Abstract:
:Addiction is characterized as a chronic debilitating disease. One devastating feature of addiction is the susceptibility of relapse (40-60%) after stretches of abstinence. One theory that may account for relapse suggests that drug cues (e.g., paraphernalia) may increase stress hormones, and this may prompt relapse. Repeatedly pairing a neutral cue with a reward is commonly utilized to measure what subjects learn about a cue that is predictive of reward. Research has shown that animals that attend to a cue more than to the reward (sign trackers) may be more vulnerable to drug addiction. Additionally, research has shown that sign tracking is associated with an increase in corticosterone, a primary stress hormone. PT150 is a novel glucocorticoid receptor antagonist that moderates the release of corticosterone. In the current experiment, it was hypothesized that subjects given repeated administration of PT150 would reduce sign tracking compared to subjects given placebo. Time spent (in seconds) near a cue that predicts reward (conditional stimulus) served as a measure of sign tracking, and PT150 or placebo was administered following sign tracking. An independent-samples t test revealed that subjects that received PT150 had reduced time spent near the conditioned stimulus compared to controls. Given the devastating effects of drug addiction, identification of a potential pharmacological intervention in the reduction of relapse would be of great value. Therefore, future research is needed to validate the use of PT150 in reducing behaviors associated with drug addiction. (PsycINFO Database Record
journal_name
Exp Clin Psychopharmacoljournal_title
Experimental and clinical psychopharmacologyauthors
Rice BA,Eaton SE,Prendergast MA,Akins CKdoi
10.1037/pha0000195subject
Has Abstractpub_date
2018-08-01 00:00:00pages
329-334issue
4eissn
1064-1297issn
1936-2293pii
2018-25403-001journal_volume
26pub_type
杂志文章abstract::Increased discounting (devaluing) of delayed rewards is associated with nearly all types of substance use disorders (SUDs) and is also present in individuals with family histories of SUDs. Early life adversity (ELA) likely contributes to these findings as it is common in both individuals with SUDs and their children a...
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pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章
doi:10.1037/1064-1297.15.6.569
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journal_title:Experimental and clinical psychopharmacology
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doi:10.1037/1064-1297.12.4.237
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journal_title:Experimental and clinical psychopharmacology
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doi:10.1037/pha0000270
更新日期:2019-12-01 00:00:00
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journal_title:Experimental and clinical psychopharmacology
pub_type: 临床试验,杂志文章
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更新日期:2000-08-01 00:00:00
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journal_title:Experimental and clinical psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037/a0027117
更新日期:2012-06-01 00:00:00
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journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037/1064-1297.16.2.165
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journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037/pha0000287
更新日期:2020-02-01 00:00:00
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journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037//1064-1297.8.1.6
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doi:10.1037/pha0000386
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journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037//1064-1297.7.2.90
更新日期:1999-05-01 00:00:00
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journal_title:Experimental and clinical psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1037//1064-1297.5.4.334
更新日期:1997-11-01 00:00:00
abstract::Existing literature supports the five-factor model (FFM) of personality (i.e., Extraversion, Agreeableness, Conscientiousness, Emotional Stability, and Intellect or Openness) as a comprehensive representation of stable aspects of mood, affect, and behavior. This study evaluated the FFM as a framework for both self-per...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037/a0036607
更新日期:2014-06-01 00:00:00
abstract::In a combined sample of more than 2600 smokers, immediate postcessation craving is shown to be prospectively associated with smokers' ability to maintain abstinence. Relapse is strikingly rapid among those reporting high levels of craving following cessation. More than 32% of those with high craving scores relapsed wi...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037//1064-1297.5.2.137
更新日期:1997-05-01 00:00:00
abstract::The present study explores the relation among 4 personality traits associated with impulsive behavior and alcohol abuse. Personality traits were measured using the 4 subscales of the UPPS Impulsive Behavior Scale (UPPS; S. P. Whiteside & D. R. Lynam, 2001). The UPPS and measures of psychopathology were administered to...
journal_title:Experimental and clinical psychopharmacology
pub_type: 临床试验,杂志文章
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journal_title:Experimental and clinical psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Experimental and clinical psychopharmacology
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更新日期:2011-06-01 00:00:00
abstract::The nonmedical use of prescription drugs is a widely recognized public health issue, and young adults are particularly vulnerable to their use. Behavioral economic drug purchase tasks capture an individual's strength of desire and motivation for a particular drug. We examined young adult prescription drug purchase and...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037/pha0000052
更新日期:2016-02-01 00:00:00
abstract::Varenicline reduces drinking in people with alcohol use disorder, but little is known about the mechanisms underlying this effect. Varenicline targets α4β2 and α7 nicotinic acetylcholine receptors, which are associated with several cognitive functions such as working memory. Varenicline may improve drinking outcomes b...
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pub_type: 杂志文章,随机对照试验
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更新日期:2018-02-01 00:00:00