Aripiprazole: effectiveness and safety under naturalistic conditions.


:A retrospective study was conducted to examine aripiprazole's effectiveness and safety in a naturalistic treatment setting in both inpatients and outpatients affected by schizophrenia and other psychotic disorders. All patients with schizophrenia, schizoaffective and delusional disorders, and schizoid and schizotypal personality disorders treated with aripiprazole from March 1, 2005, to March 1, 2006, in the authors' community mental health service were divided into outpatient (n=26) and inpatient (n=17) groups; the average treatment periods were 204 days and 25 days, respectively. Effectiveness was evaluated by improvement of symptoms (a 25% reduction of Brief Psychiatric Rating Scale [BPRS] score from baseline) and functioning level (a 50% increase of Global Assessment of Functioning [GAF] scale score from baseline), as well as dropout rate. Adverse effects and their impact on treatment course were also evaluated. The final scores of the 2 scales showed a statistically significant difference from baseline (BPRS: p<.001 in the 2 groups; GAF: p<.005 in inpatients, p<.001 in outpatients). The average improvements in BPRS and GAF were 54% and 35%, respectively, in outpatients and 71% and 71% in inpatients. Side effects included anxiety, psychomotor agitation, insomnia, and psychotic symptom worsening. The dropout rate was 24% in inpatients and 23% in outpatients, largely because of the aforementioned side effects. The data, though limited by the small sample and naturalistic methodology, suggest that aripiprazole may be effective for both long- and short-term treatment, with a greater improvement among inpatients and a similar dropout rate between groups.


Di Lorenzo R,Amoretti A,Forghieri M,Fiorini F,Genedani S,Rigatelli M




Has Abstract


2007-12-01 00:00:00














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    pub_type: 杂志文章


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    authors: Marusich JA,Beckmann JS,Gipson CD,Bardo MT

    更新日期:2010-06-01 00:00:00

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    journal_title:Experimental and clinical psychopharmacology

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    authors: Higgins ST

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    更新日期:2020-04-01 00:00:00

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    pub_type: 杂志文章,随机对照试验


    authors: Secades-Villa R,López-Núñez C,Weidberg S,González-Roz A,Alonso-Pérez F

    更新日期:2019-12-01 00:00:00

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    更新日期:1998-08-01 00:00:00

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  • Contingency management in cocaine abusers: a dose-effect comparison of goods-based versus cash-based incentives.

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    journal_title:Experimental and clinical psychopharmacology

    pub_type: 临床试验,杂志文章


    authors: Vandrey R,Bigelow GE,Stitzer ML

    更新日期:2007-08-01 00:00:00

  • Attentional bias is associated with incentive-related physiological and subjective measures.

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    authors: Waters AJ,Carter BL,Robinson JD,Wetter DW,Lam CY,Kerst W,Cinciripini PM

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    journal_title:Experimental and clinical psychopharmacology

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    authors: Easdon CM,Vogel-Sprott M

    更新日期:2000-08-01 00:00:00

  • Abstinence symptoms during withdrawal from chronic marijuana use.

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    journal_title:Experimental and clinical psychopharmacology

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    authors: Kouri EM,Pope HG Jr

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  • Effects of consuming a diet high in fat and/or sugar on the locomotor effects of acute and repeated cocaine in male and female C57BL/6J mice.

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    authors: Collins GT,Chen Y,Tschumi C,Rush EL,Mensah A,Koek W,France CP

    更新日期:2015-08-01 00:00:00

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    journal_title:Experimental and clinical psychopharmacology

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  • Risk factors in the relationship between gender and crack/cocaine.

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    authors: Lejuez CW,Bornovalova MA,Reynolds EK,Daughters SB,Curtin JJ

    更新日期:2007-04-01 00:00:00

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    journal_title:Experimental and clinical psychopharmacology

    pub_type: 临床试验,杂志文章


    authors: Rodway P,Dienes Z,Schepman A

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    journal_title:Experimental and clinical psychopharmacology

    pub_type: 评论,杂志文章


    authors: Rowlett JK

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    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章


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    更新日期:2017-04-01 00:00:00

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    journal_title:Experimental and clinical psychopharmacology

    pub_type: 评论,杂志文章


    authors: Bates ME

    更新日期:2000-11-01 00:00:00

  • Effects of acute pramipexole on male rats' preference for gambling-like rewards II.

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    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章


    authors: Johnson PS,Madden GJ,Stein JS

    更新日期:2012-06-01 00:00:00