Abstract:
:Nicotine addiction continues to be the main cause of preventable death in developed countries. Women and teen girls appear to be more vulnerable on certain aspects of nicotine addiction compared with men and boys. While the mechanism of gender differences in nicotine addiction is not yet clear, evidence suggests that while estrogen may underlie enhanced vulnerability in females, progesterone may protect females. Thus, progesterone may have therapeutic use for tobacco addiction, especially in female smokers. A greater understanding of the role of progesterone in nicotine addiction is important not only from a treatment standpoint, but also from a prevention standpoint: hormone transition phases, such as those that occur at adolescence, and during pregnancy and following birth, as well as following hormonal manipulation (e.g., using methods of hormonal birth control), may all contribute to changes in vulnerability to nicotine addiction. In this review, we summarize recent evidence from clinical and preclinical studies examining the role of progesterone in nicotine addiction focusing on its role during initiation of use and during later phases of the addiction process as a potential relapse prevention treatment. We conclude with future directions including further examination of progesterone as a potential intervention and treatment of nicotine addiction.
journal_name
Exp Clin Psychopharmacoljournal_title
Experimental and clinical psychopharmacologyauthors
Lynch WJ,Sofuoglu Mdoi
10.1037/a0021265subject
Has Abstractpub_date
2010-12-01 00:00:00pages
451-61issue
6eissn
1064-1297issn
1936-2293pii
2010-26426-001journal_volume
18pub_type
杂志文章,评审abstract::Nicotine administration has been found to enhance performance on tasks of selective attention. It has been proposed that efficient attentional filtering depends on the successful inhibition of distracting information. In the work reported here, a negative priming paradigm was adopted to test whether smoking enhanced t...
journal_title:Experimental and clinical psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1037//1064-1297.8.1.104
更新日期:2000-02-01 00:00:00
abstract::Benzodiazepines and alcohol are widely used psychoactive substances that have performance-impairing effects. Research suggests that the impairment profiles for benzodiazepines and alcohol differ, although few cognitive psychopharmacological studies have directly compared these drugs. This double-blind, double-dummy, p...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037/a0018407
更新日期:2010-02-01 00:00:00
abstract::Dopamine acts through dopamine Type I receptors (comprising D1 and D5 subtypes) and dopamine Type II receptors (comprising D2, D3, and D4 subtypes). Intracranial self-stimulation (ICSS) is 1 experimental procedure that can be used to evaluate abuse-related effects of drugs targeting dopamine receptors. This study eval...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037/pha0000067
更新日期:2016-06-01 00:00:00
abstract::In Experiment 1, the effect of repeated injections of 2.5, 5.0, or 10.0 mg/kg of chlordiazepoxide (CDP) on food intake and body weight was studied in rats on an activity anorexia (AA) regimen. For several days before CDP testing began, rats lived in activity wheels and had one 60-min meal per day. During CDP testing, ...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037//1064-1297.6.4.360
更新日期:1998-11-01 00:00:00
abstract::Two studies were conducted to determine the anger-attenuating effects of nicotine as a function of trait hostility. The 1st study examined the effects of nicotine on diary ratings of anger during a 24-hr period in a natural setting in 30 smokers and 30 nonsmokers. Participants took part in 2 monitoring sessions involv...
journal_title:Experimental and clinical psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1037//1064-1297.7.4.454
更新日期:1999-11-01 00:00:00
abstract::Effects of different response requirements, response-independent cigarette puffs, and an alternative nondrug reinforcer on cigarette smoking were assessed in 2 experiments. The response requirement to obtain 2 puffs on a cigarette was manipulated while various numbers of response-independent puffs were provided (0, 6,...
journal_title:Experimental and clinical psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1037//1064-1297.5.4.334
更新日期:1997-11-01 00:00:00
abstract::Substance use disorders and pathological gambling share similarities in terms of diagnostic criteria, epidemiology, and clinical course. However, relatively few studies have evaluated the efficacy of treatments for gambling disorders. As interest in pathological gambling grows, adaptation of effective treatments from ...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章,评审
doi:10.1037//1064-1297.10.3.184
更新日期:2002-08-01 00:00:00
abstract::Heavy smokers (N = 408, smoking more than 25 cigarettes/day) were randomized to receive high-dose (25 mg) or standard-dose (15 mg) nicotine patch therapy delivered during the daytime only (16 hr) for a period of 6 weeks. Treatment effects of each dose were similar. The percentages of participants not smoking at 2-, 6-...
journal_title:Experimental and clinical psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1037//1064-1297.7.3.226
更新日期:1999-08-01 00:00:00
abstract::Discounting is a behavioral phenomenon in which the value of an outcome diminishes as a function of its increased delay or decreased probability and is related to substance abuse research because of its theoretical ties with behavioral models of impulsive choice. Research to date suggests that hypothetical outcomes us...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037/a0024141
更新日期:2011-08-01 00:00:00
abstract::The link between social influence and drug abuse has long been established in humans. However, preclinical animal models of drug abuse have only recently begun to consider the role of social influence. Since social factors influence the initiation and maintenance of drug use in humans, it is important to include these...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037/a0024682
更新日期:2011-12-01 00:00:00
abstract::Cocaine dependence constitutes a significant public health concern. This randomized, double-blind, placebo-controlled trial tested a novel approach to reducing cocaine use among cocaine-dependent individuals with d-cycloserine, a drug known to enhance learning and some learning-based therapies. Urine samples and cocai...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1037/pha0000306
更新日期:2020-04-01 00:00:00
abstract::The present study primarily sought to (a) determine the effects of environmental context on subjective ratings of craving for alcohol and caffeinated alcohol beverages (CAB) and (b) test inhibitory control, a state behavioral aspect of impulsivity, as a mediator of the association between context and craving in a samp...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1037/pha0000160
更新日期:2017-12-01 00:00:00
abstract::Aerobic exercise can acutely reduce cigarette cravings during periods of nicotine deprivation. The primary aim of this study was to assess the differential effects of light and vigorous intensity aerobic exercise on cigarette cravings, subjective and physiological reactivity to smoking cues, and affect after overnight...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1037/a0032768
更新日期:2013-06-01 00:00:00
abstract::Cigarette smoking is highly prevalent among patients who are being treated for opioid-dependence, yet there have been limited scientific efforts to promote smoking cessation in this population. Contingency management (CM) is a behavioral treatment that provides monetary incentives contingent upon biochemical evidence ...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037/a0022039
更新日期:2011-02-01 00:00:00
abstract::Nonpharmacological cues associated with drug intake may influence subjective and reinforcing effects of those drugs. Social drinkers (N = 80) participated in 2 sessions in which they rated and then consumed ad lib their preferred beer (with participants blind to brand). Visual and olfactory stimuli were obscured durin...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037/1064-1297.11.4.269
更新日期:2003-11-01 00:00:00
abstract::It is proposed that potential drug cues are evaluated preattentively, are prioritized, and subsequently trigger somatovisceral, behavioral, and cognitive responses. Throughout, this information processing is subjected to automatized attentional and interpretative biases. These processes can enhance subjective awarenes...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章,评审
doi:10.1037//1064-1297.10.2.67
更新日期:2002-05-01 00:00:00
abstract::The present study explores the relation among 4 personality traits associated with impulsive behavior and alcohol abuse. Personality traits were measured using the 4 subscales of the UPPS Impulsive Behavior Scale (UPPS; S. P. Whiteside & D. R. Lynam, 2001). The UPPS and measures of psychopathology were administered to...
journal_title:Experimental and clinical psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1037/1064-1297.11.3.210
更新日期:2003-08-01 00:00:00
abstract::Although marijuana is the most commonly used illicit drug in the United States, it is not established whether withdrawal from chronic use results in a clinically significant abstinence syndrome. The present study was conducted to characterize symptoms associated with marijuana withdrawal following chronic use during a...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037//1064-1297.8.4.483
更新日期:2000-11-01 00:00:00
abstract::In community-based alcoholism and drug abuse treatment programs, the vast majority of interventions are delivered in a group therapy context. In turn, treatment providers and funding agencies have called for more research on interventions delivered in groups in an effort to make the emerging empirical literature on th...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章,评审
doi:10.1037/1064-1297.14.2.265
更新日期:2006-05-01 00:00:00
abstract::Evidence suggests that smoking to cope among adolescents is associated with a number of problematic outcomes (e.g., greater smoking frequency, higher rates of dependence). It is thus imperative to better understand factors that may increase the likelihood of smoking to cope among adolescents. Research suggests anxiety...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037/pha0000071
更新日期:2016-06-01 00:00:00
abstract::In this experiment, the observing-response procedure was adapted for use with drug self-administration. Rats' responding for oral ethanol was sometimes reinforced on a random-ratio schedule, whereas at other times it had no effect (i.e., extinction). Behavior producing stimuli associated with the otherwise unsignaled ...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037//1064-1297.10.1.3
更新日期:2002-02-01 00:00:00
abstract::Delayed reward discounting (DRD) is a behavioral economic measure of impulsivity that has been consistently associated with addiction. It has also been identified as a promising addiction endophenotype, linking specific sources of genetic variation to individual risk. A challenge in the studies to date is that levels ...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037/pha0000227
更新日期:2019-02-01 00:00:00
abstract::Substantial evidence links greater impulsivity and stress exposure to poorer smoking cessation outcomes. Results from adolescents also indicate that stress-related change in risk taking can impede cessation attempts. We investigated the effects of stress-related change in impulsivity, risk taking, attention and nicoti...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037/pha0000066
更新日期:2016-04-01 00:00:00
abstract::The present study investigated the effects of chronic pre-exposure to methamphetamine on sexual motivation and performance in male Japanese quail. Quail were pre-exposed to methamphetamine (1.0 or 3.0 mg/kg ip) or saline (ip) once daily for 10 days and locomotor activity was measured. After a 10 day washout period, se...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037/a0014505
更新日期:2009-02-01 00:00:00
abstract::The effects of methylphenidate (MPH) on performance of a time-production task were studied in 17 children with attention-deficit/hyperactivity disorder who participated in 1 test session on and 1 off MPH. Participants held a response lever down for at least 10 but no longer than 14 s. Administration of MPH had no effe...
journal_title:Experimental and clinical psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1037/1064-1297.12.1.57
更新日期:2004-02-01 00:00:00
abstract::Prevalence of heavy alcohol use remain high, and daily marijuana use is at an all-time high in young adults. As perceptions of drug effects may guide risky decision making, understanding subjective feelings for alcohol and marijuana use is critical. Existing laboratory-based and diary metrics (0-100 rating of "how dru...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037/pha0000344
更新日期:2020-12-01 00:00:00
abstract::Previous field research has shown that individuals consumed more alcohol and at a faster rate in environments paired with loud music. Theoretically, this effect has been linked to approach/avoidance accounts of how music influences arousal and mood, but no work has tested this experimentally. In the present study, fem...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037/a0034020
更新日期:2013-10-01 00:00:00
abstract::Previous research has shown that social drinkers continue to show attentional bias toward alcohol-related stimuli even after consuming a moderate dose of alcohol. In contrast, little is known about how alcohol acutely affects attentional bias in groups at risk to develop alcohol-related problems, such as adults with a...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037/a0026379
更新日期:2012-04-01 00:00:00
abstract::Despite considerable health risks due to lower levels of estrogen production and the compounding antiestrogenic effects of nicotine, postmenopausal females continue to smoke. These females face significant barriers to cessation, including negative affect, weight concerns, and menopausal symptom severity. The current p...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1037/pha0000191
更新日期:2018-04-01 00:00:00
abstract::Sprague-Dawley (Rattus norvegicus) rats were trained in a drug discrimination task using the state-dependent interoceptive stimulus attributes of cocaine's delayed or rebound effects (CDE) versus "normal" basal homeostasis. Rats were injected with either 32 mg/kg cocaine or equivalent volumes of saline (SAL), subcutan...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037//1064-1297.6.3.264
更新日期:1998-08-01 00:00:00