Aripiprazole: effectiveness and safety under naturalistic conditions.

Abstract:

:A retrospective study was conducted to examine aripiprazole's effectiveness and safety in a naturalistic treatment setting in both inpatients and outpatients affected by schizophrenia and other psychotic disorders. All patients with schizophrenia, schizoaffective and delusional disorders, and schizoid and schizotypal personality disorders treated with aripiprazole from March 1, 2005, to March 1, 2006, in the authors' community mental health service were divided into outpatient (n=26) and inpatient (n=17) groups; the average treatment periods were 204 days and 25 days, respectively. Effectiveness was evaluated by improvement of symptoms (a 25% reduction of Brief Psychiatric Rating Scale [BPRS] score from baseline) and functioning level (a 50% increase of Global Assessment of Functioning [GAF] scale score from baseline), as well as dropout rate. Adverse effects and their impact on treatment course were also evaluated. The final scores of the 2 scales showed a statistically significant difference from baseline (BPRS: p<.001 in the 2 groups; GAF: p<.005 in inpatients, p<.001 in outpatients). The average improvements in BPRS and GAF were 54% and 35%, respectively, in outpatients and 71% and 71% in inpatients. Side effects included anxiety, psychomotor agitation, insomnia, and psychotic symptom worsening. The dropout rate was 24% in inpatients and 23% in outpatients, largely because of the aforementioned side effects. The data, though limited by the small sample and naturalistic methodology, suggest that aripiprazole may be effective for both long- and short-term treatment, with a greater improvement among inpatients and a similar dropout rate between groups.

authors

Di Lorenzo R,Amoretti A,Forghieri M,Fiorini F,Genedani S,Rigatelli M

doi

10.1037/1064-1297.15.6.569

subject

Has Abstract

pub_date

2007-12-01 00:00:00

pages

569-75

issue

6

eissn

1064-1297

issn

1936-2293

pii

2007-18976-008

journal_volume

15

pub_type

杂志文章
  • Attentional and approach biases to alcohol cues among young adult drinkers: An ecological momentary assessment study.

    abstract::Alcohol-specific attentional biases (AttB) and approach biases (AppB) are postulated to play a role in alcohol use disorders but their association with drinking in young adults remains unknown. A subsample of young adults with risky alcohol use (N = 296) enrolled in a randomized trial, testing different text message i...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1037/pha0000343

    authors: Suffoletto B,Field M,Chung T

    更新日期:2020-12-01 00:00:00

  • Pre-adolescent alcohol expectancies: critical shifts and associated maturational processes.

    abstract::Children's alcohol expectancies shift in late childhood/early adolescence in ways thought to lead to increased risk for adolescent alcohol use. The precise nature of this shift and the maturational processes that may influence it remain to be clarified. To these ends, we compared expectancy endorsement by grade across...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1037/a0025373

    authors: Bekman NM,Goldman MS,Worley MJ,Anderson KG

    更新日期:2011-12-01 00:00:00

  • Mild stress increases attentional bias in social drinkers who drink to cope: a replication and extension.

    abstract::The authors investigated the effects of a laboratory stressor task on rapid initial orienting and delayed disengagement aspects of attentional bias for alcohol-related cues in social drinkers (N = 58). Participants were randomly allocated to receive a stress induction or control manipulation before completing a visual...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1037/a0017090

    authors: Field M,Quigley M

    更新日期:2009-10-01 00:00:00

  • Attentional bias is associated with incentive-related physiological and subjective measures.

    abstract::Drug cue reactivity is theoretically and clinically important. The modified Stroop task has been widely used to assess attention capture by drug cues (attentional bias). Attentional bias to drug cues is assumed to reflect the incentive value of those cues, but this has not been directly tested. The authors examined wh...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1037/a0016658

    authors: Waters AJ,Carter BL,Robinson JD,Wetter DW,Lam CY,Kerst W,Cinciripini PM

    更新日期:2009-08-01 00:00:00

  • Substance use and the paradox of good and bad attentional bias.

    abstract::Habitual substance use is associated with attentional bias for stimuli related to the use. The current study tested whether individuals' substance use can be predicted from their attentional bias for concern-related and substance-related stimuli. Participants (N = 71; 54% male) were selected among university students ...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1037/a0017294

    authors: Fadardi JS,Ziaee S,Shamloo ZS

    更新日期:2009-12-01 00:00:00

  • Aggressiveness, family history of alcoholism, and the heart rate response to alcohol intoxication.

    abstract::Some sons of male alcoholics (SOMAs) are characterized by an increased heart rate (HR) response to alcohol intoxication, which is thought to reflect increased sensitivity to alcohol-induced reward. Such a response has also been related to increased physical aggression. However, the confounding effect of aggression in ...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1037/1064-1297.11.2.158

    authors: Assaad JM,Pihl RO,Séguin JR,Nagin D,Vitaro F,Carbonneau R,Tremblay RE

    更新日期:2003-05-01 00:00:00

  • Dose effects of triazolam and alcohol on cognitive performance in healthy volunteers.

    abstract::Benzodiazepines and alcohol are widely used psychoactive substances that have performance-impairing effects. Research suggests that the impairment profiles for benzodiazepines and alcohol differ, although few cognitive psychopharmacological studies have directly compared these drugs. This double-blind, double-dummy, p...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1037/a0018407

    authors: Kleykamp BA,Griffiths RR,Mintzer MZ

    更新日期:2010-02-01 00:00:00

  • The effects of cadmium contamination on the discriminative stimulus properties of cocaine and related drugs.

    abstract::Rats were exposed to a diet containing 100 ppm cadmium chloride or a control diet. At 52 days of exposure, rats were trained to discriminate between saline and 5 mg/kg cocaine injections. After acquisition training, successive substitution tests were conducted using cocaine, the indirect dopamine agonist d-amphetamine...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1037//1064-1297.7.2.90

    authors: Nation JR,Miller DK

    更新日期:1999-05-01 00:00:00

  • Effects of energy drinks mixed with alcohol on information processing, motor coordination and subjective reports of intoxication.

    abstract::The consumption of alcohol mixed with energy drinks (AmED) has become a popular and controversial practice among young people. Increased rates of impaired driving and injuries have been associated with AmED consumption. The purpose of this study was to examine if the consumption of AmED alters cognitive processing and...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1037/a0026136

    authors: Marczinski CA,Fillmore MT,Henges AL,Ramsey MA,Young CR

    更新日期:2012-04-01 00:00:00

  • The effects of social contact on drug use: behavioral mechanisms controlling drug intake.

    abstract::The social environment plays a critical role in determining the likelihood that an individual will use drugs or will develop a drug use disorder. Recent evidence obtained from preclinical studies reveals that proximal social factors (i.e., those factors that are immediately present at the time of drug exposure) exert ...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章,评审

    doi:10.1037/a0034669

    authors: Strickland JC,Smith MA

    更新日期:2014-02-01 00:00:00

  • Individual differences in subjective alcohol responses and alcohol-related disinhibition.

    abstract::There are important individual differences in acute subjective responses to alcohol, which have often been assessed using self-report measures. There is also evidence of meaningful between-persons variation in alcohol's disinhibiting effects on behavior, such that some individuals become more impaired on tasks of inhi...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1037/pha0000065

    authors: Quinn PD,Fromme K

    更新日期:2016-04-01 00:00:00

  • Delay discounting decreases in those completing treatment for opioid dependence.

    abstract::Several studies examining both control and substance-dependent populations have found delay discounting to remain stable over time. In this report, we examine whether delay discounting changes in opioid-dependent individuals who complete a 12-week treatment. The 159 subjects who completed discounting assessments at ba...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1037/a0027391

    authors: Landes RD,Christensen DR,Bickel WK

    更新日期:2012-08-01 00:00:00

  • A glucocorticoid receptor antagonist reduces sign-tracking behavior in male Japanese quail.

    abstract::Addiction is characterized as a chronic debilitating disease. One devastating feature of addiction is the susceptibility of relapse (40-60%) after stretches of abstinence. One theory that may account for relapse suggests that drug cues (e.g., paraphernalia) may increase stress hormones, and this may prompt relapse. Re...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1037/pha0000195

    authors: Rice BA,Eaton SE,Prendergast MA,Akins CK

    更新日期:2018-08-01 00:00:00

  • The language of subjective alcohol effects: Do young adults vary in their feelings of intoxication?

    abstract::Among young adults, subjective feelings of alcohol's effects often guide risky decision making. The majority of studies measuring subjective effects have used singular indices ("How drunk do you feel?") which limits our understanding of young adults' full range of subjective states and their individual differences in ...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1037/pha0000416

    authors: Linden-Carmichael AN,Allen HK,Lanza ST

    更新日期:2020-07-16 00:00:00

  • Neural outcome processing of peer-influenced risk-taking behavior in late adolescence: Preliminary evidence for gene × environment interactions.

    abstract::Adolescent brains are particularly susceptible to the rewarding properties of risky decisions in social contexts. Individual differences in genetic influences on dopamine transmission moderate neural outcome processing of risky decisions and may exert pronounced effects on adolescent risk-taking behavior (RTB) and cor...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1037/pha0000105

    authors: Webber TA,Soder HE,Potts GF,Park JY,Bornovalova MA

    更新日期:2017-02-01 00:00:00

  • A behavioral economic analysis of the nonmedical use of prescription drugs among young adults.

    abstract::The nonmedical use of prescription drugs is a widely recognized public health issue, and young adults are particularly vulnerable to their use. Behavioral economic drug purchase tasks capture an individual's strength of desire and motivation for a particular drug. We examined young adult prescription drug purchase and...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1037/pha0000052

    authors: Pickover AM,Messina BG,Correia CJ,Garza KB,Murphy JG

    更新日期:2016-02-01 00:00:00

  • Opposing effects of dopamine D1- and D2-like agonists on intracranial self-stimulation in male rats.

    abstract::Dopamine acts through dopamine Type I receptors (comprising D1 and D5 subtypes) and dopamine Type II receptors (comprising D2, D3, and D4 subtypes). Intracranial self-stimulation (ICSS) is 1 experimental procedure that can be used to evaluate abuse-related effects of drugs targeting dopamine receptors. This study eval...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1037/pha0000067

    authors: Lazenka MF,Legakis LP,Negus SS

    更新日期:2016-06-01 00:00:00

  • Effects of nicotine dose and administration method on withdrawal symptoms and side effects during short-term smoking abstinence.

    abstract::The effects of using several nicotine replacement treatments on self-reported withdrawal symptoms and side effects during 2-day periods of smoking cessation, with 5 days of ad lib smoking between cessation days, were evaluated. Participants (N = 18) experienced the following conditions: nicotine gum, 24-hr patch, 16-h...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1037//1064-1297.5.1.54

    authors: Leischow SJ,Valente SN,Hill AL,Otte PS,Aickin M,Holden T,Kligman E,Cook G

    更新日期:1997-02-01 00:00:00

  • Analytic complexities associated with group therapy in substance abuse treatment research: problems, recommendations, and future directions.

    abstract::In community-based alcoholism and drug abuse treatment programs, the vast majority of interventions are delivered in a group therapy context. In turn, treatment providers and funding agencies have called for more research on interventions delivered in groups in an effort to make the emerging empirical literature on th...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章,评审

    doi:10.1037/1064-1297.14.2.265

    authors: Morgan-Lopez AA,Fals-Stewart W

    更新日期:2006-05-01 00:00:00

  • Low efficacy opioids: implications for sex differences in opioid antinociception.

    abstract::It is becoming increasingly evident that the sex of an organism is a critical determinant of responsiveness to opioid analgesics. However, the factors that determine the magnitude and direction of sex differences in opioid antinociception have not been fully elucidated. One factor that has received attention is the re...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章,评审

    doi:10.1037/1064-1297.14.1.1

    authors: Barrett AC

    更新日期:2006-02-01 00:00:00

  • Do men outperform women in smoking cessation trials? Maybe, but not by much.

    abstract::Using data from 4 smoking cessation trials conducted from 1988 to 2000, the authors investigated whether men are more successful than women in quitting smoking. Odds ratios indicated that the abstinence rates were not significantly different for men and women. Thus, there may be little value to diverting research fund...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1037//1064-1297.10.3.295

    authors: Killen JD,Fortmann SP,Varady A,Kraemer HC

    更新日期:2002-08-01 00:00:00

  • Effects of acute pramipexole on male rats' preference for gambling-like rewards II.

    abstract::Pramipexole (PPX) is a dopamine agonist medication that has been implicated in the development of pathological gambling and other impulse control disorders. Johnson, Madden, Brewer, Pinkston, and Fowler (2011) reported that PPX increased male rats' preference for gambling-like rewards (those arranged according to a va...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1037/a0027117

    authors: Johnson PS,Madden GJ,Stein JS

    更新日期:2012-06-01 00:00:00

  • Psychopharmacology of aggression in children and adolescents with primary neuropsychiatric disorders: a review of current and potentially promising treatment options.

    abstract::Research examining the role of pharmacological therapy in the treatment of children and adolescents with clinical disorders is growing. Clinical disorders that present with comorbid aggression can add a challenge to treatment. Child and adolescent neuropsychiatric disorders associated with aggression include attention...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章,评审

    doi:10.1037/a0018059

    authors: Nevels RM,Dehon EE,Alexander K,Gontkovsky ST

    更新日期:2010-04-01 00:00:00

  • Effects of sequential fluoxetine and gender on prequit depressive symptoms, affect, craving, and quit day abstinence in smokers with elevated depressive symptoms: a growth curve modeling approach.

    abstract::Although the important roles of postquit affect and withdrawal symptoms in the process of smoking cessation have been well established, little is known about the relations between prequit affective trajectories and cessation outcome on the target quit date (TQD). This study examined whether a 16-week course of fluoxet...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1037/a0037156

    authors: Minami H,Kahler CW,Bloom EL,Prince MA,Abrantes AM,Strong DR,Niaura R,Miller IW,Palm Reed KM,Price LH,Brown RA

    更新日期:2014-10-01 00:00:00

  • Modeling the effects of combined behavioral and pharmacological treatment on cigarette smoking: behavioral-economic analyses.

    abstract::Effects of different response requirements, response-independent cigarette puffs, and an alternative nondrug reinforcer on cigarette smoking were assessed in 2 experiments. The response requirement to obtain 2 puffs on a cigarette was manipulated while various numbers of response-independent puffs were provided (0, 6,...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 临床试验,杂志文章

    doi:10.1037//1064-1297.5.4.334

    authors: Bickel WK,Madden GJ,DeGrandpre RJ

    更新日期:1997-11-01 00:00:00

  • Computer-controlled drug doses for IV drug self-administration.

    abstract::This report describes a novel procedure for computer-controlled drug-dose determination for IV drug self-administration studies. By modifying the duration of each infusion of a single concentration of a drug solution, five or more unit doses (mg/kg/inj) can be dispensed from the same syringe. The advantages of this pr...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1037/a0023037

    authors: Fivel PA

    更新日期:2011-04-01 00:00:00

  • Derived relations moderate the association between changes in the strength of commitment language and cocaine treatment response.

    abstract::The psycholinguistic analysis of client-counselor interactions indicates that how individuals talk about their substance use is associated with treatment outcome. However, the processes by which client speech influences out-of-session behaviors have not been clearly delineated. This study investigated the relationship...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1037/pha0000063

    authors: Carpenter KM,Amrhein PC,Bold KW,Mishlen K,Levin FR,Raby WN,Evans SM,Foltin RW,Nunes EV

    更新日期:2016-04-01 00:00:00

  • Contingency management in cocaine abusers: a dose-effect comparison of goods-based versus cash-based incentives.

    abstract::Goods-based contingency management interventions (e.g., those using vouchers or prizes as incentives) have demonstrated efficacy in reducing cocaine use, but cost has limited dissemination to community clinics. Recent research suggests that development of a cash-based contingency management approach may improve treatm...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 临床试验,杂志文章

    doi:10.1037/1064-1297.15.4.338

    authors: Vandrey R,Bigelow GE,Stitzer ML

    更新日期:2007-08-01 00:00:00

  • The behavioral economics of the bottomless cup: The effects of alcohol cup price on consumption in college students.

    abstract::Heavy drinking among college students is a public health concern in part due to the accessibility of alcohol and promotions such as "happy hours," which discount the price of alcohol. In addition, consuming alcohol at unregulated off-campus parties may result in greater alcohol consumption, higher blood alcohol concen...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1037/pha0000360

    authors: Morrell MN,Reed DD,Martinetti MP

    更新日期:2020-03-19 00:00:00

  • Getting back to basics: commentary on McSweeney, Murphy, and Kowal (2005).

    abstract::The review article "Regulation of Drug Taking by Sensitization and Habituation" by F. K. McSweeney, E. S. Murphy, and B. P. Kowal introduces 2 basic principles of behavior, sensitization and habituation, into a comprehensive model for studying drug intake and drug addiction. A key assumption of the model is that the r...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 评论,杂志文章

    doi:10.1037/1064-1297.13.3.187

    authors: Rowlett JK

    更新日期:2005-08-01 00:00:00