Computer-controlled drug doses for IV drug self-administration.

abstract：:Dependence on and abuse of prescription opioid drugs is now a major health problem, with initiation of prescription opioid abuse exceeding cocaine in young people. Coincident with the emergence of abuse and dependence on prescription opioids, there has been an increased emphasis on the treatment of pain. Pain is now t...

journal_title：Experimental and clinical psychopharmacology

authors： Mendelson J,Flower K,Pletcher MJ,Galloway GP

更新日期：2008-10-01 00:00:00

abstract：:Addiction is characterized as a chronic debilitating disease. One devastating feature of addiction is the susceptibility of relapse (40-60%) after stretches of abstinence. One theory that may account for relapse suggests that drug cues (e.g., paraphernalia) may increase stress hormones, and this may prompt relapse. Re...

journal_title：Experimental and clinical psychopharmacology

authors： Rice BA,Eaton SE,Prendergast MA,Akins CK

更新日期：2018-08-01 00:00:00

abstract：:The consumption of caffeine has become a growing concern, partially because of the withdrawal properties of the drug. The current study examined personality correlates of caffeine consumption and dependence in 60 university students. Self-report and behavioral measures of sensation seeking, impulsivity, and risk takin...

journal_title：Experimental and clinical psychopharmacology

authors： Jones HA,Lejuez CW

更新日期：2005-08-01 00:00:00

abstract：:Some sons of male alcoholics (SOMAs) are characterized by an increased heart rate (HR) response to alcohol intoxication, which is thought to reflect increased sensitivity to alcohol-induced reward. Such a response has also been related to increased physical aggression. However, the confounding effect of aggression in ...

journal_title：Experimental and clinical psychopharmacology

authors： Assaad JM,Pihl RO,Séguin JR,Nagin D,Vitaro F,Carbonneau R,Tremblay RE

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND:Despite increases in ecstasy (MDMA) use in the United States, little is known about characteristics linked with recent-onset ecstasy use, especially psychiatric symptoms and deviant behaviors. AIMS:To test whether individuals with high levels of other drug use are more likely to be recent-onset ecstasy user...

journal_title：Experimental and clinical psychopharmacology

authors： Martins SS,Mazzotti G,Chilcoat HD

更新日期：2006-08-01 00:00:00

abstract：:This study shows that a moderate dose of alcohol (0.62 g/kg) can impair cognitive processes controlling behavioral inhibition and flexibility (i.e., inhibiting one response and making a different one). Two groups of male social drinkers (n = 8) received alcohol or a placebo and performed two change tasks that required...

journal_title：Experimental and clinical psychopharmacology

authors： Easdon CM,Vogel-Sprott M

更新日期：2000-08-01 00:00:00

abstract：:A burgeoning literature supports a link between alcohol use and panic-spectrum problems (e.g., panic attacks, disorder) among adolescents, but the direction of influence has yet to be properly examined. From a theoretical perspective, panic-spectrum problems may increase risk for problematic drinking via affect regula...

journal_title：Experimental and clinical psychopharmacology

authors： Blumenthal H,Cloutier RM,Zamboanga BL,Bunaciu L,Knapp AA

更新日期：2015-10-01 00:00:00

abstract：:The present, subjective value of a reinforcer typically decreases as a function of the delay to its receipt, a phenomenon termed delay discounting. Delay discounting, which is assumed to reflect impulsivity, is hypothesized to play an important role in drug abuse. The present study examined delay discounting of cocain...

journal_title：Experimental and clinical psychopharmacology

authors： Woolverton WL,Myerson J,Green L

更新日期：2007-06-01 00:00:00

abstract：:This study analyzed whether a contingency management (CM) for shaping cessation period implemented prior to an abstinence-only period (CMS) improves outcomes relative to CM that reinforces only a fixed abstinence criteria (CMA) among treatment-seeking patients in a community setting. A total of 110 patients were rando...

journal_title：Experimental and clinical psychopharmacology

authors： Secades-Villa R,López-Núñez C,Weidberg S,González-Roz A,Alonso-Pérez F

更新日期：2019-12-01 00:00:00

abstract：:Cigarette smoking is highly prevalent among patients who are being treated for opioid-dependence, yet there have been limited scientific efforts to promote smoking cessation in this population. Contingency management (CM) is a behavioral treatment that provides monetary incentives contingent upon biochemical evidence ...

journal_title：Experimental and clinical psychopharmacology

authors： Dunn KE,Saulsgiver KA,Sigmon SC

更新日期：2011-02-01 00:00:00

abstract：:Antipsychotic polypharmacy refers to the clinical practice of treating a patient with two or more antipsychotic drugs concurrently. There is abundant evidence in the clinical literature that treatment with antipsychotic polypharmacy is associated with an increased prevalence of drug side effects compared with monother...

journal_title：Experimental and clinical psychopharmacology

authors： Boyda HN,Procyshyn RM,Tse L,Xu J,Jin CH,Wong D,Pang CC,Honer WG,Barr AM

更新日期：2013-04-01 00:00:00

abstract：:Drug abuse and impulsive choice are related in humans. In female rats, impulsive choice predicted the rate of acquisition of IV cocaine self-administration. The objectives of the present experiments were to: (a) compare impulsive choice in males and females, (b) extend previous research on impulsive choice and acquisi...

journal_title：Experimental and clinical psychopharmacology

authors： Perry JL,Nelson SE,Carroll ME

更新日期：2008-04-01 00:00:00

abstract：:Binge drinking is frequently reported by young adults, despite being associated with a number of negative consequences. This type of heavy drinking is associated with deficits in many executive functions, including working memory. Poor working memory may contribute to increased alcohol use by limiting one's ability to...

journal_title：Experimental and clinical psychopharmacology

authors： Looby A,Norton-Baker M,Russell TD

更新日期：2018-08-01 00:00:00

abstract：:Research examining the role of pharmacological therapy in the treatment of children and adolescents with clinical disorders is growing. Clinical disorders that present with comorbid aggression can add a challenge to treatment. Child and adolescent neuropsychiatric disorders associated with aggression include attention...

journal_title：Experimental and clinical psychopharmacology

authors： Nevels RM,Dehon EE,Alexander K,Gontkovsky ST

更新日期：2010-04-01 00:00:00

abstract：:Benzodiazepines and alcohol are widely used psychoactive substances that have performance-impairing effects. Research suggests that the impairment profiles for benzodiazepines and alcohol differ, although few cognitive psychopharmacological studies have directly compared these drugs. This double-blind, double-dummy, p...

journal_title：Experimental and clinical psychopharmacology

authors： Kleykamp BA,Griffiths RR,Mintzer MZ

更新日期：2010-02-01 00:00:00

abstract：:Drug cue reactivity is theoretically and clinically important. The modified Stroop task has been widely used to assess attention capture by drug cues (attentional bias). Attentional bias to drug cues is assumed to reflect the incentive value of those cues, but this has not been directly tested. The authors examined wh...

journal_title：Experimental and clinical psychopharmacology

authors： Waters AJ,Carter BL,Robinson JD,Wetter DW,Lam CY,Kerst W,Cinciripini PM

更新日期：2009-08-01 00:00:00

abstract：:Prevalence of heavy alcohol use remain high, and daily marijuana use is at an all-time high in young adults. As perceptions of drug effects may guide risky decision making, understanding subjective feelings for alcohol and marijuana use is critical. Existing laboratory-based and diary metrics (0-100 rating of "how dru...

journal_title：Experimental and clinical psychopharmacology

authors： Linden-Carmichael AN,Masters LD,Lanza ST

更新日期：2020-12-01 00:00:00

abstract：:In an elegant series of experiments, F. Leri and J. Stewart (2002) report that exposure to heroin increases subsequent reinstatement responding if the animal has access to the drug lever during the lapse and if responding on the lever results in the presentation of conditioned cues. It is interesting that exposure to ...

journal_title：Experimental and clinical psychopharmacology

authors： Goeders NE

更新日期：2002-11-01 00:00:00

abstract：:Nicotine addiction continues to be the main cause of preventable death in developed countries. Women and teen girls appear to be more vulnerable on certain aspects of nicotine addiction compared with men and boys. While the mechanism of gender differences in nicotine addiction is not yet clear, evidence suggests that ...

journal_title：Experimental and clinical psychopharmacology

authors： Lynch WJ,Sofuoglu M

更新日期：2010-12-01 00:00:00

abstract：:This study examined prevalence and patterns of co-use of opioids and cocaine in regular users of illicit opioids (N = 729) recruited from 5 Canadian cities. Fifty-seven percent (n = 417) reported having used both opioids and cocaine in the month and week preceding the interview; of these, 73% (n = 304) were able to id...

journal_title：Experimental and clinical psychopharmacology

authors： Leri F,Stewart J,Fischer B,Jürgen R,Marsh DC,Brissette S,Bruneau J,El-Guebaly N,Noël L,Tyndall MW,Wild TC

更新日期：2005-11-01 00:00:00

abstract：:Two studies were conducted to determine the anger-attenuating effects of nicotine as a function of trait hostility. The 1st study examined the effects of nicotine on diary ratings of anger during a 24-hr period in a natural setting in 30 smokers and 30 nonsmokers. Participants took part in 2 monitoring sessions involv...

journal_title：Experimental and clinical psychopharmacology

authors： Jamner LD,Shapiro D,Jarvik ME

更新日期：1999-11-01 00:00:00

abstract：:In this experiment, the observing-response procedure was adapted for use with drug self-administration. Rats' responding for oral ethanol was sometimes reinforced on a random-ratio schedule, whereas at other times it had no effect (i.e., extinction). Behavior producing stimuli associated with the otherwise unsignaled ...

journal_title：Experimental and clinical psychopharmacology

authors： Shahan TA

更新日期：2002-02-01 00:00:00

abstract：:Six features of the report are commented on. First, the Therapeutic Workplace intervention described in the report represents a creative and promising new approach to drug abuse treatment. Second, to the author's knowledge, it represents the first intervention that has been shown in a randomized clinical trial to sign...

journal_title：Experimental and clinical psychopharmacology

authors： Higgins ST

更新日期：2001-02-01 00:00:00

abstract：:Although marijuana is the most commonly used illicit drug in the United States, it is not established whether withdrawal from chronic use results in a clinically significant abstinence syndrome. The present study was conducted to characterize symptoms associated with marijuana withdrawal following chronic use during a...

journal_title：Experimental and clinical psychopharmacology

authors： Kouri EM,Pope HG Jr

更新日期：2000-11-01 00:00:00

abstract：:The effects of using several nicotine replacement treatments on self-reported withdrawal symptoms and side effects during 2-day periods of smoking cessation, with 5 days of ad lib smoking between cessation days, were evaluated. Participants (N = 18) experienced the following conditions: nicotine gum, 24-hr patch, 16-h...

journal_title：Experimental and clinical psychopharmacology

authors： Leischow SJ,Valente SN,Hill AL,Otte PS,Aickin M,Holden T,Kligman E,Cook G

更新日期：1997-02-01 00:00:00

abstract：:In the United States, the Food and Drug Administration (FDA) has initiated a public dialogue about reducing the nicotine content of cigarettes. A reduced-nicotine standard could increase withdrawal symptoms among current smokers. We examined the impact of switching smokers to cigarettes that varied in nicotine content...

journal_title：Experimental and clinical psychopharmacology

authors： Dermody SS,McClernon FJ,Benowitz N,Luo X,Tidey JW,Smith TT,Vandrey R,Hatsukami D,Donny EC

更新日期：2018-06-01 00:00:00

abstract：:This study targeted poly-drug (cocaine plus heroin) abstinence among buprenorphine-maintained participants with a 12-week voucher-based reinforcement therapy (VBRT) phase versus a yoked control condition. Baseline levels of cocaine and heroin use were significant predictors of treatment outcome, regardless of treatmen...

journal_title：Experimental and clinical psychopharmacology

authors： Downey KK,Helmus TC,Schuster CR

更新日期：2000-05-01 00:00:00

abstract：:When 2 stimuli that occasion cocaine self-administration are presented in compound, their ability to increase cocaine-reinforced operant responding is substantially enhanced. The goal of the present experiment was to determine whether stimulus compounding could produce analogous enhancements of a classically condition...

journal_title：Experimental and clinical psychopharmacology

authors： Panlilio LV,Weiss SJ,Schindler CW

更新日期：2000-02-01 00:00:00

abstract：:Methylphenidate (MPH) is one of the most widely prescribed drugs for treating attention-deficit hyperactivity disorder. Previous research suggested that MPH is a reinforcer for rats, but not all of the manipulations to show that lever pressing is controlled by the contingency to obtain MPH have been examined. In Exper...

journal_title：Experimental and clinical psychopharmacology

authors： Marusich JA,Beckmann JS,Gipson CD,Bardo MT

更新日期：2010-06-01 00:00:00

abstract：:Maternal smoking is a leading preventable cause of poor pregnancy outcomes and infant morbidity and mortality. Whereas pregnancy has been thought of as a "window of opportunity" when women are more motivated to change health behaviors such as smoking, only 20% of pregnant women quit smoking upon learning they are preg...

journal_title：Experimental and clinical psychopharmacology

authors： Heil SH,Higgins ST,Mongeon JA,Badger GJ,Bernstein IM

更新日期：2006-05-01 00:00:00