Decreased sensitivity has been demonstrated in studies involving men, whereas the effect has been less obvious or absent in studies involving predominantly, or entirely, women. To determine whether there are gender differe...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 临床试验,杂志文章

    doi:10.1037//1064-1297.6.1.96

    authors: Jamner LD,Girdler SS,Shapiro D,Jarvik ME

    更新日期:1998-02-01 00:00:00

  • How treatments for pathological gambling can be informed by treatments for substance use disorders.

    abstract::Substance use disorders and pathological gambling share similarities in terms of diagnostic criteria, epidemiology, and clinical course. However, relatively few studies have evaluated the efficacy of treatments for gambling disorders. As interest in pathological gambling grows, adaptation of effective treatments from ...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章,评审

    doi:10.1037//1064-1297.10.3.184

    authors: Petry NM

    更新日期:2002-08-01 00:00:00

  • Stimulus compounding enhances conditioned suppression produced by cocaine-paired stimuli.

    abstract::When 2 stimuli that occasion cocaine self-administration are presented in compound, their ability to increase cocaine-reinforced operant responding is substantially enhanced. The goal of the present experiment was to determine whether stimulus compounding could produce analogous enhancements of a classically condition...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1037//1064-1297.8.1.6

    authors: Panlilio LV,Weiss SJ,Schindler CW

    更新日期:2000-02-01 00:00:00

  • Psychomotor stimulant effects of cocaine in rats and 15 mouse strains.

    abstract::Relative to intravenous drug self-administration, locomotor activity is easier to measure with high throughput, particularly in mice. Therefore its potential to predict differences in self-administration between genotypes (e.g., targeted mutations, recombinant inbred strains) is appealing, but such predictive value is...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1037/a0024798

    authors: Thomsen M,Caine SB

    更新日期:2011-10-01 00:00:00

  • Methylphenidate as a reinforcer for rats: contingent delivery and intake escalation.

    abstract::Methylphenidate (MPH) is one of the most widely prescribed drugs for treating attention-deficit hyperactivity disorder. Previous research suggested that MPH is a reinforcer for rats, but not all of the manipulations to show that lever pressing is controlled by the contingency to obtain MPH have been examined. In Exper...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1037/a0019814

    authors: Marusich JA,Beckmann JS,Gipson CD,Bardo MT

    更新日期:2010-06-01 00:00:00

  • Craving and physiological reactivity to trauma and alcohol cues in posttraumatic stress disorder and alcohol dependence.

    abstract::The high comorbidity of posttraumatic stress disorder (PTSD) and alcohol dependence (AD) has been firmly established. Although laboratory studies have examined self-reported craving in response to trauma and alcohol cues, no studies have reported on alcohol-related physiological responding in response to trauma cues i...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 临床试验,杂志文章

    doi:10.1037/a0019790

    authors: Coffey SF,Schumacher JA,Stasiewicz PR,Henslee AM,Baillie LE,Landy N

    更新日期:2010-08-01 00:00:00

  • Is self-efficacy for smoking abstinence a cause of, or a reflection on, smoking behavior change?

    abstract::Social learning theory considers self-efficacy as a causal factor in behavior change. However, in line with behavioral theory, recent clinical research suggests self-efficacy ratings may reflect, rather than cause, behavior change. To test these two disparate views, self-efficacy was related to actual smoking abstinen...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1037/a0025482

    authors: Perkins KA,Parzynski C,Mercincavage M,Conklin CA,Fonte CA

    更新日期:2012-02-01 00:00:00

  • Attentional bias is associated with incentive-related physiological and subjective measures.

    abstract::Drug cue reactivity is theoretically and clinically important. The modified Stroop task has been widely used to assess attention capture by drug cues (attentional bias). Attentional bias to drug cues is assumed to reflect the incentive value of those cues, but this has not been directly tested. The authors examined wh...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1037/a0016658

    authors: Waters AJ,Carter BL,Robinson JD,Wetter DW,Lam CY,Kerst W,Cinciripini PM

    更新日期:2009-08-01 00:00:00