Effects of repeated kappa-opioid receptor agonist U-50488 treatment and subsequent termination on intracranial self-stimulation in male and female rats.

Abstract:

:Repeated drug administration results in sensitization, tolerance, or no change in subsequent drug-induced alterations of motivated behaviors, such as intracranial self-stimulation (ICSS). For example, repeated mu-opioid agonist administration results in increased expression of mu agonist-induced facilitation of ICSS. Acute kappa-opioid receptor (KOR) agonist administration depresses ICSS; however, effects of repeated KOR agonist administration on ICSS are unknown. This study determined effects of daily KOR agonist U-50488 administration and subsequent termination on ICSS in male and female rats. Female (n = 5) and male (n = 6) Sprague-Dawley rats were trained to respond for electrical brain stimulation under a frequency-rate ICSS procedure. Sequential U-50488 dose-effect functions (1-5.6 mg/kg, intraperitoneal) were determined every 7 days over a 21-day experimental period during which saline and increasing U-50488 doses (3.2-5.6 mg/kg, intraperitoneal) were administered on intervening days. Sequential U-50488 dose-effect functions were also determined 7 and 28 days after termination of repeated U-50488 administration. U-50488 dose-dependently depressed ICSS in both female and male rats. There were no sex differences on either initial or repeated U-50488 treatment effects. Repeated 5.6 mg/kg U-50488 administration produced selective tolerance to the rate-decreasing, but not threshold-altering, effects of 5.6 mg/kg U-50488 during sequential dose-effect test sessions. Neither repeated U-50488 administration nor termination of U-50488 significantly altered baseline ICSS. Overall, these results suggest neither tolerance nor sensitization develops to the depressive-like effects of repeated KOR agonist activation. Selective tolerance to the rate-decreasing effects of repeated KOR agonist administration may have implications for elucidating the neurobiological processes involved in long-term abused drug self-administration. (PsycINFO Database Record (c) 2020 APA, all rights reserved).

authors

Faunce KE,Banks ML

doi

10.1037/pha0000287

subject

Has Abstract

pub_date

2020-02-01 00:00:00

pages

44-54

issue

1

eissn

1064-1297

issn

1936-2293

pii

2019-21966-001

journal_volume

28

pub_type

杂志文章
  • Genetic influences on delayed reward discounting: A genome-wide prioritized subset approach.

    abstract::Delayed reward discounting (DRD) is a behavioral economic measure of impulsivity that has been consistently associated with addiction. It has also been identified as a promising addiction endophenotype, linking specific sources of genetic variation to individual risk. A challenge in the studies to date is that levels ...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1037/pha0000227

    authors: MacKillop J,Gray JC,Weafer J,Sanchez-Roige S,Palmer AA,de Wit H

    更新日期:2019-02-01 00:00:00

  • Attentional bias is associated with incentive-related physiological and subjective measures.

    abstract::Drug cue reactivity is theoretically and clinically important. The modified Stroop task has been widely used to assess attention capture by drug cues (attentional bias). Attentional bias to drug cues is assumed to reflect the incentive value of those cues, but this has not been directly tested. The authors examined wh...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1037/a0016658

    authors: Waters AJ,Carter BL,Robinson JD,Wetter DW,Lam CY,Kerst W,Cinciripini PM

    更新日期:2009-08-01 00:00:00

  • Utility of component-process approaches for understanding complex alcohol-related behavior within an executive functioning framework: comment on Giancola (2000).

    abstract::P. R. Giancola's (2000) macroconstruct framework of executive functions (EF) characterizes how cognitive processes work together to inhibit aggressive responding in provocative situations, and how alcohol intoxication increases the likelihood of aggression by disrupting these processes. His framework can be considered...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 评论,杂志文章

    doi:10.1037//1064-1297.8.4.598

    authors: Bates ME

    更新日期:2000-11-01 00:00:00

  • Predicting college student prescription stimulant misuse: An analysis from ecological momentary assessment.

    abstract::Prescription stimulant misuse (PSM) is common in young adult college students, at over 10% in the past year, and it is associated with other substance use and risk behaviors. Research focused on the real-time drivers of PSM is absent, impeding prevention and intervention. This research aimed to fill that gap by examin...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1037/pha0000386

    authors: Schepis TS,Buckner JD,Klare DL,Wade LR,Benedetto N

    更新日期:2020-05-28 00:00:00

  • Development and validation of the Wisconsin Smoking Withdrawal Scale.

    abstract::The accurate assessment of nicotine withdrawal is important theoretically and clinically. A 28-item scale, the Wisconsin Smoking Withdrawal Scale, was developed that contains 7 reliable subscales tapping the major symptom elements of the nicotine withdrawal syndrome. Coefficients alpha for the subscales range from .75...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1037//1064-1297.7.4.354

    authors: Welsch SK,Smith SS,Wetter DW,Jorenby DE,Fiore MC,Baker TB

    更新日期:1999-11-01 00:00:00

  • Effects of estrogen and progesterone on the escalation of cocaine self-administration in female rats during extended access.

    abstract::Estrogen increases and progesterone decreases the acquisition and reinstatement of cocaine-seeking behavior in female rats. Here estrogen and progesterone were studied for their effects on the escalation of cocaine self-administration in female rats. The rats received ovariectomy (OVX) or sham (SH) surgery and were tr...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1037/1064-1297.15.5.461

    authors: Larson EB,Anker JJ,Gliddon LA,Fons KS,Carroll ME

    更新日期:2007-10-01 00:00:00

  • Attentional and approach biases to alcohol cues among young adult drinkers: An ecological momentary assessment study.

    abstract::Alcohol-specific attentional biases (AttB) and approach biases (AppB) are postulated to play a role in alcohol use disorders but their association with drinking in young adults remains unknown. A subsample of young adults with risky alcohol use (N = 296) enrolled in a randomized trial, testing different text message i...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1037/pha0000343

    authors: Suffoletto B,Field M,Chung T

    更新日期:2020-12-01 00:00:00

  • The effects of social contact on drug use: behavioral mechanisms controlling drug intake.

    abstract::The social environment plays a critical role in determining the likelihood that an individual will use drugs or will develop a drug use disorder. Recent evidence obtained from preclinical studies reveals that proximal social factors (i.e., those factors that are immediately present at the time of drug exposure) exert ...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章,评审

    doi:10.1037/a0034669

    authors: Strickland JC,Smith MA

    更新日期:2014-02-01 00:00:00

  • Treatment of heroin-dependent poly-drug abusers with contingency management and buprenorphine maintenance.

    abstract::This study targeted poly-drug (cocaine plus heroin) abstinence among buprenorphine-maintained participants with a 12-week voucher-based reinforcement therapy (VBRT) phase versus a yoked control condition. Baseline levels of cocaine and heroin use were significant predictors of treatment outcome, regardless of treatmen...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 临床试验,杂志文章

    doi:10.1037//1064-1297.8.2.176

    authors: Downey KK,Helmus TC,Schuster CR

    更新日期:2000-05-01 00:00:00

  • Aggressiveness, family history of alcoholism, and the heart rate response to alcohol intoxication.

    abstract::Some sons of male alcoholics (SOMAs) are characterized by an increased heart rate (HR) response to alcohol intoxication, which is thought to reflect increased sensitivity to alcohol-induced reward. Such a response has also been related to increased physical aggression. However, the confounding effect of aggression in ...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1037/1064-1297.11.2.158

    authors: Assaad JM,Pihl RO,Séguin JR,Nagin D,Vitaro F,Carbonneau R,Tremblay RE

    更新日期:2003-05-01 00:00:00

  • Getting back to basics: commentary on McSweeney, Murphy, and Kowal (2005).

    abstract::The review article "Regulation of Drug Taking by Sensitization and Habituation" by F. K. McSweeney, E. S. Murphy, and B. P. Kowal introduces 2 basic principles of behavior, sensitization and habituation, into a comprehensive model for studying drug intake and drug addiction. A key assumption of the model is that the r...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 评论,杂志文章

    doi:10.1037/1064-1297.13.3.187

    authors: Rowlett JK

    更新日期:2005-08-01 00:00:00

  • Personality correlates of caffeine dependence: the role of sensation seeking, impulsivity, and risk taking.

    abstract::The consumption of caffeine has become a growing concern, partially because of the withdrawal properties of the drug. The current study examined personality correlates of caffeine consumption and dependence in 60 university students. Self-report and behavioral measures of sensation seeking, impulsivity, and risk takin...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1037/1064-1297.13.3.259

    authors: Jones HA,Lejuez CW

    更新日期:2005-08-01 00:00:00

  • Effects of abused drugs on psychomotor performance.

    abstract::Some abused drugs have been reported to alter performance on naturalistic tasks such as driving and also on laboratory tasks. The performance effects of several drug classes were examined using a repeated measures design. Eight volunteers were administered 2 doses of ethanol, marijuana, amphetamine, hydromorphone, pen...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1037//1064-1297.5.3.235

    authors: Pickworth WB,Rohrer MS,Fant RV

    更新日期:1997-08-01 00:00:00

  • Effects of reduced nicotine content cigarettes on individual withdrawal symptoms over time and during abstinence.

    abstract::In the United States, the Food and Drug Administration (FDA) has initiated a public dialogue about reducing the nicotine content of cigarettes. A reduced-nicotine standard could increase withdrawal symptoms among current smokers. We examined the impact of switching smokers to cigarettes that varied in nicotine content...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1037/pha0000179

    authors: Dermody SS,McClernon FJ,Benowitz N,Luo X,Tidey JW,Smith TT,Vandrey R,Hatsukami D,Donny EC

    更新日期:2018-06-01 00:00:00

  • Detected, selected, and sometimes neglected: cognitive processing of cues in addiction.

    abstract::It is proposed that potential drug cues are evaluated preattentively, are prioritized, and subsequently trigger somatovisceral, behavioral, and cognitive responses. Throughout, this information processing is subjected to automatized attentional and interpretative biases. These processes can enhance subjective awarenes...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章,评审

    doi:10.1037//1064-1297.10.2.67

    authors: Ryan F

    更新日期:2002-05-01 00:00:00

  • Impulsive choice as a predictor of acquisition of IV cocaine self- administration and reinstatement of cocaine-seeking behavior in male and female rats.

    abstract::Drug abuse and impulsive choice are related in humans. In female rats, impulsive choice predicted the rate of acquisition of IV cocaine self-administration. The objectives of the present experiments were to: (a) compare impulsive choice in males and females, (b) extend previous research on impulsive choice and acquisi...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1037/1064-1297.16.2.165

    authors: Perry JL,Nelson SE,Carroll ME

    更新日期:2008-04-01 00:00:00

  • Craving is associated with smoking relapse: findings from three prospective studies.

    abstract::In a combined sample of more than 2600 smokers, immediate postcessation craving is shown to be prospectively associated with smokers' ability to maintain abstinence. Relapse is strikingly rapid among those reporting high levels of craving following cessation. More than 32% of those with high craving scores relapsed wi...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1037//1064-1297.5.2.137

    authors: Killen JD,Fortmann SP

    更新日期:1997-05-01 00:00:00

  • Modeling the effects of combined behavioral and pharmacological treatment on cigarette smoking: behavioral-economic analyses.

    abstract::Effects of different response requirements, response-independent cigarette puffs, and an alternative nondrug reinforcer on cigarette smoking were assessed in 2 experiments. The response requirement to obtain 2 puffs on a cigarette was manipulated while various numbers of response-independent puffs were provided (0, 6,...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 临床试验,杂志文章

    doi:10.1037//1064-1297.5.4.334

    authors: Bickel WK,Madden GJ,DeGrandpre RJ

    更新日期:1997-11-01 00:00:00

  • Contingency management in cocaine abusers: a dose-effect comparison of goods-based versus cash-based incentives.

    abstract::Goods-based contingency management interventions (e.g., those using vouchers or prizes as incentives) have demonstrated efficacy in reducing cocaine use, but cost has limited dissemination to community clinics. Recent research suggests that development of a cash-based contingency management approach may improve treatm...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 临床试验,杂志文章

    doi:10.1037/1064-1297.15.4.338

    authors: Vandrey R,Bigelow GE,Stitzer ML

    更新日期:2007-08-01 00:00:00

  • Role of progesterone in nicotine addiction: evidence from initiation to relapse.

    abstract::Nicotine addiction continues to be the main cause of preventable death in developed countries. Women and teen girls appear to be more vulnerable on certain aspects of nicotine addiction compared with men and boys. While the mechanism of gender differences in nicotine addiction is not yet clear, evidence suggests that ...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章,评审

    doi:10.1037/a0021265

    authors: Lynch WJ,Sofuoglu M

    更新日期:2010-12-01 00:00:00

  • Drinking to distraction: does alcohol increase attentional bias in adults with ADHD?

    abstract::Previous research has shown that social drinkers continue to show attentional bias toward alcohol-related stimuli even after consuming a moderate dose of alcohol. In contrast, little is known about how alcohol acutely affects attentional bias in groups at risk to develop alcohol-related problems, such as adults with a...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1037/a0026379

    authors: Roberts W,Fillmore MT,Milich R

    更新日期:2012-04-01 00:00:00

  • The roles of sex, anxious reactivity to bodily arousal, and anxiety sensitivity in coping motives for cigarette smoking among adolescents.

    abstract::Evidence suggests that smoking to cope among adolescents is associated with a number of problematic outcomes (e.g., greater smoking frequency, higher rates of dependence). It is thus imperative to better understand factors that may increase the likelihood of smoking to cope among adolescents. Research suggests anxiety...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1037/pha0000071

    authors: Bilsky SA,Feldner MT,Knapp AA,Rojas SM,Leen-Feldner EW

    更新日期:2016-06-01 00:00:00

  • Nicotine reduces the frequency of anger reports in smokers and nonsmokers with high but not low hostility: an ambulatory study.

    abstract::Two studies were conducted to determine the anger-attenuating effects of nicotine as a function of trait hostility. The 1st study examined the effects of nicotine on diary ratings of anger during a 24-hr period in a natural setting in 30 smokers and 30 nonsmokers. Participants took part in 2 monitoring sessions involv...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1037//1064-1297.7.4.454

    authors: Jamner LD,Shapiro D,Jarvik ME

    更新日期:1999-11-01 00:00:00

  • Dose effects of triazolam and alcohol on cognitive performance in healthy volunteers.

    abstract::Benzodiazepines and alcohol are widely used psychoactive substances that have performance-impairing effects. Research suggests that the impairment profiles for benzodiazepines and alcohol differ, although few cognitive psychopharmacological studies have directly compared these drugs. This double-blind, double-dummy, p...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1037/a0018407

    authors: Kleykamp BA,Griffiths RR,Mintzer MZ

    更新日期:2010-02-01 00:00:00

  • Characterizing nicotine withdrawal in pregnant cigarette smokers.

    abstract::Maternal smoking is a leading preventable cause of poor pregnancy outcomes and infant morbidity and mortality. Whereas pregnancy has been thought of as a "window of opportunity" when women are more motivated to change health behaviors such as smoking, only 20% of pregnant women quit smoking upon learning they are preg...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1037/1064-1297.14.2.165

    authors: Heil SH,Higgins ST,Mongeon JA,Badger GJ,Bernstein IM

    更新日期:2006-05-01 00:00:00

  • Delay discounting of cocaine by rhesus monkeys.

    abstract::The present, subjective value of a reinforcer typically decreases as a function of the delay to its receipt, a phenomenon termed delay discounting. Delay discounting, which is assumed to reflect impulsivity, is hypothesized to play an important role in drug abuse. The present study examined delay discounting of cocain...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1037/1064-1297.15.3.238

    authors: Woolverton WL,Myerson J,Green L

    更新日期:2007-06-01 00:00:00

  • Experimental study on the effects of anxiety sensitivity and somatosensory amplification on the response to the 35% CO₂ challenge in abstinent smokers.

    abstract::The relationship between nicotine abstinence and panic onset is still not well understood and the role of catastrophic misinterpretation, as possible moderator or mediator of this relationship, is unknown. We tested whether nicotine abstinence influences the response to a CO₂ panic challenge and whether catastrophic m...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1037/pha0000048

    authors: Cosci F,Ibrahim HM,Nannini A,Schruers K

    更新日期:2015-12-01 00:00:00

  • Patterns of opioid and cocaine co-use: a descriptive study in a Canadian sample of untreated opioid-dependent individuals.

    abstract::This study examined prevalence and patterns of co-use of opioids and cocaine in regular users of illicit opioids (N = 729) recruited from 5 Canadian cities. Fifty-seven percent (n = 417) reported having used both opioids and cocaine in the month and week preceding the interview; of these, 73% (n = 304) were able to id...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1037/1064-1297.13.4.303

    authors: Leri F,Stewart J,Fischer B,Jürgen R,Marsh DC,Brissette S,Bruneau J,El-Guebaly N,Noël L,Tyndall MW,Wild TC

    更新日期:2005-11-01 00:00:00

  • "Buzzwords": Crowd-sourcing and quantifying U.S. young adult terminology for subjective effects of alcohol and marijuana use.

    abstract::Prevalence of heavy alcohol use remain high, and daily marijuana use is at an all-time high in young adults. As perceptions of drug effects may guide risky decision making, understanding subjective feelings for alcohol and marijuana use is critical. Existing laboratory-based and diary metrics (0-100 rating of "how dru...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1037/pha0000344

    authors: Linden-Carmichael AN,Masters LD,Lanza ST

    更新日期:2020-12-01 00:00:00

  • Alternate versions of a fixed-choice, delay-discounting assessment for repeated-measures designs.

    abstract::Delay discounting, reflected in the tendency to prefer immediate rewards over delayed rewards, is associated with most forms of problematic substance use. When assessed multiple times to examine within-individual changes, for example, following acute drug administration or an intervention, shifts in delay discounting ...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1037/pha0000211

    authors: Kuang J,Milhorn H,Stuppy-Sullivan A,Jung S,Yi R

    更新日期:2018-10-01 00:00:00