Opposing effects of dopamine D1- and D2-like agonists on intracranial self-stimulation in male rats.

abstract：:Benzodiazepines and alcohol are widely used psychoactive substances that have performance-impairing effects. Research suggests that the impairment profiles for benzodiazepines and alcohol differ, although few cognitive psychopharmacological studies have directly compared these drugs. This double-blind, double-dummy, p...

journal_title：Experimental and clinical psychopharmacology

authors： Kleykamp BA,Griffiths RR,Mintzer MZ

更新日期：2010-02-01 00:00:00

abstract：:Adolescent brains are particularly susceptible to the rewarding properties of risky decisions in social contexts. Individual differences in genetic influences on dopamine transmission moderate neural outcome processing of risky decisions and may exert pronounced effects on adolescent risk-taking behavior (RTB) and cor...

journal_title：Experimental and clinical psychopharmacology

authors： Webber TA,Soder HE,Potts GF,Park JY,Bornovalova MA

更新日期：2017-02-01 00:00:00

abstract：:Several studies examining both control and substance-dependent populations have found delay discounting to remain stable over time. In this report, we examine whether delay discounting changes in opioid-dependent individuals who complete a 12-week treatment. The 159 subjects who completed discounting assessments at ba...

journal_title：Experimental and clinical psychopharmacology

authors： Landes RD,Christensen DR,Bickel WK

更新日期：2012-08-01 00:00:00

abstract：:Effects of different response requirements, response-independent cigarette puffs, and an alternative nondrug reinforcer on cigarette smoking were assessed in 2 experiments. The response requirement to obtain 2 puffs on a cigarette was manipulated while various numbers of response-independent puffs were provided (0, 6,...

journal_title：Experimental and clinical psychopharmacology

authors： Bickel WK,Madden GJ,DeGrandpre RJ

更新日期：1997-11-01 00:00:00

abstract：:Smokers are highly reactive to smoking-related cues that are directly linked, or most proximal, to actual smoking behavior (e.g., lit cigarettes). However, over the course of smoking, proximal cues may not be the only stimuli to become strongly associated with smoking. Distal cues, such as the environments in which sm...

journal_title：Experimental and clinical psychopharmacology

authors： Conklin CA,Robin N,Perkins KA,Salkeld RP,McClernon FJ

更新日期：2008-06-01 00:00:00

abstract：:Although marijuana is the most commonly used illicit drug in the United States, it is not established whether withdrawal from chronic use results in a clinically significant abstinence syndrome. The present study was conducted to characterize symptoms associated with marijuana withdrawal following chronic use during a...

journal_title：Experimental and clinical psychopharmacology

authors： Kouri EM,Pope HG Jr

更新日期：2000-11-01 00:00:00

abstract：:Obsessive-compulsive disorder (OCD) is a chronic neuropsychiatric disorder with complex genetic inheritance. Findings suggest a role for brain-derived neurotrophic factor (BDNF) in OCD, but reports are limited. Here we studied the association of BDNF polymorphisms rs6265 and rs2883187 with OCD and its clinical charact...

journal_title：Experimental and clinical psychopharmacology

authors： Abdolhosseinzadeh S,Alizadeh N,Shams J,Asadi S,Ahmadiani A

更新日期：2020-04-01 00:00:00

abstract：:The consumption of caffeine has become a growing concern, partially because of the withdrawal properties of the drug. The current study examined personality correlates of caffeine consumption and dependence in 60 university students. Self-report and behavioral measures of sensation seeking, impulsivity, and risk takin...

journal_title：Experimental and clinical psychopharmacology

authors： Jones HA,Lejuez CW

更新日期：2005-08-01 00:00:00

abstract：:The ability of nicotine to decrease sensitivity to pain in humans has been a subject of dispute. Decreased sensitivity has been demonstrated in studies involving men, whereas the effect has been less obvious or absent in studies involving predominantly, or entirely, women. To determine whether there are gender differe...

journal_title：Experimental and clinical psychopharmacology

authors： Jamner LD,Girdler SS,Shapiro D,Jarvik ME

更新日期：1998-02-01 00:00:00

abstract：:Delayed reward discounting (DRD) is a behavioral economic measure of impulsivity that has been consistently associated with addiction. It has also been identified as a promising addiction endophenotype, linking specific sources of genetic variation to individual risk. A challenge in the studies to date is that levels ...

journal_title：Experimental and clinical psychopharmacology

authors： MacKillop J,Gray JC,Weafer J,Sanchez-Roige S,Palmer AA,de Wit H

更新日期：2019-02-01 00:00:00

abstract：:There are important individual differences in acute subjective responses to alcohol, which have often been assessed using self-report measures. There is also evidence of meaningful between-persons variation in alcohol's disinhibiting effects on behavior, such that some individuals become more impaired on tasks of inhi...

journal_title：Experimental and clinical psychopharmacology

authors： Quinn PD,Fromme K

更新日期：2016-04-01 00:00:00

abstract：:Methylphenidate (MPH) is one of the most widely prescribed drugs for treating attention-deficit hyperactivity disorder. Previous research suggested that MPH is a reinforcer for rats, but not all of the manipulations to show that lever pressing is controlled by the contingency to obtain MPH have been examined. In Exper...

journal_title：Experimental and clinical psychopharmacology

authors： Marusich JA,Beckmann JS,Gipson CD,Bardo MT

更新日期：2010-06-01 00:00:00

abstract：:Two groups of male Japanese quail (Coturnix japonica) were trained [corrected] to discriminate cocaine from saline in a conditioned approach procedure maintained by sexual reinforcement. For 1 group, cocaine (10 mg/kg ip) was administered prior to a conditioned stimulus (CS) that predicted copulation; saline followed ...

journal_title：Experimental and clinical psychopharmacology

authors： Troisi JR 2nd,Akins C

更新日期：2004-11-01 00:00:00

abstract：:Delay discounting, the devaluation of delayed reinforcers, is one defining behavioral economic characteristic of cigarette smokers. Attempts at abstinence by smokers that result in relapse are conceptualized in this framework as preference reversals. Despite preference reversals being predicted by delay discounting mo...

journal_title：Experimental and clinical psychopharmacology

authors： Pope DA,Poe L,Stein JS,Snider SE,Bianco AG,Bickel WK

更新日期：2019-02-01 00:00:00

abstract：:This study analyzed whether a contingency management (CM) for shaping cessation period implemented prior to an abstinence-only period (CMS) improves outcomes relative to CM that reinforces only a fixed abstinence criteria (CMA) among treatment-seeking patients in a community setting. A total of 110 patients were rando...

journal_title：Experimental and clinical psychopharmacology

authors： Secades-Villa R,López-Núñez C,Weidberg S,González-Roz A,Alonso-Pérez F

更新日期：2019-12-01 00:00:00

abstract：:Alcohol and cannabis couse is highly prevalent and associated with various negative consequences. The likelihood of same day couse is high, especially among men, however, underlying mechanisms to their couse and its sex-dependent nature remain poorly understood. This study aims to elucidate the effects of controlled a...

journal_title：Experimental and clinical psychopharmacology

authors： Venegas A,Meredith LR,Green R,Cooper ZD,Ray LA

更新日期：2020-07-13 00:00:00

abstract：:Six features of the report are commented on. First, the Therapeutic Workplace intervention described in the report represents a creative and promising new approach to drug abuse treatment. Second, to the author's knowledge, it represents the first intervention that has been shown in a randomized clinical trial to sign...

journal_title：Experimental and clinical psychopharmacology

authors： Higgins ST

更新日期：2001-02-01 00:00:00

abstract：:The "social lubrication" function of alcohol during interpersonal interactions is well documented. However, less is known about the effects of alcohol consumption on group-level behavior. Empirical findings from social psychological literature suggest that individuals tend to favor those who are considered as members ...

journal_title：Experimental and clinical psychopharmacology

authors： Zhou J,Heim D,Monk R,Levy A,Pollard P

更新日期：2018-06-01 00:00:00

abstract：:In this experiment, the observing-response procedure was adapted for use with drug self-administration. Rats' responding for oral ethanol was sometimes reinforced on a random-ratio schedule, whereas at other times it had no effect (i.e., extinction). Behavior producing stimuli associated with the otherwise unsignaled ...

journal_title：Experimental and clinical psychopharmacology

authors： Shahan TA

更新日期：2002-02-01 00:00:00

abstract：:The affectively valenced scripts used by S. Tiffany (1990) suggest that different scripts produce relatively equivalent levels of cue reactivity, although it is unclear if these laboratory findings generalize to clinical samples. In this study, cessation-motivated smokers were tested 7 days before they tried to quit s...

journal_title：Experimental and clinical psychopharmacology

authors： Shadel WG,Niaura R,Abrams DB,Goldstein MG,Rohsenow DJ,Sirota AD,Monti PM

更新日期：1998-05-01 00:00:00

abstract：:Repeated drug administration results in sensitization, tolerance, or no change in subsequent drug-induced alterations of motivated behaviors, such as intracranial self-stimulation (ICSS). For example, repeated mu-opioid agonist administration results in increased expression of mu agonist-induced facilitation of ICSS. ...

journal_title：Experimental and clinical psychopharmacology

authors： Faunce KE,Banks ML

更新日期：2020-02-01 00:00:00

abstract：:Cocaine dependence constitutes a significant public health concern. This randomized, double-blind, placebo-controlled trial tested a novel approach to reducing cocaine use among cocaine-dependent individuals with d-cycloserine, a drug known to enhance learning and some learning-based therapies. Urine samples and cocai...

journal_title：Experimental and clinical psychopharmacology

authors： Johnson MW,Bruner NR,Johnson PS,Silverman K,Berry MS

更新日期：2020-04-01 00:00:00

abstract：:In this study, crack/cocaine-dependent (CD) and non-drug-using matched control (MC) participants were presented with hypothetical immediate and delayed rewards, with 16 delay conditions ranging from 5 min to 25 years. All participants were presented with hypothetical monetary rewards; however, the CD group was also pr...

journal_title：Experimental and clinical psychopharmacology

authors： Coffey SF,Gudleski GD,Saladin ME,Brady KT

更新日期：2003-02-01 00:00:00

abstract：:Lapses within the first 2 weeks of a smoking cessation attempt are strongly associated with a return to regular smoking (S. L. Kenford et al., 1994). Unfortunately, little is known about how to prevent an initial lapse from progressing to a full relapse, and presently there are no validated lapse-responsive therapeuti...

journal_title：Experimental and clinical psychopharmacology

authors： Juliano LM,Houtsmuller EJ,Stitzer ML

更新日期：2006-11-01 00:00:00

abstract：:Pramipexole (PPX) is a dopamine agonist medication that has been implicated in the development of pathological gambling and other impulse control disorders. Johnson, Madden, Brewer, Pinkston, and Fowler (2011) reported that PPX increased male rats' preference for gambling-like rewards (those arranged according to a va...

journal_title：Experimental and clinical psychopharmacology

authors： Johnson PS,Madden GJ,Stein JS

更新日期：2012-06-01 00:00:00

abstract：:Some sons of male alcoholics (SOMAs) are characterized by an increased heart rate (HR) response to alcohol intoxication, which is thought to reflect increased sensitivity to alcohol-induced reward. Such a response has also been related to increased physical aggression. However, the confounding effect of aggression in ...

journal_title：Experimental and clinical psychopharmacology

authors： Assaad JM,Pihl RO,Séguin JR,Nagin D,Vitaro F,Carbonneau R,Tremblay RE

更新日期：2003-05-01 00:00:00

abstract：:Substance use disorders and pathological gambling share similarities in terms of diagnostic criteria, epidemiology, and clinical course. However, relatively few studies have evaluated the efficacy of treatments for gambling disorders. As interest in pathological gambling grows, adaptation of effective treatments from ...

journal_title：Experimental and clinical psychopharmacology

authors： Petry NM

更新日期：2002-08-01 00:00:00

abstract：:Craving has been added as an alcohol use disorder (AUD) symptom in DSM-5 but relatively few nosological studies have directly examined the empirical basis for doing so. The current study investigated the validity of craving as an AUD symptom in a sample of heavy drinking treatment-seeking individuals. Using a semistru...

journal_title：Experimental and clinical psychopharmacology

authors： Murphy CM,Stojek MK,Few LR,Rothbaum AO,Mackillop J

更新日期：2014-02-01 00:00:00

abstract：:W. J. Lynch and M. E. Carroll (2001) suggested 3 processes that contribute to the regulation of drug intake over time when drugs serve as reinforcers. The commentator suggests that none of these processes are necessary for drugs to function as reinforcers and hence are either secondary or superfluous to the study of d...

journal_title：Experimental and clinical psychopharmacology

authors： Woods JH

更新日期：2001-05-01 00:00:00

abstract：:Varenicline reduces drinking in people with alcohol use disorder, but little is known about the mechanisms underlying this effect. Varenicline targets α4β2 and α7 nicotinic acetylcholine receptors, which are associated with several cognitive functions such as working memory. Varenicline may improve drinking outcomes b...

journal_title：Experimental and clinical psychopharmacology

authors： Roberts W,McKee SA

更新日期：2018-02-01 00:00:00